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    • Nobuhiro Yuki
    • Nobuhiro Yuki

      Nobuhiro Yuki

      Department of Neurology, Tsukuba Hospital, Tsukuba, Ibaraki, Japan | Yuki Clinic, 1-3-7 Johnan, Mito, Ibaraki 310-0803, Japan;, | Nobuhiro Yuki is at ...



      KOL Resume for Nobuhiro Yuki


      Department of Neurology, Tsukuba Hospital, Tsukuba, Ibaraki, Japan


      Yuki Clinic, 1-3-7 Johnan, Mito, Ibaraki 310-0803, Japan;,


      Nobuhiro Yuki is at the Department of Medicine, Eda Memorial Hospital, Azamino-minami 1-1-1, Aoba-ku, Yokohama, Kanagawa, 225-0012, Japan.


      Department of Neurology, Mishima Hospital, Niigata 940-2302, Japan


      Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

      University of Sydney, Sydney, NSW, Australia.


      Departments of Medicine and Physiology, National University of Singapore, Singapore, Singapore

      Brain & Mind Research Institute, University of Sydney, Sydney, Australia

      Department of Neurology, Dokkyo Medical University, Tochigi 321–0293, Japan


      Departments of Medicine and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Unit 09-01, Centre for Translational Medicine, 14 Medical Drive, 117599, Singapore, Singapore


      Department of Neurology, Dokkyo Medical University, Shimotsuga-gun, Tochigi, Japan;, Department of Medicine, Yong Loo Ling School of Medicine, National University of Singapore, Singapore


      From the Institute of Clinical Neuroimmunology (J.K.M.N., J.M., N.K., R.H., K.D., E.M.), Ludwig Maximilians University, Munich; Max Planck Institute of Neurobiology (J.K.M.N., J.M., N.K., R.H., K.D., E.M.), Martinsried, Germany; Department of Neurology and Biomedicine (T.D.), University Hospital Basel, Basel, Switzerland; Neuroimmunology Unit (M.K., T.O.), Karolinska University Hospital, Stockholm, Sweden; Division of Clinical Neuroscience (C.L.), University of Glasgow, Glasgow, UK; Department of Neurology (M.O.), Dokkyo Medical University School of Medicine, Tochigi, Japan; Department of Neurology (B.T.), Clinical Neuroimmunology Group, Philipps University, Marburg; Departments of Neurology and Experimental Neurology (H.P., J.M.S., L.H.), Charité, Berlin; Neurology Clinic (H.H.), St. Josef-Krankenhaus, Potsdam; Neurology Clinic (C.S.), University Hospital of Würzburg, Würzburg, Germany; Department of Neuroscience (M.N.R.), Baylor College of Medicine, Houston, TX; Department of Molecular Cell Biology (Y.E.-E., E.P.), Weizmann Institute of Science, Rehovot, Israel; and Department of Medicine (N.Y.), Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

      Departments of Microbiology and Medicine, National University of Singapore, 5 Science Drive 2, Blk MD4A, Level 5, 117597, Singapore; Departments of Microbiology and Medicine, National University of Singapore, 5 Science Drive 2, Blk MD4A, Level 5, 117597, Singapore


      Departments of Microbiology and Medicine, National University of Singapore, Science Drive 2, Blk MD4A, Level 5, Singapore 117597, Singapore


      From the Rudolf Magnus Institute of Neuroscience, Department of Neurology (E.A.C., S.P., J.-T.v.A., L.H.v.d.B., W.-L.v.d.P.), and Department of Clinical Neurophysiology (H.F.), University Medical Center Utrecht; Department of Neurology (B.C.J., A.P.T.-G.), Erasmus Medical Center, Rotterdam, the Netherlands; and Departments of Microbiology and Medicine (N.Y.), National University of Singapore.

