Martcheri S Keshavan: Influence Statistics

Martcheri S Keshavan

Martcheri S Keshavan

Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Boston, Massachusetts; Department of Psychiatry, Harvard Medical School, ...

Martcheri S Keshavan: Expert Impact

Concepts for which Martcheri S Keshavan has direct influence: Bipolar disorder , Psychotic disorders , Magnetic resonance , Corpus callosum , Schizophrenia patients , Cognitive enhancement therapy , Social cognition .

Martcheri S Keshavan: KOL impact

Concepts related to the work of other authors for which for which Martcheri S Keshavan has influence: Bipolar disorder , Patients schizophrenia , Mental health , Magnetic resonance , White matter , Negative symptoms , Social cognition .

KOL Resume for Martcheri S Keshavan

Year
2022

Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Boston, Massachusetts; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts.

Beth Israel Deaconess Medical Center, Massachusetts Mental Health Center, Harvard Medical School, Boston, MA, USA.

Harvard University

2021

Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

Division of Digital Psychiatry, Beth Israel Deaconess Medical Center, Massachusetts, USA

Harvard Medical School, Boston, Massachusetts

Prominent publications by Martcheri S Keshavan

KOL-Index: 16736 . BACKGROUND: Difficulty recognizing facial emotions is an important social-cognitive deficit associated with psychotic disorders. It also may reflect a familial risk for psychosis in schizophrenia-spectrum disorders and bipolar disorder. OBJECTIVE: The objectives of this study from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium were to: 1) compare emotion ...
Known for Bipolar Disorder | Emotion Recognition | Intermediate Phenotypes | Deficits Schizophrenia
KOL-Index: 16367 . OBJECTIVE: Familial neuropsychological deficits are well established in schizophrenia but remain less well characterized in other psychotic disorders. This study from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium 1) compares cognitive impairment in schizophrenia and bipolar disorder with psychosis, 2) tests a continuum model of cognitive dysfunction in ...
Known for Psychotic Bipolar | Cognitive Impairments | Disorder Schizophrenia | Intermediate Phenotypes
KOL-Index: 14207 . CONTEXT: Cognitive rehabilitation has shown efficacy in improving cognition in patients with schizophrenia but the underlying neurobiologic changes that occur during these treatments and support cognitive improvement are not well known. OBJECTIVE: To examine differential changes in brain morphology in early course schizophrenia during cognitive rehabilitation vs supportive therapy. DESIGN: ...
Known for Cognitive Enhancement Therapy | Early Schizophrenia | Gray Matter | Randomized Controlled Trial
KOL-Index: 13752 . OBJECTIVE: The study examined gray matter volume across psychosis diagnoses organized by dimensional and DSM-IV categories from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) sample. METHOD: In total, 351 probands with psychosis (146 with schizophrenia, 90 with schizoaffective disorder, and 115 with psychotic bipolar I disorder), 369 of their first-degree relatives ...
Known for Gray Matter | Intermediate Phenotypes | Schizophrenia Network | Schizoaffective Disorder
KOL-Index: 13662 . OBJECTIVE: Developing categorical diagnoses that have biological meaning within the clinical phenotype of psychosis (schizophrenia, schizoaffective disorder, and bipolar I disorder with psychosis) is as important for developing targeted treatments as for nosological goals. The Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) was formed to examine a broad array of ...
Known for Intermediate Phenotypes | Psychosis Schizophrenia | Schizoaffective Disorder | Clinical Phenotype
KOL-Index: 13363 . OBJECTIVE Both schizophrenia and bipolar disorder are hypothesized to involve disordered brain connectivity. Prior studies show low white matter integrity, measured with diffusion tensor imaging, for both disorders. The authors studied disease specificity and endophenotypic status of these abnormalities by examining patients and their unaffected relatives. METHOD The 513 participants ...
Known for Bipolar Disorder | Diffusion Tensor | Fractional Anisotropy | Probands Schizophrenia
KOL-Index: 13338 . BACKGROUND: In adults, prefrontal, thalamic, and cerebellar brain injury is associated with excessive ethanol intake. As these brain structures are actively maturing during adolescence, we hypothesized that subjects with adolescent-onset alcohol use disorders, compared with control subjects, would have smaller brain volumes in these areas. Thus, we compared prefrontal-thalamic-cerebellar ...
