Prominent publications by Lei Lei Xu

KOL Index score: 18772

We evaluated the effect of dietary supplementation with mannan oligosaccharide (MOS) on the resistance to Aeromonas hydrophi1a infection in Allogynogenetic crucian carp. The fish were randomly divided into five groups: a control group was fed with basal diet, and four treatment groups fed with basal diet supplemented with 60, 120, 240, 480 mg/kg MOS for 10 weeks, respectively. We then challenged the fish with A. hydrophi1a and recorded the mortality and the changes in serum cortisol, T3, ...

Also Ranks for: Mannan Oligosaccharide |  7d infection |  aeromonas hydrophila |  basal diet |  hsp70 gene
KOL Index score: 15997

BACKGROUND: Obesity is associated with both increased breast cancer risk and poorer prognosis after disease onset. However, little is known about the effect of obesity on treatment efficacy. We evaluated the association of obesity with outcomes and with tamoxifen efficacy in women with early-stage, hormone-responsive breast cancer participating in a multicenter cancer cooperative group clinical trial.

METHODS: The cohort consisted of 3385 women enrolled in National Surgical Adjuvant ...

Also Ranks for: Breast Cancer |  estrogen receptor |  obese women |  mortality bmi |  obesity outcomes
KOL Index score: 15825

Canine distemper virus (CDV) infects a variety of carnivores, including wild and domestic Canidae. Genetic/antigenic heterogeneity has been observed among the various CDV strains, notably in the haemagglutinin (H) gene, that appears as a good target to gather epidemiological information. Based on sequence analysis of the H gene, wild-type CDV strains cluster into distinct geographic lineages (genotypes), irrespective of the species of isolation. The sequence of the H gene of 28 CDV ...

Also Ranks for: Raccoon Dogs |  haemagglutinin gene |  china cdv |  canine distemper |  amino acid
KOL Index score: 14215

OBJECTIVE: This study was designed to evaluate the short-term efficacy and safety of once-daily lurasidone (80 mg/day and 160 mg/day) in the treatment of an acute exacerbation of schizophrenia.

METHODS: Participants, who were recently admitted inpatients with schizophrenia with an acute exacerbation of psychotic symptoms, were randomly assigned to 6 weeks of fixed-dose, double-blind treatment with lurasidone 80 mg (n=125), lurasidone 160 mg (n=121), quetiapine XR 600 mg (QXR-600 mg; ...

Also Ranks for: Lurasidone 80 |  treatment schizophrenia |  acute exacerbation |  efficacy safety |  panss total score
KOL Index score: 14123

Huang L., Liu X. and Xu L. Regional innovation and spillover effects of foreign direct investment in China: a threshold approach, Regional Studies. Using a data set on twenty-nine Chinese provinces for the period 1985–2008, this paper establishes a threshold model to analyse the relationship between spillover effects of foreign direct investment (FDI) and regional innovation in China. There is clear evidence of double-threshold effects of regional innovation on productivity spillovers ...

Also Ranks for: Regional Innovation |  foreign direct investment |  spillover effects |  fdi china |  threshold approach
KOL Index score: 14045

The activation of homeobox A10 (HOXA10) has been proved to be an important event in epithelial ovarian carcinogenesis, yet its regulation in epithelial ovarian cancer (EOC) is still not fully understood. Here, we aimed to reveal the mechanism that a predicted target miRNA regulates HOXA10 expression and the association of its expression with progression of EOC. Here, by using computer-assisted algorithms from PicTar, TargetScan, and miRBase, we identified that the predicted target miRNA ...

Also Ranks for: Hoxa10 Expression |  epithelial ovarian |  tumor suppressor |  neoplastic genes |  eoc cell
KOL Index score: 13779

BACKGROUND/AIMS: Early inflammatory responses after myocardial infarction (MI) are likely to increase myocardial fibrosis and subsequent cardiac remodeling. MCC950, a specific NLRP3 inhibitor, was previously found to effectively inhibit the release of inflammatory factors IL-18 and IL-1β. In this study, we evaluated the effect of MCC950, as a potential new treatment strategy for MI, on myocardial fibrosis and cardiac remodeling using an experimental mouse model.

METHODS: Male C57BL/6 ...

Also Ranks for: Myocardial Fibrosis |  cardiac remodeling |  mouse model |  inhibitor mcc950 |  inflammatory factors
KOL Index score: 13650

Human SIRT1 is an enzyme that deacetylates the p53 tumor suppressor protein and has been suggested to modulate p53-dependent functions including DNA damage-induced cell death. In this report, we used EX-527, a novel, potent, and specific small-molecule inhibitor of SIRT1 catalytic activity to examine the role of SIRT1 in p53 acetylation and cell survival after DNA damage. Treatment with EX-527 dramatically increased acetylation at lysine 382 of p53 after different types of DNA damage in ...

Also Ranks for: Dna Damage |  p53 acetylation |  cell survival |  sirt1 catalytic activity |  ex527 tsa
KOL Index score: 12713

BACKGROUND: On March 30, a novel influenza A subtype H7N9 virus (A/H7N9) was detected in patients with severe respiratory disease in eastern China. Virological factors associated with a poor clinical outcome for this virus remain unclear. We quantified the viral load and analysed antiviral resistance mutations in specimens from patients with A/H7N9.

