Prominent publications by IRA S Schwartz

KOL Index score: 16848

During the spring in 2005 and 2006, 39,095 northward-migrating land birds were captured at 12 bird observatories in eastern Canada to investigate the role of migratory birds in northward range expansion of Lyme borreliosis, human granulocytic anaplasmosis, and their tick vector, Ixodes scapularis. The prevalence of birds carrying I. scapularis ticks (mostly nymphs) was 0.35% (95% confidence interval [CI] = 0.30 to 0.42), but a nested study by experienced observers suggested a more ...

Also Ranks for: Migratory Birds |  scapularis ticks |  anaplasma phagocytophilum |  borrelia burgdorferi |  range expansion
KOL Index score: 16053

Borrelia spp. associated with Lyme disease possess an rRNA gene organization consisting of a single 16S rRNA gene followed by a spacer of several kilobases and a tandem repeat of a 23S (rrl)-5S (rrf) rRNA gene cluster. The restriction fragment length polymorphism (RFLP) patterns for these genes have been widely used to classify Lyme disease spirochete isolates. We analyzed the rRNA gene organization and sequences for two Ixodes ovatus isolates from Japan (IKA2 and HO14) and two group ...

Also Ranks for: Lyme Disease |  rrna gene |  borrelia andersonii |  bacterial rna |  fragment length
KOL Index score: 15658

An 11,955-bp region of the Borrelia burgdorferi chromosome containing all the genes encoding ribosomal RNA (rRNA) has been sequenced. The region contains a single gene encoding 16S rRNA and two genes encoding the 23S and 5S rRNAs. The sizes of the 16S, 23S and 5S rRNAs encoded by these genes are 1537, 2926 and 112 nucleotides, respectively. In addition, the genes encoding tRNA(Ala) and tRNA(Ile) are located in the intergenic spacer between the 16S and 23S rDNAs. The tDNAs do not encode ...

Also Ranks for: Ribosomal Rna |  borrelia burgdorferi |  lyme disease |  sequence analysis |  genes encoding
KOL Index score: 15472

Lyme disease is the most common vector-borne disease in the United States. The causative agent is the spirochete Borrelia burgdorferi. The copy number and organization of the genes encoding the rRNAs of this organism were determined. There is a single gene for 16S rRNA and two copies each of the 23S rRNA and 5S rRNA genes. All of the genes are located within a chromosomal fragment of approximately 9.5 to 10.0 kb. The 23S and 5S rRNA genes are tandemly duplicated in the order ...

Also Ranks for: Ribosomal Rna |  lyme disease |  borrelia burgdorferi |  gene organization |  sequence homology
KOL Index score: 14508

Current laboratory diagnosis of Lyme disease relies on tests for the detection of antibodies to Borrelia burgdorferi, the etiologic agent of the disease. These tests are often unreliable because of a lack of sensitivity and specificity and test-to-test variability. The purpose of this study was to evaluate the sensitivity and specificity of polymerase chain reaction (PCR) amplification for detection of B. burgdorferi in skin biopsy specimens. Forty-six 2-mm skin biopsy samples were ...

Also Ranks for: Early Lyme Disease |  polymerase chain |  culture pcr |  skin biopsies |  erythema migrans
KOL Index score: 13970

The genetic diversity of Borrelia burgdorferi sensu stricto, the agent of Lyme disease in North America, has consequences for the performance of serological diagnostic tests and disease severity. To investigate B. burgdorferi diversity in Canada, where Lyme disease is emerging, bacterial DNA in 309 infected adult Ixodes scapularis ticks collected in surveillance was characterized by multilocus sequence typing (MLST) and analysis of outer surface protein C gene (ospC) alleles. Six ticks ...

Also Ranks for: United States |  borrelia burgdorferi |  scapularis ticks |  north america |  genetic diversity
KOL Index score: 13540

Borrelia burgdorferi is the spirochetal agent of Lyme disease, a multisystemic disorder characterized by inflammation. Using global transcriptional profiling, we characterized the response of human PBMCs exposed to B. burgdorferi in an ex vivo coculture system. The expression profiles induced by B. burgdorferi were marked by the intense up-regulation of IFN-responsive transcripts and transcripts involved in the JAK/STAT signaling pathway. Transcript levels of IFN-alpha, IFN-beta, and ...

Also Ranks for: Borrelia Burgdorferi |  lyme disease |  type ifn |  tlr7 tlr9 |  human pbmcs
KOL Index score: 11832

Borrelia burgdorferi elicits a potent cytokine response through activation of multiple signaling receptors on innate immune cells. Spirochetal lipoproteins initiate expression of NF-κB-dependent cytokines primarily via TLR2, whereas type I interferon (IFN) production is induced through the endosomal receptors TLR7 and TLR9 in human dendritic cells and TLR8 in monocytes. We demonstrate that DNA and RNA are the B. burgdorferi components that initiate a type I IFN response by human ...

