Prominent publications by Kyle M Porter

KOL Index score: 16144

Background: The Afirma Gene Expression Classifier (GEC) has been used to further characterize cytologically indeterminate (cyto-I) thyroid nodules into either benign or suspicious categories. However, its relatively low positive predictive value (PPV) limited its use as a classifier for patients with suspicious results. The Afirma Gene Sequencing Classifier (GSC) was developed to improve PPV while maintaining a high negative predictive value (NPV), yet real-world assessment of its ...

Known for Gec Gsc |  Gene Expression |  Thyroid Nodules |  Sequencing Classifier |  Bethesda Iii
KOL Index score: 13971

BACKGROUND: A majority of the nearly 2 million Americans living with limb loss suffer from chronic pain in the form of neuroma-related residual limb and phantom limb pain (PLP). Targeted muscle reinnervation (TMR) surgically transfers amputated nerves to nearby motor nerves for prevention of neuroma. The objective of this study was to determine whether TMR at the time of major limb amputation decreases the incidence and severity of PLP and residual limb pain.


Known for Limb Pain |  Tmr Plp |  Targeted Muscle |  Aged Amputation |  Phantom Residual
KOL Index score: 12672

OBJECTIVE: To address how interactions between polyunsaturated fatty acid (PUFA) levels and depressive symptoms were related to proinflammatory cytokine synthesis. Depression and stress promote proinflammatory cytokine production. Dietary intakes of omega-3 (n-3) and omega-6 (n-6) PUFAs also influence inflammation; high n-6:n-3 ratios enhance proinflammatory cytokine production, although n-3 has anti-inflammatory properties.

METHODS: Blood samples from 43 older adults (mean age = 66.67 ...

Known for Fatty Acids |  Depressive Symptoms |  N3 Ratios |  Pufas Inflammation |  Omega6 Omega3
KOL Index score: 12480

STUDY OBJECTIVES: Poor sleep promotes inflammation. In turn, inflammation is a causal mechanism in term as well as preterm parturition. In the United States, a persistent racial disparity in preterm birth exists, with African Americans showing ∼1.5 times greater risk. This study examined associations among sleep quality, serum proinflammatory cytokines, and length of gestation in a racially diverse sample of 138 pregnant women.

DESIGN: Observational.

MEASUREMENTS: Women completed the ...

Known for African Americans |  Sleep Quality |  Preterm Birth |  Length Gestation |  Greater Risk
KOL Index score: 12159

OBJECTIVE: Adverse pregnancy outcomes, including preterm birth, are markedly higher among African-Americans versus Whites. Stress-induced immune dysregulation may contribute to these effects. Epstein-Barr virus (EBV) reactivation provides a robust model for examining cellular immune competence. This study examined associations of EBV virus capsid antigen immunoglobulin G (VCA IgG) with gestational stage, race, and racial discrimination in women during pregnancy and postpartum.


Known for Racial Discrimination |  Barr Virus |  Pregnancy Postpartum |  African Women |  Ebv Antibody
KOL Index score: 11686

BACKGROUND: The thyrotropin (TSH) level or duration of thyroid hormone withdrawal (THW) required to detect stimulated thyroglobulin (Tg) in differentiated thyroid cancer (DTC) monitoring is unknown. The objective of this study was to evaluate the TSH cutoff of >30 μU/mL as a means to detect stimulated Tg ≥2 ng/mL after THW (THW-Tg≥2), and sensitivity of the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) questionnaire for detecting hypothyroid symptoms.

METHODS: This ...

Known for Thyroid Cancer |  Serum Thyrotropin |  Thw Tsh |  Thyroxine Withdrawal |  Patients Tg
KOL Index score: 11371

OBJECTIVE: To compare targeted muscle reinnervation (TMR) to "standard treatment" of neuroma excision and burying into muscle for postamputation pain.

SUMMARY BACKGROUND DATA: To date, no intervention is consistently effective for neuroma-related residual limb or phantom limb pain (PLP). TMR is a nerve transfer procedure developed for prosthesis control, incidentally found to improve postamputation pain.

METHODS: A prospective, randomized clinical trial was conducted. 28 amputees with ...

Known for Phantom Pain |  Plp Tmr |  Targeted Muscle Reinnervation |  Nerve Transfer |  Major Limb
KOL Index score: 11028

Mechanistic pathways linking maternal polyunsaturated fatty acid (PUFA) status with gestational length are poorly delineated. This study examined whether inflammation and sleep quality serve as mediators, focusing on the antiinflammatory ω-3 docosahexaenoic acid (DHA; 22:6n3) and proinflammatory ω-6 arachidonic acid (AA; 20:4n6). Pregnant women (n = 135) provided a blood sample and completed the Pittsburgh Sleep Quality Index (PSQI) at 20-27 weeks gestation. Red blood cell (RBC) fatty ...

Known for Sleep Quality |  Pregnant Women |  Fatty Acid |  African Americans |  Preterm Birth
KOL Index score: 10916

BACKGROUND: Hospitalizations for heart failure are associated with a high post-discharge risk for mortality. Identification of modifiable predictors of post-discharge mortality during hospitalization may improve outcome. Sleep disordered breathing (SDB) is the most common co-morbidity in heart failure patients.

DESIGN, SETTING, AND PARTICIPANTS: Prospective cohort study of patients hospitalized with acute heart failure (AHF) in a single academic heart hospital. Between January 2007 and ...

Known for Heart Failure |  Patients Ahf |  Sleep Disordered Breathing |  Csa Osa |  Hospitalized Acute
KOL Index score: 10817

BACKGROUND: Despite high prevalence and clinical implications of disturbed sleep during pregnancy, information on changes in sleep across pregnancy and postpartum is incomplete. Moreover, predictors of differential patterns of sleep quality across the perinatal period are poorly defined.