      Departments of Neurology and Clinical Research, Niigata National Hospital, 3‐52 Akasaka, Kashiwazaki, Niigata 945‐8585, Japan

      5 Department of Medicine, National University of Singapore, 117597, Singapore


      Niigata National Hospital, Niigata, Japan



      Nobuhiro Yuki: Influence Statistics

      Sample of concepts for which Nobuhiro Yuki is among the top experts in the world.
      Concept World rank
      subclass igg #1
      podocytes chronic inflammatory #1
      systemic disorders diseases #1
      ncs findings cases #1
      igg antibody lps #1
      fucogangliosides gd1b #1
      anti galnac #1
      ataxia discovery #1
      intacttype ivig #1
      gq1b seronegative #1
      areflexia muscle weakness #1
      weakness areflexia #1
      gm1b gt1a #1
      ganglioside gangliosides humans #1
      gbs dendritic cells #1
      vascular dementia titers #1
      negative romberg sign #1
      gm1 gangliosidelike structure #1
      bovine gangliosides #1
      neuropathy autoantibodies #1
      overlap acute #1
      chickenpox antigq1b antibody #1
      guillain barré gbs #1
      molecular mimicry gq1b #1
      gm1 anti #1
      gd1a igg #1
      acute motor #1
      anti‐sgpg antibody #1
      ataxic hypersomnolence ophthalmoplegia #1
      jejuni gm1 #1
      conditions continuous spectrum #1
      ataxia cerebellar patients #1
      cidp igg antibodies #1
      mycoplasma gbs #1
      1 cidp sera #1
      anti gq1b #1
      igg anti‐gq1b antibody #1
      gbs preschool contactins #1
      gbs action #1
      paraesthesias miller #1
      overlap fisher syndrome #1
      strains cst #1
      motor axon patients #1
      areflexia gbs variant #1
      gd1b ganglioside #1
      ivig blocks #1
      antigt1aα antibodies #1
      ataxia miller #1
      igg anti‐gd1b #1
      lesion external ophthalmoplegia #1


      Prominent publications by Nobuhiro Yuki

      KOL-Index: 18432

      OBJECTIVES: To clarify the nosological relation among Miller Fisher syndrome (MFS), Guillain-Barré syndrome (GBS) with ophthalmoplegia, Bickerstaff's brain stem encephalitis (BBE), and acute ophthalmoparesis without ataxia. Serum samples from patients with each condition often have anti-GQ1b IgG antibody.

      METHODS: Information on antecedent illness, initial symptoms, neurological signs during the illness, and CSF findings were reviewed in 194 patients with anti-GQ1b IgG. It was determined ...

      Known for Bbe Gbs | Igg Anti | Patients Mfs | Acute Ophthalmoparesis | Antecedent Illness
      KOL-Index: 14762

      Guillain-Barré syndrome is divided into two major subtypes, acute inflammatory demyelinating polyneuropathy and acute motor axonal neuropathy. The characteristic electrophysiological features of acute motor axonal neuropathy are reduced amplitude or absence of distal compound muscle action potentials indicating axonal degeneration. In contrast, autopsy study results show early nodal changes in acute motor axonal neuropathy that may produce motor nerve conduction block. Because the ...

      Known for Conduction Block | Motor Axonal | Ulnar Nerve | 18 Patients | Major Subtypes
      KOL-Index: 14630

      OBJECTIVE: To investigate the presence of serum anti-GT1a IgG in Guillain-Barré syndrome (GBS) and its relation to clinical manifestations.

      BACKGROUND: Several patients with GBS and bulbar palsy have been reported to have serum anti-GT1a IgG. Most, however, also have anti-GQ1b IgG. A previous study failed to detect GT1a in human cranial nerves, but GQ1b was abundant in human ocular motor nerves. Whether anti-GT1a IgG itself determines the clinical manifestations is not yet ...

      Known for Gt1a Igg | Patients Anti | Barré Syndrome | Clinical Manifestations | Gbs Immunoglobulin
      KOL-Index: 14057

      To clarify the relations of the axonal form of Guillain-Barré syndrome (GBS) to anti-ganglioside antibodies and Campylobacter jejuni infection, 86 consecutive Japanese GBS patients were studied. Electrodiagnostic criteria showed acute inflammatory demyelinating polyneuropathy in 36% of the patients and acute motor axonal neuropathy (AMAN) in 38%. Frequent anti-ganglioside antibodies were of the IgG class and against GM1 (40%), GD1a (30%), GalNAc-GD1a (17%), and GD1b (21%). Identified ...

      Known for Jejuni Infection | Ganglioside Antibodies | Patients Aman | Axonal Guillain‐barré Syndrome | Child Child
      KOL-Index: 14034

      OBJECTIVES: To investigate the incidence of hyperreflexia in patients with Guillain-Barré syndrome (GBS), and its relation with electrodiagnosis of acute motor axonal neuropathy (AMAN), antiganglioside GM1 antibody, and Campylobacter jejuni infection. It was reported that patients with AMAN in northern China often had hyperreflexia in the recovery phase.

