Prominent publications by Elio Riboli

KOL Index score: 23482

BACKGROUND: Underweight, overweight, and obesity in childhood and adolescence are associated with adverse health consequences throughout the life-course. Our aim was to estimate worldwide trends in mean body-mass index (BMI) and a comprehensive set of BMI categories that cover underweight to obesity in children and adolescents, and to compare trends with those of adults.

METHODS: We pooled 2416 population-based studies with measurements of height and weight on 128·9 million participants ...

Known for Worldwide Trends |  Bmi Prevalence |  Pooled Analysis |  1 2 |  Boys Obesity
KOL Index score: 20200

BACKGROUND: Body weight and body mass index (BMI) are positively related to risk of colon cancer in men, whereas weak or no associations exist in women. This discrepancy may be related to differences in fat distribution between sexes or to the use of hormone replacement therapy (HRT) in women.

METHODS: We used multivariable adjusted Cox proportional hazards models to examine the association between anthropometric measures and risks of colon and rectal cancer among 368 277 men and women ...

Known for Body Size |  Rectal Cancer |  Women 95 |  Anthropometric Measures |  Whr Risk
KOL Index score: 18614

BACKGROUND: Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents.

METHODS: For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease Risk Factor Collaboration. We applied a ...

Known for Boys Girls |  Children Adolescents |  Bmi Height |  Weight Gain |  Mass Child
KOL Index score: 17885

Importance: Low-density lipoprotein cholesterol (LDL-C)-lowering alleles in or near NPC1L1 or HMGCR, encoding the respective molecular targets of ezetimibe and statins, have previously been used as proxies to study the efficacy of these lipid-lowering drugs. Alleles near HMGCR are associated with a higher risk of type 2 diabetes, similar to the increased incidence of new-onset diabetes associated with statin treatment in randomized clinical trials. It is unknown whether alleles near ...

Known for Type 2 Diabetes |  Lowering Genetic |  Density Lipoprotein |  Coronary Artery Disease |  Ldl Risk
KOL Index score: 17587

BACKGROUND: Dietary factors are thought to have an important role in gastric and esophageal carcinogenesis, but evidence from cohort studies for such a role is lacking. We examined the risks of gastric cancer and esophageal adenocarcinoma associated with meat consumption within the European Prospective Investigation Into Cancer and Nutrition (EPIC) cohort.

METHODS: A total of 521,457 men and women aged 35-70 years in 10 European countries participated in the EPIC cohort. Dietary and ...

Known for Esophageal Adenocarcinoma |  Meat Intake |  European Prospective |  Risk Gastric |  Cardia Cancer
KOL Index score: 17312

BACKGROUND: Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories.

METHODS: We used data from 1990 to 2019 on people aged 30-79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined ...

Known for Hypertension Prevalence |  Treatment Control |  Pooled Analysis |  Income Countries |  Costa Rica
KOL Index score: 17261

INTRODUCTION: Associations of hormone-receptor positive breast cancer with excess adiposity are reasonably well characterized; however, uncertainty remains regarding the association of body mass index (BMI) with hormone-receptor negative malignancies, and possible interactions by hormone replacement therapy (HRT) use.

METHODS: Within the European EPIC cohort, Cox proportional hazards models were used to describe the relationship of BMI, waist and hip circumferences with risk of ...

Known for Hormone Receptor |  Cancer Risk |  Bmi Hrt |  Replacement Therapy |  Erpr Tumors
KOL Index score: 17173

Importance: The association between increasing body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) and risk of breast cancer is unique in cancer epidemiology in that a crossover effect exists, with risk reduction before and risk increase after menopause. The inverse association with premenopausal breast cancer risk is poorly characterized but might be important in the understanding of breast cancer causation.

Objective: To investigate the ...

Known for Breast Cancer |  Premenopausal Women |  Association Bmi |  Risk Age |  Hazard Ratios
KOL Index score: 17099

BACKGROUND: Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher.

METHODS: For this analysis, we pooled national, subnational, or community population-based studies that had ...

Known for Blood Pressure |  Worldwide Trends |  Pooled Analysis |  South Asia |  Subsaharan Africa
KOL Index score: 16557

BACKGROUND: Contrasting etiologic hypotheses about the role of endogenous sex steroids in breast cancer development among premenopausal women implicate ovarian androgen excess and progesterone deficiency, estrogen excess, estrogen and progesterone excess, and both an excess or lack of adrenal androgens (dehydroepiandrosterone [DHEA] or its sulfate [DHEAS]) as risk factors. We conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition ...

Known for Breast Cancer |  Premenopausal Women |  Sex Steroids |  Menstrual Cycle |  European Prospective
KOL Index score: 16472

BACKGROUND & AIMS: Human studies examining associations between circulating levels of insulin-like growth factor 1 (IGF1) and insulin-like growth factor binding protein 3 (IGFBP3) and colorectal cancer risk have reported inconsistent results. We conducted complementary serologic and Mendelian randomization (MR) analyses to determine whether alterations in circulating levels of IGF1 or IGFBP3 are associated with colorectal cancer development.

