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    • Joseph Thomas Flynn

      Joseph Thomas Flynn

      Seattle Children's Hospital, Seattle, Washington. | Department of Pediatrics, Division of Nephrology, Seattle Children’s Hospital, 4800 Sand Point Way NE, OC.9.820 – ...



      KOL Resume for Joseph Thomas Flynn


      Seattle Children's Hospital, Seattle, Washington.

      Department of Pediatrics, University of Washington (J.T.F.).


      Department of Pediatrics, University of Washington; Division of Nephrology, Seattle Children’s Hospital, Seattle, WA, USA

      Seattle Children’s Hospital, Seattle, WA (J.T.F., C.D.H.).

      Division of Nephrology.


      Department of Pediatrics, University of Washington, Seattle


      School of Medicine, University of Washington, Seattle, Washington;

      Seattle Children’s Hospital, Seattle, Washington


      Seattle Children’s Hospital

      University of Washington


      Seattle Children's Hospital Division of Nephrology Seattle WA USA


      Department of Nephrology, Seattle Children's Hospital, Seattle, WA


      Seattle Children’s Hospital, Seattle, WA

      Due to the number of contributing authors, the affiliations are provided in the Supplemental Material


      Seattle Children's Hospital, Seattle, WA, United States


      Seattle Children's Hospital, Seattle, Washington


      Division of Nephrology, Seattle Children's Hospital, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington 48105, USA.

      From the University of Texas Health Science Center at Houston (J.S., T.P.), Houston, TX; Department of Epidemiology (D.N.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Seattle Children's Hospital (J.T.F.), Seattle, WA; Cincinnati Children's Hospital Medical Center (M.M.), Cincinnati, OH; Children's Mercy Hospital (B.A.W.), Kansas City, MO; Children's Hospital of Philadelphia (S.F.), Philadelphia, PA.

      Seattle Children’s Hospital, University of Washington School of Medicine, Seattle, WA, USA



      Joseph Thomas Flynn: Influence Statistics

      Sample of concepts for which Joseph Thomas Flynn is among the top experts in the world.
      Concept World rank
      abnormal abpm phenotype #1
      respondents diagnostic evaluation #1
      safety antihypertensive medications #1
      secondary n308 hypertension #1
      elevated bpmanagement #1
      rational antihypertensive medications #1
      common childhood hypertension #1
      htn adolescent #1
      myocontractility #1
      proper blood pressure #1
      lean bmi 15th85th #1
      obese persons elevated #1
      prehypertension retrospective #1
      microalbuminuria abp #1
      lack routine measurements #1
      ninetyseven abpm studies #1
      paucity longterm outcome #1
      children central role #1
      renal disease hps #1
      elevated bps factors #1
      guidelines antihypertensive medications #1
      141 initial doses #1
      progression abpm #1
      choice initial agent #1
      focused evaluation thromboembolism #1
      shortacting nifedipine treatment #1
      daytime diastolic load #1
      45 apparent clearances #1
      approach abpm #1
      time hypertension male #1
      treatment courses control #1
      albuminuria endopat score #1
      chronic reninangiotensin strategies #1
      hypertension achievement #1
      ras abp #1
      fdaapproved labeling children #1
      74±55 months #1
      aged 521 years #1
      varying blood #1
      ebp recognition addition #1
      2017 aap cpg #1
      continuous hemofiltration hemodiafiltration #1
      evidence treatmentresistant hypertension #1
      drug user rate #1
      18±16 #1
      therapy childhood hypertension #1
      patients contradictory recommendations #1
      pediatric antihypertensive drugs #1
      largest groups medications #1
      317 young adults #1


      Prominent publications by Joseph Thomas Flynn

      KOL-Index: 14949

      Left ventricular hypertrophy (LVH) associates with increased risk for cardiovascular disease. Hypertension leads to LVH in adults, but its role in the pathogenesis of LVH in children is not as well established. To examine left ventricular mass and evaluate factors associated with LVH in children with stages 2 through 4 chronic kidney disease (CKD), we analyzed cross-sectional data from children who had baseline echocardiography (n = 366) and underwent ambulatory BP monitoring (n = 226) ...

      Known for Ventricular Hypertrophy | Lvh Children | Masked Hypertension | Ambulatory Monitoring | Cardiovascular Disease
      KOL-Index: 14919

      BACKGROUND: Few studies have prospectively evaluated the progression of chronic kidney disease (CKD) in children and adolescents, as well as factors associated with progression.

      STUDY DESIGN: Prospective multicenter observational cohort study.