Also Ranks for: Borrelia Burgdorferi |  iii interferons |  type ifn |  receptor 7 |  interferon regulatory
KOL Index score: 11731

Borrelia burgdorferi sensu lato, the spirochete that causes human Lyme borreliosis (LB), is a genetically and phenotypically divergent species. In the past several years, various molecular approaches have been developed and used to determine the phenotypic and genetic heterogeneity within the LB-related spirochetes and their potential association with distinct clinical syndromes. These methods include serotyping, multilocus enzyme electrophoresis, DNA-DNA reassociation analysis, rRNA ...

Also Ranks for: Borrelia Burgdorferi |  sensu lato |  molecular typing |  dna bacterial |  analysis species
KOL Index score: 11723

Borrelia burgdorferi (Bb) adapts to its arthropod and mammalian hosts by altering its transcriptional and antigenic profiles in response to environmental signals associated with each of these milieus. In studies presented here, we provide evidence to suggest that mammalian host signals are important for modulating and maintaining both the positive and negative aspects of mammalian host adaptation mediated by the alternative sigma factor RpoS in Bb. Although considerable overlap was ...

Also Ranks for: Rpos Regulon |  enzootic cycle |  mammalian host |  borrelia burgdorferi |  genes expression
KOL Index score: 11654

Lyme borreliosis, caused by the tick-borne bacterium Borrelia burgdorferi, has become the most common vector-borne disease in North America over the last three decades. To understand the dynamics of the epizootic spread and to predict the evolutionary trajectories of B. burgdorferi, accurate information on the population structure and the evolutionary relationships of the pathogen is crucial. We, therefore, developed a multilocus sequence typing (MLST) scheme for B. burgdorferi based on ...

Also Ranks for: Housekeeping Genes |  north america |  geographic population structure |  borrelia burgdorferi |  european origin
KOL Index score: 11471

In the northeastern United States, the Lyme disease agent, Borrelia burgdorferi sensu stricto, is maintained by enzoonotic transmission, cycling between white-footed mice (Peromyscus leucopus) and black-legged ticks (Ixodes scapularis). B. burgdorferi sensu stricto is genetically variable and has been divided into three major genotypes based on 16S-23S ribosomal DNA spacer (RST) analysis. To better understand how genetic differences in B. burgdorferi sensu stricto may influence ...

Also Ranks for: Sensu Stricto |  borrelia burgdorferi |  bl206 b348 |  xenodiagnostic ticks |  whitefooted mice
KOL Index score: 11345

The etiologic agent of Lyme borreliosis, Borrelia burgdorferi sensu lato, has been isolated from many biologic sources in North America and Eurasia, and isolates have been divided into three distinct genospecies (B. burgdorferi sensu stricto, Borrelia garinii, and Borrelia afzelii). In order to explore the possible association of genospecies with disease manifestation, 60 isolates of B. burgdorferi sensu lato were subjected to 5S rDNA-linked restriction fragment length polymorphism ...

Also Ranks for: Sensu Lato |  molecular typing |  fragment length |  borrelia burgdorferi |  polymorphism analysis
KOL Index score: 11304

The genes coding for threonyl-tRNA synthetase (thrS), translation initiation factor 3 (infC) and ribosomal protein L20 (rplT) are clustered in the Escherichia coli genome. Previous studies had suggested the possibility that the expression of these genes is coupled. The transcriptional events in this operon have now been examined by S1 nuclease mapping and promoter fusion studies. The results indicate that infC-containing mRNAs are initiated from three separate promoters. Two of these are ...

Also Ranks for: Escherichia Coli |  rplt operon |  promoter regions |  bacterial proteins |  ribosomal protein

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IRA S Schwartz:Expert Impact

Concepts for whichIRA S Schwartzhas direct influence:Borrelia burgdorferi,  Lyme disease,  Erythema migrans,  Early lyme disease,  Escherichia coli,  Human granulocytic ehrlichiosis,  Sensu stricto,  New york.

IRA S Schwartz:KOL impact

Concepts related to the work of other authors for whichfor which IRA S Schwartz has influence:Lyme disease,  Borrelia burgdorferi,  Sensu lato,  Erythema migrans,  United states,  Anaplasma phagocytophilum,  Escherichia coli.


 

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Department of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA. | Department of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, NY, USA. | Department of Microbiology and Immunology,