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    • Christian Candrian

      Christian Candrian

      Faculty of Biomedical Sciences, Università della Svizzera Italiana, Via Buffi 13, 6900 Lugano, Switzerland | Service of Orthopaedics and Traumatology, Department of Surgery, ...



      KOL Resume for Christian Candrian


      Faculty of Biomedical Sciences, Università della Svizzera Italiana, Via Buffi 13, 6900 Lugano, Switzerland


      Facoltà di Scienze Biomediche


      Regenerative Medicine Technologies Lab

      Ente Ospedaliero Cantonale (EOC)

      6900 Lugano


      Unit, di Traumatologia e Ortopedia, Ente Ospedaliero Cantonale (EOC), Via Tesserete 46, 6900, Lugano, Switzerland


      Unità di Traumatologia e Ortopedia, Ente Ospedaliero Cantonale (EOC), Via Tesserete 46, 6900 Lugano, Switzerland


      Ospedale Regionale di Lugano Civico e Italiano, Lugano, Ticino, Switzerland


      Unità di Traumatologia ed Ortopedia ORL, Ente Ospedaliero Cantonale (EOC), Via Tesserete 46, 6900, Lugano, Switzerland


      Department of Surgery and Orthopaedic Surgery, Ospedale Regionale, Lugano, Switzerland


      Department of Surgery and Orthopaedics, Lugano, Switzerland


      Department of Surgery, Ospedale Regionale di Lugano, Lugano, Switzerland


      Department of Orthopaedic Surgery and Traumatology, Ospedale Regionale di Lugano, Via Tesserete 46, Lugano, 6900, Switzerland


      Department of Orthopaedic Surgery and Traumatology, Kantonsspital, Bruderholz, Switzerland


      Departments of Orthopaedic Surgery and Traumatology, Bruderholzspital, Basel, Switzerland


      University Hospital Basel, Basel, Switzerland


      Departments of Surgery and of Research, University Hospital Basel, Basel, Switzerland



      Christian Candrian: Influence Statistics

      Sample of concepts for which Christian Candrian is among the top experts in the world.
      Concept World rank
      proprioception preoperative #4
      evidence subjective ikdc #4
      evidence synthesis influence #4
      ikdc low #4
      complex phenomena achip #4
      prosthesis design proprioception #4
      meniscectomies lysholm #4
      ikdc secondary #4
      area distribution pattern #4
      worms femur #4
      development tegner #4
      multifactorial musculoskeletal #4
      1601 records #4
      meniscectomies difference #4
      terms knee development #4
      design proprioception #4
      bruises pediatric #4
      interactions multiple tissues #4
      pediatric patients cross #4
      case bone tumors #4
      envisaged application issues #4
      area bone bruise #4
      nerves neuromuscular diseases #4
      influencing proprioception #4
      differences mpfl reconstruction #5
      placebo injectable treatments #5
      154 fulltext articles #5
      1403 knees #5
      three‐dimensional expansion #5
      oamethodsa systematic review #5
      biological hypothesis genetic #5
      mpfl reconstruction differences #5
      prp injections placebo #5
      medial patellar restraint #5
      microfluidic models extravasation #5
      acl tears prevalence #5
      surgery proprioception #5
      hac scaffolds #5
      evidence supporting safety #5
      autologous paradigm #5
      influence prosthesis design #5
      clinical approaches mscs #5
      majority clinical approaches #5
      olt osteoarthritis #5
      direct chondrocyte culture #5
      tka proprioception #5
      scaffolds 2d expansion #5
      impingement discoid #5
      proteome umbilical cord #5
      direct expansion scaffolds #5


      Prominent publications by Christian Candrian

      KOL-Index: 10691

      PurposeDuring anterior cruciate ligament (ACL) injury, the large external forces responsible for ligament rupture cause a violent impact between tibial and femoral articular cartilage, which is transferred to bone resulting in bone bruise detectable at MRI. Several aspects remain controversial and await evidence on how this MRI finding should be managed while addressing the ligament lesion. Thus, the aim of the present review was to document the evidence of all available literature on ...

      Known for Bone Bruise | Cruciate Ligament | Acl Injury | Injuries Anterior | Articular Cartilage
      KOL-Index: 10375

      OBJECTIVES: The aim of this study was to test the hypothesis that magnetic resonance imaging (MRI) of the knee with 10-minute 3-dimensional (3D) controlled aliasing in parallel imaging results in higher acceleration (CAIPIRINHA) sampling perfection with application optimized contrast using different flip angle evolutions (SPACE) turbo spin echo (TSE) protocols can replace 20-minute 2-dimensional (2D) TSE standard-of-reference protocols for the diagnosis of internal derangement.

