• Disease
  • Parkinson
  • Parkinson Disease
  • Stanley Fahn

    Prominent publications by Stanley Fahn

    KOL Index score: 16888

    Glucocerebrosidase (GBA) mutations have been associated with Parkinson's disease in numerous studies. However, it is unknown whether the increased risk of Parkinson's disease in GBA carriers is due to a loss of glucocerebrosidase enzymatic activity. We measured glucocerebrosidase enzymatic activity in dried blood spots in patients with Parkinson's disease (n = 517) and controls (n = 252) with and without GBA mutations. Participants were recruited from Columbia University, New York, and ...

    Also Ranks for: Glucocerebrosidase Activity |  gba mutations |  parkinson disease |  mutation carriers |  dried blood spots
    KOL Index score: 13660

    BACKGROUND: Despite the known benefit of levodopa in reducing the symptoms of Parkinson's disease, concern has been expressed that its use might hasten neurodegeneration. This study assessed the effect of levodopa on the rate of progression of Parkinson's disease.

    METHODS: In this randomized, double-blind, placebo-controlled trial, we evaluated 361 patients with early Parkinson's disease who were assigned to receive carbidopa-levodopa at a daily dose of 37.5 and 150 mg, 75 and 300 mg, or ...

    Also Ranks for: Levodopa Placebo |  progression parkinsons disease |  updrs baseline |  daily dose |  40 weeks
    KOL Index score: 13609

    This article presents the revision process, major innovations, and clinimetric testing program for the Movement Disorder Society (MDS)-sponsored revision of the Unified Parkinson's Disease Rating Scale (UPDRS), known as the MDS-UPDRS. The UPDRS is the most widely used scale for the clinical study of Parkinson's disease (PD). The MDS previously organized a critique of the UPDRS, which cited many strengths, but recommended revision of the scale to accommodate new advances and to resolve ...

    Also Ranks for: Clinimetric Testing |  movement disorder society |  rating scale |  unified parkinson |  mdsupdrs updrs
    KOL Index score: 13003

    OBJECTIVE: To evaluate the frequency of leucine-rich repeat kinase gene (LRRK2) mutations and single nucleotide polymorphisms (SNPs) in early-onset Parkinson disease (EOPD) and late-onset Parkinson disease (LOPD).

    METHODS: We genotyped five previously reported LRRK2 mutations (G2019S, L1114L, I1122V, R1441C, and Y1699C) and 17 coding SNPs for haplotype analysis in 504 cases with PD and 314 controls enrolled in the Genetic Epidemiology of PD Study. Cases and controls were recruited ...

    Also Ranks for: Lrrk2 Mutations |  onset parkinson |  g2019s mutation |  disease genetic |  threonine protein
    KOL Index score: 12317

    OBJECTIVE: To evaluate the frequency of glucocerebrosidase (GBA) mutations in cases and controls enrolled in the Genetic Epidemiology of Parkinson's Disease (GEPD) study.

    METHODS: We sequenced all exons of the GBA gene in 278 Parkinson disease (PD) cases and 179 controls enrolled in GEPD, with a wide range of age at onset (AAO), and that included a subset of 178 Jewish cases and 85 Jewish controls. Cases and controls were recruited without knowledge of family history of PD, and cases ...

    Also Ranks for: Glucocerebrosidase Gene |  parkinson disease |  gba mutations |  age onset |  50 years
    KOL Index score: 11813

    IMPORTANCE: Information on age-specific risk for Parkinson disease (PD) in patients with Gaucher disease (GD) and glucocerebrosidase (GBA) heterozygotes is important for understanding the pathophysiology of the genetic association and for counseling these populations.

    OBJECTIVE: To estimate the age-specific risk for PD in Ashkenazi Jewish patients with type 1 GD and in GBA heterozygotes.

    DESIGN, SETTING, AND PARTICIPANTS: The study included patients with GD from 2 tertiary centers, ...