      METHODS: In 54 consecutive Japanese patients with GBS, sequential findings of tendon reflexes were reviewed. By electrodiagnostic ...

      Known for Patients Hyperreflexia | Acute Motor | Gbs Aman | Barré Syndrome | Abnormal Reflex
      KOL-Index: 13865

      Neurofascin-186 (NF186), neuronal cell adhesion molecule (NrCAM), and gliomedin are adhesion molecules playing a central role in the formation of nodes of Ranvier. In Guillain-Barré syndrome (GBS), immune attack toward the nodes may participate in the disabilities. Autoantibodies to NF186 and gliomedin have been detected in a rat model of GBS. Here, we investigated the prevalence of antibodies against nodal adhesion molecules in patients with GBS or chronic inflammatory demyelinating ...

      Known for Target Antigens | Nodal Proteins | Nf186 Gliomedin | Guillain‐barré Syndrome | Patients Cidp
      KOL-Index: 13191

      IgA has an important function in the gastrointestinal immune system. We investigated IgA anti-ganglioside antibodies in Guillain-Barré syndrome (GBS) and Fisher's syndrome (FS) subsequent to Campylobacter jejuni enteritis. In previous studies, serological diagnosis of C. jejuni infection was based on the detection of IgG, IgA, and IgM anti-C. jejuni antibodies. Our study, however, showed that the detection of IgG anti-C. jejuni antibody alone was sufficient for the serological diagnosis ...

      Known for Jejuni Infection | Iga Anti | Gbs Patients | Ganglioside Gangliosides | Enteritis Gm1
      KOL-Index: 12498

      Autoantibodies against gangliosides GM1 or GD1a are associated with acute motor axonal neuropathy (AMAN) and acute motor-sensory axonal neuropathy (AMSAN), whereas antibodies to GD1b ganglioside are detected in acute sensory ataxic neuropathy (ASAN). These neuropathies have been proposed to be closely related and comprise a continuous spectrum, although the underlying mechanisms, especially for sensory nerve involvement, are still unclear. Antibodies to GM1 and GD1a have been proposed to ...

      Known for Sensory Nerves | Nodes Ranvier | Mediated Neuropathies | Ganglioside Antibody | Common Mechanism
      KOL-Index: 12407

      BACKGROUND: Whether or not antiganglioside antibodies are related to axonal or demyelinating Guillain-Barré syndrome (GBS) is still a matter of controversy, as detailed in previous studies conducted in Western and Asian countries.

      OBJECTIVE: To clarify whether antiganglioside antibodies are associated with axonal dysfunction in Japanese and Italian GBS patient cohorts.

      METHODS: Clinical and electrophysiological profiles were reviewed for 156 GBS patients collected from Japan (n=103) and ...

      Known for Antiganglioside Antibodies | Axonal Guillain | Gbs Japan | Barré Syndrome | Female Gm1
      KOL-Index: 12237

      Paranodal axo-glial junctions are important for ion channel clustering and rapid action potential propagation in myelinated nerve fibers. Paranode formation depends on the cell adhesion molecules neurofascin (NF) 155 in glia, and a Caspr and contactin heterodimer in axons. We found that antibody to ganglioside GM1 labels paranodal regions. Autoantibodies to the gangliosides GM1 and GD1a are thought to disrupt nodes of Ranvier in peripheral motor nerves and cause Guillain-Barré syndrome, ...

      Known for Myelinated Nerve Fibers | Paranodal Junctions | Gangliosides Gm1 | Nodes Ranvier | Ion Channel
      KOL-Index: 11488

      Some patients developed Guillain-Barré syndrome (GBS) after being given bovine gangliosides. Patients with GBS subsequent to Campylobacter jejuni enteritis frequently have IgG antibody to GM1 ganglioside. Miller Fisher syndrome (MFS), a variant of GBS, is associated with IgG antibody to GQ1b ganglioside. The existence of molecular mimicry between GM1 and lipopolysaccharide of C. jejuni isolated from a GBS patient and that between GQ1b and C. jejuni lipopolysaccharides from patients with ...

