Prominent publications by Deepak Kumar Mishra

KOL Index score: 927

An adequate understanding of the relationships between radiographic and genomic features in diffuse intrinsic pontine glioma (DIPG) is essential, especially in the absence of universal biopsy, to further characterize the molecular heterogeneity of this disease and determine which patients are most likely to respond to biologically-driven therapies. Here, a radiogenomics analytic approach was applied to a cohort of 28 patients with DIPG. Tumor size and imaging characteristics from all ...

Known for Diffuse Intrinsic |  Tumor Microenvironment |  Pontine Glioma |  Craniospinal Irradiation |  Mutational Burden
KOL Index score: 623

Diffuse intrinsic pontine glioma (DIPG) is a poor-prognosis pediatric brain tumor with a median survival of less than 1 year. No effective therapy is currently available, and no therapeutic advances have been made in several decades. We have previously identified BMI-1 as a potential therapeutic target in DIPG and have shown that BMI-1 is highly expressed in DIPG tumors regardless of histone 3 subtype. In the present study, we show that the modulation of BMI-1 leads to DNA damage, M ...

Known for Dna Damage Response |  Pediatric Brain |  Potential Therapeutic |  Patient Derived

Key People For Diffuse Intrinsic

Top KOLs in the world
Darren R Hargrave
pediatric patients braf v600 brain tumors
Eric Bouffet
germ cell pediatric patients brain tumors
Alberto Broniscer
radiation therapy brain tumors pediatric patients
Ute Katharina Bartels
germ cell pediatric patients weekly vinblastine
Amar J Gajjar
brain tumors radiation therapy pediatric patients
Chris Jones
pediatric glioblastoma wilms tumor situ hybridization

Deepak Kumar Mishra:Expert Impact

Concepts for whichDeepak Kumar Mishrahas direct influence:Diffuse intrinsic,  Features diffuse.

Deepak Kumar Mishra:KOL impact

Concepts related to the work of other authors for whichfor which Deepak Kumar Mishra has influence:Diffuse midline gliomas,  Midline glioblastomas,  Advanced solid tumors,  Expression signature,  Tubulin‐binding agent,  Dna repair phggs,  Treatment decision processes.



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Center for Childhood Cancer & Blood Disorders, Nationwide Children’s Hospital, Columbus, OH USA | Brain Tumor Center, Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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