Prominent publications by Bernard J Fisher

KOL Index score: 24688

CONTEXT: Among cancer-free women aged 35 years or older, tamoxifen reduced the incidence of estrogen receptor (ER)-positive but not ER-negative breast cancer. The effect of tamoxifen on breast cancer incidence among women at extremely high risk due to inherited BRCA1 or BRCA2 mutations is unknown.

OBJECTIVE: To evaluate the effect of tamoxifen on incidence of breast cancer among cancer-free women with inherited BRCA1 or BRCA2 mutations.


Also Ranks for: Breast Cancer |  inherited mutations |  women brca1 |  tamoxifen incidence |  prevention trial
KOL Index score: 23524

BACKGROUND: In 1982, the National Surgical Adjuvant Breast and Bowel Project initiated a randomized, double-blinded, placebo-controlled trial (B-14) to determine the effectiveness of adjuvant tamoxifen therapy in patients with primary operable breast cancer who had estrogen receptor-positive tumors and no axillary lymph node involvement. The findings indicated that tamoxifen therapy provided substantial benefit to patients with early stage disease. However, questions arose about how long ...

Also Ranks for: Tamoxifen Therapy |  5 years |  breast cancer |  survival disease |  positive tumors
KOL Index score: 18640

BACKGROUND: The finding of a decrease in contralateral breast cancer incidence following tamoxifen administration for adjuvant therapy led to the concept that the drug might play a role in breast cancer prevention. To test this hypothesis, the National Surgical Adjuvant Breast and Bowel Project initiated the Breast Cancer Prevention Trial (P-1) in 1992.

METHODS: Women (N=13388) at increased risk for breast cancer because they 1) were 60 years of age or older, 2) were 35-59 years of age ...

Also Ranks for: Breast Cancer |  bowel project |  risk tamoxifen |  national surgical |  lobular carcinoma situ
KOL Index score: 18043

In 1985 we presented results of a randomized trial involving 1843 women followed for five years that indicated that segmental breast resection (lumpectomy) followed by breast irradiation is appropriate therapy for patients with Stage I or II breast cancer (tumor size, less than or equal to 4 cm), provided that the margins of the resected specimens are free of tumor. Women with positive axillary nodes received adjuvant chemotherapy. Lumpectomy followed by irradiation resulted in a ...

Also Ranks for: Total Mastectomy |  breast cancer |  lumpectomy irradiation |  adjuvant chemotherapy |  local recurrence tumor
KOL Index score: 17516

BACKGROUND: Tamoxifen reduces the risk for contralateral breast cancer by approximately 30%-50%, with benefits probably limited to women with estrogen receptor (ER)-positive primary disease. In a retrospective analysis of data from National Surgical and Adjuvant Breast and Bowel Project trials B-18, B-22, and B-25, we determined whether the ER status of primary breast cancer predicts the ER status of a subsequent contralateral breast cancer and whether tamoxifen treatment affects this ...

Also Ranks for: Contralateral Breast |  estrogen receptor |  tamoxifen patients |  primary cancer |  hormonal biomarkers
KOL Index score: 16877

To obtain information regarding the immunologic capacity of regional lymph nodes (RLNs) in patients with cancer, investigations were performed utilizing lymph nodes and/or blood lymphocytes from 140 patients with operable breast or colon cancers, benign breast disease, or cardiac problems requiring open heart surgery. Cells of all regional lymph nodes (RLNCs) from breast cancer patients responded to PHA stimulation. The response of stimulated and non-stimulated RLNCs from patients with ...

Also Ranks for: Rlncs Patients |  breast cancer |  regional lymph |  node cells |  pha stimulation
KOL Index score: 16552

BACKGROUND: In women with breast cancer, the role of radical mastectomy, as compared with less extensive surgery, has been a matter of debate. We report 25-year findings of a randomized trial initiated in 1971 to determine whether less extensive surgery with or without radiation therapy was as effective as the Halsted radical mastectomy.

