• Disease
  • Acute
  • Acute Stroke
  • Cynthia Chen

    Prominent publications by Cynthia Chen

    KOL Index score: 16055

    BACKGROUND: Trials of fluoxetine for recovery after stroke report conflicting results. The Assessment oF FluoxetINe In sTroke recoverY (AFFINITY) trial aimed to show if daily oral fluoxetine for 6 months after stroke improves functional outcome in an ethnically diverse population.

    METHODS: AFFINITY was a randomised, parallel-group, double-blind, placebo-controlled trial done in 43 hospital stroke units in Australia (n=29), New Zealand (four), and Vietnam (ten). Eligible patients were ...

    Also Ranks for: Acute Stroke |  functional outcome |  6 months |  fluoxetine placebo |  bone fractures
    KOL Index score: 9319

    Structural protein 4.1, which has crucial interactions within the spectrin-actin lattice of the human red cell membrane skeleton, also is widely distributed at diverse intracellular sites in nucleated cells. We previously showed that 4.1 is essential for assembly of functional nuclei in vitro and that the capacity of 4.1 to bind actin is required. Here we report that 4.1 and actin colocalize in mammalian cell nuclei using fluorescence microscopy and, by higher-resolution ...

    Also Ranks for: Nuclear Actin |  fluorescence microscopy |  protein 41 |  xenopus egg |  cell nuclei
    KOL Index score: 9226

    PURPOSE. This study seeks to characterize corneal functions and complications in a streptozocin (STZ)-induced rat model of type I diabetes mellitus (DM) and to understand the pathogenesis of diabetic keratopathy. METHODS. DM was induced via STZ injection in Sprague-Dawley rats. Body weight, length, and corneal size were measured and compared with the age-matched normal controls. Corneal morphology and histology were evaluated with slit lamp, digital confocal microscopy and hematoxylin ...

    Also Ranks for: Corneal Complications |  diabetic rats |  wound healing |  induced type |  experimental diabetes mellitus
    KOL Index score: 8708

    AIM: The present study aimed to assess the benefits of two-stent techniques for patients with DEFINITION criteria-defined complex coronary bifurcation lesions.

    METHODS AND RESULTS: In total, 653 patients with complex bifurcation lesions at 49 international centres were randomly assigned to undergo the systematic two-stent technique (two-stent group) or provisional stenting (provisional group). The primary endpoint was the composite of target lesion failure (TLF) at the 1-year follow-up, ...

    Also Ranks for: Provisional Stenting |  bifurcation lesions |  complex coronary |  cardiac death |  1 year
    KOL Index score: 8504

    BACKGROUND: Prostate cancer is the most commonly diagnosed malignancy in men in Sweden and Geneva, and the third most common in men in Singapore. This population-based study describes trends in the incidence and mortality rates of prostate cancer in Singapore, Sweden and Geneva (Switzerland) from 1973 to 2006 and explores possible explanations for these different trends.

    METHODS: Data from patients diagnosed with prostate cancer were extracted from national cancer registries in Singapore ...

    Also Ranks for: Prostate Cancer |  mortality rates |  period cohort |  prostatic neoplasms
    KOL Index score: 8455

    BACKGROUND: We previously described a t(2;11)(p21;q23) chromosomal translocation found in patients with myelodysplasia or acute myeloid leukemia that leads to over-expression of the microRNA miR-125b, and we showed that transplantation of mice with murine stem/progenitor cells overexpressing miR-125b is able to induce leukemia. In this study, we investigated the mechanism of myeloid transformation by miR-125b.

    DESIGN AND METHODS: To investigate the consequences of miR-125b ...

    Also Ranks for: Stem Cell |  myeloid differentiation |  nude mice |  humans leukemia |  mir125b apoptosis
    KOL Index score: 8382

    This study investigates the sensitivity of on-street parking demand using the automatic transaction data from parking pay stations obtained before and after a parking rate change that was implemented in Seattle in early 2011. The parking rate implementation is based on performance-based pricing where rates are increased, decreased, or not changed in neighborhoods with occupancy levels higher than, lower than, or within the desired level. We calculated the price elasticity of on-street ...

    Also Ranks for: Parking Demand |  price elasticity |  time day |  street response |  based pricing
    KOL Index score: 8285

    Children with neurodevelopmental disorders are at increased risk for sleep issues, which affect quality of life, cognitive function, and behavior. To determine the prevalence of sleep problems in children with the common neurodevelopmental disorder neurofibromatosis type 1, a cross-sectional study was performed on 129 affected subjects and 89 unaffected siblings, age 2 to 17 years, using the Sleep Disturbance Scale for Children questionnaire. Children with neurofibromatosis type 1 were ...

    Also Ranks for: Neurofibromatosis Type |  sleep disturbances |  cognitive impairment |  neurodevelopmental disorders |  crosssectional study
    KOL Index score: 7252

    BACKGROUND: Early rehospitalization after kidney transplantation (KTx) is common and is considered a quality metric. Recipient and donor risk factors for early readmission after KTx are well studied. Little data exist on discharge-level factors associated with readmission.

    METHODS: We performed a single-center, retrospective cohort study between 2011 and 2015 of adult KTx recipients to examine readmission indication, risk factors, and opportunities for reduction.

    RESULTS: Of 462 KTxs, ...

    Also Ranks for: Early Readmission |  kidney transplantation |  multivariate analysis |  graft function |  ktx recipients
    KOL Index score: 6437

    This study examines the connection between the built environment, perceived safety from crime and walking behaviour by conducting a travel survey in King County, Washington State, U.S. and employing a two-stage least squares model. We seek to answer two research questions: how does the built environment affect perceived safety from crime and walking behaviour; and how does one’s perception of safety from crime affect his/her walking behaviour. Our results show that the built environment ...

