Prominent publications by Nirmal B Charan

KOL Index score: 9005

BACKGROUND: Asthma death rates are rising, with the greatest rise and highest death rates in old age. A reduced cardiovascular response in the elderly may lead to the underestimation by physicians of the severity of acute asthma attacks. This would be compounded if elderly patients had reduced awareness of bronchoconstriction.

METHODS: Methacholine provoked bronchoconstriction was compared in 34 elderly (17 asthmatic, 17 normal; age 60-83, mean 68 years) and 33 young subjects (16 ...

Known for Elderly Asthmatic |  Normal Subjects |  Asthma Awareness |  Bronchoconstriction Methacholine |  Expiratory Volume
KOL Index score: 8469

The anatomy of the bronchial artery in sheep has recently been described. However, the course of the bronchial veins has not been well established. It has been suggested that the bronchial veins are the major site of fluid leakage following histamine infusion, and it has been postulated that the bronchial circulation may play a role in fluid reabsorption. We studied the anatomy of the bronchial circulation in 18 sheep with emphasis on bronchial venous drainage and bronchopulmonary ...

Known for Bronchial Circulation |  Pulmonary Artery |  Electron Microscopy |  Sheep Anatomy |  Precapillary Level
KOL Index score: 8213

Corticosteroids are often used in the outpatient treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD). To date, there are few data documenting the benefit of this practice. The objective of this randomized, double-blind, placebo-controlled trial was to assess the efficacy of corticosteroids in the outpatient treatment of COPD exacerbations. Twenty-seven patients presenting with acute COPD exacerbation were studied. In addition to continuing their previous ...

Known for Oral Prednisone |  Controlled Trial |  Acute Copd |  Outpatient Treatment |  Mm Hg
KOL Index score: 7788

Asthma is associated with dysfunction of the beta-adrenergic receptor adenylyl cyclase signal transduction pathway. It has been argued that this results from receptor down-regulation by beta-agonist therapy. This study examined the relationship between nonspecific bronchial responsiveness (NSBR) to methacholine (Newcastle dosimeter method) and beta-adrenergic receptor density (Bmax) and affinity (%KH) in membranes from peripheral blood mononuclear leukocytes (MNL) in 12 male (27.3 +/- ...

Known for Bronchial Responsiveness |  Adrenergic Receptor |  Peripheral Mononuclear |  Multiple Regression Analysis |  Provocation Tests
KOL Index score: 6997

Independent lung ventilation using two ventilators has been attempted in the treatment of acute respiratory failure due to unilateral lung disease. However, this method has been found to be cumbersome and difficult to use. We reasoned that a bifurcated endotracheal tube with a variable resistance valve may enable us to change the inspiratory airway pressures and, hence, the inspired tidal volume to one lung using a single ventilator. We tested this hypothesis in eight anesthetized sheep ...

Known for Single Ventilator |  Independent Lung Ventilation |  Bronchopleural Fistula |  Resistance Valve |  Tidal Volume
KOL Index score: 5836

BACKGROUND: As beta adrenoceptor dysfunction occurs in both the normal elderly subject and in young asthmatic patients, the hypothesis was examined that age related beta adrenoceptor changes are important in the pathogenesis of late onset asthma in old age.

METHODS: Subjects were non-smokers who comprised 17 young normal subjects of mean (SE) age 29.4 (1.3) years, 17 elderly normal subjects of 67.2 (1.3) years, seven young asthmatic patients of 31.0 (2.8) years, and 17 elderly asthmatic ...

Known for Asthmatic Patients |  Late Onset Asthma |  Beta Adrenoceptor |  Study Day |  Newcastle Dosimeter Method
KOL Index score: 5645

We postulated that if the bronchial circulation affects lung fluid balance, increases in bronchial venous pressures may influence lung lymph flow. This hypothesis was tested in eight anesthetized sheep prepared with acute lung lymph fistulas. After control data, we increased bronchial venous pressure by infusing saline directly into the bronchial vein at a controlled infusion pressure of 20-25 cmH2O. Evans blue dye (2.5 mg/ml) was added into the saline as a marker for assessing leakage ...

Known for Lung Lymph |  Venous Pressure |  Bronchial Circulation |  Pulmonary Veins
KOL Index score: 4903

Inhaled corticosteroids are often used in the treatment of stable chronic obstructive pulmonary disease (COPD), however, studies of these agents have had mixed results. Previous trials have often excluded subjects with bronchodilator response, have failed to evaluate effect on gas exchange, and have usually looked at only post- rather than prebronchodilator forced expiratory volume (FEV). Our objective was to better assess the efficacy of topical corticosteroids in the treatment of COPD. ...

Known for Severe Copd |  Controlled Trial |  Fluticasone Propionate |  Inhaled Corticosteroids |  Disease Chronic
KOL Index score: 4887

We studied the effects of left pulmonary artery (LPA) ligation on the bronchial circulatory system (BCS) by using a sheep model. LPA was ligated in the newborn lambs soon after birth (n = 8), and when the sheep were approximately 3 yr of age anatomic studies revealed marked angiogenesis in BCS. Bronchial blood flow and cardiac output were studied by placing flow probes around the bronchial and pulmonary arteries in four adult sheep. After LPA ligation, bronchial blood flow increased from ...

Known for Pulmonary Artery |  Bronchial Circulatory |  Sheep Model |  Gas Exchange |  Cardiac Output


Nirmal B Charan: Influence Statistics

Sample of concepts for which Nirmal B Charan is among the top experts in the world.
Concept World rank
bronchial vein #1

Key People For Bronchial Circulation

Top KOLs in the world
John Butler
volcanic ash bronchial circulation lung volume
Nirmal B Charan
bronchial circulation bronchopulmonary anastomoses blood flow
Elisabeth M Baile
blood flow bronchial vasculature dry air
Peter D Paré
smooth muscle lung function gene expression
Sambasiva Lakshminarayan
bronchial circulation blood flow bronchopulmonary anastomoses
Mark E Deffebach
bronchial circulation lung cancer pulmonary flow

Nirmal B Charan:Expert Impact

Concepts for whichNirmal B Charanhas direct influence:Bronchial circulation,  Bronchial blood flow,  Bronchopulmonary anastomoses,  Sulfur dioxide,  Bronchial blood,  Blood flow,  Single ventilator,  Aerosolized acetylcholine.

Nirmal B Charan:KOL impact

Concepts related to the work of other authors for whichfor which Nirmal B Charan has influence:Acute exacerbations,  Chronic obstructive,  Pulmonary disease,  Bronchial circulation,  Blood flow,  Lung transplantation,  Systemic corticosteroids.



Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

Department of Radiology, VA Medical Center, Boise, ID, USA | Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, WA 98195, USA | Section of Pulmonary and Critical Care Medicine, VA Medical Cent

FREE Custom List