METHODS: Serum levels of IGF1 were measured in ...

Known for Colorectal Cancer |  Mendelian Randomization |  Growth Factor |  Circulating Levels |  Binding Protein
KOL Index score: 16381

BACKGROUND: Recently, several genome-wide association studies have identified various genetic susceptibility loci for breast cancer. Relatively little is known about the possible interactions between these loci and the established risk factors for breast cancer.

METHODS: To assess interactions between single-nucleotide polymorphisms (SNPs) and established risk factors, we prospectively collected DNA samples and questionnaire data from 8576 breast cancer case subjects and 11 892 control ...

Known for Breast Cancer |  Genetic Variants |  Estrogen Receptors |  Cohort Consortium |  Snps Risk
KOL Index score: 16215

BACKGROUND: Circulating levels of insulin-like growth factor I (IGF-I) and its main binding protein, IGF binding protein 3 (IGFBP-3), have been associated with risk of several types of cancer. Heritable factors explain up to 60% of the variation in IGF-I and IGFBP-3 in studies of adult twins.

METHODS: We systematically examined common genetic variation in 18 genes in the IGF signaling pathway for associations with circulating levels of IGF-I and IGFBP-3. A total of 302 single nucleotide ...

Known for Binding Protein |  Circulating Levels |  Growth Factor |  Breast Cancer |  Pathway Genes
KOL Index score: 15622

BACKGROUND: It is widely believed that cancer can be prevented by high intake of fruits and vegetables. However, inconsistent results from many studies have not been able to conclusively establish an inverse association between fruit and vegetable intake and overall cancer risk.

METHODS: We conducted a prospective analysis of the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to assess relationships between intake of total fruits, total vegetables, and total ...

Known for Cancer Risk |  Vegetable Intake |  European Prospective |  Nutrition Epic |  Aged Alcohol
KOL Index score: 15537

BACKGROUND: Some, but not all, published results have shown an association between circulating blood levels of some insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) and the subsequent risk for prostate cancer.

PURPOSE: To assess the association between levels of IGFs and IGFBPs and the subsequent risk for prostate cancer.

DATA SOURCES: Studies identified in PubMed, Web of Science, and CancerLit.

STUDY SELECTION: The principal investigators of all studies that ...

Known for Prostate Cancer |  Binding Protein |  Growth Factor |  Igfs Igfbps |  Blood Collection


Elio Riboli: Influence Statistics

Sample of concepts for which Elio Riboli is among the top experts in the world.
Concept World rank
crc risk ptrend #1
associations body shape #1
t2d association ferritin #1
circulatory death exposure #1
epic centres #1
epic–eurgast #1
nutrition background #1
‐2 #1
defined breast cancer #1
eighteen prospective studies #1
body shape phenotypes #1
bmi sic #1
levels free testosterone #1
102395 #1
dietary nitrosamines #1
nutrition study #1
2 controls #1
dietary factors isc #1
concentrations prostate #1
29560 #1
rs7452888 #1
absi cancers #1
reduction gc risk #1
risk tumors #1
eppl #1
ragusa naples #1
risk circulatory death #1
absi hip #1
133018 #1
rs8034191 rs16969968 #1
36 037 subjects #1
prospective studies association #1
predictive blood biomarker #1
abdominal general adiposity #1
dietcancer #1
rcc incidence mortality #1
nutrition concentrations #1
27 redefined centres #1
european #1
pc4 pc2 #1
lower risks breast #1
intake specific carotenoids #1
igfbp3 concentrations risk #1
cw binns #1
rs34676223 #1
centers intake #1
igfi association serum #1
atmmvp2a #1
nutrients dietary questionnaires #1
rs16969968 rs4324798 #1

Key People For Breast Cancer

Top KOLs in the world
Ahmedin M Jemal
united states breast cancer addis ababa
Gabriel N Hortobagyi
breast cancer neoadjuvant chemotherapy estrogen receptors
Rebecca L Siegel
united states colorectal cancer incidence rates
Charles M Perou
breast cancer gene expression intrinsic subtypes
Freddie Ian Bray
cancer incidence nordic countries mortality rates
Jacques Ferlay
cancer incidence global burden latin america

Elio Riboli:Expert Impact

Concepts for whichElio Ribolihas direct influence:Breast cancer,  Cancer risk,  Prostate cancer,  Colorectal cancer,  Lung cancer,  Physical activity,  Pancreatic cancer,  European prospective.

Elio Riboli:KOL impact

Concepts related to the work of other authors for whichfor which Elio Riboli has influence:Breast cancer,  Physical activity,  Type 2 diabetes,  Metabolic syndrome,  Mediterranean diet,  Cardiovascular disease,  Alcohol consumption.



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Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom. | Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK | Department of Epide

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