      Known for Molecular Mimicry | Campylobacter Jejuni | Fisher Syndrome | Patients Gbs | Gm1 Ganglioside
      KOL-Index: 11462

      OBJECTIVES: To investigate the pathophysiology of selective absence of F waves and its relation with antiganglioside antibodies in Guillain-Barré syndrome (GBS). Some patients with GBS show the absence of F waves as an isolated conduction abnormality, which has been interpreted as demyelination in the proximal nerve segments.

      METHODS: In 62 consecutive patients with GBS, sequential nerve conduction and F wave studies were reviewed, and antibodies against ganglioside GM1, GM1b, GD1a, ...

      Known for Antiganglioside Antibodies | Gbs Patients | Guillainbarré Syndrome | Nerve Conduction | Motor Axonal
      KOL-Index: 11437

      Molecular mimicry between microbial and self-components is postulated as the mechanism that accounts for the antigen and tissue specificity of immune responses in postinfectious autoimmune diseases. Little direct evidence exists, and research in this area has focused principally on T cell-mediated, antipeptide responses, rather than on humoral responses to carbohydrate structures. Guillain-Barré syndrome, the most frequent cause of acute neuromuscular paralysis, occurs 1-2 wk after ...

      Known for Carbohydrate Mimicry | Barré Syndrome | Ganglioside Gm1 | Campylobacter Jejuni | Peripheral Nerves
      KOL-Index: 11433

      Bickerstaff reported eight patients who, in addition to acute ophthalmoplegia and ataxia, showed drowsiness, extensor plantar responses or hemisensory loss. This condition has been named Bickerstaff's brainstem encephalitis (BBE). One patient had gross flaccid weakness in the four limbs. Presumably because of the rarity of this disorder, there has been no reported study on a large number of patients with BBE. To clarify its clinical features, we reviewed detailed clinical profiles and ...

      Known for Barré Syndrome | Patients Bbe | Brainstem Encephalitis | Disturbance Consciousness | Ataxia Autoantibodies
      KOL-Index: 11361

      OBJECTIVES: To identify valuable antiganglioside antibodies that support the diagnosis of Guillain-Barré syndrome (GBS) and its variants in patients showing bulbar palsy as an initial symptom.

      METHODS: Medical records of 602 patients with GBS or its variants were reviewed. Fifteen patients had bulbar palsy as an initial symptom. Serum antibodies against GM1, GM1b, GD1a, GalNAc-GD1a, GT1a, and GQ1b were examined in 13 of them.

      RESULTS: Serum antiganglioside antibodies were positive in 11 ...

      Known for Bulbar Palsy | Igg Anti | Barré Syndrome | Pcb Gbs | Female Gm1

      Key People For Barré Syndrome

      Top KOLs in the world
      Richard A C Hughes
      plasma exchange chronic inflammatory intravenous immunoglobulin
      David Reid Cornblath
      chronic inflammatory barré syndrome multifocal motor
      Pieter Antoon van Doorn
      pompe disease chronic inflammatory intravenous immunoglobulin
      Nobuhiro Yuki
      barré syndrome campylobacter jejuni chronic inflammatory
      Bart Casper Jacobs
      barré syndrome campylobacter jejuni gbs patients
      Arthur K Asbury
      axolemmal fraction nerve biopsy genetic testing

      Nobuhiro Yuki:Expert Impact

      Concepts for whichNobuhiro Yukihas direct influence:Barré syndrome,  Fisher syndrome,  Campylobacter jejuni,  Guillainbarré syndrome,  Chronic inflammatory,  Miller fisher syndrome,  Igg antibody,  Patients gbs.

      Nobuhiro Yuki:KOL impact

      Concepts related to the work of other authors for whichfor which Nobuhiro Yuki has influence:Barré syndrome,  Campylobacter jejuni,  Chronic inflammatory,  Intravenous immunoglobulin,  Gbs patients,  Molecular mimicry,  Plasma exchange.



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      Department of Neurology, Tsukuba Hospital, Tsukuba, Ibaraki, Japan | Yuki Clinic, 1-3-7 Johnan, Mito, Ibaraki 310-0803, Japan;, | Nobuhiro Yuki is at the Department of Medicine, Eda Memorial Hospital, Azamino-minami 1-1-1, Aob

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