Prominent publications by Jia Fan

KOL Index score: 11266

Diabetes is a complex metabolic syndrome that is characterized by prolonged high blood glucose levels and frequently associated with life-threatening complications1,2. Epidemiological studies have suggested that diabetes is also linked to an increased risk of cancer3–5. High glucose levels may be a prevailing factor that contributes to the link between diabetes and cancer, but little is known about the molecular basis of this link and how the high glucose state may drive genetic and/or ...

Known for Tet2 Ampk |  Diabetes Cancer |  Glucose Levels |  Dna 5 |  Metformin Mice
KOL Index score: 10512

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there ...

Known for Autophagosomes Autolysosomes |  Monitoring Autophagy |  Humans Models |  Interpretation Assays |  Autophagic Process
KOL Index score: 9472

In hepatocellular carcinoma (HCC), biomarkers for prediction of prognosis and response to immunotherapy such as interferon-α (IFN-α) would be very useful in the clinic. We found that expression of retinoic acid-inducible gene-I (RIG-I), an IFN-stimulated gene, was significantly downregulated in human HCC tissues. Patients with low RIG-I expression had shorter survival and poorer response to IFN-α therapy, suggesting that RIG-I is a useful prognosis and IFN-α response predictor for HCC ...

Known for Hepatocellular Carcinoma |  Rig Tumor Suppressor |  Ifn Α |  Hcc Patients |  Stat1 Activation
KOL Index score: 8922

Poor detection of low-abundant proteins is a common problem in two-dimensional electrophoresis (2-DE) for separation of proteins in a proteome analysis. This is attributed partially, at least, to the existence of high-abundant proteins, e.g. ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) in plants. They engage a large proportion of the whole-cell proteins and thus prevent low-abundant proteins from being up-taken by immobilized pH gradient (IPG) strip, consequently making the ...

Known for Abundant Proteins |  Plant Proteome |  Dimensional Electrophoresis |  Polyethylene Glycol |  Protein Samples
KOL Index score: 6212

The combination of a camera and a 2D laser rangefinder (LRF) is widely used in robotics, mapping, and unmanned driving to simultaneously obtain the 3D geometry and color texture of a scene. However, data misregistration between the camera and the LRF frequently occurs due to the difficulty of precise installation and alignment between them. Extrinsic calibration between the camera and the LRF is necessary. In this study, a photogrammetric control field is used to perform a robust and ...

Known for Extrinsic Calibration |  2d Laser Rangefinder |  Camera Lrf |  Control Field |  Perspective Point
KOL Index score: 5234

The bystin-like (BYSL) gene was previously characterized to encode an accessory protein for cell adhesion that participates in early embryo implantation. It is also involved in 40S ribosomal subunit biogenesis and is found to be expressed in rapidly growing embryo and cancer cell lines. In order to explore the role of BYSL in cancer cell proliferation and growth, we used hepatocellular carcinoma (HCC) as a model. Here, we report that BYSL is crucial for HCC cell growth both in vitro and ...

Known for Hepatocellular Carcinoma |  Cell Proliferation |  Role Bysl |  Liver Neoplasms |  Embryo Implantation
KOL Index score: 4655

BackgroundThis study aimed to investigate potential miRNAs and genes associated with the prognosis of hepatocellular carcinoma (HCC).MethodsWeighted co-expression network analysis was utilized to analyze the mRNA and miRNA sequencing data of HCC from TCGA (The Cancer Genome Atlas) database. Significant network modules were identified, and then functions of genes in the gene network modules and target genes of miRNAs in the miRNA network modules were explored. Additionally, correlations ...

Known for Hepatocellular Carcinoma |  Expression Gene |  Mir363 5p |  Network Analysis |  Hcc Patients
KOL Index score: 4201

INTRODUCTION: Glucocorticoids (GCs), especially low-dose GCs, are commonly prescribed for rheumatoid arthritis (RA), although the risk/benefit ratio is controversial. A randomized, double-blind clinical trial was performed to evaluate the efficacy and safety of low-dose oral GCs combined with methotrexate (MTX) and hydroxychloroquine (HCQ) in early RA (ERA).

METHODS: Eighty untreated ERA patients were randomized into the trial (GCs + MTX + HCQ) and control (placebo + MTX + HCQ) groups, ...

Known for Rheumatoid Arthritis |  Glucocorticoids Combined |  Methotrexate Hydroxychloroquine |  Efficacy Safety |  Antirheumatic Agents
KOL Index score: 4166

Gallium oxide thin films were deposited by pulsed spray pyrolysis in air using ethanol solution of gallium trichloride as precursor. X-ray diffraction measurements showed that monoclinic gallium oxide thin films were formed. The optical band-gap of the film deposited on quartz substrates was 5.16eV, and the transmittance was greater than 80% for λ>275nm, as determined by UV–vis absorption spectrum. Photoconductivity of Ga2O3 film with inter-digital electrodes showed a weak sensitivity to ...

