• Disease
  • Bipolar
  • Bipolar Disorder
  • Robert H Yolken

    Prominent publications by Robert H Yolken

    KOL Index score: 15818

    OBJECTIVES: We investigated the effect of elevated levels of C-reactive protein (CRP) and exposure to Herpes simplex virus type 1 (HSV-1) on the severity of cognitive impairment in individuals with schizophrenia.

    METHODS: We measured the levels of CRP and of antibodies to HSV-1 in serum samples from 588 individuals with schizophrenia by enzyme immunoassay tests. Cognitive functioning was measured with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and ...

    Also Ranks for: Cognitive Impairment |  herpes simplex |  individuals schizophrenia |  elevated levels |  reactive protein
    KOL Index score: 15772

    Importance: Infections have been associated with increased risks for mental disorders, such as schizophrenia and depression. However, the association between all infections requiring treatment and the wide range of mental disorders is unknown to date.

    Objective: To investigate the association between all treated infections since birth and the subsequent risk of development of any treated mental disorder during childhood and adolescence.

    Design, Setting, and Participants: Population-based ...

    Also Ranks for: Mental Disorders |  subsequent risk |  nationwide study |  association infections |  children adolescents
    KOL Index score: 15344

    Abstract.We investigated the levels of antibodies to infectious

    agents in the serum and cerebral spinal fluids (CSFs) of

    individuals with recent onset schizophrenia and compared these

    levels to those of controls without psychiatric disease. We found

    that untreated individuals with recent onset schizophrenia had

    significantly increased levels of serum and CSF IgG antibody to

    cytomegalovirus and Toxoplasma

    gondii as compared to controls. The levels of serum

    IgM class antibodies to these ...

    Also Ranks for: Onset Schizophrenia |  infectious agents |  human herpesvirus |  antibodies toxoplasma |  serum cytomegalovirus
    KOL Index score: 14180

    BACKGROUND: In a previous investigation, we found an association between reduced cognitive functioning and the prevalence of antibodies to herpes simplex virus type 1 in individuals with schizophrenia. The current study was undertaken to determine if this association also occurs in individuals with bipolar disorder.

    METHODS: Cognitive functioning and serologic evidence of infection with potentially neurotropic herpesviruses were measured in 117 individuals with bipolar disorder and in ...

    Also Ranks for: Bipolar Disorder |  simplex virus type |  cognitive functioning |  infection herpes |  serologic evidence
    KOL Index score: 13227

    OBJECTIVE: This study examined the prevalence of cigarette smoking and the quantity of cigarettes consumed by individuals with schizophrenia or bipolar disorder and by those with no psychiatric disorder in the period 1999-2011.

    METHODS: A total of 991 individuals with schizophrenia, bipolar disorder, or no psychiatric illness provided information about their cigarette smoking at recruitment into a research study for which they were selected without regard to their smoking status. ...

    Also Ranks for: Cigarette Smoking |  bipolar disorder |  individuals schizophrenia |  psychiatric illness |  study prevalence
    KOL Index score: 12980

    OBJECTIVES: To describe and to evaluate the longitudinal growth of children born to mothers with human immunodeficiency virus (HIV) infection.

    DESIGN: Measurements of weight, length (measured in infants in a recumbent position) and height (measured in older children in an upright position), and head circumference were documented and evaluated longitudinally using generalized estimating equations in a group of children born to HIV-infected mothers. Children infected with HIV were compared ...

    Also Ranks for: Children Born |  weight age |  hiv infected |  immunodeficiency virus |  linear growth
    KOL Index score: 12960

    An approximate 10% suspension in water of the first available stool sample from 411 infants and young children with acute gastroenteritis was examined by electron microscopy (EM) after 2 min of negative staining. This procedure enabled the detection of 88% of the 199 rotavirus infections, all of the 22 adenovirus infections, and 47% of the 15 approximately 27-nm virus infections ultimately detected by a combination of techniques, including immune electron microscopy (IEM) and rotavirus ...

    Also Ranks for: Electron Microscopy |  immunosorbent assay |  rotavirus enzyme |  human adenoviruses |  acute gastroenteritis
    KOL Index score: 12338

    Influenza A virus infections are a major cause of morbidity and mortality worldwide. Standard diagnostic methods either are not efficient in identifying infected individuals in a timely manner or lack sensitivity. We developed a PCR-enzyme immunoassay (PCR-EIA) for the detection of influenza A virus RNA in respiratory secretions. A reverse transcription PCR was performed with oligonucleotide primers directed at a highly conserved area of the influenza A matrix gene. Amplified DNA was ...

    Also Ranks for: Influenza Virus |  clinical samples |  viral sensitivity |  enzyme immunoassay |  eia pcr
    KOL Index score: 12095

    Increasingly, abnormalities of glial cell function have been implicated in pathological studies of the major mental illnesses (schizophrenia, bipolar disorder, and major depression). In a recent proteomic study, four isoforms of astrocytic glial fibrillary acidic protein (GFAP) were decreased in one or more of these diseases. In the current study, we sought to determine the immunohistochemical localization of phosphorylated GFAP (pGFAP) in the prefrontal cortex and hippocampus and to ...

