Prominent publications by William Alwyn Lishman

KOL Index score: 8480

BACKGROUND: The schizophrenia-like psychoses of epilepsy (SLPE) might represent a secondary form of schizophrenia in which the pathology is relatively confined to the temporal lobe. To test this possibility we have compared the neuropsychological profile of schizophrenia and SLPE. Our main hypothesis was that both psychotic groups would show deficits of temporal lobe function but that prefrontal impairment, as measured by tests of executive function, would be found only in the primary ...

Also Ranks for: Epilepsy Slpe |  neuropsychological comparison |  patients schizophrenia |  executive function |  temporal lobe
KOL Index score: 7097

The extent to which psychiatric disability after head injury depends upon the brain damage which has occurred remains a problem of considerable practical and theoretical interest. In 1904 Adolf Meyer saw the need for caution in approaching this question since there was “no direct measure of the damage of a concussion”; similarly in 1945 Denny-Brown saw that the most serious obstacles to better understanding still lay in the difficulty of obtaining a reliable estimate of the severity of ...

Also Ranks for: Brain Damage |  head injury |  psychiatric disability |  compulsive disorder |  frontal lobe
KOL Index score: 5200

Twenty-five male and 13 female patients with alcoholic Korsakoff's syndrome (AKS) were compared with age- and sex-matched non-Korsakoff chronic alcoholics and healthy volunteers in a neuropsychological study, which included computer-administered tests of cognitive function. The performance of male Korsakoff patients was significantly inferior to that of healthy male controls, not only in tests of memory, but also in visuo-perceptual tasks with a speed or motor component, and on category ...

Also Ranks for: Korsakoff Patients |  cognitive function |  neuropsychological tests |  thiamine deficiency |  female controls
KOL Index score: 4680

Twenty-five male alcoholic Korsakoff patients were compared with age and sex-matched non-Korsakoff chronic alcoholics and healthy volunteers on clinical and CT brain scan parameters. The scans were assessed by planimetry, visual grading procedures and computerized analysis. Reliable measures of third ventricular size were developed. The Korsakoff patients had wider third ventricles, larger lateral ventricles and wider interhemispheric fissures than the comparison groups; but sulcal and ...

Also Ranks for: Korsakoff Patients |  diencephalic lesions |  thiamine deficiency |  ventricular size |  dual aetiology
KOL Index score: 4596

BACKGROUND: The association between temporal lobe epilepsy and schizophrenia suggests that the critical abnormality may be pathology within the temporal lobes. People with schizophrenia-like psychosis of epilepsy (SLPE) provide a useful group in which to examine the importance of temporal and frontal lobe dysfunction in schizophrenia.

METHOD: A verbal fluency activation paradigm and a 99mTc HMPAO SPET were used to study frontotemporal function in people with SLPE (n = 12), schizophrenia ...

Also Ranks for: Verbal Fluency |  temporal lobe |  epilepsy schizophrenia |  anterior cingulate |  blood flow
KOL Index score: 3810

Computer-assisted methods of CT brain scan analysis offer considerable advantages over visual inspection, particularly in research; and several semi-automated methods are currently available. A new computer-assisted program is presented which provides fully automated processing of CT brain scans, depending on “anatomical knowledge” of where cerebrospinal fluid (CSF)-containing spaces are likely to lie. After identifying these regions of interest quantitative estimates are then provided ...

Also Ranks for: Brain Absorption Density |  cerebrospinal fluid spaces |  scan analysis |  computer assisted |  ventricular volume
KOL Index score: 3716

A brief survey, using a standardized questionnaire, has been made of hand preference patterns in a series of patients admitted to hospital with functional psychiatric disorders. A small but significant shift towards left hand preference has been observed, more marked in the young patients and virtually confined to the males. Psychotic patients show such a shift more clearly than neurotic or personality disordered patients. Simple genetic factors do not appear to be responsible for these ...

Also Ranks for: Hand Preference |  psychiatric patients |  sex factors |  personality disorders |  findings relation
KOL Index score: 3560


The review deals mainly with the more chronic psychiatric sequelae of head injury. The constellation of factors—psychological, social, and organic—which may contribute to enduring disability are discussed. Principal areas of disability are then considered in detail—namely, intellectual impairments, change of personality, psychotic illness, and neurotic disorders.