      SETTING & PARTICIPANTS: 496 children and adolescents with CKD enrolled in the Chronic Kidney Disease in Children (CKiD) Study.

      PREDICTORS: Proteinuria, hypoalbuminemia, blood pressure, dyslipidemia, and anemia.

      OUTCOMES: Parametric failure-time ...

      Known for Kidney Disease | Children Ckd | Rapid Progression | Composite Event | 50 Decline
      KOL-Index: 12770

      OBJECTIVE: To determine whether casual blood pressure (BP) or ambulatory BP monitoring (ABPM) measurements obtained at the initial visit of a child with confirmed hypertension (HTN) might predict left ventricular hypertrophy (LVH), possibly obviating the need for echocardiography.

      STUDY DESIGN: We conducted a cross-sectional study of 184 children aged 3 to 20 years who were referred for initial evaluation of elevated BP at 3 tertiary care centers. Casual BP and various ambulatory BP ...

      Known for Ventricular Hypertrophy | Lvh Children | Blood Pressure | Primary Hypertension | Ambulatory Child Child
      KOL-Index: 11375

      BACKGROUND: Ambulatory blood pressure monitoring (ABPM) is widely utilized for the evaluation and management of hypertension in adults but has not been routinely used in the care of hypertensive children.

      DESIGN: To examine the potential impact that the routine use of ABPM might have on the evaluation and management of hypertension in children, we reviewed our early experience with this technique, comparing management decisions based on ABPM with those based on casual blood pressure ...

      Known for Blood Pressure | Hypertension Children | Evaluation Management | Abpm Studies | Ambulatory Child Child
      KOL-Index: 11260

      Cyclosporin (Cs-A) is an effective treatment for difficult cases of nephrotic syndrome (NS), but its use can be complicated by renal toxicity and a high incidence of relapses after withdrawal. We reviewed the charts of 10 Cs-A-dependent patients and 4 patients with steroid-dependent nephrotic syndrome (SDNS) not previously treated with Cs-A therapy. All patients had persistent NS, even after prior treatment with oral cyclophosphamide. Of 10 patients treated with Cs-A, 4 had surveillance ...

      Known for Mmf Patients | Mycophenolate Mofetil | Frequency Relapses | Sdns Csa | Nonsteroidal Child Child
      KOL-Index: 10347

      To characterize the distribution of blood pressure (BP), prevalence, and risk factors for hypertension in pediatric chronic kidney disease, we conducted a cross-sectional analysis of baseline BPs in 432 children (mean age 11 years; 60% male; mean glomerular filtration rate 44 mL/min per 1.73 m(2)) enrolled in the Chronic Kidney Disease in Children cohort study. BPs were obtained using an aneroid sphygmomanometer. Glomerular filtration rate was measured by iohexol disappearance. Elevated ...

      Known for Chronic Kidney Disease | Blood Pressure | Antihypertensive Medications | Kidney Failure | Glomerular Filtration
      KOL-Index: 10117

      Ambulatory blood pressure (BP) monitoring (ABPM) is the best method of detecting abnormal BP in patients with chronic kidney disease (CKD), whose hypertension may be missed with casual BP measurements. We report ABPM findings in 332 children 1 year after entry in the Chronic Kidney Disease in Children cohort study. All of the subjects underwent casual and ambulatory BP measurement. BP was categorized based on casual and ABPM results into normal (42%), white-coat (4%), masked (35%), and ...

      Known for Chronic Kidney Disease | Ambulatory Blood | Enzyme Inhibitors | Abpm Children | Hypertension Kidney
      KOL-Index: 9835

      Dyslipidemia, a known risk factor for atherosclerosis, is frequent among both adults and children with chronic kidney disease. Here, we describe the prevalence and pattern of dyslipidemia from a cross-sectional analysis of 391 children aged 1-16 years, enrolled in the multicenter Chronic Kidney Disease in Children (CKiD) study, with a median glomerular filtration rate (GFR), measured by the plasma disappearance of iohexol, of 43 ml/min per 1.73 m2. Multivariate analysis was applied to ...

      Known for Kidney Disease | Dyslipidemia Children | Bmi Gfr | Ckid Study | Cholesterol Hdl
      KOL-Index: 9676

      PURPOSE: Renal transplantation in children with end stage renal disease due to congenital urological malformations has traditionally been associated with a poor outcome compared to transplantation in those with a normal urinary tract. In addition, the optimal urological treatment for such children remains unclear. To address these issues, we retrospectively reviewed our experience with renal transplantation in this population.

