Prominent publications by Morris Schambelan

KOL Index score: 15312

OBJECTIVE: Fructose feeding induces hypertension, insulin-resistance and hypertriglyceridemia in Sprague-Dawley rats. The mechanisms of fructose-induced hypertension are as yet unknown. Here we investigate the effects of fructose feeding and of varying salt intake on blood pressure, glucose tolerance, plasma renin activity, and tissue angiotensinogen, renin, and AT1 receptor mRNA levels in this model of hypertension.

DESIGN AND METHODS: To investigate the role of the renin-angiotensin ...

Also Ranks for: Tissue Renin |  fructose feeding |  blood pressure |  at1 receptor |  induced hypertension
KOL Index score: 14903

Insulin resistance is present in some strains of rats with genetic hypertension. To determine whether this abnormality is present at the level of the insulin receptor, we compared insulin sensitivity, insulin receptor binding, and mRNA levels in tissues of 10-week-old spontaneously hypertensive rats (SHR) and their normotensive Wistar-Kyoto (WKY) controls. Because we have previously demonstrated an inverse relationship between dietary sodium intake and renal insulin receptor density and ...

Also Ranks for: Insulin Receptor |  shr wky |  mrna levels |  salt diet |  hypertensive rats
KOL Index score: 14329

Abnormalities in glomerular function have been observed frequently in the early stages of both clinical and experimental diabetes mellitus. Because prostaglandins (PGs) are present in the glomerulus and have profound effects on glomerular hemodynamics, and because abnormalities of PG metabolism have been noted in other tissues from diabetics, we studied PG biosynthesis in glomeruli obtained from rats in the early stages of experimental diabetes mellitus. Streptozotocin, 60 mg/kg, was ...

Also Ranks for: Diabetes Mellitus |  glomeruli rats |  diabetic animals |  prostaglandin production |  early stages
KOL Index score: 13187

OBJECTIVE: Alterations in glucose and lipid metabolism, lactic acidemia, bone disorders, and abnormal body fat distribution have been recognized recently as frequent complications associated with HIV-1 infection and potent antiretroviral therapy, but limited data are available regarding the appropriate management of these disorders. These recommendations were developed to guide physicians actively involved in HIV care in the management of metabolic complications that occur primarily ...

Also Ranks for: Metabolic Complications |  antiretroviral therapy |  hiv1 infection |  lactic acidemia |  aids society
KOL Index score: 13153

We employed a novel immunoradiometric assay to measure plasma levels of active renin and prorenin in physiologic and pharmacologic studies designed to characterize renin biosynthesis and processing in response to both chronic and acute stimuli of renin secretion in normal human subjects. Stimulation of renin secretion with prolonged dietary sodium restriction or amiloride resulted in marked increases in the plasma levels of prorenin, active renin, and plasma renin activity (PRA); ...

Also Ranks for: Active Renin |  plasma levels |  secretory granules |  immunoradiometric assay |  regulated pathway
KOL Index score: 12971

INTRODUCTION: Altered gut and pancreatic hormone secretion may bolster resolution of insulin resistance after Roux-en-Y gastric bypass (RYGB), but the independent effects of weight loss and hormonal secretion on peripheral glucose disposal are unknown.

METHODS: Two groups of nondiabetic morbidly obese patients were studied: RYGB followed by standardized caloric restriction (RYGB, n = 12) or caloric restriction alone (diet, n = 10). Metabolic evaluations (euglycemic-hyperinsulinemic ...

Also Ranks for: Weight Loss |  gastric bypass surgery |  insulin glucose |  groups rygb |  caloric restriction
KOL Index score: 12211

CONTEXT: Patients receiving dialysis commonly experience malnutrition, reduced muscle mass (sarcopenia), and fatigue for which no effective treatment has been identified. Anabolic steroids are known to increase muscle mass and strength in healthy individuals, but their effect on the sarcopenia and fatigue associated with long-term dialysis has not been evaluated.

OBJECTIVE: To assess the effects of an anabolic steroid, nandrolone decanoate, on lean body mass (LBM), functional status, and ...

Also Ranks for: Nandrolone Decanoate |  anabolic effects |  6 months |  patients placebo |  muscle mass
KOL Index score: 11963

Most of the biological effects of the renin-angiotensin system are mediated by the binding of angiotensin II (Ang II) to the type 1 Ang II (AT1) receptor, the predominant receptor subtype present after fetal life. To study tissue-specific regulation of the expression of the AT1 receptor in the rat, we altered activity of the renin-angiotensin system by feeding rats a low (0.07% NaCl), normal (0.3% NaCl), or high (7.5% NaCl) salt chow for 14 days; infusing Ang II (200 ng/kg per minute IP) ...

Also Ranks for: Receptor Mrna |  type 1 |  renin angiotensin |  messenger rats |  drinking water
KOL Index score: 11321

Systemic and renal acid-base effects of chronic dietary potassium depletion in humans. We investigated the chronic renal and systemic acid-base response of normal men to dietary potassium depletion. Subjects did not receive mineralocorticoids or other experimental maneuvers known to independently affect acid-base homeostasis. We induced potassium depletion without changing the dietary anion content by substituting neutral sodium phosphate for an equimolar amount of neutral potassium ...

Also Ranks for: Potassium Depletion |  renal acid |  plasma bicarbonate |  hydrogen ion |  11 15
KOL Index score: 10997

Body wasting is an increasingly prevalent AIDS-defining condition and an independent risk factor for mortality in patients infected with HIV. Largely on the basis of studies conducted early in the epidemic, HIV-associated wasting has been assumed to feature a disproportionate loss of lean tissue. We report the results obtained from cross-sectional and longitudinal studies that differ from these earlier observations. In a cross-sectional analysis, weight and body composition determined by ...

Also Ranks for: Hiv Infection |  body composition |  weight loss |  lean tissue |  longitudinal studies
KOL Index score: 10892

BACKGROUND: Therapy with HIV protease inhibitors (PI) causes insulin resistance even in the absence of HIV infection, hyperlipidemia or changes in body composition. The mechanism of the effects on insulin action is unknown. In vitro studies suggest that PI selectively and rapidly inhibit the activity of the insulin-responsive glucose transporter GLUT-4. We hypothesized that a single dose of the PI indinavir resulting in therapeutic plasma concentrations would acutely decrease ...

Also Ranks for: Glucose Disposal |  indinavir insulin |  single dose |  body composition |  hiv protease inhibitors

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Morris Schambelan:Expert Impact

Concepts for whichMorris Schambelanhas direct influence:Insulin resistance,  Growth hormone,  Mrna levels,  Body composition,  Hiv infection,  Lactate level,  Primary aldosteronism,  Spraguedawley receptors.

Morris Schambelan:KOL impact

Concepts related to the work of other authors for whichfor which Morris Schambelan has influence:Insulin resistance,  Blood pressure,  Hiv infection,  Growth hormone,  Antiretroviral therapy,  Primary aldosteronism,  Body composition.



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Division of Endocrinology, San Francisco General Hospital, San Francisco, CA, 94110, USA | Department of Medicine, University of California, San Francisco, San Francisco, CA, 94143, USA | Touro University (J.M.S., A.D., J.L.P., N.B.), Vallejo, Califo