Jingbo Wang

Survivin is involved in multiple signaling mechanisms in tumor maintenance, and accumulated studies elucidate that knockdown of survivin in endothelial cells could inhibit angiogenesis; however, the role of survivin in tumor cells to regulate tumor-derived angiogenesis remains largely unclear. In the present study 80 cases of brain glioma were chosen and protein expressions of survivin, vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and platelet-derived ...

PURPOSE: The purpose of this study is to develop a deep learning (DL) method for producing four-dimensional computed tomography (4DCT) ventilation imaging and to evaluate the accuracy of the DL-based ventilation imaging against single-photon emission-computed tomography (SPECT) ventilation imaging (SPECT-VI). The performance of the DL-based method is assessed by comparing with density change- and Jacobian-based (HU and JAC) methods.

MATERIALS AND METHODS: Fifty patients with esophagus or ...

BACKGROUND: Differential diagnosis of the mucosa-associated lymphoid tissue lymphoma (MALToma) and tumor-like benign lymphoepithelial lesion (BLEL) in the parotid gland is difficult.

PURPOSE: To distinguish MALToma and BLEL with multimodality MRI including hydrogenproton magnetic resonance spectroscopy (1 H-MRS), diffusion-weighted imaging (DWI-MR), and dynamic contrast-enhanced (DCE-MR), and evaluate each sequence.

STUDY TYPE: Retrospective.

POPULATION: Twenty-five patients with parotid ...

The present study aimed to compare 4 techniques in the planning of locoregional irradiation including internal mammary nodal region for left-sided breast cancer. Ten patients with left-sided breast cancer undergoing breast conservation surgery were enrolled. For each patient, 4 treatment plans were performed: a helical tomotherapy (HT) plan, a volumetric modulated arc therapy (VMAT) plan, a static intensity modulated radiation therapy (IMRT) plan, and a hybrid IMRT plan, designed to ...

The MDR1 multidrug transporter represents one of the better characterized drug transporters that play an important role in protecting the body against xenobiotic insults. Single nucleotide polymorphisms (SNPs) and SNP haplotypes within this gene have been variously associated with differences in MDR1 expression/function, drug response as well as disease susceptibility. Nonetheless, the effect of polymorphisms at the MDR1 promoter region on its promoter activity remains less ...

Pyrolysis characteristics and kinetic of five lignocellulosic biomass pine wood sawdust, fern (Dicranopteris linearis) stem, wheat stalk, sugarcane bagasse and jute (Corchorus capsularis) stick were investigated using thermogravimetric analysis. The pyrolysis of five lignocellulosic biomass could be divided into three stages, which correspond to the pyrolysis of hemicellulose, cellulose and lignin, respectively. Single Gaussian activation energy distributions of each stage are ...

Delineation of organs at risk (OARs) is important but time consuming for radiotherapy planning. Automatic segmentation of OARs based on convolutional neural network (CNN) has been established for lung cancer patients at our institution. The aim of this study is to compare automatic segmentation based on CNN (AS-CNN) with automatic segmentation based on atlas (AS-Atlas) in terms of the efficiency and accuracy of OARs contouring.The OARs, including the lungs, esophagus, heart, liver, and ...

To explore the efficacy, and safety of the intensive conditioning regimen consisting of cladribine, cytarabine (Ara-C), and granulocyte colony-stimulating factor (G-CSF) plus modified busulfan (Bu) combined with cytoxan (Cy) (BuCy), prior to allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with refractory, or relapsed acute myeloid leukemia (R/R AML).Thirty-Six R/R AML patients scheduled to receive allo-HSCT were consecutively, enrolled in this prospective ...

Objective To evaluate the safety and efficacy of chimeric antigen receptors T cells (CAR-T) in childhood acute B lymphoblastic leukemia (B-ALL) to probe the prognosis-related factors. Methods Forty-eight children, 29 boys and 19 girls, aged 3-17years old (median age was 8 years old) , with recurrent or refractory CD19 positive B-ALL, were treated by the CD19 specific CAR-T cells. A total of 48 cases received 61 infusions. Flow cytometry or real-time quantitative polymerase chain ...

In order to enhance energy recovery efficiency from MSW (municipal solid waste), an in-situ steam gasification method for hydrogen production where CaO was used as CO2 sorbent and catalyst in the process was proposed. The effects of moisture content, the molar ratio of CaO to carbon in wet MSW ([Ca]/[C]) and reactor temperature on H2 yield and gas composition were investigated. The results showed that maximum hydrogen volumetric concentration (49.42 vol%) and hydrogen yield (277.67 ml/g ...

The balance between bone formation and resorption is compromised in diabetes, which may contribute to the high risk of fractures in diabetic patients. However, the mechanism by which high glucose affects bone turnover remains to be elucidated. The present study demonstrated that high glucose inhibited receptor activator of nuclear factor‑κB ligand (RANKL)‑induced osteoclastogenesis. In order to examine the mechanism involved in the inhibition of osteoclastogenesis, the present study ...

The purpose of this study was to investigate the effects of yeast polysaccharide (YPS) on growth and flavonoid accumulation in sprout cultures of Fagopyrum tataricum (tartary buckwheat). Without obvious change in the appearance of the sprouts, the exogenous YPS notably stimulated the production of functional metabolites in F. tataricum sprouts, and the stimulation effect was concentration-dependent. With 400 mg/L of YPS applied to the sprout cultures on day 6, the total rutin and ...

The fabella is a sesamoid bone of the knee that can degenerate in some patients with osteoarthritis. The purpose of this study was to examine the prevalence and degeneration grades of fabellae in the Chinese population and to analyse their relationships with subject ages and knee osteoarthritis grades. The anteroposterior and lateral knee roentgenograms of 1150 subjects were recruited from the institutional database. The Kellgren-Lawrence scoring system was used to evaluate knee ...

Photocatalytic hydrogen (H2) production using sunlight is a promising solution for obtaining clean renewable energy. Therefore, the study of efficient, nontoxic and stable photocatalysts is very important. A novel ternary carbon dots/cobalt monoxide/graphitic carbon nitride (CDs/CoO/g‐C3N4) composite photocatalyst was prepared by a simple solvothermal method for photocatalytic H2 production under visible light irradiation (λ > 420 nm). Compared with single semiconductors CoO and g‐C3N4, ...

OBJECTIVE: To evaluate the safety and efficacy of chimeric antigen receptors T cells (CAR-T) in childhood acute B lymphoblastic leukemia (B-ALL).

METHODS: A relapsed B-ALL child after allogeneic hematopoietic stem cell transplantation (allo-HSCT) was treated with CAR-T, and the related literatures were reviewed.

RESULT: An 11-year-old girl with TEL-AML1 fusion gene positive BALL who suffered a bone marrow relapse 28 months after remission from conventional chemotherapy. During the second ...