• Disease
  • Burkitt
  • Burkitt Lymphoma
  • Martine M Raphaël

    Prominent publications by Martine M Raphaël

    KOL Index score: 15666

    BACKGROUND: Post-transplantation lymphoproliferative disorder (PTLD) develops in 1-10% of transplant recipients and can be Epstein-Barr virus (EBV) associated. To improve long-term efficacy after rituximab monotherapy and to avoid the toxic effects of CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone) chemotherapy seen in first-line treatment, we initiated a phase 2 trial to test whether the subsequent use of rituximab and CHOP would improve the outcome of patients with ...

    Also Ranks for: Chop Chemotherapy |  treatment ptld |  transplant lymphoproliferative |  70 patients |  phase 2
    KOL Index score: 14555

    This study was undertaken to show that a high survival rate can be obtained in B-cell (Burkitt and large B-cell) lymphoma and L3 leukemia with multiagent chemotherapy adapted to the tumor burden (stage, resection status, percentage of blasts in bone marrow, and central nervous system [CNS] involvement) and early response to chemotherapy, to investigate actual prognostic factors, and to see if large B-cell lymphoma can be treated with the same regimen as Burkitt lymphoma. Patients were ...

    Also Ranks for: Cell Lymphoma |  tumor burden |  lmb89 protocol |  multiagent chemotherapy |  cns involvement
    KOL Index score: 14266

    The Rel/NF-kappa B proteins, p50, p52, p65, c-Rel, and RelB, constitute a family of transcription factors involved in the positive regulation of a variety of genes during the immune response. Recently, it has been shown that RelB knockout mice have no dendritic cells (DC). An overexpression of p50 has been described in follicular dendritic cells (FDC). A constitutive NF-kappa B activity has been reported in mature macrophages. This led to the hypothesis that some of the Rel/NF-kappa B ...

    Also Ranks for: Immune Response |  p50 p52 |  nf kappa |  relb transcription |  cells nuclear
    KOL Index score: 11865

    PURPOSE: Adolescents (age 15 to 21 years) compared with younger children with mature B-cell non-Hodgkin's lymphoma (NHL) have been historically considered to have an inferior prognosis. We therefore analyzed the impact of age and other diagnostic factors on the risk of treatment failure in children and adolescents treated on the French-American-British Mature B-Cell Lymphoma 96 (FAB LMB 96) trial.

    PATIENTS AND METHODS: Patients were divided by risk: group A (limited), group B ...

    Also Ranks for: Advanced Stage |  lactate dehydrogenase |  fab lmb |  adolescent age |  96 study
    KOL Index score: 11529

    Constitutive activation of signal transducer and activator of transcription 1 (STAT1) is a distinctive feature of Epstein-Barr virus (EBV)-immortalized B cells (lymphoblastoid cell lines [LCLs]). The expression of STAT1 in these cells is modulated by the latent membrane protein 1 (LMP1), but the mechanism of STAT1 activation has remained unclear. We demonstrate that the tyrosine phosphorylation of STAT1 in LCLs results from an indirect pathway encompassing an NF-kappaB-dependent ...

    Also Ranks for: Latent Membrane Protein |  stat1 lcls |  tumor cell transformation |  barr virus |  tyrosine phosphorylation
    KOL Index score: 11131

    We investigated 49 acquired immunodeficiency syndrome-related lymphomas (ARLs) for Epstein-Barr virus (EBV) by Southern blotting and in situ hybridization and, in positive cases, used cryostat immunohistology to compare EBV-latent gene expression (EBV encoded small RNA-1 [EBER-1], EBV nuclear antigen-2 [EBNA-2], latent membrane protein-1 [LMP-1] and host cell immunophenotype (CD11a, CD18, CD54, CD58, CD21, CD23, CD30, CD39, CDw70, immunoglobulin) patterns with those reported in other EBV ...

    Also Ranks for: Viral Latency |  gene expression |  barr virus |  immunodeficiency syndrome |  preschool dna
    KOL Index score: 11096

    Primary effusion lymphoma (PEL) selectively involves the serous body cavities, occurs predominantly in immunodeficient patients and is infected consistently by human herpesvirus type-8. PEL is also frequently infected by Epstein–Barr virus (EBV). The precise pathogenetic role of EBV coinfection in PEL is not fully understood. The lymphoma fails to express the EBV transforming proteins EBNA-2 and LMP-1, whereas it expresses EBNA-1 (latency I phenotype). Some studies have hypothesized that ...

    Also Ranks for: Barr Virus |  effusion lymphoma |  tumor cells |  ebna1 gene |  regulation viral
    KOL Index score: 10254

    Using Southern blotting for the diagnosis of clonality in peripheral T-cell lymphomas (PTCLs), analysis of the T-cell receptor (TCR) gamma gene rearrangement was shown to be more informative than that of the TCR beta gene rearrangement. In order to amplify every VJ gamma rearrangement, a polymerase chain reaction (PCR) procedure using newly designed GC-clamp primers has been developed. All primers can be mixed in a single multiplex PCR. PCR products are analysed by denaturing gradient ...

