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    • John H Laragh
    • John H Laragh

      John H Laragh

      Department of Cardiothoracic Surgery, Weill Cornell Medical College, New York, New York | Weill Cornell Medical College, New York, NY 10065-4896, USA | Professor of Medicine, ...

       

       

      KOL Resume for John H Laragh

      Year
      2013

      Department of Cardiothoracic Surgery, Weill Cornell Medical College, New York, New York

      2012

      Professor of Medicine, Keenan Chair in Medical Research at St. Michael’s Hospital, Oreopoulos-Baxter Division Director of Nephrology at the University of Toronto, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

      Director, Rappaport Research Institute

      Director Emeritus, Renal Division, and Senior Physician, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts

      2011

      Department of Cardiothoracic Surgery, Weill Cornell Medical College, New York, New York, USA

      2010

      Department of Medicine; Weill Cornell Medical College; New York, NY (Sealey) Robert Rosenstein; Veterans' Affairs Medical Center; West Palm Beach, Fla (Parra) Cardiovascular Center, Department of Cardiothoracic Surgery; New York Presbyterian Hospital and; Weill Cornell Medical College; New York, NY (Laragh)

      2009

      Cardiovascular Center, Department of Cardiothoracic Surgery, NewYork-Presbyterian Hospital, Weill Cornell Medical College, New York, New York, USA

      Memorial Sloan-Kettering Cancer Center, New York, NY; Weill Cornell Medical College, New York, NY; Temple University School of Medicine, Philadelphia, PA; UCSF Comprehensive Cancer Center, San Francisco, CA

      2008

      Department of Medicine, Weil Cornell Medical College, New York, NY (Sealey) Department of Cardiothoracic Surgery, Weil Cornell Medical College and New York, Presbyterian Hospital, New York, NY (Laragh)

      2007

      Department of Cardiothoracic Surgery, New York Presbyterian Hospital and Weill Medical College of Cornell University, New York, New York

      2006

      Cornell Medical Center, New York, New York, USA

      2005

      Cardiovascular Center, Weill Medical College of Cornell University at New York Presbyterian Hospital, 1300 York Avenue, New York, NY 10021, USA

      2004

      Cardiovascular Center, Department of Cardiothoracic Surgery, Weill Medical College, Cornell University, New York, New York, USA

      Cornell University Medical College, New York, New York

      2003

      Cardiovascular Center, Department of Cardiothoracic Surgery, New York Presbyterian Hospital, and Joan and Sanford I. Weill Medical College of Cornell University, New York, New York 10021, USA.

      2002

      From the Divisions of Cardiology, Departments of Medicine, aUniversity of Massachusetts Medical Center, Worcester, Mass, and bNew York Hospital–Cornell University Medical Center, New York, NY

      Department of Medicine, New York Presbyterian Hospital-Weill Cornell Medical Center, New York, New York, USA

      2001

      The Rogosin Institute and The Department of Cardiothoracic Surgery, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, New York, USA

      1Ullevaal University Hospital Oslo Norway

      From the Cardiovascular Center, Weill Medical College of Cornell University, New York, NY.

      2000

      University of Michigan, Ann Arbor, MI, USA, Ullevaal University Hospital, Oslo, Norway

      The Cardiovascular Center, New York Presbyterian Hospital-Cornell Campus and Weill Medical College, New York, New York, USA

      1999

      Ullevaal University Hospital, Oslo, Norway.

      Cardiovascular Center (JDB, JES, AB, JHL), Department of Medicine, New York Presbyterian Hospital, New York, New York, USA

      University of MI, Ann Arbor, MI U.S.A.

      1998

      Department of Nephrology, New York Hospital—Cornell University Medical Center, New York, NY

      The Cardiovascular Center, The New York Hospital–Cornell Medical Center, New York, New York, USA

      1997

      Department of Medicine, Cornell University Medical College, Cardiovascular Center, New York Hospital, New York, NY, USA

      1996

      New York Hospital—Cornell Medical Center, New York City, New York, USA

      1995

      Cardiovascular Center, Department of Medicine, Cornell University Medical College, New York, USA.