    Also Ranks for: Prefrontal Cortex |  bipolar disorder |  glial fibrillary |  major depression |  blood vessels
    KOL Index score: 11729

    Cognitive impairment is a core feature of schizophrenia. Previous studies have indicated that exposure to neurotropic infectious agents such as Herpes Simplex Virus type 1 may contribute to cognitive deficits and neuroanatomical abnormalities in individuals with schizophrenia. We examined the association between exposure to neurotropic infectious agents and cognitive function in 1308 participants in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) trial. This ...

    Also Ranks for: Herpes Simplex Virus |  cognitive deficits |  type 1 |  individuals schizophrenia |  serological evidence
    KOL Index score: 11614

    BACKGROUND: Small intestinal bacterial overgrowth (SIBO) has been associated with anatomical and motility-related abnormalities. Specifically, obesity has been postulated to alter small bowel motility, leading to SIBO.

    AIMS: (i) Assess the prevalence of SIBO in obesity; (ii) determine the relationship of obesity and SIBO, using small bowel transit time (SBTT) and pH; (iii) profile the gut microbiome in obese and non-obese patients with SIBO.

    METHODS: Thirty consecutive participants ...

    Also Ranks for: Obesity Sibo |  small intestinal |  bacterial overgrowth |  gut microbiome |  humans intestine
    KOL Index score: 11554

    BACKGROUND: Bipolar disorder is associated with deficits in cognitive functioning. The etiology of cognitive impairment in bipolar disorder may relate to both genetic and environmental factors. A valine/methionine polymorphism of the catechol O-methyltransferase gene at amino acid 158 (COMT Val158Met polymorphism) has been identified as a risk factor for cognitive impairment in schizophrenia. Serological evidence of infection with herpes simplex virus type 1 (HSV-1) has also been ...

    Also Ranks for: Cognitive Impairment |  bipolar disorder |  val158met polymorphism |  serological evidence |  herpes simplex
    KOL Index score: 11536

    Latent infection with neurotropic herpes viruses, such as herpes simplex virus, type 1 (HSV1), has been generally considered benign in most immunocompetent individuals except for rare cases of encephalitis. However, several recent studies have shown impaired cognitive functions among individuals with schizophrenia exposed to HSV1 compared with schizophrenia patients not exposed to HSV1. Such impairments are robust and are prominently observed in working memory, verbal memory, and ...

    Also Ranks for: Cognitive Impairment |  simplex virus |  hsv1 exposure |  type 1 |  schizophrenia patients


    Robert H Yolken: Influence Statistics

    Sample of concepts for which Robert H Yolken is among the top experts in the world.
    Concept World rank
    immune inflammatory cascades #1
    toxoplasmainfected mice infection #1
    protocol toxoplasma #1
    disorders gondii #1
    demographic factors toxoplasma #1
    mania increased levels #1
    ervwe1 infection #1
    1494 persons #1
    coronavirus immunoreactivity #1
    clinical diagnosis formats #1
    casein alphas #1
    effects type infection #1
    risk predictive performance #1
    lower risk asd #1
    toxoplasma ultraviolet rays #1
    gastrointestinal inflammation #1
    improvement antibodies #1
    nutritional intake persons #1
    individuals cognitive functioning #1
    elevated levels measles #1
    volunteers attenuated influenza #1
    levels celiac disease #1
    ≤ measles #1
    cf11 powder rotavirus #1
    protozoan antibodies #1
    pregnancy human humans #1
    casein or00001 #1
    rtpcr fecal specimens #1
    gondii infection schizophrenia #1
    antibodies suicide #1
    t7 rna pcr #1
    exposure infectious #1
    idir gbr #1
    gda crmp1 #1
    gut microbiome probiotics #1
    human rotavirus systems #1
    total synthesis nostodione #1
    crp psychomotor disorders #1
    males mir132 #1
    milk factor binding #1
    biomarkers microbiome #1
    infectious agents association #1
    12 genomic studies #1
    scalable protocol nscs #1
    mortality78 #1
    specific siga antigens #1
    individuals hospitalized #1
    increased levels antibodies #1
    virus postinfection samples #1
    identification signature #1

    Key People For Bipolar Disorder

    Top KOLs in the world
    Eduardo Eduard
    bipolar disorder cognitive impairment acute mania
    Robert M Post
    bipolar disorder affective illness depressed patients
    Susan L McElroy
    bipolar disorder binge eating bulimia nervosa
    Paul E Keck
    bipolar disorder acute mania united states
    Joseph R Calabrese
    bipolar disorder suicidal ideation rapid cycling
    Gary S Sachs
    bipolar disorder rapid cycling acute mania

    Robert H Yolken:Expert Impact

    Concepts for whichRobert H Yolkenhas direct influence:Bipolar disorder,  Cognitive functioning,  Toxoplasma gondii,  Schizophrenia bipolar disorder,  Infectious agents,  Psychiatric disorders,  Individuals schizophrenia,  Acute mania.

    Robert H Yolken:KOL impact

    Concepts related to the work of other authors for whichfor which Robert H Yolken has influence:Bipolar disorder,  Gene expression,  Toxoplasma gondii,  Dna methylation,  Gut microbiota,  Patients schizophrenia,  Oxidative stress.



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    Stanley Division of Developmental Neurovirology, Johns Hopkins University, Baltimore, MD, USA | Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA. | Stanley Neuroviro