    Also Ranks for: Gradient Gel Electrophoresis |  chain reaction |  cell lymphomas |  southern blotting |  gamma rearrangement
    KOL Index score: 10117

    BACKGROUND: The European Cancer Registry-based project on hematologic malignancies (HAEMACARE), set up to improve the availability and standardization of data on hematologic malignancies in Europe, used the European Cancer Registry-based project on survival and care of cancer patients (EUROCARE-4) database to produce a new grouping of hematologic neoplasms (defined by the International Classification of Diseases for Oncology, Third Edition and the 2001/2008 World Health Organization ...

    Also Ranks for: Lymphoid Neoplasms |  hematologic malignancies |  relative survival patients |  european regions |  child child
    KOL Index score: 9936

    HIV infection is associated with a high incidence of AIDS-related lymphomas (ARLs). Since the use of highly active antiretroviral therapy (HAART), the incidence of AIDS-defining illnesses has decreased, leading to a significant improvement in survival of HIV-infected patients. The consequences of HAART use on ARL are under debate. This study compared the incidence and the characteristics of ARL before and after the use of HAART in a large population of HIV-infected patients in the French ...

    Also Ranks for: Highly Active |  haart arl |  hiv fhdh |  lymphoma aids |  incidence systemic
    KOL Index score: 9822

    B-cell chronic lymphocytic leukemia (B-CLL) follows a heterogeneous clinical course, and several biological parameters have been investigated to try to predict its clinical outcome. New staging systems including cytogenetics and CD38 expression as predictive values have been developed. Deletions of 11q22.3 approximately q23.1 detected at diagnosis in cases of CLL patients have been associated with a relatively aggressive disease. This region, which contains the ataxia telangiectasia ...

    Also Ranks for: Lymphocytic Leukemia |  situ hybridization |  cd38 expression |  ataxia telangiectasia |  cll patients


    Martine M Raphaël: Influence Statistics

    Sample of concepts for which Martine M Raphaël is among the top experts in the world.
    Concept World rank
    fludarabine bl2b958 #1
    hhv8 ptld #1
    cll senegalese patients #1
    tumor gene suppressor #1
    ebv clinical contexts #1
    prephase lowdose steroids #1
    large cells ebv #1
    hodgkin acquired #1
    resistance fludarabineinduced apoptosis #1
    dwdl #1
    hiv sections #1
    systemic nhls #1
    twentyone polypeptides #1
    patients aidsassociated nhl #1
    hivassociated tumors #1
    france infant lymphoma #1
    mathematical morphology graphs #1
    positive skewness coefficient #1
    p50 subunit induction #1
    cnloh adult bls #1
    tdependent iga response #1
    6 hhv6 patients #1
    209 stage iii #1
    dlbcl ngc #1
    neighborhood relationships cells #1
    gfa april #1
    syndrome lymphomas #1
    sujet infecté #1
    système immunitaire dans #1
    hhv8 ebv #1
    tools mm #1
    paradoxe reflète dune #1
    electrophoresis techniques #1
    expression arls #1
    rearranged lymphoma #1
    contrast lymphocytic proliferation #1
    percentage blood smear #1
    opportunistic ebv infection #1
    epsteinbarr virus latent #1
    bcell male multigene #1
    arls epstein #1
    cyclophosphamide monotherapy cpm #1
    senegalese series #1
    hivspecific igas #1
    cellular apoptotic programme #1
    loss cd80 antigen #1
    nuclei shape size #1
    aids‐related non‐hodgkin #1
    50 italian patients #1
    lymphoma cells azc #1

    Key People For Burkitt Lymphoma

    Top KOLs in the world
    Elaine S Jaffe
    cell lymphoma lymphoid neoplasms situ hybridization
    Ian T Magrath
    burkitt lymphoma cell lines developing countries
    Martine M Raphaël
    burkitt lymphoma hiv infection barr virus
    Wyndham Hopkins Wilson
    cell lymphoma moxetumomab pasudotox diffuse large
    Louis Michael Staudt
    cell lymphoma gene expression diffuse large
    Harald Stein†
    cell lymphoma monoclonal antibodies situ hybridization

    Martine M Raphaël:Expert Impact

    Concepts for whichMartine M Raphaëlhas direct influence:Burkitt lymphoma,  Hiv infection,  Barr virus,  Cell lymphoma,  Smudge cells,  French registry,  Chronic lymphocytic leukemia.

    Martine M Raphaël:KOL impact

    Concepts related to the work of other authors for whichfor which Martine M Raphaël has influence:Human herpesvirus,  Burkitt lymphoma,  Barr virus,  Hiv infection,  Kaposi sarcoma,  Castleman disease,  Central nervous.



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    University Paris Sarclay, Paris, France. | University of Paris Sud, Paris, France | Université Paris-Sud, Université Paris-Saclay, Institut Gustave Roussy, Paris, France | UMR 8126, Université Paris-Sud Paris-Saclay, CNRS, Institut Gustave Roussy, Vi