      Department of Medicine and Hypertension Center, The New York Hospital—Cornell Medical Center, New York, New York, USA

      The New York Hospital‐Cornell Medical Center New York, New York 10021

      1994

      Cardiovascular Center, New York Hospital-Cornell University Medical College, NY 10021.

      From the Division of Cardiology, The New York Hospital-Cornell Medical Center, New York, New York, USA

      Division of Endocrinology/Hypertension, Wayne State University Medical Center, Detroit, Michigan 48201.

      1993

      Department of Anesthesiology, Hospital for Special Surgery, New York,New York.

      Cardiovascular Center, New York Hospital-Cornell Medical Center, New York, New York, USA

      1992

      Cardiovascular Center, New York Hospital-Cornell Medical Center, New York 10021.

      Department of Medicine, University of California, San Francisco 94143.

      New York, New York

      1991

      Cardiovascular Center, New York Hospital, Cornell University MedicalCollege, New York 10021.

      From the Cardiology Division and Hypertension Center, Department of Medicine, the New York Hospital-Cornell University Medical Center, New York, New York, USA

       

       

      John H Laragh: Influence Statistics

      Sample of concepts for which John H Laragh is among the top experts in the world.
      Concept World rank
      pressor responses patients #1
      adaptive hypernatriuresis nephrons #1
      addition diuretic administration #1
      lower runners #1
      tilt diuretics #1
      effects auriculin #1
      angiotensin bloodpressure #1
      excess renin #1
      kidney diuresis #1
      vasopressin normal #1
      teprotide patients #1
      rvdi nacl #1
      inactive renin patients #1
      small active renin #1
      renin pressor #1
      sodium populations #1
      tubular delivery #1
      24 hours hypocalciuria #1
      ethacrynic acid development #1
      renin substrate rate #1
      complete inhibition enzyme #1
      prorenin natural antagonist #1
      regular diet rvdi #1
      control renin levels #1
      reninsodium profile #1
      olmesartan normal subjects #1
      administration meralluride #1
      concurrent diuretic therapy #1
      renin values mechanisms #1
      cent decrease #1
      sodium volume dependency #1
      depressor responses cent #1
      renin teprotide #1
      nonresponders arterial pressure #1
      valsartan 80 160 #1
      renin secretion reasons #1
      women prorenin #1
      natriuresis angiotensin #1
      human kidney plasma #1
      highrenin states #1
      potassium deprivation plasma #1
      normal subjects natriuresis #1
      blood pressure highrenin #1
      enduring direct association #1
      cure renovascular hypertension #1
      antireninsystem drug #1
      surgical cure cent #1
      50 renin #1
      normal renin forms #1
      parenteral natriuresis #1

       

      Prominent publications by John H Laragh

      KOL-Index: 17673

      From renin measurements made in blood collected simultaneously from renal veins, aorta and vena cava, an equation was developed for estimating renin secretion rates in patients with three renin subtypes of essential hypertension. From these data a second equation was derived for estimating differential renal plasma flow in patients with unequal kidney perfusion. The latter equation achieves maximum precision when there is no renin secretion from one side.Plasma renin activity was ...

      Known for Essential Hypertension | Renin Secretion | Renal Vein | Plasma Flow | Cent Patients
      KOL-Index: 16022

      We measured plasma prorenin and renin levels, renal renin mRNA, renal anti-renin and anti-prorenin-prosequence immunoreactivity, and blood pressure in maturing Brookhaven Dahl salt-sensitive (Dahl S) and salt-resistant (Dahl R) rats during 14 days of low (0%), medium (0.4%), or high 4%) NaCl diets. Blood pressure was higher in Dahl S rats and did not increase with high NaCl. Seven-week-old Dahl R rats had twofold and sixfold higher levels of plasma prorenin and renal prosequence ...

      Known for Blood Pressure | Dahl Rats | Plasma Renin | Salt Diet | Rna Messenger
      KOL-Index: 15446

      PURPOSE: The purpose of this study was to determine the sensitivity, specificity, and clinical usefulness of renography performed in combination with captopril administration ("captopril renography") in diagnosing renal artery stenosis.

