• Type 2 Diabetes
    • Tuomilehto Tuomilehto
    • Tuomilehto Tuomilehto: Influence Statistics

      Tuomilehto Tuomilehto

      Tuomilehto Tuomilehto

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      Population Health Unit, Finnish Institute for Health and Welfare, 00271 Helsinki, Finland;, tiia.ngandu@thl.fi, (T.N.);, esko.levalahti@thl.fi, (E.L.);, ...

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      Tuomilehto Tuomilehto:Expert Impact

      Concepts for whichTuomilehto Tuomilehtohas direct influence:Type 2 diabetes,Blood pressure,2 diabetes,Physical activity,Type 2,Metabolic syndrome,North karelia,Type 1 diabetes.

      Tuomilehto Tuomilehto:KOL impact

      Concepts related to the work of other authors for whichfor which Tuomilehto Tuomilehto has influence:Metabolic syndrome,Type 2 diabetes,Blood pressure,Physical activity,Insulin resistance,Cardiovascular disease,Weight loss.

      KOL Resume for Tuomilehto Tuomilehto


      Population Health Unit, Finnish Institute for Health and Welfare, 00271 Helsinki, Finland;, (T.N.);, (E.L.);, (T.L.);, (J.L.);, (J.T.)

      Department of International Health, National School of Public Health, Instituto de Salud Carlos III, Madrid, Spain.

      Saudi Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia

      South Ostrobothnia Central Hospital, Hanneksenrinne 7, 60220, Seinäjoki, Finland

      National School of Public Health, Madrid, Spain


      Department of Public Health, University of Helsinki, Helsinki, Finland; Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address:

      South Ostrobothnia Central Hospital, , Seinäjoki, , Finland

      Dasman Diabetes Institute, Kuwait

      Centre for Vascular Prevention, Danube-University Krems, Krems, Austria

      Saudi Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.


      Dasman Diabetes Institute, P.O. Box 1180, Dasman, 15462 Kuwait

      Department of Public Health, University of Helsinki, Tukholmankatu 8B, PO Box 20, 00014 Helsinki, Finland, E-mail:

      Saudi Diabetes Research Group, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 3270, Saudi Arabia;, (S.B.);, (M.M.);, (H.J.);, (B.E.);, (J.A.-A.);, (R.A.R.);, (G.A.);, (A.B.);, (J.T.)

      South Ostrobothnia Central Hospital, Seinäjoki, Finland.

      Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland

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      Sample of concepts for which Tuomilehto Tuomilehto is among the top experts in the world.
      Concept World rank
      women strokes #1
      fatal chd subjects #1
      rs9678851 #1
      rs10920534 #1
      serum indolepropionic acid #1
      waist circumference hip #1
      sex distribution finland #1
      sbp15y sbp #1
      pregnancy postpartum risk #1
      24760 #1
      1140a #1
      wsr bmi #1
      m326i #1
      488526 #1
      diabetes criteria #1
      mild osa intervention #1
      findrisc ppv #1
      eckenrode #1
      sbp reduction sbp #1
      diabetes finnish #1
      nondiabetic european #1
      iddm prevalence #1
      hladpb1030101 #1
      fpg igt #1
      angptl5 ± #1
      siblings diagnosis #1
      hour plasma glucose #1
      sex factors finland #1
      gdm physical activity #1
      treated subjects definitions #1
      diabetes joint #1
      expression tlr10 #1
      fpg 6169 mmol #1
      g250g genotype conversion #1
      ace ht #1
      sensitivity icd codes #1
      incidence finland #1
      chd events hdr #1
      igt insulin secretion #1
      mauritius incidence #1
      hazards ratios #1
      watching time #1
      finland childhood diabetes #1
      highest tertile bmi7y #1
      podosa south asians #1
      bmi6m #1
      diabetes mellitus finland #1
      finnish #1
      reversion normoglycemia #1
      impaired glucose tolerance #1
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      Prominent publications by Tuomilehto Tuomilehto

      KOL-Index: 23482

      BACKGROUND: Underweight, overweight, and obesity in childhood and adolescence are associated with adverse health consequences throughout the life-course. Our aim was to estimate worldwide trends in mean body-mass index (BMI) and a comprehensive set of BMI categories that cover underweight to obesity in children and adolescents, and to compare trends with those of adults.

