John H Laragh: Influence Statistics

John H Laragh

John H Laragh

Department of Cardiothoracic Surgery, Weill Cornell Medical College, New York, New York | Weill Cornell Medical College, New York, NY 10065-4896, USA | Professor of Medicine, ...

John H Laragh: Expert Impact

Concepts for which John H Laragh has direct influence: Blood pressure , Essential hypertension , Plasma renin , Ventricular mass , Plasma prorenin , Atrial natriuretic factor , Hypertensive patients .

John H Laragh: KOL impact

Concepts related to the work of other authors for which for which John H Laragh has influence: Blood pressure , Heart failure , Ventricular hypertrophy , Essential hypertension , Hypertensive patients , Atrial natriuretic , Cardiovascular disease .

KOL Resume for John H Laragh

Year
2013

Department of Cardiothoracic Surgery, Weill Cornell Medical College, New York, New York

2012

Professor of Medicine, Keenan Chair in Medical Research at St. Michael’s Hospital, Oreopoulos-Baxter Division Director of Nephrology at the University of Toronto, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

Director, Rappaport Research Institute

Director Emeritus, Renal Division, and Senior Physician, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts

2011

Department of Cardiothoracic Surgery, Weill Cornell Medical College, New York, New York, USA

2010

Department of Medicine; Weill Cornell Medical College; New York, NY (Sealey) Robert Rosenstein; Veterans' Affairs Medical Center; West Palm Beach, Fla (Parra) Cardiovascular Center, Department of Cardiothoracic Surgery; New York Presbyterian Hospital and; Weill Cornell Medical College; New York, NY (Laragh)

2009

Cardiovascular Center, Department of Cardiothoracic Surgery, NewYork-Presbyterian Hospital, Weill Cornell Medical College, New York, New York, USA

Memorial Sloan-Kettering Cancer Center, New York, NY; Weill Cornell Medical College, New York, NY; Temple University School of Medicine, Philadelphia, PA; UCSF Comprehensive Cancer Center, San Francisco, CA

2008

Department of Medicine, Weil Cornell Medical College, New York, NY (Sealey) Department of Cardiothoracic Surgery, Weil Cornell Medical College and New York, Presbyterian Hospital, New York, NY (Laragh)

2007

Department of Cardiothoracic Surgery, New York Presbyterian Hospital and Weill Medical College of Cornell University, New York, New York

2006

Cornell Medical Center, New York, New York, USA

2005

Cardiovascular Center, Weill Medical College of Cornell University at New York Presbyterian Hospital, 1300 York Avenue, New York, NY 10021, USA

2004

Cardiovascular Center, Department of Cardiothoracic Surgery, Weill Medical College, Cornell University, New York, New York, USA

Cornell University Medical College, New York, New York

2003

Cardiovascular Center, Department of Cardiothoracic Surgery, New York Presbyterian Hospital, and Joan and Sanford I. Weill Medical College of Cornell University, New York, New York 10021, USA.

2002

From the Divisions of Cardiology, Departments of Medicine, aUniversity of Massachusetts Medical Center, Worcester, Mass, and bNew York Hospital–Cornell University Medical Center, New York, NY

Department of Medicine, New York Presbyterian Hospital-Weill Cornell Medical Center, New York, New York, USA

2001

The Rogosin Institute and The Department of Cardiothoracic Surgery, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, New York, USA

1Ullevaal University Hospital Oslo Norway

From the Cardiovascular Center, Weill Medical College of Cornell University, New York, NY.

2000

University of Michigan, Ann Arbor, MI, USA, Ullevaal University Hospital, Oslo, Norway

The Cardiovascular Center, New York Presbyterian Hospital-Cornell Campus and Weill Medical College, New York, New York, USA

1999

Ullevaal University Hospital, Oslo, Norway.

Cardiovascular Center (JDB, JES, AB, JHL), Department of Medicine, New York Presbyterian Hospital, New York, New York, USA

University of MI, Ann Arbor, MI U.S.A.

1998

Department of Nephrology, New York Hospital—Cornell University Medical Center, New York, NY

The Cardiovascular Center, The New York Hospital–Cornell Medical Center, New York, New York, USA

1997

Department of Medicine, Cornell University Medical College, Cardiovascular Center, New York Hospital, New York, NY, USA

1996

New York Hospital—Cornell Medical Center, New York City, New York, USA

1995

Cardiovascular Center, Department of Medicine, Cornell University Medical College, New York, USA.