METHODS: This study examined subjective sleep quality using the Pittsburgh Sleep Quality Index during each trimester of pregnancy and at 4-11 weeks postpartum among 133 women inclusive of nulliparous and ...

Known for Sleep Quality |  Trimester Pregnancy |  Postpartum Period |  African Americans |  Clinical Implications
KOL Index score: 10679

BACKGROUND & AIMS: Imaging patterns from endoscopic ultrasound (EUS)-guided needle-based confocal laser endomicroscopy (nCLE) have been associated with specific pancreatic cystic lesions (PCLs). We compared the accuracy of EUS with nCLE in differentiating mucinous from nonmucinous PCLs with that of measurement of carcinoembryonic antigen (CEA) and cytology analysis.

METHODS: We performed a prospective study of 144 consecutive patients with a suspected PCL (≥20 mm) who underwent EUS with ...

Known for Endoscopic Ultrasound |  Eus Ncle |  Pancreatic Cystic Lesions |  Guided Confocal |  Mucinous Pcls
KOL Index score: 10357

BACKGROUND: Hospitalized heart failure patients have a high readmission rate. We sought to determine the independent risk due to central sleep apnea (CSA) of readmission in patients with systolic heart failure (SHF).

METHODS AND RESULTS: This was a prospective observational cohort study of hospitalized patients with SHF. Patients underwent sleep studies during their hospitalization and were followed for 6 months to determine their rate of cardiac readmissions; 784 consecutive patients ...

Known for Central Sleep Apnea |  Heart Failure |  Hospitalized Patients |  Sdb Csa |  Sleep Studies
KOL Index score: 10236

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC), pancreatic neuroendocrine tumors (pNET), and metastatic lesions (pMET) are the most common neoplastic solid pancreatic lesions (SPLs). Early diagnosis enables prompt treatment.

OBJECTIVE: To identify factors differentiating PDAC from non-PDAC lesions and assess the accuracy of EUS-guided FNA.

DESIGN AND SETTING: Retrospective tertiary center.

PATIENTS AND INTERVENTION: Consecutive patients referred for EUS evaluation of SPLs from 2004 ...

Known for Pancreatic Lesions |  Eusfna Pdac |  Neoplastic Spls |  Ductal Adenocarcinoma |  Positive Predictive
KOL Index score: 10032

OBJECTIVE: Self-rated health is a strong independent predictor of mortality after accounting for objective health status, behavioral risk factors, and sociodemographic characteristics. However, mechanisms underlying this association are largely unexplained. Inflammation has been associated with increased risk of morbidity and mortality in the elderly. The current study aimed to: (1) examine associations between self-rated health and serum inflammatory markers in older adults; (2) examine ...

Known for Rated Health |  Inflammatory Markers |  Association Inflammation |  Relative Strength |  Creactive Protein
KOL Index score: 9863

BACKGROUND: The maternal immune system undergoes substantial changes to support healthy pregnancy. Although obesity is a primary driver of inflammation and predictive of perinatal complications, additive effects of pregnancy and obesity on changes in inflammatory processes are not well delineated.

METHODS: This study examined serum proinflammatory markers interleukin(IL)-6, IL-8, tumor necrosis factor (TNF)-α, IL-1β, and C-reactive protein (CRP) during each trimester of pregnancy and 4-6 ...

Known for Pregnancy Postpartum |  Maternal Body Mass |  Obese Women |  Proinflammatory Markers |  Serum Crp


Kyle M Porter: Influence Statistics

Sample of concepts for which Kyle M Porter is among the top experts in the world.
Concept World rank
ingestion vce #1
physical activity vce #1
exposure heterologous cells #1
ltrs trends #1
pedigree construction intervention #1
prior cancer survivors #1
vce 93 patients #1
susceptibility mucosal infection #1
total transit #1
780–735 #1
calendar year mortality #1
time vce #1
95 transit #1
cellular material susceptibility #1
ingestion endoscopic #1
deployment oral #1
bmi vce #1
bmi vce completion #1
vce ingestion #1
survivorship identity individuals #1
687 vce #1
endoscopic deployment patients #1
definitions cancer survivorship #1
vce hospitalized patients #1
117–178 #1
vce oral ingestion #1
oral endoscopic delivery #1
280 oral ingestion #1
36 endoscopic deployment #1
media exposed controls #1
heterologous cells percentage #1
pedigrees communication #1
collection pedigrees #1
shorter bowel #1
intention male medical #1
communication collection #1
cd4 antigens positive #1
vce bmi #1
heterologous cells pathogenesis #1
25054 ltrs #1
identification familial cancer #1
20 endoscopic deployment #1
definitions survivorship #1
351 oral ingestion #1
vce completion #1

Key People For Bariatric Surgery

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Kyle M Porter:Expert Impact

Concepts for whichKyle M Porterhas direct influence:Bariatric surgery,  African americans,  Health behaviors,  Cancer risk,  Nonoperative management,  Video capsule,  Depressive symptoms,  Thyroid cancer.

Kyle M Porter:KOL impact

Concepts related to the work of other authors for whichfor which Kyle M Porter has influence:Heart failure,  Thyroid cancer,  Sleep apnea,  Pregnant women,  Depressive symptoms,  Bariatric surgery,  Fatty acids.



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Department of Biostatistics, The Ohio State University, Columbus, OH 43210, United States | Center for Biostatistics, Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio | Center for Biostatistics, Department of Biomedical

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