Known for Gallium Oxide Films |  Blind Uv |  Ga2o3 Film |  Quartz Substrates |  Optical Band Gap
KOL Index score: 4035

The liver is the most common anatomical site for hematogenous metastases from colorectal cancer. Therefore effective treatment of liver metastases is one of the most challenging elements in the management of colorectal cancer. However, there is rare available clinical consensus or guideline only focusing on colorectal liver metastases. After six rounds of discussion by 195 clinical experts of the Shanghai International Consensus Expert Group on Colorectal Liver Metastases (SINCE) from 29 ...

Known for Colorectal Liver Metastases |  Liver Neoplasms
KOL Index score: 3602

Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma (HCC) have resulted in improved response rates. This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection, a 'conversion therapy' strategy. However, conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being ...

Known for Conversion Therapy |  Hepatocellular Carcinoma |  Patients Hcc |  Clinical Experience
KOL Index score: 3431

A simple, efficient, one-pot method has been developed for the synthesis of tetrahydro-4H-chromene derivatives by concurrent reaction of aryl aldehydes, active methylene compounds, and 1,3-cyclohexanedins using a catalytic amount of lithium bromide in aqueous media. The present approach offers several advantages such as shorter reaction times, good yields, low cost, recycling of the catalyst, and simple workup.

Known for Aqueous Media |  Chromene Derivatives |  Recyclable Catalyst |  Low Cost |  Simple Workup
KOL Index score: 2988

In this letter, in situ imaging of the photocatalytic activity of titanium dioxide (TiO2) nanotubes for the degradation of an organic pollutant (i.e., Rhodamine B (RhB)) is realized with nanometer resolution using scanning ion conductance microscopy (SICM). Upon illumination, the separated electrons and holes at the nanotubes induce oxidation of RhB to produce the more positively charged Rhodamine 123 (Rh 123), which leads to increased ionic current through the capillary orifice and an ...

Known for Photocatalytic Activity |  Ion Conductance Microscopy |  Tio2 Nanotubes |  Titanium Dioxide
KOL Index score: 2982

We studied the outcomes of children with APL treated by the Beijing Children's Hospital's (BCH) acute promyelocytic leukemia (APL) 2005 protocol (BCH-APL2005). The clinical data of 77 patients enrolled from January 2005 to June 2015 were analyzed retrospectively. The hematologic complete remission (CR) rate and overall survival (OS) rate were evaluated between standard-risk (SR) and high-risk (HR) groups. Prognostic factors and complications were investigated in these two groups. CR in ...

Known for Promyelocytic Leukemia |  Risk Groups |  Early Death |  Combined Chemotherapy |  Preschool China


Jia Fan: Influence Statistics

Sample of concepts for which Jia Fan is among the top experts in the world.
Concept World rank
camera lrf #1
extrinsic calibration camera #1
generalized chirp #1
arc gear #1
glucocorticoids combined #2
neighbor finding #2
2d laser rangefinder #2
za3 #2
time neighbor #2
double circular #4
bystinlike bysl gene #4
role bysl #5
gear parameters #5
tool static #5
tumor lci #5
glycol fractionation #5
aims cancer #6
retailer pricing #7
verifiable random function #8
gallium oxide films #8
thrombosis paroxysmal #8
domain authentication #8
peg fractions #9

Key People For Hepatocellular Carcinoma

Top KOLs in the world
Jordi Bruix
hepatocellular carcinoma liver transplantation patients hcc
Josep María Llovet
hepatocellular carcinoma advisory consultancy liver transplantation
Vincenzo Mazzaferro
hepatocellular carcinoma liver transplantation patients hcc
Freddie Ian Bray
cancer incidence nordic countries mortality rates
Jacques Ferlay
cancer incidence global burden latin america
united states hepatocellular carcinoma veterans affairs

Jia Fan:Expert Impact

Concepts for whichJia Fanhas direct influence:Hepatocellular carcinoma,  Conversion therapy,  Bear bile,  Curative resection,  Hepatocellular carcinoma hcc,  Colorectal liver metastases,  Extrinsic calibration,  Aqueous media.

Jia Fan:KOL impact

Concepts related to the work of other authors for whichfor which Jia Fan has influence:Cell death,  Autophagic flux,  Oxidative stress,  Autophagy inhibition,  Endoplasmic reticulum,  Reactive oxygen species,  Signal transduction.



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Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Fudan University, Shanghai, China | Key Laboratory of Carcinogenesis and C

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