Prominent publications by Robin MacGregor Murray

KOL Index score: 17852

OBJECTIVES: To determine the clinical and cost-effectiveness of different classes of antipsychotic drug treatment in people with schizophrenia responding inadequately to, or having unacceptable side-effects from, their current medication.

DESIGN: Two pragmatic, randomised controlled trials (RCTs) were undertaken. The first RCT (band 1) compared the class of older, inexpensive conventional drugs with the class of new atypical drugs in people with schizophrenic disorders, whose current ...

Also Ranks for: Quality Life |  conventional antipsychotic |  randomised controlled trials |  drug costs |  1 year
KOL Index score: 16031

BACKGROUND: Cannabis use following the onset of first-episode psychosis has been linked to both increased risk of relapse and non-adherence with antipsychotic medication. Whether poor outcome associated with cannabis use is mediated through an adverse effect of cannabis on medication adherence is unclear.

METHODS: In a prospective analysis of data acquired from four different adult inpatient and outpatient units of the South London and Maudsley Mental Health National Health Service ...

Also Ranks for: Medication Adherence |  episode psychosis |  risk relapse |  2 years |  clinical notes
KOL Index score: 15357

Using the Structured Clinical Interview for DSM-IV, patient and non-patient version (SCID-P/NP), this study investigated 351 patients with schizophrenia, 122 with obsessive-compulsive disorder (OCD), and 238 unrelated healthy volunteers in a Chinese Han population. The relative risks posed by advanced paternal age for schizophrenia and OCD in offspring were computed under logistic regression analyses and adjusted for the participant's sex, age and co-parent age at birth. Compared to the ...

Also Ranks for: Paternal Age |  compulsive disorder |  risk schizophrenia |  chinese population |  male maternal
KOL Index score: 15336

Importance: Cannabis use after first-episode psychosis is associated with poor outcomes, but the causal nature of this association is unclear.

Objective: To examine the precise nature of the association between continued cannabis use after the onset of psychosis and risk of relapse of psychosis.

Design, Setting, and Participants: This prospective cohort study followed up for at least 2 years after the onset of psychosis 220 patients who presented to psychiatric services in South London, ...

Also Ranks for: Continued Cannabis |  episode psychosis |  risk relapse |  years onset |  longitudinal studies
KOL Index score: 15332

BACKGROUND: Although cannabis use after a first episode of psychosis has been associated with relapse, little is known about the determinants of this most preventable risk factor for relapse of psychosis. Here we aimed to study whether the effects on outcome vary depending on the type of cannabis consumed and usage pattern.

METHODS: In this observational study, we prospectively recruited and followed up patients aged 18-65 years who presented with their first episode of psychosis to ...

Also Ranks for: Onset Psychosis |  2 years |  patients episode |  cannabis frequency |  south london
KOL Index score: 15176

BACKGROUND: Structural brain abnormalities in schizophrenia have been repeatedly demonstrated in magnetic resonance imaging (MRI) studies, but it remains unclear whether these are static or progressive in nature. While longitudinal MRI studies have been traditionally used to assess the issue of progression of brain abnormalities in schizophrenia, information from cross-sectional neuroimaging studies directly comparing first-episode and chronic schizophrenia patients to healthy controls ...

Also Ranks for: Gray Matter |  image processing |  schizophrenia patients |  illness duration |  age onset
KOL Index score: 15130

BACKGROUND: We conducted a systematic review of incidence rates in England over a sixty-year period to determine the extent to which rates varied along accepted (age, sex) and less-accepted epidemiological gradients (ethnicity, migration and place of birth and upbringing, time).

OBJECTIVES: To determine variation in incidence of several psychotic disorders as above.

DATA SOURCES: Published and grey literature searches (MEDLINE, PSycINFO, EMBASE, CINAHL, ASSIA, HMIC), and identification ...

Also Ranks for: Incidence Schizophrenia |  affective psychoses |  england systematic review |  psychotic disorders |  rates age
KOL Index score: 14911

CONTEXT: Second-generation (atypical) antipsychotics (SGAs) are more expensive than first-generation (typical) antipsychotics (FGAs) but are perceived to be more effective, with fewer adverse effects, and preferable to patients. Most evidence comes from short-term efficacy trials of symptoms.

OBJECTIVE: To test the hypothesis that in people with schizophrenia requiring a change in treatment, SGAs other than clozapine are associated with improved quality of life across 1 year compared ...

