• Disease
  • Ventricular
  • Ventricular Tachycardia
  • Douglas P Zipes

    Prominent publications by Douglas P Zipes

    KOL Index score: 15461

    BACKGROUND: Fragmented QRS (fQRS) on a 12-lead electrocardiogram (ECG) is associated with myocardial scar in patients with coronary artery disease (CAD).

    OBJECTIVE: We postulated that fQRS is a predictor of cardiac events and mortality in patients who have known CAD or who are being evaluated for CAD.

    METHODS: The cardiac events (myocardial infarction, need for revascularization, or cardiac death) and all-cause mortality were retrospectively reviewed in 998 patients (mean age 65.5 +/- ...

    Also Ranks for: Cardiac Events |  coronary artery disease |  fragmented qrs |  patients cad |  lead ecg
    KOL Index score: 15242

    OBJECTIVES: We compared the electrophysiologic effects on atrioventricular (AV) node physiology of selective "fast" versus selective "slow" pathway radiofrequency ablation in 42 patients with drug-resistant AV node reentrant tachycardia who underwent 51 ablation attempts to prevent tachycardia recurrence while preserving AV conduction.

    BACKGROUND: The recent introduction of radiofrequency ablation to treat AV node reentrant tachycardia allows the opportunity to study the effects of ...

    Also Ranks for: Node Reentrant Tachycardia |  radiofrequency ablation |  slow pathway |  13 patients |  atrioventricular nodal
    KOL Index score: 15136

    OBJECTIVES: The aim of this study was to determine whether patients with ventricular arrhythmias in the absence of coronary artery disease also have abnormalities in sympathetic innervation.

    BACKGROUND: We have previously shown by cardiac sympathetic scintigraphy using iodine-123-metaiodobenzylguanidine (I-123-MIBG) that patients with ventricular tachycardia after myocardial infarction have regional cardiac sympathetic denervation. It is not known whether patients with ventricular ...

    Also Ranks for: Cardiac Sympathetic |  coronary artery disease |  ventricular tachycardia |  12 patients |  myocardial infarction
    KOL Index score: 14748

    We examined the influence of ventricular tachycardia (VT) cycle length and antiarrhythmic drugs on the frequency of VT termination and acceleration by single and double extrastimuli and right ventricular burst pacing. In 57 patients, 89 episodes of sustained VT (32 control, 57 drug) were induced by programmed electrical stimulation. Overall, 60 of 89 (67%) episodes of ventricular tachycardia were terminated by means of programmed electrical stimulation. In patients with relatively slow ...

    Also Ranks for: Cycle Length |  ventricular tachycardia |  antiarrhythmic drugs |  termination acceleration |  double extrastimuli
    KOL Index score: 14506

    The vagal nerves modulate adrenergic effects on sinus cycle length, atrioventricular (AV) nodal conduction, and refractoriness of atria and ventricles. We tested whether varying levels of vagal-sympathetic input could yield the same spontaneous sinus cycle length but also alter effective refractory periods of the right atrium, right ventricle, and left ventricle and AV nodal conduction times. Dogs anesthetized by alpha-chloralose were studied in the open-chest, neurally decentralized ...

    Also Ranks for: Sinus Cycle Length |  vagal stimulation |  atrioventricular nodal |  ansae subclaviae |  ventricular refractoriness
    KOL Index score: 13968

    INTRODUCTION: We have shown previously that acute atrial dilation prolonged atrial refractoriness. We hypothesized that this increase in refractoriness might be heterogeneous and could create an electrophysiologic substrate leading to atrial fibrillation. The purpose of the present study was to test that hypothesis.

    METHODS AND RESULTS: We studied 23 anesthetized open chest dogs. Bipolar plunge electrodes were placed in the medial free wall of the right atrium (thin region) and in the ...

    Also Ranks for: Atrial Fibrillation |  free wall |  crista terminalis |  atrioventricular pacing |  normal saline
    KOL Index score: 13854

    BACKGROUND: The purpose of this study was to investigate the functional pathways of efferent vagal innervation to the atrial myocardium and sinus and atrioventricular (AV) nodes.

    METHODS AND RESULTS: Using vagally induced atrial effective refractory period shortening, slowing of spontaneous sinus rate, and prolongation of AV nodal conduction time as end points of vagal effects, we determined the actions of phenol and epicardial radiofrequency catheter ablation (RFCA) applied to different ...

    Also Ranks for: Fat Pad |  sinus nodes |  canine atria |  vena cava |  vagal innervation
    KOL Index score: 13722

    BACKGROUND: Conduction abnormalities serve as a substrate for ventricular fibrillation (VF) in patients with Brugada syndrome (BS). Signal-averaged electrograms can detect late potentials, but the significance of conduction abnormalities within the QRS complex is still unknown. The latter can present as multiple spikes within the QRS complex (fragmented QRS [f-QRS]). We hypothesized that f-QRS could indicate a substrate for VF and might predict a high risk of VF for patients with ...