Department of Medicine and Hypertension Center, The New York Hospital—Cornell Medical Center, New York, New York, USA

The New York Hospital‐Cornell Medical Center New York, New York 10021

1994

Cardiovascular Center, New York Hospital-Cornell University Medical College, NY 10021.

From the Division of Cardiology, The New York Hospital-Cornell Medical Center, New York, New York, USA

Division of Endocrinology/Hypertension, Wayne State University Medical Center, Detroit, Michigan 48201.

1993

Department of Anesthesiology, Hospital for Special Surgery, New York,New York.

Cardiovascular Center, New York Hospital-Cornell Medical Center, New York, New York, USA

1992

Cardiovascular Center, New York Hospital-Cornell Medical Center, New York 10021.

Department of Medicine, University of California, San Francisco 94143.

New York, New York

1991

Cardiovascular Center, New York Hospital, Cornell University MedicalCollege, New York 10021.

From the Cardiology Division and Hypertension Center, Department of Medicine, the New York Hospital-Cornell University Medical Center, New York, New York, USA

Prominent publications by John H Laragh

KOL-Index: 17673 . From renin measurements made in blood collected simultaneously from renal veins, aorta and vena cava, an equation was developed for estimating renin secretion rates in patients with three renin subtypes of essential hypertension. From these data a second equation was derived for estimating differential renal plasma flow in patients with unequal kidney perfusion. The latter equation ...
Known for Essential Hypertension | Renin Secretion | Renal Vein | Plasma Flow
KOL-Index: 16022 . We measured plasma prorenin and renin levels, renal renin mRNA, renal anti-renin and anti-prorenin-prosequence immunoreactivity, and blood pressure in maturing Brookhaven Dahl salt-sensitive (Dahl S) and salt-resistant (Dahl R) rats during 14 days of low (0%), medium (0.4%), or high 4%) NaCl diets. Blood pressure was higher in Dahl S rats and did not increase with high NaCl. Seven-week-old ...
Known for Blood Pressure | Dahl Rats | Plasma Renin | Salt Diet
KOL-Index: 15446 . PURPOSE: The purpose of this study was to determine the sensitivity, specificity, and clinical usefulness of renography performed in combination with captopril administration ("captopril renography") in diagnosing renal artery stenosis. PATIENTS AND METHODS: Fifty-five patients with suspected renal artery stenosis underwent renography prior to performance of renal angiography. Renography ...
Known for Renal Artery Stenosis | Captopril Renography | Sensitivity Specificity | Patients Bilateral
KOL-Index: 15274 . Oversecretion of aldosterone is a consistent finding in the syndrome of malignant hypertension. Infusion of angiotensin has been consistently shown to induce an increased secretion of aldosterone by the adrenal cortex in normal human subjects. Because renal damage is so prominent in malignant hypertension, it seems possible that renin release and then aldosterone oversecretion by the ...
Known for Aldosterone Secretion | Angiotensin Norepinephrine | Adrenal Cortex | Malignant Hypertension
KOL-Index: 15088 . Auriculin is a potent vasoactive and natriuretic peptide that was recently isolated and purified from rat atrial tissue. Since this peptide could be of great importance for renal, cardiovascular, and volume homeostasis, its functional properties have been characterized in dogs. The effects of synthetic auriculin on renal function, mean blood pressure, plasma renin activity, renin secretory ...
Known for Blood Pressure | Renal Function | Atrial Natriuretic | Plasma Renin
KOL-Index: 14924 . The availability of specific inhibitors of the renin-angiotensin system has made it possible to evaluate precisely the contribution of this system to the maintenance of normal blood pressure and of various hypertensive situations encountered in animal models and in man. Furthermore, by combining the blockade of the renin system with accurate measurements of sodium balance, it is possible ...
Known for Blood Pressure | Renal Hypertension | Renin Sodium | Angiotensin Blockade
KOL-Index: 14785 . OBJECTIVES: We sought to determine whether growth influences the relation between left ventricular mass and body size and whether use of different body size indexes affects the ability of ventricular mass to predict complications of hypertension. BACKGROUND: Allometric (or growth) signals between left ventricular mass and height have recently been reported to improve previous approaches ...
