 | Claire V Murphy |
Prominent publications by Claire V Murphy
OBJECTIVE: To evaluate recent comparative studies regarding the safety and efficacy of dexmedetomidine in adults.
DATA SOURCES: Articles evaluating safety and efficacy of dexmedetomidine were identified from an English-language MEDLINE search (1996-July 2009), with a focus on data published since our previous review in 2007 to the present. MeSH terms included dexmedetomidine, medetomidine, alpha2-agonist, and sedation. References from selected articles were also reviewed for additional ...
| Also Ranks for: Dexmedetomidine Delirium | critically patients | efficacy safety | critical illness | sedation procedures |
High-Dose Dexmedetomidine for Sedation in the Intensive Care Unit: An Evaluation of Clinical Efficacy and Safety
[ PUBLICATION ]
BACKGROUND: Dexmedetomidine is an α(2)-receptor agonist used for sedation in the intensive care unit (ICU). Although dexmedetomidine is labeled for sedation in critically ill patients at doses up to 0.7 μg/kg/h, recent studies have used more liberal dosing regimens. However, to our knowledge, no study has assessed the clinical impact of doses greater than 0.7 μg/kg/h when compared to doses within the Food and Drug Administration--approved labeling.
OBJECTIVE: To compare the clinical ...
| Also Ranks for: Dose Dexmedetomidine | hypotension bradycardia | intensive unit | goal sedation | 07 μg |
STUDY OBJECTIVES: To determine the frequency of nephrotoxicity associated with colistin therapy by using a standardized definition and to identify risk factors for colistin-induced nephrotoxicity in critically ill patients.
DESIGN: Single-center, retrospective cohort analysis.
SETTING: University-affiliated tertiary care center.
PATIENTS: Forty-nine adults admitted to an intensive care unit who received intravenous colistin for at least 48 hours between July 2007 and July ...
| Also Ranks for: Intravenous Colistin | nephrotoxicity patients | intensive unit | kidney disease | 48 hours |
BACKGROUND: One of the hallmarks of modern medicine is the improving management of chronic health conditions. Long-term control of chronic disease entails increasing utilization of multiple medications and resultant polypharmacy. The goal of this study is to improve our understanding of the impact of polypharmacy on outcomes in trauma patients 45 years and older.
MATERIALS AND METHODS: Patients of age ≥45 years were identified from a Level I trauma center institutional registry. Detailed ...
| Also Ranks for: Trauma Patients | injury polypharmacy | complications cps | comorbid conditions | multivariate analysis |
BACKGROUND: Recent studies have suggested that early goal-directed resuscitation of patients with septic shock and conservative fluid management of patients with acute lung injury (ALI) can improve outcomes. Because these may be seen as potentially conflicting practices, we set out to determine the influence of fluid management on the outcomes of patients with septic shock complicated by ALI.
METHODS: A retrospective analysis was performed at Barnes-Jewish Hospital (St. Louis, MO) and in ...
| Also Ranks for: Fluid Management | lung injury | septic shock | hospital mortality | patients ali |
Comparison of heparin dosing based on actual body weight in non-obese, obese and morbidly obese critically ill patients
[ PUBLICATION ]
BACKGROUND: Obesity is endemic in the United States and obese patients are at increased risk of thromboembolism but little data are available for dosing unfractionated heparin (UFH). We evaluated the relationship between obesity and UFH efficacy during critical illness by examining UFH infusions in non-obese, obese, and morbidly obese critically ill patients.
MATERIALS AND METHODS: Retrospective review of UFH infusions in non-obese, obese, and morbidly obese critically ill patients. ...
| Also Ranks for: Heparin Dosing | actual body weight | obese patients | therapeutic aptt | 12 units |
Comorbidity‐Polypharmacy Scoring Facilitates Outcome Prediction in Older Trauma Patients
[ PUBLICATION ]
OBJECTIVES: To determine the association between comorbidity-polypharmacy score (CPS) and clinical outcomes in a large sample of older trauma patients, focusing on outcome prognostication.
DESIGN: The CPS combines number of preinjury medications and comorbidities to more objectively quantify the severity of comorbid conditions.
SETTING: An urban tertiary care level 1 trauma center in the Midwest.
PARTICIPANTS: Trauma patients aged 45 and older.
METHODS: Participants were stratified into ...
| Also Ranks for: Trauma Patients | higher cps | discharge facility | mortality complications | injury severity |
Adjunctive aerosolized colistin for multi-drug resistant gram-negative pneumonia in the critically ill: a retrospective study
[ PUBLICATION ]
BACKGROUND: The incidence of multi-drug resistant (MDR) gram-negative (GN) organisms including Pseudomonas and Acinetobacter spp has increased in the last decade, prompting re-evaluation of colistin for the management of these infections. Aerosolized colistin as an adjunct to intravenous therapy is a current option for the management of MDR-GN pneumonia, although data supporting this practice is limited. This study evaluates the efficacy of adjunctive aerosolized colistin in combination ...
| Also Ranks for: Aerosolized Colistin | clinical cure | critically patients | mdrgn pneumonia | resistant gram |
Colistin combination therapy improves microbiologic cure in critically ill patients with multi-drug resistant gram-negative pneumonia
[ PUBLICATION ]
Currently, in vitro synergy with colistin has not translated into improved clinical outcomes. This study aimed to compare colistin combination therapy to colistin monotherapy in critically ill patients with multi-drug resistant gram-negative (MDR-GN) pneumonia. This was a retrospective analysis of critically ill adult patients receiving intravenous colistin for MDR-GN pneumonia comparing colistin combination therapy to colistin monotherapy with a primary endpoint of clinical cure. ...
| Also Ranks for: Combination Therapy | clinical cure | resistant gram | critically patients | intravenous colistin |
Comorbidity-polypharmacy score: a novel adjunct in post-emergency department trauma triage.