Also Ranks for: Schizophrenia Study |  randomized controlled trial |  sgas fgas |  antipsychotic drug |  quality life
KOL Index score: 14304

CONTEXT: While concordant parent/offspring risks for specific mental disorders are well established, knowledge of the broader range of psychiatric outcomes among offspring with parental history of mental disorder is lacking.

OBJECTIVE: To examine the full range of mental health outcomes among offspring of parents with serious and other mental disorders compared with those whose parents had no such history.

DESIGN: Population-based cohort study. Offspring were followed up from their 14th ...

Also Ranks for: Mental Disorder |  psychiatric outcomes |  offspring parents |  danish population |  outcome measures
KOL Index score: 14275

OBJECTIVE: Schizophrenia and psychotic bipolar disorder have a number of overlapping symptoms and risk factors, but it is not yet clear if the disorders are characterized by similar deviations in brain morphometry or whether any such deviations reflect the impact of shared susceptibility genes on brain structure. The authors used region-of-interest morphometry to volumetrically assess brain structures frequently implicated in psychotic illness in families affected with schizophrenia or ...

Also Ranks for: Unaffected Relatives |  bipolar disorder |  patients schizophrenia |  lateral ventricles |  magnetic resonance
KOL Index score: 14258

OBJECTIVE: Despite clear gender differences in the symptoms and course of bipolar affective disorder, studies investigating age at onset by gender have yielded inconsistent results. The authors investigated gender differences in age at onset and incidence of first-episode mania and bipolar disorder in an epidemiological catchment area in southeast London over a 35-year period.

METHOD: All adult cases of first-episode psychosis, mania, or hypomania presenting to services in Camberwell, ...

Also Ranks for: Bipolar Disorder |  gender differences |  age onset |  episode mania |  year period
KOL Index score: 14232

CONTEXT: Abnormalities of the thalamus are thought to be central to the pathophysiology of schizophrenia. These abnormalities include altered structure and shape of the thalamus itself and possibly changes to the adhesio interthalamica (or massa intermedia), the gray matter bridge connecting the 2 thalamic lobes. However, it is not clear to what extent these abnormalities are determined by the genetic liability for schizophrenia.

OBJECTIVE: To investigate thalamic volume and the presence ...

Also Ranks for: Adhesio Interthalamica |  magnetic resonance |  twins schizophrenia |  thalamic volume |  groups age
KOL Index score: 14087

CONTEXT: A major limitation on the development of biomarkers and novel interventions for schizophrenia is that its pathogenesis is unknown. Although elevated striatal dopamine activity is thought to be fundamental to schizophrenia, it is unclear when this neurochemical abnormality develops in relation to the onset of illness and how this relates to the symptoms and neurocognitive impairment seen in individuals with prodromal symptoms of schizophrenia.

OBJECTIVES: To determine whether ...

Also Ranks for: Striatal Dopamine |  prodromal symptoms |  patients schizophrenia |  associative striatum |  positron emission
KOL Index score: 13998

Schizophrenia in the mother may imply an increased risk of adverse pregnancy outcome. However, inconclusive findings, unknown pathological mechanisms and possible confounding by social factors and smoking requests further explorations. The aim of this study were to (1) examine non-optimal pregnancy outcome using data from a population-based cohort, controlling for covariates known to influence fetal growth; and (2) perform separate analyses of women diagnosed before childbirth and women ...

Also Ranks for: Pregnancy Outcome |  women schizophrenia |  infant death |  low birth weight |  preterm delivery
KOL Index score: 13986

Very preterm (VPT) birth is associated with altered cortical development and long-term neurodevelopmental sequelae. We used voxel-based morphometry to investigate white (WM) and grey matter (GM) distribution in VPT adolescents and controls, and the association with gestational age and neonatal ultrasound findings in the VPT individuals. GM and WM volumes were additionally investigated in relation to adolescent neurodevelopmental outcome. Structural MRI data were acquired with a 1.5 Tesla ...

Also Ranks for: Neurodevelopmental Outcome |  preterm adolescents |  vpt individuals |  premature infant |  cognitive impairment

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Robin MacGregor Murray:Expert Impact

Concepts for whichRobin MacGregor Murrayhas direct influence:Bipolar disorder,  Episode psychosis,  Psychotic disorders,  Obstetric complications,  Schizophrenic patients,  Patients schizophrenia,  Psychotic symptoms,  Unaffected relatives.

Robin MacGregor Murray:KOL impact

Concepts related to the work of other authors for whichfor which Robin MacGregor Murray has influence:Bipolar disorder,  Patients schizophrenia,  Mental health,  Psychotic symptoms,  White matter,  Dna methylation,  Childhood trauma.



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National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London, London, UK | Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuro