Leslie N Sutton: Influence Statistics

Leslie N Sutton

Leslie N Sutton

Division of Neurosurgery, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA | Department of Neurosurgery, University of Pennsylvania, 3400 Spruce Street, 3rd ...

Leslie N Sutton: Expert Impact

Concepts for which Leslie N Sutton has direct influence: Brain tumors , Intracranial pressure , Fetal surgery , Brain neoplasms , Spinal deformity , Arnold chiari , Posterior fossa .

Leslie N Sutton: KOL impact

Concepts related to the work of other authors for which for which Leslie N Sutton has influence: Spina bifida , Brain tumors , Fetal surgery , Central nervous , Magnetic resonance , Radiation therapy , Pediatric patients .

KOL Resume for Leslie N Sutton

Year
2016

Division of Neurosurgery, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA

2015

Department of Neurosurgery and.

2014

Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, Pa., USA

6Department of Neurosurgery, University of Pennsylvania, Philadelphia; and

2013

Department of Neurosurgery, University of Pennsylvania, Philadelphia, USA

2012

Emeritus Professor of Surgery, Section of Pediatric Surgery, University of Michigan Medical School and C. S. Mott Children's Hospital, Ann Arbor, Michigan

Professor of Surgery, Division of Pediatric Surgery, New York University Medical School, New York, New York

Department of Neurosurgery, University of Pennsylvania School of Medicine, and, Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, Pa., Division of Neurosurgery, St. Louis Children’s Hospital, St. Louis, Mo., and, Division of Cardiothoracic Surgery, Primary Children’s Medical Center, University of Utah, Salt Lake City, Utah, USA

2011

Management of Myelomeningocele Study (MOMS)

From the Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia (N.S.A., M.P.J., L.J.H., L.N.S.)

Department of Neurosurgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA

*Children’s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA; †George Washington University Biostatistics Center, Washington, DC; ‡Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD; §Vanderbilt University Medical Center, Nashville, TN; ∥University of California, San Francisco, Benioff Children’s Hospital, and the USCF School of Medicine, San Francisco, CA; and ¶Columbia University College of Physicians and Surgeons, New York, NY.

Chief, Spine Service, Pennsylvania Hospital; Clinical Professor, Orthopaedic Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

2010

Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

2009

The Center for Fetal Diagnosis and Treatment, The Children's Hospital, Philadelphia, USA

2008

Division of Neurosurgery, Children’s Hospital of Philadelphia, Wood Center, 6th Floor, 34th and Civic Center Blvd, 19104, Philadelphia, PA, USA

Department of Neurosurgery,

2007

Department of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

2006

Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA.

Division of Neurosurgery, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA

Children's Hospital of Philadelphia, Center for Fetal Diagnosis and Treatment, Philadelphia, Pennsylvania

2005

Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104

2004

Department of Neurosurgery, The Children's Hospital of Philadelphia, USA

From the Divisions of *Orthopaedic Surgery and †Neurosurgery, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania.

2003

Division of Neurological Surgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

Dr. Sutton is Professor of Neurosurgery, University of Pennsylvania School of Medicine, and Chief of Neurosurgery, Department of Neurosurgery, Children's Hospital of Philadelphia, 34th and Civic Center Blvd., Philadelphia, PA 19104; E‐mail:

2002

Providence, R.I., and Philadelphia, Pa.

Departments of Surgery (PM, HJS, NSA, LNS) and Radiology (LTB), The Center for Fetal Diagnosis and Treatment, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania

Division of Neurosurgery, Joseph Stokes Research Institute #515G, 3516 Civic Center Blvd, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA

2001

Department of Neurosurgery, The Children's Hospital of Philadelphia, PA 19104, USA

2000

From the Division of OncologyHuman Genetics, Biostatistics, and Neurosurgery and Department of Pathology, The Children’s Hospital of Philadelphia; and Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA.

1999

Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, PA 19104, USA

1998

Division of Neurosurgery, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA, US

Neurosurgery, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

1997

Departments of Pediatrics and Neurology, New York University Medical Center, New York, N.Y., Department of Neurology, University of Medicine and Dentistry, Newark, N.J., and Departments of Neurosurgery, Neuropathology and Neurology and Pediatrics, Children’s Hospital of Philadelphia, Pa., USA

The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

1996

Department of Neurosurgery, Children's Hospital of Philadelphia, Pennsylvania, USA.

Neurosurgery Service, The Children's Hospital of Philadelphia, Philadelphia, PA 19104 USA

1995

From the Children’s Hospital of Philadelphia; and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

The Children’s Hospital of Philadelphia and Siemens Medical Systems, Philadelphia, Pa., USA

1994

Children's Hospital of Philadelphia, Pennsylvania.

Division of Pediatric Neurosurgery, and Neurology, Hospital of The University of Pennsylvania U.S.A.

Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pa., USA

1993

Children’s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pa., USA

Division of Neurosurgery, University of Pennsylvania School of Medicine and Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Prominent publications by Leslie N Sutton

KOL-Index: 18637 . It has previously been reported in a single-institution trial that progression-free survival of children with medulloblastoma treated with radiotherapy and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), cisplatin, and vincristine chemotherapy during and after radiotherapy was better than the outcome in children treated with radiotherapy alone. To better characterize long-term outcome ...
Known for Chemotherapy Radiotherapy | Medulloblastoma Treated | Adjuvant Child Child | Metastatic Disease
KOL-Index: 15901 . OBJECT: The Management of Myelomeningocele Study (MOMS) was a multicenter randomized trial comparing the safety and efficacy of prenatal and postnatal closure of myelomeningocele. The trial was stopped early because of the demonstrated efficacy of prenatal surgery, and outcomes on 158 of 183 pregnancies were reported. Here, the authors update the 1-year outcomes for the complete trial, ...
Known for Prenatal Surgery | Shunt Placement | Ventricle Size | Cerebrospinal Fluid
KOL-Index: 15155 . OBJECT: One hundred seventy-two children with high-grade astrocytomas were treated by members of the Children's Cancer Group in a prospective randomized trial designed to evaluate the role of two chemotherapy regimens. Seventy-six percent of the patients (131 children) in whom a diagnosis of either anaplastic astrocytoma or glioblastoma multiforme was confirmed by central pathological ...
Known for Malignant Gliomas | Radical Resection | Glioblastoma Multiforme | Anaplastic Astrocytoma
KOL-Index: 13523 . As survival rates have risen for children with malignant primary brain tumors, so has the concern that many survivors have significant permanent cognitive deficits. Cranial irradiation (CRT) has been implicated as the major cause for cognitive dysfunction. To clarify the etiology, incidence, and severity of intellectual compromise in children with brain tumors after CRT, a prospective ...
Known for Children Brain Tumors | Cognitive Function | Age Diagnosis | Decline Fsiq
KOL-Index: 12564 . CONTEXT: Hindbrain herniation occurs in a large percentage of children with myelomeningocele and is the leading cause of death in this population. The effect of early fetal closure of myelomeningocele on hindbrain herniation is unknown. OBJECTIVE: To determine whether early fetal closure of myelomeningocele affects hindbrain herniation. DESIGN: Case series of patients undergoing fetal ...
Known for Hindbrain Herniation | Fetal Surgery | Resonance Imaging | Gestational Age
KOL-Index: 12336 . In the present study, DNA from 28 pediatric low-grade astrocytomas was analyzed using Illumina HumanHap550K single-nucleotide polymorphism oligonucleotide arrays. A novel duplication in chromosome band 7q34 was identified in 17 of 22 juvenile pilocytic astrocytomas and three of six fibrillary astrocytomas. The 7q34 duplication spans 2.6 Mb of genomic sequence and contains approximately 20 ...
Known for Braf Fusion | Situ Hybridization | Nucleotide Polymorphism | Pediatric Low‐grade Astrocytomas
KOL-Index: 11929 . BACKGROUND: Gliomas of the hypothalamus and optic pathways (H/OPG) comprise 5% of pediatric intracranial tumors, present most frequently in patients younger than age 5 years, and may have a more aggressive course in younger children. This study examined clinical characteristics and consequences of treatment of young children diagnosed with H/OPG: METHODS: The authors reviewed the course, ...
Known for 5 Years | Optic Pathway | Children Age | Tumor Progression
KOL-Index: 11800 . BACKGROUND: Prenatal repair of myelomeningocele, the most common form of spina bifida, may result in better neurologic function than repair deferred until after delivery. We compared outcomes of in utero repair with standard postnatal repair. METHODS: We randomly assigned eligible women to undergo either prenatal surgery before 26 weeks of gestation or standard postnatal repair. One ...
Known for Postnatal Repair | 30 Months | Prenatal Surgery | Motor Function
KOL-Index: 11680 . OBJECT: Posterior fossa decompression with duraplasty is routinely used for the treatment of Chiari malformations. It has been traditionally believed that this procedure requires a watertight seal with primary closure of the dura with either pericranium or allograft. In this study, the authors evaluated two synthetic dural substitutes in this patient population for feasibility of use and ...
Known for Chiari Malformations | Posterior Fossa Decompression | Csf Leak | Collagen Matrix
KOL-Index: 11258 . BACKGROUND: Children younger than 5 years who have posterior fossa (PF) primitive neuroectodermal tumors (PNET) have a poor prognosis. Because the use of low-dose craniospinal radiation therapy (CSRT) alone has been associated with a higher relapse rate in these patients, and because standard dose CSRT is associated with profound late sequelae, the authors embarked on a study using a ...
Known for Adjuvant Child | Radiation Therapy | Dose Craniospinal | Germ Cell
KOL-Index: 11189 . Upon binding of tumour necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL), the agonistic TRAIL receptors DR4 and DR5 activate caspase-8 leading to apoptosis. In primitive neuroectodermal brain tumour (PNET) cell lines, TRAIL-induced apoptosis was recently shown to correlate with caspase-8 mRNA expression (Grotzer MA, Eggert A, Zuzak TJ, et al. Oncogene 2000, 19, 4604-4610). In ...
Known for Mrna Expression | Neuroectodermal Brain | Messenger Rna | Pnet Cell Lines
KOL-Index: 10384 . PURPOSE: Children under 5 years old with medulloblastoma (MB) have a poor prognosis. They are more susceptible to the deleterious effects of craniospinal irradiation (CSART) and have a higher relapse rate when treated with low-dose CSART alone. We, thus, embarked on a prospective trial testing the usefulness of very low dose CSART and adjuvant chemotherapy. This is an update of a previous ...
Known for Craniospinal Irradiation | Primitive Neuroectodermal | Chemotherapy Children | 10 Patients
KOL-Index: 10333 . Deletions of chromosome 22 have been identified in 3 types of childhood primary brain tumor: meningiomas, rhabdoid or atypical teratoid tumors (ATT) and ependymomas. This implicates the involvement of tumor suppressor genes on chromosome 22 in the genesis of these rare tumors. One such candidate tumor suppressor gene is the recently cloned neurofibromatosis 2 (NF2) locus. The purpose of ...
Known for Nf2 Gene | Pediatric Ependymomas | Rhabdoid Tumors | Preschool Chromosomes

Key People For Brain Tumors

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allelic loss central nervous situ hybridization
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central nervous glioblastoma multiforme brain tumors
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brain tumors surgical resection magnetic resonance
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p53 mutations secondary glioblastomas dna methylation
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Darell D D Bigner
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Michael Weller
glioma cells newly diagnosed glioblastoma multiple sclerosis

Division of Neurosurgery, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA | Department of Neurosurgery, University of Pennsylvania, 3400 Spruce Street, 3rd Floor Silverstein Pavilion, 19104, Philadelphia, PA, USA | Department of Neuros