Prominent publications by Robert A Good

KOL Index score: 14282

The 65-kDa heat-shock protein (HSP65) is thought to play a role in host defense against infections with various microbial pathogens and in autoimmune inflammatory disorders. We investigated the biological function and expression mechanism of HSP65 in macrophages of mice infected with Trypanosoma cruzi. BALB/c mice, which are susceptible to T. cruzi, showed high levels of parasitemia, and 80% of these mice died within 42 days after the infection, whereas resistant C57BL/6 or DBA/2 mice ...

Known for Trypanosoma Cruzi |  Hsp65 Macrophages |  Cd4 Cells |  Role Apoptosis |  Shock Protein
KOL Index score: 13560

We investigated the roles of gamma delta T, NK, and NK1.1(+) T-like (NKT) cells in protective immunity against infection with Toxoplasma gondii. gamma delta T cells, NKT and NK cells, and NK cells in BALB/c mice were depleted by treatment with anti-TCR-gamma delta monoclonal antibody (mAb), anti-interleukin-2 receptor beta chain (IL-2R beta) mAb, and anti-asialoGM1 Ab, respectively, and these mice were infected with T. gondii. Treatment of mice with anti-TCR-gamma delta mAb aggravated ...

Known for Nkt Cells |  Heat Shock Protein |  Toxoplasma Gondii |  Gamma Delta |  Macrophages Mice
KOL Index score: 13536

Activation of the transcription factor nuclear factor kappa B (NF-kappaB) is controlled by proteolysis of its inhibitory subunit (IkappaB) via the ubiquitin-proteasome pathway. Signal-induced phosphorylation of IkappaBalpha by a large multisubunit complex containing IkappaB kinases is a prerequisite for ubiquitination. Here, we show that FWD1 (a mouse homologue of Slimb/betaTrCP), a member of the F-box/WD40-repeat proteins, is associated specifically with IkappaBalpha only when ...

Known for Box Protein |  Ubiquitination Ikappabalpha |  Ubiquitin Ligase |  Hela Cells |  Ikappab Kinases
KOL Index score: 13372

Human T cell subpopulations (Tμ and Tγ) were examined for their distribution in the peripheral blood, cord blood, bone marrow, tonsils, thymus, lymph nodes and spleen. The proportions of Tμ and Tγ cells are comparable in the peripheral blood, tonsils and bone marrow. The proportions of Tγ cells in cord blood are significantly higher than those in the peripheral blood. Almost complete lack of Tγ cells was observed in lymph nodes. Spleen has very high proportions of Tγ cells. Thymuses have ...

Known for Peripheral Blood |  Bone Marrow |  Lymph Nodes |  Tγ Cells |  Proportions Tμ
KOL Index score: 13098

Human T lymphocyte subpopulations recently have been defined by monoclonal antibodies that recognize cell-surface antigens selectively expressed on functionally distinct T cell subsets. The majority (approximately 90%) of the peripheral blood sheep erythrocyte-rosette-forming cells carry the OKT3 antigen. Helper cells are OKT4(+), whereas cytotoxic/suppressor cells are OKT5(+) and OKT8(+). We investigated the effect of several monoclonal antibodies recognizing T cell antigens on certain ...

Known for Monoclonal Antibodies |  Specific Cell |  Absence Complement |  Surface Cytotoxicity |  Proliferative Response
KOL Index score: 13003

Effector cells mediating natural killer (NK) cell activity and antibody-dependent cellular cytotoxicity (ADCC) have been receiving considerable interest recently as they may represent an additional cellular defense mechanism against maglinancy. Spleen cells from normal young C3H (MTV+) female mice were found to have relatively high natural killer (NK) activities toward RL 1 and YAC-1 tumor cell lines and high antibody-dependent cell-mediated cytotoxicity (ADCC) activities toward chicken ...

Known for Natural Killer |  Cellular Cytotoxicity |  Nk Adcc |  Dependent Cell |  Mammary Adenocarcinoma
KOL Index score: 12791

In the present report we describe a CD4+8- heat stable antigen-negative (HSA-) thymocyte subpopulation that expresses a distinguishably low density of alpha beta T-cell antigen receptors (TCRlo) from the majority of CD4+8- high-density TCR (TCRhi) mature-type thymocytes. This subpopulation appears relatively late in life. Analysis of MEL-14, Pgp-1 (CD44), ICAM-1 (CD54), and NK1.1 expression on this subpopulation revealed that the CD4+8- TCRlo population was a population having unique ...

