• Disease
  • Memory
  • Memory Consolidation
  • James Lafayette Mcgaugh

    Prominent publications by James Lafayette McGaugh

    KOL Index score: 18066

    Involvement of the hippocampus and caudate nucleus in place and response learning was examined by functionally inactivating these brain regions bilaterally with infusions of lidocaine. Rats were trained to approach a consistently baited arm in a cross-maze from the same start box (four trials/day/14 total days). On Days 8 and 16 a single probe trial was given, in which rats were placed in the start box opposite that used in training and allowed to approach a maze arm. Three minutes prior ...

    Also Ranks for: Response Learning |  caudate nucleus |  hippocampus rats |  lidocaine injections |  extended training
    KOL Index score: 17112

    Infusion of a beta-adrenoceptor antagonist into the basolateral nucleus of the amygdala (BLA) blocks memory enhancement induced by systemic or intra-BLA administration of a glucocorticoid receptor (GR) agonist. As there is evidence that glucocorticoids interact with the noradrenergic signalling pathway in activating adenosine 3prime prime or minute,5prime prime or minute-cyclic monophosphate (cAMP), the present experiments examined whether glucocorticoids influence the ...

    Also Ranks for: Memory Consolidation |  adrenergic beta |  basolateral amygdala |  camp bla |  glucocorticoids interact
    KOL Index score: 16611

    These observations indicate that the long-lasting trace of an experience is not completely fixed, consolidated, or coded at the time of the experience. Consolidation requires time, and under at least some circumstances the processes of consolidation appear to be susceptible to a variety of influences- both facilitating and impairing- several hours after the experience. There must be, it seems, more than one kind of memory trace process (31). If permanent memory traces consolidate slowly ...

    Also Ranks for: Memory Storage |  time processes |  consolidation evidence |  term long |  learning animals
    KOL Index score: 15526

    Previous findings indicate that administration of abeta-adrenoceptor antagonist systemically blocks glucocorticoid impairment of memory retrieval. Here, we report that beta-adrenoceptor activation in the hippocampus and the basolateral complex of the amygdala (BLA) is implicated in the impairing effects of glucocorticoids on memory retrieval. The specific glucocorticoid receptor (GR) agonist 11beta,17beta-dihydroxy-6,21-dimethyl-17alpha-pregna-4,6-trien-20yn-3-one (RU 28362) (15 ng) ...

    Also Ranks for: Memory Retrieval |  basolateral amygdala |  glucocorticoid effects |  receptors adrenergic |  retention testing
    KOL Index score: 15391

    Considerable evidence indicates that the basolateral complex of the amygdala (BLA) interacts with efferent brain regions in mediating glucocorticoid effects on memory consolidation. Here, we investigated whether glucocorticoid influences on the consolidation of memory for emotionally arousing training depend on functional interactions between the BLA and the medial prefrontal cortex (mPFC), a brain region involved in higher-order cognitive and affective processing. The glucocorticoid ...

    Also Ranks for: Memory Consolidation |  glucocorticoid effects |  medial prefrontal cortex |  basolateral amygdala |  spraguedawley receptors
    KOL Index score: 15145

    Evidence from previous studies indicates that the noradrenergic and GABAergic influences within the basolateral amygdala (BLA) modulate the consolidation of memory for fear conditioning. The present experiments investigated whether the same modulatory influences are involved in regulating the extinction of fear-based learning. To investigate this issue, male Sprague Dawley rats implanted with unilateral or bilateral cannula aimed at the BLA were trained on a contextual fear conditioning ...

    Also Ranks for: Basolateral Amygdala |  extinction memory |  dorsal hippocampus |  gabaergic systems |  fear conditioning
    KOL Index score: 14929

    Evidence indicates that the modulatory effects of the adrenergic stress hormone epinephrine as well as several other neuromodulatory systems on memory storage are mediated by activation of beta-adrenergic mechanisms in the amygdala. In view of our recent findings indicating that the amygdala is involved in mediating the effects of glucocorticoids on memory storage, the present study examined whether the glucocorticoid-induced effects on memory storage depend on beta-adrenergic activation ...