      MATERIALS ...

      Known for Caipirinha Space | Tse Mri | Knee Joint | Parallel Imaging | Structural Abnormalities
      KOL-Index: 8916

      OBJECTIVE: To evaluate effectiveness, in terms of patient-reported outcome measures, of platelet-rich plasma (PRP) injections for knee osteoarthritis compared to placebo and other intraarticular treatments.

      DESIGN: PubMed, Cochrane Library, Scopus, Embase, Web of Science, as well as the gray literature were searched on January 17, 2020. Randomized controlled trials (RCTs) comparing PRP injections with placebo or other injectable treatments, in any language, on humans, were included. Risk ...

      Known for Knee Osteoarthritis | Prp Injections | Hyaluronic Acid | Cochrane Library | Randomized Controlled
      KOL-Index: 8838

      BACKGROUND: Patellar tendinopathy is a condition characterized by anterior knee activity-related pain. It has a high incidence among athletes engaged in jumping sports and may become a chronic condition. Nonoperative management is the first choice in these patients, and several nonsurgical treatment options have been proposed. Nonetheless, clear indications on the most effective approach to address patellar tendinopathy are still lacking.

      PURPOSE: To analyze the evidence on nonoperative ...

      Known for Patellar Tendinopathy | Nonsurgical Treatment | Rich Plasma | Eccentric Exercise | Systematic Review Metaanalysis
      KOL-Index: 8742

      Chondrocytes for tissue engineering strategies are typically expanded in monolayer (2D), leading to cell dedifferentiation but allowing to generate large cell numbers for seeding into scaffolds. Direct chondrocyte culture in scaffolds, instead, may support better maintenance of the differentiated phenotype but reduce the extent of proliferation and thus the resulting cell density. This study investigates whether the quality of cartilaginous tissues generated in vitro by human articular ...

      Known for Seeding Density | Human Articular | Collagen Type | 2d Expansion | Tissue Scaffolds
      KOL-Index: 8304

      INTRODUCTION: Oxygen is a critical parameter proposed to modulate the functions of chondrocytes ex-vivo as well as in damaged joints. This article investigates the effect of low (more physiological) oxygen percentage on the biosynthetic and catabolic activity of human articular chondrocytes (HAC) at different phases of in vitro culture.

      METHODS: HAC expanded in monolayer were cultured in pellets for two weeks (Phase I) or up to an additional two weeks (Phase II). In each Phase, cells ...

      Known for Human Articular | Type Collagen | 5 O2 | Hypoxiainducible Factor | Differentiation Culture
      KOL-Index: 8265

      BackgroundMuscle lesions account for one-third of sport-related injuries, thus representing a substantial problem for both players and their teams. The use of platelet-rich plasma (PRP) injections is rapidly growing in clinical practice, prompted by an unmet clinical need with a large commercial market. However, after early reports of positive preliminary experience, higher quality studies recently questioned the real benefit provided by PRP injections to promote muscle healing and ...

      Known for Rich Plasma | Prp Injections | Muscle Injuries | Return Sport | Pain Function
      KOL-Index: 7828

      The expansion of chondrocytes in automated bioreactors for clinical use requires that a relevant number of cells be generated, starting from variable initial seeding densities in one passage and using autologous serum. We investigated whether the growth factor combination transforming growth factor beta 1/fibroblast growth factor 2/platelet-derived growth factor BB (TFP), recently shown to enhance the proliferation capacity of human articular chondrocytes (HACs), allows the efficiency of ...

      Known for Growth Factor | Human Articular | Cultured Chondrocytes | Bioreactor Systems | Expansion Hacs
      KOL-Index: 7796

      BACKGROUND: Injury-to-surgery time has been identified as a key point in anterior cruciate ligament (ACL) reconstruction, with early versus delayed treatment remaining a debated and controversial topic in the management of ACL tears.

      PURPOSE/HYPOTHESIS: The aim was to quantitatively synthesize the best literature evidence by including only randomized controlled trials (RCTs) comparing early versus delayed ACL reconstruction, with a clear and univocal definition of cutoffs of early or ...

      Known for Anterior Cruciate | Ligament Reconstruction | 3 Weeks | Acl Surgery | Early Delayed
      KOL-Index: 7330

      PURPOSE: To provide a direct comparison between medial patellofemoral ligament (MPFL) reconstruction and the other medial patellofemoral soft-tissue surgeries in the restoration of the medial patellar restraint after lateral patellar dislocations in the absence of untreated predisposing factors such as high grade trochlear dysplasia, knee malalignment, patella alta or high tibial tubercle-trochlear groove distance.

