Angela Manns

Angela Manns

Viral And Environmental Epidemiology Branches, National Cancer Institute, Bethesda, Md, Usa

Direct Impact

Concepts for which Angela Manns has direct influence:

brain lymphoma
lymphotropic virus
west africa
t-cell leukemia
immune activation
infective dermatitis
prostate carcinoma

External impact

Concepts related to the work of other authors for which Angela Manns has influence:

hpv dna
hiv infection
peripheral blood
t-cell leukemia virus
vaginal carcinoma
transfusion recipients
sjögrens syndrome

Prominent publications by Angela Manns

KOL-Index: 72 This chapter focuses on the current knowledge regarding the transmission of four groups of viruses with well‐documented links to human cancer, i.e., the herpesviruses (particularly Epstein‐Barr virus (EBV) and human herpesvirus 8 (HHV‐8)), the papovaviruses (primarily human papillomavirus (HPV)), the hepatitis viruses, and the retroviruses (human T‐cell lymphotropic virus type I (HTLV‐I)), ...
Known for
Ebv Herpesvirus | Agents Primary | Epidemiology Htlv‐i | Cancer Chapter
KOL-Index: 58 Human T-cell lymphotropic virus type I (HTLV-I) is the first human retrovirus to be associated with malignant disease--namely, adult T-cell leukaemia/lymphoma. HTLV-I has also been associated with several non-malignant conditions, notably the chronic neurodegenerative disorder, HTLV-I associated myelopathy (also known as tropical spastic paraparesis), infective dermatitis of children and ...
Known for
Htlv Malignant | Lymphotropic
KOL-Index: 29 A state of T-cell activation, reflected by a marked degree of spontaneous proliferation in vitro, exists among patients with human T-cell lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) but not in those with retroviral-induced adult T-cell leukemia (ATL). We wished to define the mechanism by which the immune activation of circulating cells from ...
Known for
Htlv-I-Associated | Il-2 Receptor Alpha Chain | Deregulated Autocrine Process | Px Transactivator
KOL-Index: 24 Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an inflammatory neurological disease caused by HTLV-I infection. It has been shown that HAM/TSP patients have high proviral loads and an extraordinarily high frequency of circulating CD8 + cytotoxic T lymphocytes specific for HTLV-I in their peripheral blood when compared to ...
Known for
Competitive Polymerase Chain Reaction | Ifn-Γ Cd8 Lymphocytes | Virus-Specific Cd8 | Pbl Tsp
KOL-Index: 22 Seroprevalence of HHV-8 has been studied in Malaysia, India, Sri Lanka, Thailand, Trinidad, Jamaica and the USA, in both healthy individuals and those infected with HIV. Seroprevalence was found to be low in these countries in both the healthy and the HIV-infected populations. This correlates with the fact that hardly any AIDS-related Kaposi's sarcoma has been reported in these countries. In ...
Known for
Aids-Related Kaposis Sarcoma | Hiv Seroprevalence | Zambia | Usa Infected
KOL-Index: 21 BACKGROUND: The presence of human papillomavirus (HPV) in the prostate and its role in prostate carcinoma are in dispute. To address these issues, two laboratories with extensive HPV experience were selected to test specimens from two populations at different risk for prostate carcinoma, using three different polymerase chain reaction (PCR) assays and two serologic assays for HPV. METHODS: ...
Known for
E6 Pcr | Prostate Carcinoma Tissue | Liquid Nitrogen | Specimens My09
KOL-Index: 20 Human papillomavirus (HPV) types differ in their association with cervical cancer. Therefore, the types of HPV in precancerous lesions are important. In many regions with high cancer incidence, the HPV types in precancerous lesions have not been well studied. In Jamaica, a country that has high cervical cancer incidence, 174 colposcopy patients were tested for HPV DNA using polymerase chain ...
Known for
Severe Neoplasia | Hpv-45 | 174 Colposcopy | Cancer Hpv
KOL-Index: 20 Mother-to-child transmission of human T-cell lymphotropic virus type I (HTLV-I) is primarily due to prolonged breast-feeding (>6 months) in the postnatal period. Most infant infections are not identifiable until 12 to 18 months of age by available whole virus Western blot serologic tests because of their inability to distinguish passively transferred maternal antibody from infant antibody. ...
Known for
Iga Igm | Htlv-I Proviral Dna | Determined Virus | Antibody Infant
KOL-Index: 20 Human herpesvirus-6 (HHV-6) infection seems to be ubiquitous early in life, but antibody responses vary by geographic area. We compared HHV-6 antibody titer in 123 West African and 122 Caribbean serum samples. A quantitative immunofluorescence assay (IFA) using antigens derived from an HSB-2 cell line was used to test for IgG HHV-6 (GS strain) antibodies. The prevalence of HHV-6 antibodies ...
Known for
Middle Age | 123 West African | Herpesvirus-6 Hhv-6 Infection | Ifa
KOL-Index: 18 To investigate the genetic background of the black populations of Colombia and Jamaica, we determined HLA types of 78 Colombian and 98 Jamaican blacks from 2 different socioeconomic groups (Jamaican #1 and Jamaican #2) and estimated the frequencies of HLA genes and haplotypes. A phylogenetic tree based on the HLA gene frequencies revealed that Jamaican #1 and Jamaican #2 were distinct from ...
Known for
Colombian Jamaican | African Blacks | Hla Genes | Genetic Subpopulations

Viral and Environmental Epidemiology Branches, National Cancer Institute, Bethesda, MD, USA

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