    Also Ranks for: Memory Storage |  glucocorticoid enhancement |  noradrenergic activation |  basolateral amygdala |  adrenergic beta
    KOL Index score: 14841

    Extensive evidence indicates that norepinephrine modulates memory storage through an activation of beta-adrenoceptors in the basolateral nucleus of the amygdala (BLA). Recent findings suggest that the effects of beta-adrenergic activation on memory storage are influenced by alpha1-adrenoceptor stimulation. Pharmacological findings indicate that activation of postsynaptic alpha1-adrenoceptors potentiates beta-adrenoceptor-mediated activation of cAMP formation. The present study examined ...

    Also Ranks for: Memory Storage |  bla findings |  adrenergic alpha receptors |  beta adrenoceptor |  02 microliter
    KOL Index score: 14761

    There is extensive evidence that glucocorticoid hormones impair the retrieval of memory of emotionally arousing experiences. Although it is known that glucocorticoid effects on memory retrieval impairment depend on rapid interactions with arousal-induced noradrenergic activity, the exact mechanism underlying this presumably nongenomically mediated glucocorticoid action remains to be elucidated. Here, we show that the hippocampal endocannabinoid system, a rapidly activated retrograde ...

    Also Ranks for: Contextual Fear Memory |  hippocampal endocannabinoid |  spraguedawley receptor |  glucocorticoid effects |  freezing reaction
    KOL Index score: 14599

    Extensive evidence from contextual fear conditioning experiments suggests that the hippocampus is involved in processing memory for contextual information. Evidence also suggests that the rostral anterior cingulate cortex (rACC) may be selectively involved in memory for nociceptive stimulation. In contrast, many findings indicate that the basolateral amygdala (BLA) is more broadly involved in modulating the consolidation of different kinds of information. To investigate further the ...

    Also Ranks for: Basolateral Amygdala |  differential involvement |  memory context |  footshock training |  anterior cingulate
    KOL Index score: 14442

    Neuronal immediate-early gene (IEG) expression is regulated by synaptic activity and plays an important role in the neuroplastic mechanisms critical to memory consolidation. IEGs can be divided into two functional classes: (1) regulatory transcription factors (RTFs), which can broadly influence cell function depending on the "downstream" genes they regulate, and (2) "effector" proteins, which may directly modulate specific cellular functions. The objective of the current study was to ...

    Also Ranks for: Arc Zif268 |  rat hippocampus |  early gene |  situ hybridization |  spatial learning
    KOL Index score: 14392

    Previous findings indicate that the basolateral complex of the amygdala (BLA) interacts with other brain regions in regulating stress hormone effects on memory functions. Lesions of the BLA or infusions of a beta-adrenoceptor antagonist into the BLA block glucocorticoid effects on both memory consolidation and retrieval when administered either systemically or directly into the hippocampus. The present experiments examined BLA and beta-adrenoceptor involvement in regulating ...

    Also Ranks for: Glucocorticoid Effects |  medial prefrontal cortex |  memory impairment |  mpfc bla |  basolateral amygdala
    KOL Index score: 14391

    Glucocorticoid-induced memory enhancement is known to depend on beta-adrenoceptor activation in the basolateral amygdala (BLA). Additionally, inactivation of muscarinic cholinergic receptors in the rat amygdala blocks memory enhancement induced by concurrent beta-adrenergic activation. Together, these findings suggest that glucocorticoid-induced modulation of memory consolidation requires cholinergic as well as adrenergic activation in the BLA. Two experiments investigated this issue. ...

    Also Ranks for: Memory Consolidation |  basolateral amygdala |  muscarinic receptor antagonism |  spraguedawley receptors |  bla rats
    KOL Index score: 14160

    These experiments examined the involvement of alpha1-adrenoceptors in the basolateral amygdala and their interaction with beta-adrenoceptors in modulating memory storage. In Experiment 1, male Sprague-Dawley rats, implanted with bilateral cannulae in the basolateral amygdala, were trained in a one-trial inhibitory avoidance task and immediately after training, were given microinfusions (0.2 microl/side) of the selective alpha1-adrenoceptor antagonist, prazosin (0.1-1.0 microg). Retention ...

