• Brain Edema
    • Andrés T Blei
    • Andrés T Blei: Influence Statistics

      Andrés T Blei

      Andrés T Blei

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      Northwestern Memorial Hospital Division of Gastroenterology Chicago IL USA | Div. of Gastroenterology, Northwestern University, Chicago, IL, United States | Department of ...

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      Andrés T Blei:Expert Impact

      Concepts for whichAndrés T Bleihas direct influence:Brain edema,Hepatic encephalopathy,Acute liver failure,Portal hypertension,Portacaval anastomosis,Intracranial hypertension,Intracranial pressure,Liver failure.

      Andrés T Blei:KOL impact

      Concepts related to the work of other authors for whichfor which Andrés T Blei has influence:Hepatic encephalopathy,Liver transplantation,Portal hypertension,Cirrhotic patients,Hepatorenal syndrome,Brain edema,Hepatocellular carcinoma.

      KOL Resume for Andrés T Blei


      Northwestern Memorial Hospital Division of Gastroenterology Chicago IL USA


      Div. of Gastroenterology, Northwestern University, Chicago, IL, United States


      Department of Medicine, Northwestern University, Chicago, Illinois, USA


      Northwestern University Feinberg School of Medicine, Division of Hepatology, Searle 10‐541, 303 E. Chicago Avenue, Chicago, IL 60611


      Northwestern University, Chicago, IL, USA

      Division of Hepatology, Department of Medicine


      Divisions of Hepatology

      Department of Medicine of Northwestern University


      Chief of Hepatology, Division of Gastroenterology and Hepatology, Saint Louis University Liver Center, Saint Louis University School of Medicine, St Louis, MO, USA

      Professor of Clinical Education

      Medicine, Northwestern University Feinberg School of Medicine, Children's Memorial Hospital, Chicago, Illinois

      James F King MD Endowed Chair in Gastroenterology

      Consultant Gastroenterologist


      Division of Hepatology, Department of Medicine, Lakeside VA Medical Center and Northwestern University Feinberg School of Medicine, Tarry Building – Room 14-707, 303 E Chicago Ave, Chicago, IL 60611, USA

      Northwestern University Medical School, 303 E. Chicago, Searle 10‐573, Chicago, IL 60611


      Northwestern University Feinberg School of Medicine, 303 E Chicago Seale 10-573, 60611, Chicago, IL, USA


      Northwestern University, Chicago, Illinois, USA


      Northwestern University Medical School, Chicago, Illinois, 60611-2923and, Nextran, Princeton, New Jersey, 08540

      Editor, HEPATOLOGY


      Department of Medicine (111E), VA Chicago Health Care System, Lakeside Division, 333 E. Huron St., Chicago, IL 60611. Fax: 312‐695‐5998


      Passavant 726, Northwestern Memorial Hospital, Superior St and Fairbanks Ct, Chicago, IL 60611. Telephone: 312‐695‐9286; FAX: 312‐695‐5998

      Northwestern University Medical School, Chicago, IL


      Department of Medicine/111E, Chicago, IL 60611 fax: 312‐908‐5998


      Department of Medicine, Veterans Administration Lakeside Medical Center and Northwestern University, Chicago, IL, USA

      Chicago, IL 60611. Fax: (312) 908‐0036


      Department of Medicine and


      Department of Medicine, Lakeside Veterans Affairs Medical Center,Chicago, Illinois, USA.

      Divisions of Gastroenterology, Lakeside Veterans Administration Medical Center and Northwestern University, Chicago, Illinois, U.S.A.


      Department of Medicine, Lakeside Veterans Administration Medical Center, and Department of Medicine, Northwestern University, Chicago, Illinois USA

      Andres T. Blei, MD, Northwestern Memorial Hospital, Passavant Pavilion, Suite‐726, Superior St and Fairbanks Ct, Chicago, IL 60611

      Lakeside VA Medical Center and Northwester University, Chicago, IL


      Lakeside VA Medical Center, Department of Medicine/111E, 333 East Huron Street, Chicago, IL 60611


      Department of Medicine, Lakeside Veterans Affairs Medical Center and Northwestern University, Chicago, Illinois 60611