      METHODS: We pooled 2416 population-based studies with measurements of height and weight on 128·9 million participants ...

      Known for Worldwide Trends | Bmi Prevalence | Pooled Analysis | 1 2 | Boys Obesity
      KOL-Index: 22675

      CONTEXT: Geographic variations in cardiovascular disease (CVD) and associated risk factors have been recognized worldwide. However, little attention has been directed to potential differences in hypertension between Europe and North America.

      OBJECTIVE: To determine whether higher blood pressure (BP) levels and hypertension are more prevalent in Europe than in the United States and Canada.

      DESIGN, SETTING, AND PARTICIPANTS: Sample surveys that were national in scope and conducted in the ...

      Known for United States | European Countries | Hypertension Prevalence | Blood Pressure | Mm Hg
      KOL-Index: 21864

      BACKGROUND: Observational epidemiological studies have shown a positive association between hypertension and risk of incident dementia; however, the effects of antihypertensive therapy on cognitive function in controlled trials have been conflicting, and meta-analyses of the trials have not provided clear evidence of whether antihypertensive treatment reduces dementia incidence. The Hypertension in the Very Elderly trial (HYVET) was designed to assess the risks and benefits of treatment ...

      Known for Incident Dementia | Cognitive Function | Elderly Trial | Treatment Hypertension | Blood Pressure
      KOL-Index: 21450

      BACKGROUND: Coronary artery disease is a major cause of morbidity and mortality worldwide, and is a consequence of acute thrombotic events involving activation of platelets and coagulation proteins. Factor Xa inhibitors and aspirin each reduce thrombotic events but have not yet been tested in combination or against each other in patients with stable coronary artery disease.

      METHODS: In this multicentre, double-blind, randomised, placebo-controlled, outpatient trial, patients with stable ...

      Known for Coronary Artery | Rivaroxaban Aspirin | Major Bleeding | Myocardial Infarction | Combination Factor
      KOL-Index: 20983

      OBJECTIVE: To compare BMI with waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-stature ratio (WSR) in association with diabetes or hypertension.

      METHODS AND PROCEDURES: Cross-sectional data from 16 cohorts from the DECODA (Diabetes Epidemiology: Collaborative Analysis of Diagnostic criteria in Asia) study, comprising 9,095 men and 11,732 women, aged 35-74 years, of different ethnicities were included in this meta-analysis.

      RESULTS: Age-adjusted odds ratios (ORs) for ...

      Known for Wsr Bmi | Diabetes Hypertension | Wc Whr | Obesity Indicators | Women Aged
      KOL-Index: 20808

      BACKGROUND: Patients with peripheral artery disease have an increased risk of cardiovascular morbidity and mortality. Antiplatelet agents are widely used to reduce these complications.

      METHODS: This was a multicentre, double-blind, randomised placebo-controlled trial for which patients were recruited at 602 hospitals, clinics, or community practices from 33 countries across six continents. Eligible patients had a history of peripheral artery disease of the lower extremities (previous ...

      Known for Rivaroxaban Aspirin | Carotid Artery | Major Bleeding | Myocardial Infarction | Cardiovascular Death
      KOL-Index: 19519

      Stroke mortality has decreased during the last decade in many industrialized countries, but there has been no clear evidence for a decline in the incidence of stroke. The present study analyzes the trends in the incidence, mortality and case-fatality of stroke in Finland from 1983 to 1989. We used data from the FINMONICA stroke register, a community based register collecting information on all suspected stroke cases aged 25-74 in three geographical areas of Finland. Annual attack rate, ...

      Known for Incidence Stroke | Declining Trends | Geographic Areas | Cerebral Infarction | Case Fatality
      KOL-Index: 18614

      BACKGROUND: Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents.

      METHODS: For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease Risk Factor Collaboration. We applied a ...

      Known for Boys Girls | Children Adolescents | Bmi Height | Weight Gain | Mass Child
      KOL-Index: 18587

      BACKGROUND: Modifiable vascular and lifestyle-related risk factors have been associated with dementia risk in observational studies. In the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), a proof-of-concept randomised controlled trial, we aimed to assess a multidomain approach to prevent cognitive decline in at-risk elderly people from the general population.