    Also Ranks for: Basolateral Amygdala |  memory storage |  retention performance |  adrenergic alpha1 |  beta antagonists
    KOL Index score: 13917

    The present experiment examined the role of the central nucleus and basolateral complex in the retention of inhibitory avoidance training by reversibly inactivating these regions with lidocaine immediately following training. Male Sprague-Dawley rats were surgically implanted bilaterally with cannulae aimed at the central nucleus or the basolateral complex. One week later, they received one trial inhibitory avoidance training (0.45 mA; 1 s), followed immediately by infusions of lidocaine ...

    Also Ranks for: Basolateral Complex |  inhibitory avoidance training |  infusions lidocaine |  retention performance |  central nucleus


    James Lafayette McGaugh: Influence Statistics

    Sample of concepts for which James Lafayette McGaugh is among the top experts in the world.
    Concept World rank
    task retention #1
    performance impairment amygdala #1
    brain seizure thresholds #1
    lidocaine cerebellum #1
    memorymodulatory effects #1
    bla cholinergic activation #1
    oxotremorine memory #1
    rats retention retention #1
    cfc tasks ymaze #1
    male memory nmethylaspartate #1
    posttraining administration amphetamine #1
    training trial mice #1
    blamediated modulation #1
    adrenergic amnesia #1
    ymaze discrimination task #1
    amygdalae bilateral infusions #1
    retention original training #1
    etherized mice #1
    posttraining intraamygdala #1
    glucocorticoids noradrenergic activation #1
    c57bl6j amnesia thresholds #1
    cannabinoid learning benzamides #1
    intraamygdala infusions oxotremorine #1
    amygdala 03 micrograms #1
    amygdala infusions #1
    exposure conditioned stressor #1
    addition blood sugar #1
    cortex training conditions #1
    operant idazoxan inhibition #1
    memory retrieval memory #1
    training 3 #1
    hsam new insights #1
    interactions brain regions #1
    lesions dzp #1
    dl4ohamphetamine #1
    oxotremorine pirenzepine rats #1
    midbrain aged rats #1
    memory adrenal #1
    rats increased training #1
    amygdala memory #1
    amygdala cascades #1
    amygdaloid nuclei lesions #1
    experiences memory modulation #1
    stress hormone influences #1
    infusions bla #1
    learning memory bla #1
    activation bla #1
    corticosterone memory #1
    cnqxtreated groups #1
    retention unstimulated rats #1

    Key People For Memory Consolidation

    Top KOLs in the world
    James Lafayette McGaugh
    memory consolidation basolateral amygdala inhibitory avoidance
    Jan G P Born
    memory consolidation rem sleep slow oscillations
    Robert J Stickgold
    memory consolidation rem sleep individual differences
    Bruce L McNaughton
    path integration place fields granule cells
    Iván Antonio Izquierdo
    entorhinal cortex inhibitory avoidance memory consolidation
    Matthew P Walker
    sleep deprivation memory consolidation rapid eye movement

    James Lafayette McGaugh:Expert Impact

    Concepts for whichJames Lafayette McGaughhas direct influence:Memory consolidation,  Basolateral amygdala,  Memory storage,  Inhibitory avoidance,  Retrograde amnesia,  Noradrenergic activation,  Brain seizures,  Inhibitory avoidance training.

    James Lafayette McGaugh:KOL impact

    Concepts related to the work of other authors for whichfor which James Lafayette McGaugh has influence:Memory consolidation,  Basolateral amygdala,  Synaptic plasticity,  Fear conditioning,  Prefrontal cortex,  Spatial learning,  Alzheimer disease.



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    Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-3800 | Department of Neurobiology and Behavior, University of California, Irvine, 92697-3800 Irvine, CA, USA; Cent