Chen Chen Lei

AIMS: The purpose of the present study was to investigate the roles of transporters in the renal excretion of entecavir.

MAIN METHODS: We analyzed the effect of probenecid, cimetidine, sulfobromophthalein sodium (BSP), verapamil, inhibitors of organic anion transporter (OAT), organic cation transporter (OCT), multidrug resistance-associated protein 2 (MRP2) and P-glycoprotein respectively, on the excretion of entecavir. The area under plasma concentration-time curve (AUC), body ...

It has been proposed that ROS production, including H(2)O(2), may lead to neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease. Catalpol, an iridoid glycoside, presents in the root of Rehmannia glutinosa, protects cells and mice from damage caused by a variety of toxic stimuli. In this study, we investigated whether catalpol could protect astrocytes from oxidant stress induced by H(2)O(2) because of the critical role of astrocytes in the brain and found the ...

Propofol is one of the extensively commonly used intravenous anesthetic agents. Previous studies have indicated that propofol has the ability to influence the biological behavior of several human cancer cells. However, the effect of propofol on osteosarcoma and its related molecular mechanisms are still not clear. Here we found that propofol significantly elevated the expression of miR-143, inhibited cell proliferation and invasion, and promoted apoptosis in osteosarcoma cell line MG63. ...

Signal transducer and activator of transcription 3 (STAT3) promotes tumor progression in many types of cancer. In this study, we analyzed the prognostic value of this marker in human intrahepatic cholangiocarcinoma (ICC). Using real-time PCR, western blot and immunohistochemistry assays, we found that STAT3 is overexpressed in ICC patients. STAT3 expression correlated with several clinicopathological features, including tumor size, pathological satellite, vascular invasion, ...

Bone morphogenetic proteins (BMPs) play important roles in skeletal development and repair. Previously, we found fibroblast growth factor 2 (FGF2) induced up-regulation of BMP2, 3, 4 in the process of rabbit articular cartilage repair, which resulted in satisfactory repair effects. As BMP2/4 show a clearly positive effect for cartilage repair, we investigated the functions of BMP3 in rabbit articular cartilage repair. In this paper, we find that BMP3 inhibits the repair of ...

OBJECTIVE: The purpose of our study was to introduce the surgical procedure and long-term follow-up of finger-pulp defect treated with the homodigital laterodorsal fasciocutaneous flap, which is based on the dorsal branches of the proper palmar digital artery.

METHODS: Seven cases with finger-pulp defect, which were treated by the homodigital laterodorsal fasciocutaneous flap based on the dorsal branches of the proper palmar digital artery, were involved in this study. The defect size ...

Based on core description, conventional thin section, cast thin section and scanning electron microscope (SEM) analysis, combined with general physical analysis, the physical properties of the braided river delta sandstone reservoirs and the range of reservoir quality of the Sha 1 member have been analyzed in the southern Nanpu Sag of the Bohai Bay Basin. The characteristics and controlling factors of the southern provenance of Sha 1 reservoirs are examined to reveal the causes for the ...

Parameter uncertainty involved in hydrological and sediment modeling often refers to the parameter dispersion and the sensitivity of the parameter. However, a limitation of the previous studies lies in that the assignment of range and specification of probability distribution for each parameter is usually difficult and subjective. Therefore, there is great uncertainty in the process of parameter calibration and model prediction. In this study, the impact of probability parameter ...

This paper presents the results of field measurements on mercury speciation in six power plants of China by applying the Ontario hydro method. During the tests, flue gas was sampled simultaneously before and after particulate control devices (electrostatic precipitator and fabric filter baghouse) along with the pulverized coal, bottom ash and fly ash sampling. The amount of oxidized mercury in gas phase before and after ESP/FF suggests that mercury oxidation after combustion is a ...

PurposeMeta-analysis was conducted to estimate whether MiTLIF could reduce the complication rate while maintaining the similar clinical result to that of open procedures.MethodsA search of the literature was conducted on pubmed or EMBASE. A database including patient clinical information was created. A systematic review of eligible studies with multivariate regression analysis was performed to quantitatively review the correlation of VAS improvement rate and the performance of ...

Intratumoral heterogeneity greatly hinders efficiency of target therapy in glioblastoma (GBM). To decipher the underlying mechanisms of heterogeneity, patient-derived adult GBM cells were separately isolated from margins of T1 gadolinium enhancing tumor lesions (PNCs) and T1 gadolinium enhancing core lesions (ECs). Single clone culture was conducted in ECs and U87MG cell line to screen clones with distinct biological phenotypes. Single cell clones with diverse phenotypes were ...

This paper presents adsorption isotherms and isosteric heats of adsorption for methanol vapor adsorption for two commercially available activated carbon samples207EA granules and WS-480 pellets (Calgon Carbon, U.S.A.)which were also fully characterized using nitrogen sorption at 77 K. The heat of adsorption of methanol as a function of loading was determined using the Clausius–Clapeyron approach with isotherms obtained at 5 °C, 15 °C, and 25 °C. The isosteric heats of adsorption ...

The four-terminal tandem solar cell consisting of a bottom cell, which employs crystalline silicon (c-Si) as an absorber layer, and a top cell, which employs methyl ammonium lead halide (CH3NH3PbI3 ) as an absorber layer, was constructed. In order to improve solar cell performance, antireflection layers were employed to reduce reflection and enhance photon transmission. In this study, we explored the effect of antireflection layers on tandem solar cells performance with Silvaco Atlas. ...