      PATIENTS AND METHODS: Fifty-five patients with suspected renal artery stenosis underwent renography prior to performance of renal angiography. Renography was performed on two consecutive days using technetium-99m-diethylenetiamine pentaacetic acid (DTPA) ...

      Known for Renal Artery Stenosis | Captopril Renography | Sensitivity Specificity | Patients Bilateral | Acid Kidney
      KOL-Index: 15274

      Oversecretion of aldosterone is a consistent finding in the syndrome of malignant hypertension. Infusion of angiotensin has been consistently shown to induce an increased secretion of aldosterone by the adrenal cortex in normal human subjects. Because renal damage is so prominent in malignant hypertension, it seems possible that renin release and then aldosterone oversecretion by the adrenal cortex are involved in the pathogenesis of this disorder. These findings support the possibility ...

      Known for Aldosterone Secretion | Angiotensin Norepinephrine | Adrenal Cortex | Malignant Hypertension | Cirrhosis Ascites
      KOL-Index: 15088

      Auriculin is a potent vasoactive and natriuretic peptide that was recently isolated and purified from rat atrial tissue. Since this peptide could be of great importance for renal, cardiovascular, and volume homeostasis, its functional properties have been characterized in dogs. The effects of synthetic auriculin on renal function, mean blood pressure, plasma renin activity, renin secretory rate, and plasma aldosterone levels were determined. Auriculin was administered intravenously as a ...

      Known for Blood Pressure | Renal Function | Atrial Natriuretic | Plasma Renin | Anesthetized Dogs
      KOL-Index: 14924

      The availability of specific inhibitors of the renin-angiotensin system has made it possible to evaluate precisely the contribution of this system to the maintenance of normal blood pressure and of various hypertensive situations encountered in animal models and in man. Furthermore, by combining the blockade of the renin system with accurate measurements of sodium balance, it is possible to expose and quantify latent or manifest abnormalities in renal sodium handling that operate ...

      Known for Blood Pressure | Renal Hypertension | Renin Sodium | Angiotensin Blockade | Artery Obstruction
      KOL-Index: 14785

      OBJECTIVES: We sought to determine whether growth influences the relation between left ventricular mass and body size and whether use of different body size indexes affects the ability of ventricular mass to predict complications of hypertension.

      BACKGROUND: Allometric (or growth) signals between left ventricular mass and height have recently been reported to improve previous approaches for normalization of ventricular mass for body size.

      METHODS: Residuals of left ventricular ...

      Known for Ventricular Mass | Cardiovascular Risk | Body Height | Children Adults | Hypertension Hypertrophy
      KOL-Index: 14723

      We previously demonstrated an inactive form of renin, termed prorenin, in the plasma of normal, hypertensive and anephric patients. Prorenin activity can be determined in plasma from the total renin activity after activation, minus the prior endogenous plasma renin activity. In the present study, conditions for cryoactivation of prorenin have been defined. Plasma prorenin is slowly converted to active renin-like material at -5 degrees C at pH 7.4. Activation takes four days and does not ...

      Known for Plasma Prorenin | Renin Substrate | Normal Subjects | Freezing Humans | Inactive Form
      KOL-Index: 14504

      The antihypertensive effect of propranolol was evaluated in 96 patients with various forms of hypertension preclassified according to plasma renin activity considered in relation to urinary sodium excretion.In essential hypertension (no = 74) 74 percent of high-renin patients (14 of 19) exhibited striking blood pressure reductions and 66 percent of normal-renin patients (25 of 38) achieved diastolic pressures less than or equal to 95 mm Hg. In sharp contrast, propranolol was completely ...

      Known for Antihypertensive Action | Hypertension Renin | Sodium Excretion | Blood Pressure | Propranolol Renal
      KOL-Index: 14386

      The role of hormones that can influence renal tubular reabsorption of salt and water in congestive heart failure and other states of abnormal fluid retention has been discussed. Available evidence indicates that the antidiuretic hormone of the neurohypophysis plays a nonessential role in the pathogenesis of edema. Oversecretion of aldosterone can be an important, or even an essential, mechanism in the pathogenesis of certain states of edema, such as those of nephrosis and cirrhosis. ...

