 | Xiao Ying HuiShow email addressDermatology Department, University of California, San Francisco, San Francisco, California, USA | Department of Dermatology, School of Medicine, University of California San ... |
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Xiao Ying Hui:Expert Impact
Concepts for whichXiao Ying Huihas direct influence:Percutaneous absorption,Boric acid,Skin decontamination,Human skin,Percutaneous penetration,Stratum corneum,Human nail,Skin penetration.
Xiao Ying Hui:KOL impact
Concepts related to the work of other authors for whichfor which Xiao Ying Hui has influence:Percutaneous absorption,Drug delivery,Human skin,Nail plate,Accelerator mass spectrometry,Stratum corneum,Boric acid.
KOL Resume for Xiao Ying Hui
| Year | |
|---|---|
| 2020 | Dermatology Department, University of California, San Francisco, San Francisco, California, USA |
| 2019 | Department of Dermatology, School of Medicine, University of California San Francisco, San Francisco, CA, USA |
| 2018 | Department of Dermatology, School of Medicine, University of California, San Francisco, CA, 94143, USA |
| 2017 | University of California, San Francisco, San Francisco, California, United States |
| 2016 | Department of Dermatology University of California San Francisco San Francisco CA USA |
| 2015 | University of California San Francisco Department of Dermatology CA USA |
| 2014 | University of California San Francisco, Department of Dermatology, Surge 110, Box 0989, 90 Medical Center Way, San Francisco, CA 94143, United States |
| 2013 | Dermatology Department, University of California, San Francisco, 90 Medical Center Way, Surge Building, Room 110, San Francisco, CA 94143-0989, USA |
| 2012 | Department of Dermatology, University of California San Francisco, San Francisco, CA, Dermatology, University of California San Francisco, 90 Medical Center Way, Surge 110, Box 0989, San Francisco, CA 94143-0989, United States |
| 2009 | Department of Dermatology, School of Medicine, University of California, San Francisco, CA, USA |
| 2008 | Department of Dermatology, University of California, School of Medicine, Box 0989, Surge 110, 90 Medical Center Way, San Francisco, CA 94143-0989, USA |
| 2007 | Department of Dermatology, University of California San Francisco, Box 0989, 90 Medical Center Way, San Francisco, California 94143 |
| 2006 | Department of Dermatology, School of Medicine, University of California San Francisco, San Francisco, California, USA |
| 2005 | Department of Dermatology, Surge Building, Room 110, 90 Medical Center Way, University of California at San Francisco, San Francisco, CA, 94143, USA |
| 2004 | Department of Dermatology, University of California–San Francisco, 90 Medical Center Way, Surge 110, Box 0989, San Francisco, California 94143 |
| 2003 | Department of Dermatology, University of California San Francisco, Surge £110, Box 0989, 90 Medical Center Way, San Francisco, California 94143‐0989. Telephone: 415‐502‐7761; Fax: 415‐753‐5304 |
| 2002 | Dermatology Department, University of California, San Francisco, California 94143‐0989 |
| 2001 | Department of Dermatology, University of California San Francisco, Surge 110, Box 0989, San Francisco, California 94143‐0989. Telephone: 415‐476‐2717; Fax: 415‐753‐5304 |
| 1999 | University of California, San Francisco. |
| 1998 | Department of Dermatology, University of California, San Francisco, CA |
| 1996 | Department of Dermatology UCSF Medical Center, 94143-0989, San Francisco, CA, USA |
| Concept | World rank |
|---|---|
| consumer dermatotoxicants | #2 |
| –water wash | #2 |
| geraniol receptor | #2 |
| cutaneously directed | #2 |
| alleged fragrance | #2 |
| ideal decontamination protocols | #2 |
| emphasizing decontamination | #2 |
| penetration abilities effects | #2 |
| flowthrough diffusion methods | #2 |
| decontamination protocols methodology | #2 |
| materials skin absorption | #2 |
| penetration abilities geraniol | #2 |
| 5 geraniol materials | #2 |
| decontamination morbidity | #2 |
| total molecular penetration | #2 |
| abilities geraniol | #2 |
| penetration geraniol | #2 |
| citronellol low | #2 |
| 19 5 citronellol | #2 |
| 19 2 geraniol | #2 |
| soap –water wash | #2 |
| allergens cadaver | #2 |
| monoterpenes aged | #2 |
| absorption emphasizing | #2 |
| percutaneous absorption decontamination | #2 |
| flowthrough diffusion study | #2 |
| post dermal | #2 |
| corneum partial | #2 |
| physicochemical array | #2 |
| geraniol recovered | #2 |
| complexities penetration | #2 |
| wide physicochemical array | #2 |
| methodology percutaneous penetration | #2 |
| binding affinity amounts | #3 |
| paraoxon surface wash | #3 |
| panthenol tape strips | #3 |
| nail plate bed | #3 |
| sls application p005 | #3 |
| epidermal penetration study | #3 |
| chemical absorption compounds | #3 |
| evaporated 10 | #3 |
| deemed inhibit | #3 |
| receptor fluid dctfp | #3 |
| 30 post application | #3 |
| 15 moisturizer | #3 |
| me1111 onychopharmacokinetics | #3 |
| nail absorption | #3 |
| panthenol vitro | #3 |
| vitro skin study | #3 |
| dctfp human skin | #3 |
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Prominent publications by Xiao Ying Hui
Literature from the first half of this century report concern for toxicity from topical use of boric acid, but assessment of percutaneous absorption has been impaired by lack of analytical sensitivity. Analytical methods in this study included inductively coupled plasma-mass spectrometry which now allows quantitation of percutaneous absorption of 10B in 10B-enriched boric acid, borax, and disodium octaborate tetrahydrate (DOT) in biological matrices. This made it possible, in the ...