Also Ranks for: Head Injury |  psychiatric sequelae |  brain damage |  post traumatic |  personality disorders
KOL Index score: 3515

An experiment is described in which depressed patients were asked to recall pleasant or unpleasant experiences from their past life in response to a standard series of stimulus words. The ratio between the time for recall of pleasant and unpleasant experiences was found to fall progressively with increasing severity of depression or of "neuroticism" and to be significantly related to each. Among patients who scored relatively low on depression or neuroticism pleasant memories were ...

Also Ranks for: Depressed Patients |  pleasant unpleasant |  speed recall |  male memory |  disorders personality
KOL Index score: 3293

The principle of distinguishing between selective memory deterioration and global intellectual decline has been applied to 38 patients with alcoholic Korsakoff's syndrome. Indices were developed for each type of deficit and their distributions explored. Considerable variation was seen in both parameters, the transition from pure memory loss to global intellectual deficits appearing to be gradual. Differences were found in the sex and CT scan associations of the indices. The implications ...

Also Ranks for: Global Intellectual Deficits |  alcoholic korsakoffs syndrome |  memory loss |  amnestic disorder |  ray computed
KOL Index score: 3217


A method is described for comparing the speed of recall of pleasant and unpleasant experiences. Pleasant experiences have proved to be recalled significantly more quickly than unpleasant experiences in healthy volunteer subjects, and especially in those scoring low on neuroticism or high on extraversion as measured by the Eysenck Personality Inventory. The overall pleasant/unpleasant differential was found to persist on re-testing some months later with an ...

Also Ranks for: Unpleasant Experiences |  speed recall |  psychological tests |  male memory |  word association
KOL Index score: 3077

The association between developmental defects of the corpus callosum and major psychiatric disturbance is discussed with a review of published cases. Seven new cases are presented, of which four had clear psychotic symptoms, two receiving a diagnosis of schizophrenia. Of the remainder, one had a developmental disorder affecting social interaction and speech which could be classed as Asperger's syndrome, one had a personality disorder with depressive and conversion symptoms, and the last ...

Also Ranks for: Corpus Callosum |  magnetic resonance |  callosal anomalies |  clinical manifestations |  publication adult agenesis
KOL Index score: 3046

A signal detection analysis was used in a recognition memory task involving material of varying hedonic tone. Major differences were found between the control and depressed states. Although overall recognition rates were the same, pleasant material was recognised less and unpleasant material more easily by depressives. Neutral material was recognised equally well by both groups. In the depressed state, response biases were altered such that unpleasant material was handled in a ...

Also Ranks for: Hedonic Tone |  signal detection analysis |  male memory |  psychological tests |  response biases
KOL Index score: 2991

Dementia in alcoholics may depend to a large degree on cortical cholinergic deficiency resulting from involvement of key basal forebrain nuclei in a Wernicke-type pathology. Other neurotransmitter functions may also be implicated. Such a model accounts for the difficulty in establishing alcoholic dementia as a distinct disorder and in distinguishing it from Alzheimer's disease.

Also Ranks for: Alcoholic Dementia |  alzheimers disease |  wernicke encephalopathy |  amnestic disorder |  cerebral cortex

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William Alwyn Lishman:Expert Impact

Concepts for whichWilliam Alwyn Lishmanhas direct influence:Scanning measures,  Psychiatric patients,  Brain damage,  Brain structure,  Ventricular size,  Detoxified chronic alcoholics,  Chronic alcoholism,  Computerized tomography.

William Alwyn Lishman:KOL impact

Concepts related to the work of other authors for whichfor which William Alwyn Lishman has influence:Brain injury,  Anorexia nervosa,  Corpus callosum,  Major depression,  Korsakoff syndrome,  Thiamine deficiency,  Cognitive impairment.



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Section of Neuropsychiatry, Institute of Psychiatry, London | Institute of Psychiatry, De Crespigny Park, London, UK. | Institute of Psychiatry, De Crespigny Park, London SE5 8AF, and Maudsley Hospital, Denmark Hill, London SE5 8AZ | Department of Ps