Gianrico F. Farrugia

Gianrico F. Farrugia

Department Of Physiology And Biophysics, Center For Single Molecule Biophysics, State University Of New York, Buffalo, Ny, Usa

Direct Impact

Concepts for which Gianrico F Farrugia has direct influence:

interstitial cells
gastric emptying
diabetic gastroparesis
smooth muscle
gastrointestinal tract
carbon monoxide
nitric oxide

External impact

Concepts related to the work of other authors for which Gianrico F Farrugia has influence:

interstitial cells
gastric emptying
smooth muscle
nitric oxide
slow waves
idiopathic gastroparesis
myenteric plexus

Prominent publications by Gianrico F. Farrugia

KOL-Index: 88 BACKGROUND & AIMS: Chronic nausea and vomiting with normal gastric emptying is a poorly understood syndrome; we analyzed its characteristics. METHODS: We collected and analyzed data from 425 patients with chronic nausea and vomiting, enrolled at 6 centers by the ...
Known for
2 4 Hours | Chronic Idiopathic Nausea | Delayed Gastric Emptying | Gastroparesis Cardinal Symptom Scores
KOL-Index: 63 Mechanosensation, the ability to properly sense mechanical stimuli and transduce them into physiologic responses, is an essential determinant of gastrointestinal (GI) function. Abnormalities in this process result in highly prevalent GI functional and motility disorders. In the GI tract, several cell types sense mechanical forces and transduce them into electrical signals, which elicit ...
Known for
Ability Smooth | Channels Specialized | Mechanoreceptors Detect | Function Mechanotransduction
KOL-Index: 61 BACKGROUND: Wireless motility capsule (WMC) findings are incompletely defined in suspected gastroparesis. We aimed to characterize regional WMC transit and contractility in relation to scintigraphy, etiology, and symptoms in patients undergoing gastric emptying testing. METHODS: A total of 209 patients with ...
Known for
Validated Questionnaires | 209 | Gastroparesis Abstracttext | Wmcs
KOL-Index: 56 The term gastrointestinal neuromuscular disease describes a clinically heterogeneous group of disorders of children and adults in which symptoms are presumed or proven to arise as a result of neuromuscular, including interstitial cell of Cajal, dysfunction. Such disorders commonly have impaired motor activity, i.e. slowed or obstructed transit with radiological evidence of transient or ...
Known for
Guidelines Histological | Tissue Diagnostic | Biopsy Thickness
KOL-Index: 48 Interstitial cells of Cajal (ICC) act as pacemaker cells in the gastrointestinal tract by generating electrical slow waves to regulate rhythmic smooth muscle contractions. Intrinsic Ca(2+) oscillations in ICC appear to produce the slow waves by activating pacemaker currents, currently thought to be carried by the Ca(2+)-activated Cl(-) channel anoctamin 1 (Ano1). In this article we present a ...
Known for
Small Cyclical Depolarizations | Store-Operated Ca2 Entry | Rhythmic Smooth Muscle Contractions | Voltage-Dependent Ca2
KOL-Index: 48 OBJECTIVES: Diabetic gastroparesis (Gp) occurs more often in type 1 diabetes mellitus (T1DM) than in type 2 diabetes mellitus (T2DM). Other diabetic end-organ complications include peripheral neuropathy, nephropathy, and retinopathy (together termed triopathy). This study determines the prevalence of diabetic complications (retinopathy, nephropathy, and peripheral neuropathy) in diabetic ...
Known for
Diabetic Symptoms | Complications Retinopathy | Electrogastrography | Emptying Associates
KOL-Index: 45 BACKGROUND: Gastric electrical stimulation (GES) for treating gastroparesis symptoms is controversial. METHODS: We studied 319 idiopathic or diabetic gastroparesis symptom patients from the Gastroparesis Clinical Research Consortium (GpCRC) observational studies: 238 without GES and 81 with GES. We assessed the effects of GES using change in GCSI total score and nausea/vomiting subscales ...
Known for
1 Point | Inferences | Gcsi Nausea | Larger Sample
KOL-Index: 45 The cellular and molecular understanding of human gastroparesis has markedly improved due to studies on full-thickness gastric biopsies. A decrease in the number of interstitial cells of Cajal (ICC) and functional changes in ICC constitutes the hallmark cellular feature of gastroparesis. More recently, in animal models, macrophages have also been identified to play a central role in ...
Known for
Gastroparesis Loss | Macrophages Identified
KOL-Index: 43 Stem cell factor (mouse: Kitl, human: KITLG) and insulin-like growth factor-1 (IGF1), acting via KIT and IGF1 receptor (IGF1R), respectively, are critical for the development and integrity of several tissues. Autocrine/paracrine KITLG-KIT and IGF1-IGF1R signaling are also activated in several cancers including gastrointestinal stromal tumors (GIST), the most common sarcoma. In murine gastric ...
Known for
Pathways Igf1 | Stem Factor | Kitl Kitlg
KOL-Index: 43 Intestinal barrier function and microbiota are integrally related and play critical roles in maintenance of host physiology. Sex is a key biologic variable for several disorders. Our aim was to determine sex-based differences in response to perturbation and subsequent recovery of intestinal barrier function and microbiota in healthy humans. Twenty-three volunteers underwent duodenal ...
Known for
Duodenal Microbiota Composition | Fecal Microbiota | Chen | Sex-Specific

Department of Physiology and Biophysics, Center for Single Molecule Biophysics, State University of New York, Buffalo, NY, USA

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