    Also Ranks for: Gaucher Disease |  patients gd |  gba heterozygotes |  age onset |  new york
    KOL Index score: 11674

    Essential tremor can cause significant functional disability in some patients. The arms are the most common body part affected and cause the most functional disability. The treatment of essential tremor includes medications, surgical options and other forms of therapy. Presently there is no cure for essential tremor nor are there any medications that can slow the progression of tremor.Treatment for essential tremor is recommended if the tremor causes functional disability. If the tremor ...

    Also Ranks for: Essential Tremor |  deep brain stimulation |  propranolol primidone |  functional disability |  pharmacological treatments
    KOL Index score: 11426

    We examined the status of dopamine (DA) D1 and D2 receptors by using [3H]SCH 23390 and [3H]spiperone binding, respectively, and DA uptake sites by using [3H]mazindol binding in spontaneously hypertensive rats (SHR) and Sprague-Dawley (SD) rats. SHR showed significantly higher [3H]SCH 23390 and [3H]spiperone binding in the caudate-putamen (CPu), the nucleus accumbens (NAc) and the olfactory tubercle (OT) in comparison to the SD rats. There were no significant differences in ...

    Also Ranks for: Dopamine Receptors |  uptake sites |  rats shr |  spontaneously hypertensive |  caudate putamen
    KOL Index score: 11373

    BACKGROUND: Transplantation of human embryonic dopamine neurons into the brains of patients with Parkinson's disease has proved beneficial in open clinical trials. However, whether this intervention would be more effective than sham surgery in a controlled trial is not known.

    METHODS: We randomly assigned 40 patients who were 34 to 75 years of age and had severe Parkinson's disease (mean duration, 14 years) to receive a transplant of nerve cells or sham surgery; all were to be followed ...

    Also Ranks for: Patients Sham Surgery |  dopamine neurons |  improvement transplantation |  severe parkinson |  brain tissue

    Freezing of gait in PD

    KOL Index score: 11318

    OBJECTIVE: To study the development of freezing of gait in PD.

    BACKGROUND: Freezing of gait is a common, disabling, and poorly understood symptom in PD.

    METHODS: The authors analyzed data from 800 patients with early PD from the Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism (DATATOP) clinical trial who were assigned either placebo, deprenyl, tocopherol, or the combination of deprenyl and tocopherol. The primary outcome measure was the time from randomization until the ...

    Also Ranks for: Freezing Gait |  rigidity bradykinesia |  deprenyl tocopherol |  800 patients |  aged parkinson
    KOL Index score: 11246

    Levodopa therapy, as originally established by George Cotzias [2, 3], is the most powerful treatment for Parkinson’s disease (PD). Levodopa’s toxicity to neurons in vitro has raised concerns if it might hasten the progression of PD, although in vivo animal studies suggest it may be neuroprotective.ObjectiveTo discuss the results of the ELLDOPA trial that was carried out to determine if levodopa therapy influences the rate of progression of Parkinson’s disease (PD).DesignELLDOPA was a ...

    Also Ranks for: Rate Progression |  levodopa therapy |  parkinson disease |  dopamine transporter |  updrs baseline
    KOL Index score: 11182

    Idiopathic torsion dystonia (ITD) is a neurological disorder characterized by sustained muscle contractions that appear as twisting movements of the limbs, trunk, and/or neck, which can progress to abnormal postures. Most familial forms of ITD follow autosomal dominant transmission with reduced penetrance. The frequency of ITD in the Ashkenazi Jewish population is five to ten times greater than that in other groups. Recently, a gene for ITD (DYT1) in a non-Jewish kindred was located on ...

    Also Ranks for: Dystonia Gene |  ashkenazi jewish |  chromosome 9 |  human pair |  reduced penetrance
    KOL Index score: 11149

    Administration of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to mammals causes damage to the nigrostriatal dopaminergic pathway similar to that observed in Parkinson's disease. It has been suggested that the mechanism by which MPTP kills dopamine (DA) neurons involves an energy crisis due to the inhibition of mitochondrial complex I. In addition, superoxide radicals (O2-), generated subsequent to the blockade of mitochondrial complex I, may also be involved in MPTP-induced ...