| Known for Boric Acid | Percutaneous Absorption | Disodium Octaborate | Human Skin | Borax 50 |
The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D), used for control of weeds in agriculture, forestry, and rights of way, can accumulate as a residual chemical in soil. The objective was to determine percutaneous absorption of 2,4-D from soil, with emphasis on soil load and skin contact time. With control acetone vehicle, in vivo absorption of 2,4-D in the rhesus monkey was 8.6 +/- 2.1% of the dose, which compared closely to published human absorption of 6.0 +/- 2.4%. Percutaneous ...
| Known for Percutaneous Absorption | Human Skin | Dichlorophenoxyacetic Acid | Cm2 Soil | Contact Time |
Accelerator mass spectrometry (AMS) has been applied to the detection of 14C-labeled urinary metabolites of the triazine herbicide, atrazine, and the analytical performance of AMS has been directly compared to that of liquid scintillation counting (LSC). Ten human subjects were given a dermal dose of 14C-labeled atrazine over 24 h, and urine from the subjects was collected over a 7-day period. Concentrations of 14C in the samples have been determined by AMS and LSC and range from 1.8 ...
| Known for Human Urine | Accelerator Mass Spectrometry | Scintillation Counting | Ams Detection | Atrazine Metabolites |
HPLC−Accelerator MS Measurement of Atrazine Metabolites in Human Urine after Dermal Exposure
[ PUBLICATION ]
Metabolites of atrazine were measured in human urine after dermal exposure using HPLC to separate and identify metabolites and accelerator mass spectrometry (AMS) to quantify them. Ring-labeled [14C]atrazine was applied for 24 h with a dermal patch to human volunteers at low (0.167 mg, 6.45 muCi) and high (1.98 mg, 24.7 muCi) doses. Urine was collected for 7 days. The urine was centrifuged to remove solids, and the supernatant was measured by liquid scintillation counting prior to ...
| Known for Human Urine | Atrazine Metabolites | Dermal Exposure | Parent Compound | Liquid Scintillation Counting |
Effect of topically applied menthol on thermal, pain and itch sensations and biophysical properties of the skin
[ PUBLICATION ]
The effect of menthol and alcohol as its vehicle on thermal sensations, pain, experimental itch and irritation were studied in 18 subjects, using a computerized thermal sensory analyzer, laser Doppler flowmetry and an evaporimeter for transepidermal water loss (TEWL). Menthol had a subjective cooling effect lasting up to 70 min in 12/18 subjects; however, it did not affect cold and heat threshold, nor did it affect cold and heat pain threshold. Alcohol produced an immediate cold ...
| Known for Histamine Injection | Cold Sensation | Pain Threshold | Menthol Thermal | 18 Subjects |
The human nail penetration of the antifungal ciclopirox was determined for marketed gel containing 0.77% of ciclopirox, an experimental gel containing 2% of ciclopirox, and a marketed lacquer containing 8% of ciclopirox. After 14 days dosing, unabsorbed drug remaining on the surface, drug within the infection-prone area, and the amount that had penetrated through the nail were determined. Ciclopirox delivery into and through the nail was significantly greater from the marketed gel, than ...