      Known for Heart Failure | Aldosterone Angiotensin | Sodium Balance | Adrenal Cortex | Cirrhosis Ascites
      KOL-Index: 14040

      Inactive renin comprises well over half the total renin in normal human plasma. There is a direct relationship between active and inactive renin levels in normal and hypertensive populations, but the proportion of inactive renin varies inversely with the active renin level; as much as 98% of plasma renin is inactive in patients with low renin, whereas the proportion is consistently lower (usually 20-60%) in high-renin states. Two hypertensive patients with proven renin-secreting ...

      Known for Inactive Renin | Plasma Active | Activation Enzyme | Levels Normal | Humans Hypertension
      KOL-Index: 13538

      The weak relation of systolic blood pressure to left ventricular mass in hypertensive patients is often interpreted as evidence of nonhemodynamic stimuli to muscle growth. To test the hypothesis that left ventricular chamber size, reflecting hemodynamic volume load and myocardial contractility, influences the development of left ventricular hypertrophy in hypertension, we studied actual and theoretic relations of left ventricular mass to left ventricular diastolic chamber volume, ...

      Known for Ventricular Mass | Systolic Blood Pressure | Hemodynamic Load | Contractile Performance | Multivariate Analysis
      KOL-Index: 13187

      The effect of potassium administration and of dietary potassium deprivation on plasma renin activity and aldosterone excretion has been studied in 10 normal subjects and in 12 hypertensive patients maintained on a constant dietary regimen. Potassium administration reduced plasma renin activity in 18 of 28 studies of both normal and hypertensive subjects. Suppression of renin often occurred despite sodium diuresis induced by potassium administration. The renin suppression was related to ...

      Known for Plasma Renin | Potassium Administration | Hypertensive Subjects | Sodium Balance | Aldosterone Excretion
      KOL-Index: 13152

      BACKGROUND: The Valsartan Antihypertensive Long-term Use Evaluation (VALUE) trial was designed to test the hypothesis that for the same blood-pressure control, valsartan would reduce cardiac morbidity and mortality more than amlodipine in hypertensive patients at high cardiovascular risk.

      METHODS: 15?245 patients, aged 50 years or older with treated or untreated hypertension and high risk of cardiac events participated in a randomised, double-blind, parallel-group comparison of therapy ...

      Known for Cardiovascular Risk | Hypertensive Patients | Valsartan Amlodipine | Blood Pressure | Randomised Trial
      KOL-Index: 13150

      Plasma prorenin is an inactive form of renin (EC 3.4.99.19) that can be converted to active renin in acid-treated plasma by an endogenous serine protease that is active at alkaline pH (alkaline phase activation). To identify this enzyme we first tested the ability of Hageman factor fragments, plasma kallikrein (EC 3.4.21.8), and plasmin (EC 3.4.21.7) to activate prorenin in acid-treated plasma. All three enzymes initiated prorenin activation; 50% activation was achieved with Hageman ...

      Known for Hageman Factor | Plasma Prorenin | Alkaline Phase | Acid Activation | Active Renin

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      John H Laragh:Expert Impact

      Concepts for whichJohn H Laraghhas direct influence:Blood pressure,  Essential hypertension,  Plasma renin,  Ventricular mass,  Plasma prorenin,  Atrial natriuretic factor,  Hypertensive patients,  Plasma renin activity.

      John H Laragh:KOL impact

      Concepts related to the work of other authors for whichfor which John H Laragh has influence:Blood pressure,  Heart failure,  Ventricular hypertrophy,  Essential hypertension,  Hypertensive patients,  Atrial natriuretic,  Cardiovascular disease.


       

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      Department of Cardiothoracic Surgery, Weill Cornell Medical College, New York, New York | Weill Cornell Medical College, New York, NY 10065-4896, USA | Professor of Medicine, Keenan Chair in Medical Research at St. Michael’s Hospital, Oreopoulos-Baxt

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