    Also Ranks for: Transgenic Mice |  superoxide dismutase |  mitochondrial complex |  mptp injection |  dopamine neurons
    KOL Index score: 11143

    The phenotype of Parkinson's disease (PD) in patients with and without leucine-rich repeat kinase 2 (LRRK2) G2019S mutations reportedly is similar; however, large, uniformly evaluated series are lacking. The objective of this study was to characterize the clinical phenotype of Ashkenazi Jewish (AJ) PD carriers of the LRRK2 G2019S mutation. We studied 553 AJ PD patients, including 65 patients who were previously reported, from three sites (two in New York and one in Tel-Aviv). ...

    Also Ranks for: Lrrk2 G2019s |  ashkenazi jews |  parkinson disease |  age onset |  mutation carriers


    Stanley Fahn: Influence Statistics

    Sample of concepts for which Stanley Fahn is among the top experts in the world.
    Concept World rank
    tdpd tremor #1
    motor ratings pdrp #1
    performance eopd noncarriers #1
    treatment local injections #1
    neurologists george cotzias #1
    intractable movement #1
    doses srif #1
    class maob inhibitors #1
    definite myoclonus #1
    infusion phno #1
    vit fluinduced increases #1
    development freezing #1
    rapid determination dopa #1
    therapeutic trial milacemide #1
    dopamine dopamine agonists #1
    drd gch1 #1
    conservative diagnosis kappa #1
    gba lrrk2 carriers #1
    8oh3hdpat #1
    parkin gene performance #1
    reserpine tetrabenazine #1
    620 years range #1
    1193 µmol #1
    msa pdrp #1
    chlorpromazine methiodide rats #1
    improvement effective doses #1
    nb69 chp126 #1
    infusaid pumps monkeys #1
    total 53 patients #1
    metabolism receptor supersensitivity #1
    lan5 nb69 #1
    tdd treatment level #1
    persistent abnormalities idpn #1
    dlbd 100 dlbd #1
    disorder female fluorodeoxyglucose #1
    predilection age #1
    hip gshpx #1
    elldopa #1
    vit dopac #1
    basal ganglia hemidystonia #1
    age torticollis #1
    cpzmi rotation #1
    mouse neutralization #1
    modified mesencephalic #1
    potent comt inhibitor #1
    dopamine intracerebral infusion #1
    dyskinesias sleep #1
    tbr slopes #1
    risk action tremor #1
    dystonia filipino #1

    Key People For Parkinson Disease

    Top KOLs in the world
    Andrew John Andrew
    parkinsons disease progressive supranuclear motor fluctuations
    Anthony Edward Lang
    parkinson disease movement disorders subthalamic nucleus
    Werner H Poewe
    parkinson disease multiple atrophy restless legs syndrome
    Christopher G Goetz
    parkinson disease movement disorders rating scales
    Charles W Olanow
    parkinson disease oxidative stress motor complications
    Joseph J Jankovic
    movement disorders parkinson disease essential tremor

    Stanley Fahn:Expert Impact

    Concepts for whichStanley Fahnhas direct influence:Parkinson disease,  Movement disorders,  Parkinsons disease,  Botulinum toxin,  Idiopathic torsion dystonia,  Essential tremor,  Rat brain,  Torsion dystonia.

    Stanley Fahn:KOL impact

    Concepts related to the work of other authors for whichfor which Stanley Fahn has influence:Parkinson disease,  Movement disorders,  Botulinum toxin,  Essential tremor,  Cervical dystonia,  Deep brain stimulation,  Dopaminergic neurons.



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    Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA | Department of Neurology, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA | H. Houston Merritt Professor Emeritus of