Known for Prefrontal Cortex | Cerebellar Volumes | Onset Alcohol | Mental Disorders
KOL-Index: 12648 . BACKGROUND: Schizophrenia and bipolar disorder share overlapping symptoms and genetic etiology. Functional brain dysconnectivity is seen in both disorders. METHODS: We compared 70 schizophrenia and 64 psychotic bipolar probands, their respective unaffected first-degree relatives (n = 70, and n = 52), and 118 healthy subjects, all group age-, gender-, and ethnicity-matched. We used ...
Known for Magnetic Resonance | Network Connectivity | Bipolar Probands | State Functional
KOL-Index: 12648 . This study examined hippocampal volume as a putative biomarker for psychotic illness in the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) psychosis sample, contrasting manual tracing and semiautomated (FreeSurfer) region-of-interest outcomes. The study sample (n = 596) included probands with schizophrenia (SZ, n = 71), schizoaffective disorder (SAD, n = 70), and ...
Known for Manual Tracing | Schizoaffective Disorder | Hippocampal Volume | Psychotic Bipolar
KOL-Index: 12070 . Importance: Cognitive impairment occurs across the psychosis spectrum and is associated with functional outcome. However, it is unknown whether these shared manifestations of cognitive dysfunction across diagnostic categories also reflect shared neurobiological mechanisms or whether the source of impairment differs. Objective: To examine whether the general cognitive deficit observed ...
Known for Psychotic Disorders | Transdiagnostic Associations | Brain Network | Global Efficiency
KOL-Index: 11724 . OBJECTIVE: The profile of neuropsychological impairment associated with unipolar psychotic depression remains unclear. The authors used a neuropsychological test battery to characterize the neuropsychiatric profile of patients with unipolar psychotic depression, relative to that of patients with nonpsychotic unipolar depression, patients with schizophrenia, and healthy comparison ...
Known for Psychotic Depression | Neuropsychological Dysfunction | Patients Schizophrenia | Verbal Memory
KOL-Index: 11644 . A central question in schizophrenia research is which brain abnormalities are independent of psychosis and which evolve before and after psychosis begins. This question can be addressed by longitudinal neuroimaging studies beginning in the prodrome, but at present there is only one published study. We reviewed the literature on structural brain imaging in persons with chronic and first ...
Known for Parahippocampal Gyrus | Temporal Lobe | Magnetic Resonance | Genetic Risk
KOL-Index: 11451 . Both early (i.e., pre- and perinatal periods) and late (i.e., adolescent period) neurodevelopmental processes are thought to participate in the etiology and pathophysiology of schizophrenia. However, whether markers of these processes would be expected to predict an imminent onset of psychosis, as is hoped in the current generation of prodromal research programs, depends on whether their ...
Known for Psychotic Symptoms | Risk Factors Schizophrenia | Illness Phenotype | Genetic Factors
KOL-Index: 11277 . IMPORTANCE: Structural alterations in the hippocampus and other medial temporal lobe regions have been observed in schizophrenia. How these alterations and hippocampal subfields might differ across the psychosis spectrum remains unclear. OBJECTIVES: To characterize medial temporal lobe structures, including hippocampal subfields, using magnetic resonance imaging and to examine their ...
Known for Hippocampal Subfields | Temporal Lobe | Psychotic Disorders | Psychosis Spectrum
KOL-Index: 11184 . INTRODUCTION: A broad range of psychopathology, including externalizing disorders is seen in offspring at genetic risk for schizophrenia. However, it is unclear whether such psychopathology may underlie a higher predisposition to the premorbid antecedents of schizophrenia. We examined the prevalence and correlates of psychopathology in an ongoing study of offspring genetically at risk for ...
Known for Psychopathology Offspring | Parents Schizophrenia | Disorders Child | Genetic Risk

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Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Boston, Massachusetts; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts. | Department of Psychiatry, Beth Israel Deaconess M