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      Sample of concepts for which Andrés T Blei is among the top experts in the world.
      Concept World rank
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      minimal pse #1
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      mso cbf #1
      nonacetaminophen induced alf #1
      cbf glutamine #1
      regional differences etiology #1
      clinical activity approaches #1
      complication fulminant #1
      primary ehpvt pse #1
      eeg arterial ammonia #1
      cerebral perfusion rise #1
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      cbf animal hepatic #1
      publication esophageal surgical #1
      tests minimal pse #1
      olt accuracy #1
      human disease fhf #1
      evidence endotoxinemia #1
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      intracranial hypertension focus #1
      generalized vasopressin #1
      liver disease relation #1
      time mild hypothermia #1
      nature neuropsychological deficits #1
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      Prominent publications by Andrés T Blei

      KOL-Index: 15172

      BACKGROUND & AIMS: Administration of terlipressin plus albumin is effective in reversing type 1 HRS as compared to albumin alone. However, only about 1/3 of patients respond to treatment, therefore, predictors of response and survival would help identify the patients most likely to benefit from treatment.

      METHODS: We analyzed our controlled trial of terlipressin vs. placebo (Gastroenterology 2008;134:1360) to define factors predictive of a response and to correlate hemodynamic changes to ...

      Known for Serum Creatinine | Hrs Reversal | Treatment Terlipressin | Hepatorenal Syndrome | Albumin Patients
      KOL-Index: 14741

      BACKGROUND & AIMS: Hepatorenal syndrome (HRS) type 1 is a progressive functional renal failure in subjects with advanced liver disease. The aim of this study was to evaluate the efficacy and safety of terlipressin, a systemic arterial vasoconstrictor, for cirrhosis type 1 HRS.

      METHODS: A prospective, randomized, double-blind, placebo-controlled clinical trial of terlipressin was performed. Subjects with type 1 HRS were randomized to terlipressin (1 mg intravenously every 6 hours) or ...

      Known for Type 1 | Hepatorenal Syndrome | Terlipressin Placebo | Hrs Reversal | Controlled Trial
      KOL-Index: 13201

      OBJECTIVES: Children with primary extrahepatic portal vein thrombosis (EHPVT) have portal-systemic shunting, which may lead to disturbed neurocognitive function similar to portal-systemic encephalopathy (PSE) seen with chronic liver disease and cirrhosis. The functions most affected are those involving fluid cognitive ability, which comprise neurocognitive domains such as attention, processing speed, and short-term memory, that are particularly vulnerable to systemic illness or diffuse ...

      Known for Blood Flow | Portal Vein | Ehpvt Children | Liver Disease | Venous Thrombosis
      KOL-Index: 12472

      Monitoring of intracranial pressure (ICP) in acute liver failure (ALF) is controversial as a result of the reported complication risk (approximately 20%) and limited therapeutic options for intracranial hypertension. Using prospectively collected information from 332 patients with ALF and severe encephalopathy, we evaluated a recent experience with ICP monitoring in the 24 centers constituting the U.S. ALF Study Group. Special attention was given to the rate of complications, changes in ...

      Known for Icp Monitoring | Intracranial Pressure | Acute Liver Failure | Severe Encephalopathy | Cohort Complications
      KOL-Index: 12287

      Patients with fulminant hepatic failure (FHF) die with brain edema, exhibiting an increased cerebral blood flow (CBF) at the time of cerebral swelling. Mild hypothermia prevents brain edema in experimental models and in humans with FHF, an effect associated with normalization of CBF. To study the effects of alterations of CBF on the development of brain edema, we administered intravenous (IV) indomethacin to rats receiving an ammonia infusion after portacaval anastomosis. This model ...

      Known for Brain Edema | Portacaval Anastomosis | Increase Cbf | Mild Hypothermia | Rats Ammonia Infusion
      KOL-Index: 12255

      Brain edema, leading to intracranial hypertension and brain herniation, is a major cause of death in fulminant liver failure. Astrocyte swelling is a prominent neuropathological feature in experimental fulminant liver failure. It has been postulated that the osmotic effects of glutamine, generated in astrocytes from ammonia and glutamate in a reaction catalyzed by glutamine synthetase, could mediate brain swelling. Normal rats and rats that received a portacaval anastomosis were infused ...

      Known for Intracranial Hypertension | Brain Edema | Portacaval Anastomosis | Ammonium Acetate | Osmotic Effects
      KOL-Index: 11772

      Evaluation of the living donor for liver transplantation is a complex process involving such invasive studies as liver biopsy and angiography. It is important to establish the likelihood and extent of hepatic steatosis in living donors by clinical, imaging, and biochemical parameters to avoid performing a liver biopsy, if possible. In this study, the predictive value of body mass index (BMI), liver chemistry tests, and imaging studies was compared with liver histological examination in ...