      METHODS: In a double-blind randomised controlled trial we enrolled individuals aged ...

      Known for Randomised Controlled Trial | Elderly People | Vascular Risk | Cognitive Training | Multidomain Intervention
      KOL-Index: 18418

      BACKGROUND AND PURPOSE: The trends in stroke incidence reported so far have not been entirely consistent, although declining trends in mortality from stroke have been reported from a number of studies around the world. This study aims to evaluate the 10-year trends (from 1983 through 1992) in incidence, attack rate, and mortality of stroke in the Finnish population.

      METHODS: A population-based stroke register was set up in the early 1980s to collect data on all suspected events of acute ...

      Known for Stroke Incidence | Women Mortality | Year Trends | Sex Factors | Population Aged
      KOL-Index: 18257

      AIMS: Three methods are used to identify dysglycaemia: fasting plasma glucose (FPG), 2-h post-load plasma glucose (2hPG) from the oral glucose tolerance test (OGTT), and glycated haemoglobin A1c (HbA1c). The aim was to describe the yield and concordance of FPG, HbA1c, and 2hPG alone, or in combination, to identify dysglycaemia in patients with coronary artery disease.

      METHODS AND RESULTS: In EUROASPIRE IV, a cross-sectional survey of patients aged 18-80 years with coronary artery disease ...

      Known for Coronary Artery Disease | Fpg Hba1c | Glucose Tolerance | Dysglycaemia Patients | European Society
      KOL-Index: 18114

      OBJECTIVE: To determine the risk of death from coronary heart disease, stroke, all cardiovascular disease and all-cause mortality associated with systolic blood pressure and in particular with isolated systolic hypertension among the middle-aged population.

      METHODS AND DESIGN: A prospective 15-year cohort study of two independent cross-sectional random samples of subjects participating in baseline surveys in 1972 and 1977. Each survey included a self-administered questionnaire, ...

      Known for Isolated Systolic Hypertension | Cardiovascular Disease | Blood Pressure | Risk Stroke | Allcause Mortality
      KOL-Index: 17999

      BACKGROUND: The effect of the α-glucosidase inhibitor acarbose on cardiovascular outcomes in patients with coronary heart disease and impaired glucose tolerance is unknown. We aimed to assess whether acarbose could reduce the frequency of cardiovascular events in Chinese patients with established coronary heart disease and impaired glucose tolerance, and whether the incidence of type 2 diabetes could be reduced.

      METHODS: The Acarbose Cardiovascular Evaluation (ACE) trial was a ...

      Known for Impaired Glucose Tolerance | Coronary Heart Disease | Cardiovascular Death | Chinese Patients | Diabetes Outcomes
      KOL-Index: 17625

      OBJECTIVE: We wanted to determine whether obesity, abdominal fat distribution, and physical inactivity act similarly and independently as risk factors for noninsulin-dependent diabetes mellitus (NIDDM) and impaired glucose tolerance (IGT) in Hindu and Muslim Asian Indians, African-origin Creoles, and Chinese Mauritians.

      RESEARCH DESIGN AND METHODS: We examined a population-based random cluster sample of 5080 adult subjects from the Indian Ocean island of Mauritius. Glucose tolerance was ...

      Known for Physical Inactivity | Chinese Mauritians | Abdominal Obesity | Glucose Tolerance | Igt Niddm
      KOL-Index: 17523

      BACKGROUND: Indian Asians, who make up a quarter of the world's population, are at high risk of developing type 2 diabetes. We investigated whether DNA methylation is associated with future type 2 diabetes incidence in Indian Asians and whether differences in methylation patterns between Indian Asians and Europeans are associated with, and could be used to predict, differences in the magnitude of risk of developing type 2 diabetes.

      METHODS: We did a nested case-control study of DNA ...

      Known for Dna Methylation | Type 2 | Indian Asians | Peripheral Blood | Nested Case

      Key People For Type 2 Diabetes

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      Population Health Unit, Finnish Institute for Health and Welfare, 00271 Helsinki, Finland;, tiia.ngandu@thl.fi, (T.N.);, esko.levalahti@thl.fi, (E.L.);, tiina.laatikainen@thl.fi, (T.L.);, jaana.lindstrom@thl.fi, (J.L.);, jaakko.tuomilehto@thl.fi, (J.

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