Known for Ventricular Mass | Cardiovascular Risk | Body Height | Children Adults
KOL-Index: 14723 . We previously demonstrated an inactive form of renin, termed prorenin, in the plasma of normal, hypertensive and anephric patients. Prorenin activity can be determined in plasma from the total renin activity after activation, minus the prior endogenous plasma renin activity. In the present study, conditions for cryoactivation of prorenin have been defined. Plasma prorenin is slowly ...
Known for Plasma Prorenin | Renin Substrate | Normal Subjects | Freezing Humans
KOL-Index: 14504 . The antihypertensive effect of propranolol was evaluated in 96 patients with various forms of hypertension preclassified according to plasma renin activity considered in relation to urinary sodium excretion.In essential hypertension (no = 74) 74 percent of high-renin patients (14 of 19) exhibited striking blood pressure reductions and 66 percent of normal-renin patients (25 of 38) achieved ...
Known for Antihypertensive Action | Hypertension Renin | Sodium Excretion | Blood Pressure
KOL-Index: 14386 . The role of hormones that can influence renal tubular reabsorption of salt and water in congestive heart failure and other states of abnormal fluid retention has been discussed. Available evidence indicates that the antidiuretic hormone of the neurohypophysis plays a nonessential role in the pathogenesis of edema. Oversecretion of aldosterone can be an important, or even an essential, ...
Known for Heart Failure | Aldosterone Angiotensin | Sodium Balance | Adrenal Cortex
KOL-Index: 14040 . Inactive renin comprises well over half the total renin in normal human plasma. There is a direct relationship between active and inactive renin levels in normal and hypertensive populations, but the proportion of inactive renin varies inversely with the active renin level; as much as 98% of plasma renin is inactive in patients with low renin, whereas the proportion is consistently lower ...
Known for Inactive Renin | Plasma Active | Activation Enzyme | Levels Normal
KOL-Index: 13538 . The weak relation of systolic blood pressure to left ventricular mass in hypertensive patients is often interpreted as evidence of nonhemodynamic stimuli to muscle growth. To test the hypothesis that left ventricular chamber size, reflecting hemodynamic volume load and myocardial contractility, influences the development of left ventricular hypertrophy in hypertension, we studied actual ...
Known for Ventricular Mass | Systolic Blood Pressure | Hemodynamic Load | Contractile Performance
KOL-Index: 13187 . The effect of potassium administration and of dietary potassium deprivation on plasma renin activity and aldosterone excretion has been studied in 10 normal subjects and in 12 hypertensive patients maintained on a constant dietary regimen. Potassium administration reduced plasma renin activity in 18 of 28 studies of both normal and hypertensive subjects. Suppression of renin often occurred ...
Known for Plasma Renin | Potassium Administration | Hypertensive Subjects | Sodium Balance
KOL-Index: 13152 . BACKGROUND: The Valsartan Antihypertensive Long-term Use Evaluation (VALUE) trial was designed to test the hypothesis that for the same blood-pressure control, valsartan would reduce cardiac morbidity and mortality more than amlodipine in hypertensive patients at high cardiovascular risk. METHODS: 15?245 patients, aged 50 years or older with treated or untreated hypertension and high risk ...
Known for Cardiovascular Risk | Hypertensive Patients | Valsartan Amlodipine | Blood Pressure
KOL-Index: 13150 . Plasma prorenin is an inactive form of renin (EC 3.4.99.19) that can be converted to active renin in acid-treated plasma by an endogenous serine protease that is active at alkaline pH (alkaline phase activation). To identify this enzyme we first tested the ability of Hageman factor fragments, plasma kallikrein (EC 3.4.21.8), and plasmin (EC 3.4.21.7) to activate prorenin in acid-treated ...
Known for Hageman Factor | Plasma Prorenin | Alkaline Phase | Acid Activation

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Department of Cardiothoracic Surgery, Weill Cornell Medical College, New York, New York | Weill Cornell Medical College, New York, NY 10065-4896, USA | Professor of Medicine, Keenan Chair in Medical Research at St. Michael’s Hospital, Oreopoulos-Baxt