    Also Ranks for: Built Environment |  perceived safety |  walking behaviour |  travel survey |  addition association
    KOL Index score: 6369

    Currently, traditional immunochemistry technologies such as enzyme-linked immunosorbent assays (ELISA) are the predominant analytical tool used to measure levels of recombinant proteins expressed in genetically engineered (GE) plants. Recent advances in agricultural biotechnology have created a need to develop methods capable of selectively detecting and quantifying multiple proteins in complex matrices because of increasing numbers of transgenic proteins being coexpressed or "stacked" ...

    Also Ranks for: Tandem Mass Spectrometry |  protein quantitation |  liquid chromatography |  plants genetically |  enzyme linked
    KOL Index score: 6060

    The Middle Paleozoic Maksyutov Complex is an important component of the Eurasian collisional orogeny. It consists of dominant mica-rich garnet schist and mica-poor quartzofeldspathic gneiss enclosing minor mafic eclogite boudins (unit no. 1). Employing Raman spectroscopy, we identified three cuboidal microdiamond inclusions (~2-3 micrometers in diameter) in garnet hosts from two different mica-poor gneissic samples. Broad spectral bands and high magnification SEM images suggest that the ...

    Also Ranks for: South Ural Mountains |  metamorphic complex |  quartzofeldspathic gneisses |  inclusions garnet |  coesite stability field
    KOL Index score: 6057

    Ambient assisted living (AAL) technologies can provide assistance and support to persons with dementia. They might allow them the possibility of living at home for longer whilst maintaining their comfort and security as well as offering a way towards reducing the huge economic and personal costs forecast as the incidence of dementia increases worldwide over coming decades. However, the development, introduction and use of AAL technologies also trigger serious ethical issues. This paper ...

    Also Ranks for: Aal Technologies |  ethical issues |  assisted living |  people dementia |  informed consent
    KOL Index score: 5868

    The idea of using transit-oriented development (TOD) in reducing automobile dependency and improving the sustainability of transportation activities has gained wider support in recent years. Research findings have shown that residents living in TOD neighborhood used transit more frequently than people having similar socio-economic characteristics but living elsewhere. Most of the existing studies on TOD and transit ridership used recently developed sites or suburban neighborhoods as case ...

    Also Ranks for: Hong Kong |  oriented development |  case studies |  station characteristics |  new york
    KOL Index score: 5448

    Objectives: We aim to determine the prevalence of vision impairment (VI) and its cumulative impact on multimorbidity, frailty, physical and cognitive function, and quality of life. Method: In all, 780 community-dwelling older adults were interviewed for demographic data and a one-off physical activity screening. Covariate measurements include vision via Snellen chart, multimorbidity, five-item FRAIL (Fatigue, Resistance, Ambulation, Illnesses, & Loss of Weight) scale and Mini-Mental ...

    Also Ranks for: Intrinsic Capacity |  visual impairment |  living aged |  female frailty |  multimorbidity prevalence


    Cynthia Chen: Influence Statistics

    Sample of concepts for which Cynthia Chen is among the top experts in the world.
    Concept World rank
    neighborhoods occupancy #1
    neighborhoods decreased rates #1
    parking occupancy time #1
    neighborhoods increased rates #1
    parking pay stations #1
    occupancy block #1
    hours motorists #1
    duration motorists #1
    cosmetic mucosal tattoos #1
    pricing parking duration #1
    price elasticity time #1
    increased rates neighborhoods #1
    elasticity street #1
    motorists park #1
    cosmetic mucosal #1
    parking occupancy peakhours #1
    parking pay #1
    price elasticity street #1
    mucosal tattoos #1
    street parking demand #1
    mucosa tattooing #1
    street response #2
    1 leftcensoring #2
    psychological delay factor #2
    demand supply hypothesis #2
    lags asymmetric behaviour #2
    fall gasoline #2
    gasoline price transit #2
    obligations temporal #2
    question survival model #2
    built environment support #2
    gasoline price year #2
    elasticity parking #2
    2 partial observation #2
    study price elasticity #2
    ridership rise #2
    pay stations #2
    lag discretionary #2
    symmetry ridership #2
    behavioral life shock #2
    channels search space #2
    life shock question #2
    fall gasoline price #2
    human adaptivity hypothesis #2
    3 multitype exits #2
    paper response lag #2
    relative magnitude factors #2
    ridership symmetry #2
    multiple factors lags #2
    ridership relationship #3

    Key People For Acute Stroke

    Top KOLs in the world
    Werner MD Hacke
    atrial fibrillation ischemic stroke thrombolytic therapy
    Jeffrey L Saver
    acute ischemic stroke endovascular thrombectomy united states
    Geoffrey Alan Donnan
    ischemic stroke atrial fibrillation intracerebral haemorrhage
    Harold P Jr Adams
    ischemic stroke cerebral infarction subarachnoid hemorrhage
    Thomas G Brott
    ischemic stroke carotid endarterectomy intracerebral hemorrhage
    Joseph P Broderick
    intracerebral hemorrhage ischemic stroke endovascular therapy

    Cynthia Chen:Expert Impact

    Concepts for whichCynthia Chenhas direct influence:Acute stroke,  New york city,  Built environment,  Neurofibromatosis type,  Fuel price,  Intrinsic capacity,  Perceived safety,  Discretionary time.

    Cynthia Chen:KOL impact

    Concepts related to the work of other authors for whichfor which Cynthia Chen has influence:Built environment,  Nuclear actin,  Public transport,  Transit ridership,  Neurofibromatosis type,  Travel behavior,  Sleep disorders.



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    Institute for Work & Health, Toronto, ON, Canada | Center for Translational Pain Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital/Harvard Medical School Boston, MA, USA. | Department of Anesthesia, C