METHODS: A total of 1079 women with clinically negative axillary nodes underwent radical mastectomy, total mastectomy without axillary dissection but ...

Also Ranks for: Radical Mastectomy |  positive nodes |  hazard ratio |  year follow |  survival women
KOL Index score: 16199

In 1976 we began a randomized trial to evaluate breast conservation by a segmental mastectomy in the treatment of Stage I and II breast tumors less than or equal to 4 cm in size. The operation removes only sufficient tissue to ensure that margins of resected specimens are free of tumor. Women were randomly assigned to total mastectomy, segmental mastectomy alone, or segmental mastectomy followed by breast irradiation. All patients had axillary dissections, and patients with positive ...

Also Ranks for: Segmental Mastectomy |  positive nodes |  radiation breast tumor |  clinical trial |  treatment stage
KOL Index score: 15997

BACKGROUND: Obesity is associated with both increased breast cancer risk and poorer prognosis after disease onset. However, little is known about the effect of obesity on treatment efficacy. We evaluated the association of obesity with outcomes and with tamoxifen efficacy in women with early-stage, hormone-responsive breast cancer participating in a multicenter cancer cooperative group clinical trial.

METHODS: The cohort consisted of 3385 women enrolled in National Surgical Adjuvant ...

Also Ranks for: Breast Cancer |  estrogen receptor |  obese women |  mortality bmi |  obesity outcomes
KOL Index score: 15954

The National Surgical Adjuvant Breast and Bowel Project (NSABP) conducted two sequential randomized clinical trials to aid in resolving uncertainty about the treatment of women with small, localized, mammographically detected ductal carcinoma in situ (DCIS). After removal of the tumor and normal breast tissue so that specimen margins were histologically tumor-free (lumpectomy), 818 patients in the B-17 trial were randomly assigned to receive either radiation therapy to the ipsilateral ...

Also Ranks for: Invasive Breast |  ductal carcinoma |  bowel project |  dcis lcis |  lumpectomy radiation
KOL Index score: 15850

BACKGROUND: Initial findings from the National Surgical Adjuvant Breast and Bowel Project Breast Cancer Prevention Trial (P-1) demonstrated that tamoxifen reduced the risk of estrogen receptor-positive tumors and osteoporotic fractures in women at increased risk for breast cancer. Side effects of varying clinical significance were observed. The trial was unblinded because of the positive results, and follow-up continued. This report updates our initial findings.

METHODS: Women (n = ...

Also Ranks for: Breast Cancer |  1000 women |  placebo tamoxifen |  net benefit |  5 years
KOL Index score: 15697

BACKGROUND: The B-20 study of the National Surgical Adjuvant Breast and Bowel Project (NSABP) was conducted to determine whether chemotherapy plus tamoxifen would be of greater benefit than tamoxifen alone in the treatment of patients with axillary lymph node-negative, estrogen receptor-positive breast cancer.

METHODS: Eligible patients (n = 2306) were randomly assigned to one of three treatment groups following surgery. A total of 771 patients with follow-up data received tamoxifen ...

Also Ranks for: Chemotherapy Tamoxifen |  estrogen receptor |  breast cancer |  lymph node |  tumor size

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Bernard J Fisher:Expert Impact

Concepts for whichBernard J Fisherhas direct influence:Breast cancer,  Bowel project,  Primary breast cancer,  National surgical,  Total mastectomy,  Adjuvant chemotherapy,  Adjuvant breast,  Radical mastectomy.

Bernard J Fisher:KOL impact

Concepts related to the work of other authors for whichfor which Bernard J Fisher has influence:Breast cancer,  Neoadjuvant chemotherapy,  Ductal carcinoma,  Lymph node,  Radiation therapy,  Estrogen receptor,  Postmenopausal women.



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Division of Pulmonary Disease and Critical Care Medicine, Virginia Commonwealth University, Richmond | Department of Internal Medicine, Division of Pulmonary Disease and Critical Care Medicine, Virginia Commonwealth University, USA | Department of In