      METHODS: PubMed, Cochrane-library, Web of Science, and gray literature ...

      Known for Mpfl Reconstruction | Predisposing Factors | Patellar Dislocation | Patellofemoral Ligament | Knee Joint
      KOL-Index: 7029

      BACKGROUND: The purpose of our study was to analyze the clinical and radiological long-term outcomes of surgically treated traumatic knee dislocations and determine prognostic factors for outcome.

      METHODS: Retrospective consecutive series of patients treated surgically for traumatic knee dislocation with reconstruction/refixation of the anterior (ACL) and posterior cruciate ligaments (PCL) and primary complete repair of collaterals and posteromedial and posteromedial corner structures. ...

      Known for Traumatic Knee | Stress Radiographs | Ikdc Score | Single Stage | Surgical Procedures
      KOL-Index: 6876

      OBJECTIVES: To quantify the placebo effect of intraarticular injections for knee osteoarthritis in terms of pain, function, and objective outcomes. Factors influencing placebo effect were investigated.

      DESIGN: Meta-analysis of randomized controlled trials; Level of evidence, 2. PubMed, Web of Science, Cochrane Library, and grey literature databases were searched on January 8, 2020, using the string: (knee) AND (osteoarthritis OR OA) AND (injections OR intra-articular) AND (saline OR ...

      Known for Knee Osteoarthritis | Placebo Injections | Cochrane Library | Randomized Controlled Trials | Pain Function
      KOL-Index: 6772

      OBJECTIVE: To determine whether engineered cartilage generated by nasal chondrocytes (ECN) is responsive to different regimens of loading associated with joint kinematics and previously shown to be stimulatory of engineered cartilage generated by articular chondrocytes (ECA).

      METHODS: Human nasal and articular chondrocytes, harvested from 5 individuals, were expanded and cultured for 2 weeks into porous polymeric scaffolds. The resulting ECN and ECA were then maintained under static ...

      Known for Nasal Chondrocytes | Engineered Cartilage | Physical Forces | 2 Weeks | Collagen Type
      KOL-Index: 6761

      BACKGROUND: There is no agreement on the best treatment for displaced midshaft clavicle fractures (MCFs), which are currently addressed by nonoperative or surgical approaches.

      PURPOSE: To compare fracture healing and functional outcome after surgical versus nonsurgical treatment of MCFs, to help specialists in deciding between these different strategies by providing a synthesis of the best literature evidence.

      STUDY DESIGN: Meta-analysis.

      METHODS: A systematic research of the literature ...

      Known for Midshaft Clavicle Fractures | Constant Score | Time Union | Fracture Fixation | Functional Outcome
      KOL-Index: 6522

      Objectives: Falls occur frequently in patients with impaired ambulation and may dramatically affect the elderly population. Aim was to document the incidence of falls in knee osteoarthritis (OA) patients undergoing total knee arthroplasty (TKA), and to identify factors and treatments that may influence the risk of falls.

      Methods: A systematic literature search was conducted on three medical electronic databases, PubMed, PeDRO, and Cochrane Collaboration. The Preferred Reporting Items for ...

      Known for Knee Osteoarthritis | Evidence Synthesis | Falls Patients | Bias Analysis | Cochrane Collaboration

      Key People For Bone Bruise

      Top KOLs in the world
      Kurt Paul Spindler
      acl reconstruction anterior cruciate meniscal tear
      Jerrold H Mink
      patellofemoral joint computed tomography magnetic resonance imaging
      Andrew L Deutsch
      patellofemoral joint magnetic resonance imaging marathon runners
      Peter J Fowler
      cruciate ligament tibial osteotomy arthroscopic surgery
      Jack T Andrish
      anterior cruciate acl reconstruction 2 years
      Paul H Marks
      cruciate ligament bankart repair suretac device

      Christian Candrian:Expert Impact

      Concepts for whichChristian Candrianhas direct influence:Bone bruise,  Knee osteoarthritis,  Human articular,  Prp injections,  Meniscal repair,  Nonoperative treatment,  Anterior cruciate ligament,  Anterior cruciate.

      Christian Candrian:KOL impact

      Concepts related to the work of other authors for whichfor which Christian Candrian has influence:Tissue engineering,  Knee osteoarthritis,  Articular cartilage,  Mesenchymal stem cells,  Patellar tendinopathy,  Regenerative medicine,  Rich plasma.



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      Faculty of Biomedical Sciences, Università della Svizzera Italiana, Via Buffi 13, 6900 Lugano, Switzerland | Service of Orthopaedics and Traumatology, Department of Surgery, EOC, 6900, Lugano, Switzerland | Service of Orthopaedics and Traumatology, D

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