[ PUBLICATION ]
OBJECTIVE: Post-emergency department triage of older trauma patients continues to be challenging, as morbidity and mortality for any given level of injury severity tend to increase with age. The comorbidity-polypharmacy score (CPS) combines the number of pre-injury medications with the number of comorbidities to estimate the severity of comorbid conditions. This retrospective study examines the relationship between CPS and triage accuracy for older (≥45y) patients admitted for traumatic ...
| Also Ranks for: Injury Severity | polypharmacy score | cps patients | comorbid conditions | emergency department |
Glucose management in patients with burn injury is often difficult because of their hypermetabolic state with associated hyperglycemia, hyperinsulinemia, and insulin resistance. Recent studies suggest that time to glycemic control is associated with improved outcomes. The authors sought to determine the influence of early glycemic control on the outcomes of critically ill patients with burn injury. A retrospective analysis was performed at the Ohio State University Medical Center. ...
| Also Ranks for: Burn Injury | early glycemic control | critically patients | insulin resistance | intensive unit |
Low Vitamin D Level on Admission for Burn Injury Is Associated With Increased Length of Stay
[ PUBLICATION ]
Currently, there have been few studies that have evaluated the incidence of vitamin D deficiency in adult burn patients or correlated vitamin D levels with burn-related outcomes. The primary objective of the study was to identify the incidence of vitamin D deficiency and insufficiency in an adult burn population. The secondary objective was to determine the impact of vitamin D deficiency and insufficiency on clinical outcomes in burn care. A single-center, retrospective, and ...
| Also Ranks for: Burn Injury | vitamin deficiency | retrospective studies | primary objective | hospital mortality |
INTRODUCTION: Emergence of multidrug-resistant (MDR) gram-negative (GN) pathogens and lack of novel antibiotics have increased the use of colistin, despite unknown optimal dosing. This study aimed to evaluate the safety and efficacy of a colistin loading dose, high-dose (LDHD) maintenance regimen in patients with MDR-GN pneumonia.
METHODS: A retrospective cohort analysis was performed comparing critically ill patients with MDR-GN pneumonia pre- and postimplementation of a colistin LDHD ...
| Also Ranks for: Colistin Loading Dose | critically patients | clinical cure | resistant gram | negative bacterial |
Argatroban is a parenteral direct thrombin inhibitor labeled for anticoagulation in patients with confirmed or suspected heparin-induced thrombocytopenia in the United States. Currently there are no studies evaluating bleeding risk factors in Intensive Care Unit patients.To determine bleeding risk factors associated with argatroban therapy in the critically ill. Critically ill patients admitted between July 2007–June 2008 who received argatroban were included in this retrospective cohort ...
| Also Ranks for: Argatroban Therapy | bleeding risk | critically patients | retrospective studies | pipecolic acids |
Claire V Murphy: Influence Statistics
| Concept | World rank |
|---|---|
| patients mdrgn pneumonia | #1 |
| transaminitis tbsa | #1 |
| ldhd guideline | #1 |
| fluid balance hospital | #1 |
| clevidipine perioperative | #1 |
| improvement microbiological | #1 |
| prediabetes burn injury | #1 |
| rates hyperbaric | #1 |
| admission prediabetics | #1 |
| late fluid | #1 |
| preinjury glucose control | #1 |
| 42 preimplementation | #1 |
| prediabetes burn | #1 |
| low fluid balance | #1 |
| burn injury continuum | #1 |
| oxandrolone retrospective | #1 |
| desired limits surgery | #1 |
| mdrgn pneumonia | #1 |
| critically pediatric adult | #1 |
| controls prediabetics | #1 |
| perioperative control | #1 |
| oxandrolone transaminitis | #1 |
| colistin ldhd guideline | #1 |
| transaminitis oxandrolone | #1 |
| total 2450 patients | #1 |
| 54 prediabetics | #1 |
| prediabetes ratio | #1 |
| critically patients ketamine | #1 |
| transaminitis length | #1 |
| late fluid balance | #1 |
| colistin ldhd | #1 |
| methadone critically | #1 |
| postimplementation colistin | #1 |
| transaminitis adult | #1 |
| dose ldhd | #1 |
| controls prediabetic | #1 |
| injury prediabetes | #1 |
| ast length | #1 |
| patients preimplementation period | #1 |
| gn pneumonia | #1 |
| oxandrolone risk factors | #1 |
| risk factors transaminitis | #1 |
| nephrotoxicity intravenous colistin | #1 |
Key People For Burn Injury
Claire V Murphy:Expert Impact
Concepts for whichClaire V Murphyhas direct influence:Burn injury, Trauma patients, Glycemic control, Nebulized heparin, Hospital mortality, Critically patients, Septic shock, Intravenous colistin.
Claire V Murphy:KOL impact
Concepts related to the work of other authors for whichfor which Claire V Murphy has influence:Septic shock, Fluid overload, Acute kidney injury, Critically patients, Severe sepsis, Intensive unit, Hospital mortality.
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