      MATERIALS AND METHODS: Between 1986 and 1998, 12 boys and 6 ...

      Known for Renal Transplantation | Urinary Tract | Severe Lower | Serum Creatinine | 11 Children
      KOL-Index: 9658

      These pediatric hypertension guidelines are an update to the 2004 "Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents." Significant changes in these guidelines include (1) the replacement of the term "prehypertension" with the term "elevated blood pressure," (2) new normative pediatric blood pressure (BP) tables based on normal-weight children, (3) a simplified screening table for identifying BPs needing further evaluation, (4) a ...

      Known for Clinical Practice Guideline | Pressure Blood | Diagnosis Management | Heart Association | Ambulatory Monitoring
      KOL-Index: 9594

      OBJECTIVE: To determine whether ambulatory blood pressure monitoring (ABPM) can help differentiate children with secondary hypertension from those with primary hypertension.

      METHODS: Ninety-seven ABPM studies obtained from 85 children followed in a pediatric hypertension clinic were analyzed. Forty studies were performed in patients with primary hypertension, and 57 studies were performed in patients with secondary hypertension. Mean patient age was 13.8 +/- 3.5 [mean +/- standard ...

      Known for Secondary Hypertension | Ambulatory Blood | Pressure Monitoring | Children Abpm | Detailed Evaluation
      KOL-Index: 9392

      The efficacy and safety of valsartan were studied in 90 children (mean age: 3.2 years; 60% male; 30% black) with systolic blood pressure (SBP) > or =95th percentile. Nineteen percent received valsartan in addition to previous antihypertensive therapy. Subjects were randomly assigned to low-, medium-, or high-dose valsartan for 2 weeks (phase 1) and then reassigned randomly to placebo or to remain on the same valsartan dose for 2 additional weeks (phase 2). After this, subjects were ...

      Known for Angiotensin Receptor | Children Age | Safety Valsartan | 2 Weeks | 95th Percentile
      KOL-Index: 9246

      BACKGROUND AND OBJECTIVES: Children with chronic kidney disease (CKD) are at risk for cognitive dysfunction, and over half have hypertension. Data on the potential contribution of hypertension to CKD-associated neurocognitive deficits in children are limited. Our objective was to determine whether children with CKD and elevated BP (EBP) had decreased performance on neurocognitive testing compared with children with CKD and normal BP.


      Known for Chronic Kidney Disease | Neurocognitive Function | Blood Pressure | Children Ckd | Child Behavior
      KOL-Index: 8764

      BACKGROUND AND OBJECTIVES: Dyslipidemia, a risk factor for cardiovascular disease, is common in CKD but its change over time and how that change is influenced by concurrent progression of CKD have not been previously described.

      DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In the CKD in Children study we prospectively followed children with progressive CKD and utilized multivariable, linear mixed-effects models to quantify the longitudinal relationship between within-subject changes in ...

      Known for Children Ckd | Filtration Rate | Proteinuria Renal | Cardiovascular Disease | Independently Concomitant
      KOL-Index: 8538

      BACKGROUND AND OBJECTIVES: Congenital anomalies of the kidney and urinary tract and genetic disorders cause most cases of CKD in children. This study evaluated the relationships between baseline proteinuria and BP and longitudinal changes in GFR in children with these nonglomerular causes of CKD.

      DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Urine protein-to-creatinine ratio, casual systolic and diastolic BP (normalized for age, sex, and height), and GFR decline were assessed in the ...

      Known for Pediatric Ckd | Ckid Cohort | Baseline Gfr | Progression Children | Urinary Tract

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      Joseph Thomas Flynn:Expert Impact

      Concepts for whichJoseph Thomas Flynnhas direct influence:Blood pressure,  Chronic kidney disease,  Antihypertensive medications,  Severe hypertension,  Primary hypertension,  Peritoneal dialysis,  Kidney disease,  Ventricular hypertrophy.

      Joseph Thomas Flynn:KOL impact

      Concepts related to the work of other authors for whichfor which Joseph Thomas Flynn has influence:Blood pressure,  Chronic kidney disease,  Children adolescents,  Peritoneal dialysis,  Type 1 diabetes,  Metabolic syndrome,  Pediatric patients.



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      Seattle Children's Hospital, Seattle, Washington. | Department of Pediatrics, Division of Nephrology, Seattle Children’s Hospital, 4800 Sand Point Way NE, OC.9.820 – Nephrology, Seattle, WA 98105, USA | Division of Nephrology, Seattle Children’s Hosp

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