Known for Cell Antigen |  Cd4 8 |  Bone Marrow |  Inbred Strains Receptors |  Beta Lymphocyte
KOL Index score: 12183

CD4+8- or CD4-8+ thymocytes have been regarded as direct progenitors of peripheral T cells. However, recently, we have found a novel NK1.1+ subpopulation with skewed T cell antigen receptor (TcR) V beta family among heat-stable antigen negative (HSA-) CD4+8- thymocytes. In the present study, we show that these NK1.1+ CD4+8- thymocytes, which represent a different lineage from the major NK1.1- CD4+8- thymocytes or CD4+ lymph node T cells, vigorously secrete interleukin (IL)-4 and ...

Known for Thymocytes Cd4 |  Ly Antigens |  Tcr Beta |  Bone Marrow |  Cells Nk11
KOL Index score: 12128

A new method of cyclophosphamide (CP)-induced skin allograft tolerance in mice that can regularly overcome fully allogeneic (major H-2 plus non-H-2) antigen barriers in mice has been established. The components of the method are intravenous or intraperitoneal administration of 50-100 micrograms of anti-Thy-1.2 mAb on day -1, intravenous injection of 90 x 10(6) allogeneic spleen cells mixed with 30 x 10(6) allogeneic bone marrow cells from the same donor on day 0, and intraperitoneal ...

Known for Multiminor Histocompatibility |  Adult Mice |  Allograft Tolerance |  Reactive Cells |  Antigen Barriers


Robert A Good: Influence Statistics

Sample of concepts for which Robert A Good is among the top experts in the world.
Concept World rank
clq patients #1
“reconstitution #1
birds cyclophosphamide #1
dietary restriction development #1
compatible bone #1
scid htla #1
mice parabiosis #1
autoimmune prone #1
relative numbers lymphocytes #1
function lymphoid #1
antiserum igg receptor #1
preschool cytotoxicity tests #1
ca19267 #1
adrenal steroid therapy #1
58000 peptide #1
bone marrow thymus #1
tgamma cells #1
tvarphi #1
young nzb mice #1
fabricius humans #1
fts levels #1
lymphopoiesis1–3 #1
impaired proliferative response #1
laminar airflow room #1
hybrid mice #1
generalized shwartzman #1
gondii infection treatment #1
human marrow lymphocytes #1
engraftment radiation #1
animals 6 protein #1
cells tcr thymocytes #1
chickens thymectomized #1
blaberus craniifer hemocytes #1
bone‐marrow #1
development lymphoid #1
normal structure patients #1
cd4 cd8 populations #1
t‐lymphocyte marker #1
receptors igm #1
huntely #1
receptors mouse erythrocytes #1
bertucio3 #1
lymphosblastoid #1
acquired cmv chorioretinitis #1
hyaluronidase inhibitor #1
hsf histamine #1
presence humoral factors #1
fts gradient layer #1
mumtv antiserum #1
complement patient #1

Key People For Bone Marrow

Top KOLs in the world
Irving Lerner Weissman
stem cells bone marrow inbred balb mice
Rainer F Rainer
marrow transplantation host disease aplastic anemia
Darwin J Prockop
osteogenesis imperfecta stem cells transgenic mice
E Donnal L Thomas
marrow transplantation host disease aplastic anemia
David T Scadden
bone marrow stem cell multiple myeloma
Mark F Pittenger
stem cells myocardial infarction bone marrow

Robert A Good:Expert Impact

Concepts for whichRobert A Goodhas direct influence:Bone marrow,  Marrow transplantation,  Peripheral blood,  Spleen cells,  Bone marrow transplantation,  Host reaction.

Robert A Good:KOL impact

Concepts related to the work of other authors for whichfor which Robert A Good has influence:Bone marrow,  Host disease,  Stem cell,  Peripheral blood,  Immune response,  Monoclonal antibodies,  Rheumatoid arthritis.



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Department of Paediatrics, All Children's Hospital, College of Medicine. University of South Florida, St. Petersburg, FL, USA | Department of Pediatrics, College of Medicine University of South Florida, 12901 Bruce B. Downs Boulevard, 33612, Tampa, F

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