| Known for Ciclopirox Delivery | Human Nail Plate | Nail Lacquer | Antifungal Agents | Gel Formulation |
Due to the large surface area of the skin, percutaneous absorption has the potential to contribute significantly to the total bioavailability of some compounds. Breath elimination data, acquired in real-time using a novel MS/MS system, was assessed using a PBPK model with a dermal compartment to determine the percutaneous absorption of methyl chloroform (MC) in rats and humans from exposures to MC in non-occluded soil or occluded water matrices. Rats were exposed to MC using a dermal ...
| Known for Percutaneous Absorption | Methyl Chloroform | Biological Rats Rats | Pbpk Model | Dermal Exposures |
This study compared the efficiency for in vitro human skin decontamination using DDGel and RSDL when applied at different timepoints (5 min and 90 min). Experiments were performed using in vitro human skin models, in which skin was mounted onto Flow-Through diffusion cells. The mass of 14-C DIMP removed from skin surface after decontamination was quantitated by measuring radioactivity with a liquid scintillation spectrometer. Both decontaminants removed more than 90% recovery dose of ...
| Known for Skin Decontamination | Vitro Human | Diisopropyl Methylphosphonate | Chemical Warfare | Administration Cutaneous |
Correlation of transepidermal water loss with skin barrier properties in vitro: comparison of three evaporimeters
[ PUBLICATION ]
AIM: This study investigates the relationship between transepidermal water loss (TEWL) and skin permeability to tritiated water as a rapid assessment of the integrity of the barrier properties of skin as part of in vitro skin permeation studies.
METHODS: TEWL values before and during the experimental period were measured using three evaporimeters (A, B, and C) representing different measuring principles and technologies. Single application of tritiated water was dosed on dermatomed human ...
| Known for Transepidermal Water Loss | Skin Barrier | Tewl Values | Vitro Techniques | Closed Chamber |
The development and validation of noninvasive techniques for estimating the dermal bioavailability of solvents in contaminated soil and water can facilitate the overall understanding of human health risk. To assess the dermal bioavailability of trichloroethylene (TCE), exhaled breath was monitored in real time using an ion trap mass spectrometer (MS/MS) to track the uptake and elimination of TCE from dermal exposures in rats and humans. A physiologically based pharmacokinetic (PBPK) ...
| Known for Percutaneous Absorption | Rats Humans | Soil Water | Trichloroethylene Tce | Pbpk Model |
In Vitro penetration of a novel oxaborole antifungal (AN2690) into the human nail plate
[ PUBLICATION ]
Onychomycosis is a challenging fungal infection to treat topically, likely due to the unique properties of the nail plate. This seemingly impenetrable barrier has high resistance to the passage of antifungal drugs in sufficient concentrations to kill the causative fungi deep in the nail bed. Recently, a new class of antifungal agent was described, termed oxaboroles, which have broad-spectrum activity. These oxaboroles were designed with properties believed to be required to allow for ...
| Known for Nail Plate | Vitro Penetration | An2690 Onychomycosis | Antifungal Agent | New Class |
This study was conducted to evaluate the dermal absorption of arsenic from residues present on the surface of wood preserved with chromated copper arsenate (CCA). The research reported herein used methods parallel to those of earlier research on the dermal absorption of radiolabeled arsenic (R. C. Wester et al., 1993, Fund. Appl. Toxicol. 20, 336-340), with modifications to allow use of environmental matrices that are not radiolabeled. These modifications include the surface area of ...
| Known for Treated Wood | Arsenic Absorption | Chromated Copper Arsenate | Environmental Pollutants | Macaca Mulatta |
Skin decontamination is a primary interventional method used to decrease dermal absorption of hazardous contaminants, including chemical warfare agents, pesticides and industrial pollutants. Soap and water wash, the most common and readily available decontamination system, may enhance percutaneous absorption through the "wash-in effect." To understand better the effect of soap-water wash on percutaneous penetration, and provide insight to improving skin decontamination methods, in vitro ...
| Known for Benzoic Acid | –water Wash | Human Epidermal Penetration | Skin Decontamination | Absorption Chemical |
Measuring transepidermal water loss: a comparative in vivo study of condenser‐chamber, unventilated‐chamber and open‐chamber systems
[ PUBLICATION ]
BACKGROUND/AIMS: Two main systems have been utilized for measuring transepidermal water loss (TEWL): open chamber and closed chamber. Yet, further validation and standardization studies may be necessary to reveal the sensitivity, precision, and robustness of these instruments.
METHODS: Three instruments are compared for their applicability to assess TEWL: unventilated chamber, open chamber and condenser chamber. The comparative study was performed on human forearm skin (n=6), in the ...
| Known for Transepidermal Water Loss | Tewl Values | Chamber Condenser | Forearm Skin | Physiological Phenomena |