METHODS: We studied 14 patients with A/H7N9 disease admitted to the Shanghai Public Health Clinical Centre (SPHCC), China, between April 4, ...

Also Ranks for: H7n9 Virus |  viral shedding |  corticosteroid treatment |  oseltamivir patients |  sequence china
KOL Index score: 11954

Englerin A is a structurally unique natural product reported to selectively inhibit growth of renal cell carcinoma cell lines. A large scale phenotypic cell profiling experiment (CLiP) of englerin A on ¬over 500 well characterized cancer cell lines showed that englerin A inhibits growth of a subset of tumor cell lines from many lineages, not just renal cell carcinomas. Expression of the TRPC4 cation channel was the cell line feature that best correlated with sensitivity to englerin A, ...

Also Ranks for: Cation Channels |  tumor cell |  trpc4 expression |  membrane depolarization |  vivo experiments
KOL Index score: 11381

Pigment epithelium-derived factor (PEDF) is a pleiotropic gene with anti-inflammatory, antioxidant and anti-angiogenic properties. However, recent reports about the effects of PEDF on cardiomyocytes are controversial, and it is not known whether and how PEDF acts to inhibit hypoxic or ischemic endothelial injury in the heart. In the present study, adult Sprague-Dawley rat models of acute myocardial infarction (AMI) were surgically established. PEDF-small interfering RNA ...

Also Ranks for: Cardiomyocyte Apoptosis |  cardiac function |  acute myocardial infarction |  vascular permeability |  myocardial infarct size
KOL Index score: 11023

Atherosclerosis (AS) is a common vascular disease, which can cause apoptosis of vascular endothelial cells. Notoginsenoside R1 (NGR1) is considered an anti-AS drug. MicroRNAs (miRNAs) are believed to play a vital role in cell apoptosis and angiogenesis. This study aimed to explore the mechanism of NGR1 for treating AS through miRNAs. Flow cytometry was used to detect the apoptosis rate. The levels of inflammatory cytokines interleukin (IL)-6 and IL-1β were detected using ELISA. Reactive ...

Also Ranks for: Oxidative Stress |  notoginsenoside r1 |  tlr4 nfκb pathway |  flow cytometry |  nf κb
KOL Index score: 10991

We have examined the aerodynamic effects of corrugation in model insect wings that closely mimic the wing movements of hovering insects. Computational fluid dynamics were used with Reynolds numbers ranging from 35 to 3400, stroke amplitudes from 70 to 180 deg and mid-stroke angles of incidence from 15 to 60 deg. Various corrugated wing models were tested (care was taken to ensure that the corrugation introduced zero camber). The main results are as follows. At typical mid-stroke angles ...

Also Ranks for: Aerodynamic Effects |  flapping insect wings |  hovering flight |  flow wing |  lift drag
KOL Index score: 10723

Respiratory variation in the inferior vena cava (ΔIVC) has been extensively studied with respect to its value in predicting fluid responsiveness, but the results are conflicting. This systematic review was aimed at investigating the diagnostic accuracy of ΔIVC in predicting fluid responsiveness. Databases including Medline, Embase, Scopus and Web of Knowledge were searched from inception to May 2013. Studies exploring the diagnostic performance of ΔIVC in predicting fluid responsiveness ...

Also Ranks for: Fluid Responsiveness |  respiratory variation |  inferior vena |  ultrasonographic measurement |  mechanical ventilation
KOL Index score: 10648

BACKGROUND/AIMS: The elucidation of the molecular mechanism of adipocyte differentiation in mesenchymal stem cells is of essential importance for the development of treatments for metabolic diseases, such as obesity and diabetes.

METHODS: The expression levels of miR-342-3p and carboxy-terminal binding protein 2 (CtBP2) were regulated by oligonucleotide transfection. Adipogenic differentiation was induced by adipogenic medium containing indomethacin, dexamethasone and ...

Also Ranks for: Mesenchymal Stem Cells |  adipogenic differentiation |  mir342 3p |  binding proteins |  adipose tissue

Key People For Bayesian Ying

Top KOLs in the world
Lei *** **
acute pancreatitis facial nerve paralysis heart failure
Lei **
byy harmony learning model selection local factor analysis
Erkki ***
independent component analysis nonnegative matrix factorization hough transform
Hirotugu ******
markovian representation prior distribution immunologic networks
Geoffrey * ******
neural networks boltzmann machines deep belief nets
Lei **
radial basis function multiple classifiers associative switch

Lei Lei Xu:Expert Impact

Concepts for whichLei Lei Xuhas direct influence:Bayesian ying,  Deep learning,  Numerical simulation,  Thyroid carcinoma,  Ischemic stroke,  Acute pancreatitis,  Gastric carcinoma,  Gastric cancer.

Lei Lei Xu:KOL impact

Concepts related to the work of other authors for whichfor which Lei Lei Xu has influence:Reference genes,  Breast cancer,  Gene expression,  Primary aldosteronism,  Resistant hypertension,  Influenza virus,  Acute pancreatitis.



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Department of Orthopedics, Chengdu Seventh People's Hospital, Chengdu, Sichuan 610213, P.R. China | Suining Central Hospital | School of Information Engineering, East China Jiaotong University | School of Civil Engineering, Central South University,