      Known for Hepatic Steatosis | Liver Biopsy | Body Mass Bmi | Living Donors | Imaging Studies
      KOL-Index: 11658

      Brain myo-inositol, an organic osmolyte, is decreased in cirrhotic patients with hepatic encephalopathy but appears unchanged in fulminant hepatic failure. An osmoregulatory response to the increase in brain glutamine may explain the decrease in brain myo-inositol; if this is the case, organic osmolytes may account for differences in the development of brain edema seen in acute or chronic liver failure. The response of myo-inositol and nine other organic osmolytes to the increase in ...

      Known for Brain Edema | Organic Osmolytes | Surgical Rats Rats | Myo Inositol | Osmoregulatory Response
      KOL-Index: 11060

      BACKGROUND & AIMS: The pathogenesis of brain edema in fulminant hepatic failure is still unresolved. Mild hypothermia (33 degrees-35 degreesC) can ameliorate brain edema after traumatic brain injury. We evaluated mild hypothermia in a model of ammonia-induced brain edema in which accumulation of brain glutamine has been proposed as a key pathogenic factor.

      METHODS: After portacaval anastomosis, anesthetized rats were infused with ammonium acetate at 33 degrees, 35 degrees, and 37 ...

      Known for Mild Hypothermia | Brain Edema | Surgical Rats Rats | Intracranial Pressure | Portacaval Shunt
      KOL-Index: 11027

      The pathogenesis of brain edema in acute liver failure is poorly understood. We have previously shown that rats with ischemic acute liver failure (portacaval anastomosis followed by hepatic artery ligation) exhibit brain edema and intracranial hypertension, with swelling of cortical astrocytes as the most prominent neuropathological abnormality. Because ammonia has been shown to induce swelling of astrocytes in vivo and in vitro, we examined the relationship between brain ammonia, amino ...

      Known for Amino Acids | Brain Edema | Portacaval Anastomosis | Liver Failure | Glutamine Alanine
      KOL-Index: 10949

      In living liver donation, a fatty liver poses risks for both recipient and donor. Currently, liver biopsy is the standard for assessing the presence and extent of steatosis. The goals of this study were to correlate a steatosis index derived from magnetic resonance imaging (MRI) to the histologic grade on biopsy as well as to determine the topographic distribution of steatosis within the liver. We examined the ability of dual-echo, chemical shift gradient-echo MRI to predict the degree ...

      Known for Hepatic Steatosis | Magnetic Resonance | Liver Biopsy | Chemical Shift | Imaging Mri
      KOL-Index: 10774

      BACKGROUND & AIMS: Body temperature may critically affect mechanisms of liver injury in acetaminophen (APAP) hepatotoxicity. In addition, mild hypothermia is used to treat intracranial hypertension in human liver failure without detailed information on its effects on the injured liver itself. Therefore, we investigated the effects of body temperature on the progression of APAP-induced liver injury in mice.

      METHODS: Male C57BL6 mice treated with saline or APAP (300 mg/kg ...

      Known for Mild Hypothermia | Liver Injury | Body Temperature | Acetaminophen Toxicity | Apap Induced
      KOL-Index: 10613

      BACKGROUND/AIM: Brain edema is a common fatal complication in acute liver failure. It is related to an acute change in brain osmolarity secondary to the glial accumulation of glutamine. Since high cerebral blood flow (CBF) precedes cerebral herniation in fulminant hepatic failure we first determined if an increase in brain water and glutamine are prerequisite to a rise in CBF in a model of ammonia-induced brain edema. Secondly, we determined if such a cerebral hyperperfusion is mediated ...

      Known for Cerebral Hyperemia | Brain Edema | Nitric Oxide | Rise Cbf | Intracranial Hypertension
      KOL-Index: 9858

      BACKGROUND & AIMS: Progression of hepatic encephalopathy (HE) is a major determinant of outcome in acute liver failure (ALF). Our aim was to identify predictive factors of worsening HE, including the relation of encephalopathy with the systemic inflammatory response (SIRS) and infection.

      METHODS: We included 227 consecutive patients with stage I-II HE prospectively enrolled in the U.S. Acute Liver Failure Study. Univariate and multivariate analysis of 27 variables at admission were ...

      Known for Hepatic Encephalopathy | Liver Failure | Patients Acetaminophen | Sirs Admission | Predictive Factors

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      Northwestern Memorial Hospital Division of Gastroenterology Chicago IL USA | Div. of Gastroenterology, Northwestern University, Chicago, IL, United States | Department of Medicine, Northwestern University, Chicago, Illinois, USA | Department of Medic

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