    Also Ranks for: Vf Patients |  brugada syndrome |  fragmented qrs |  conduction abnormalities |  risk syncope
    KOL Index score: 13570

    BACKGROUND: Radiofrequency energy has been used safely and successfully to eliminate accessory pathways in patients with the Wolff-Parkinson-White syndrome and the substrate for atrioventricular nodal reentrant tachycardia. However, this form of ablation has had only limited success in eliminating ventricular tachycardia in patients with structural heart disease. In contrast, direct-current catheter ablation has been used successfully to eliminate ventricular tachycardia in patients with ...

    Also Ranks for: Ventricular Tachycardia |  structural heart disease |  radiofrequency catheter |  female heart |  accessory pathways
    KOL Index score: 13353

    This study examined the usefulness of programmed electrical stimulation in managing 83 patients who had ventricular tachycardia not due to coronary artery disease. Among 39 patients with a history of sustained ventricular tachycardia, programmed stimulation induced ventricular tachycardia in 14 of 14 patients with mitral valve prolapse or primary electrical disease (arrhythmias without evidence of structural heart disease) and in 13 of 25 with cardiomyopathy (total 27 of 39, 69 percent). ...

    Also Ranks for: Coronary Artery Disease |  ventricular tachycardia |  electrophysiologic testing |  programmed stimulation |  drug therapy
    KOL Index score: 13339

    To examine the effects of ischemic preconditioning on efferent autonomic responses following acute transmural myocardial ischemia/infarction (MI), the time course and extent of efferent sympathetic and vagal denervation were compared between control dogs that received a one-stage sustained coronary occlusion and preconditioned dogs that received four 5-minute coronary occlusions separated by 5 minutes of reperfusion before sustained occlusion. Effective refractory periods (ERP) basal and ...

    Also Ranks for: Autonomic Denervation |  myocardial infarction |  apical sites |  preconditioning ischemia |  sustained occlusion
    KOL Index score: 13338

    To determine the time course of efferent sympathetic denervation after transmural myocardial infarction (TMI) and of efferent vagal denervation after transmural or nontransmural myocardial infarction (NTMI), we measured effective refractory periods (ERP) basal and apical to TMI or NTMI in secobarbital-anesthetized, open-chest dogs. In eight dogs with latex-induced TMI, bilateral ansae subclaviae stimulation shortened ERP at all 45 apical and basal test sites before latex injection. After ...

    Also Ranks for: Efferent Sympathetic |  erp shortening |  apical sites |  coronary artery |  canine heart
    KOL Index score: 13113

    Transmural myocardial infarction in dogs produces denervation of sympathetic nerves in viable myocardium apical to the infarct that may be arrhythmogenic. It is unknown whether sympathetic denervation occurs in humans. The purpose of this study was to use iodine-123-metaiodobenzylguanidine (MIBG), a radiolabeled guanethidine analog that is actively taken up by sympathetic nerve terminals, to image noninvasively the cardiac sympathetic nerves in patients with and without ventricular ...

    Also Ranks for: Sympathetic Denervation |  myocardial infarction |  ventricular arrhythmias |  mibg uptake |  electrophysiologic study
    KOL Index score: 12758

    OBJECTIVE: To assess the out-of-hospital cardiac arrest (OHCA) survival advantage after providing police with automated external defibrillators (AEDs) in rural and suburban Indiana.

    METHODS: An observational evaluation was conducted in six Indiana counties (population: 464,741) before (retrospective) and after (prospective) training and equipping police with AEDs. The primary outcome evaluated was survival to hospital discharge for all cases of ventricular tachycardia/ventricular ...

    Also Ranks for: Cardiac Arrest |  hospital discharge |  cases police |  automated external |  survival benefit


    Douglas P Zipes: Influence Statistics

    Sample of concepts for which Douglas P Zipes is among the top experts in the world.
    Concept World rank
    duration bipolar electrograms #1
    preexcitation atrial preexcitation #1
    sustained atrial flutter #1
    idiopathic lqts channels #1
    wb eads #1
    bradycardia prolongation #1
    patients easier #1
    20 joule patient #1
    antarrhythmic approaches #1
    5 hours shortening #1
    action potentials transplants #1
    retention atria #1
    musculature atrial junctions #1
    3 sudden death #1
    verapamil isoproterenol #1
    transmural surfaces #1
    qtc circadian variation #1
    verps rapid pacing #1
    ventricular site verps #1
    international coalition #1
    patients intravenous enoximone #1
    task force arrhythmias #1
    tissues ventricular tachycardia #1
    tachycardia sympathetic #1
    atrial tachycardia degenerating #1
    4minute #1
    eads vts #1
    nonantiarrhythmic drugs #1
    raerp peak pressure #1
    apical sites #1
    dogs basal sites #1
    ect arrhythmias #1
    amiodarone 600 day #1
    chronic heart defeathf #1
    erythromycin development #1
    drugs conduction delay #1
    dogs latex #1
    aprindine #1
    verapamil prolongation #1
    ecg features rvot #1
    selective vagal denervation #1
    aads lvef #1
    escape intervals #1
    benoxathian 3 μm #1
    scs feasibility #1
    aad survival #1
    isolation recurrent #1
    atrial pcl #1
    aprindine dogs #1

    Key People For Ventricular Tachycardia

    Top KOLs in the world
    ventricular tachycardia atrial fibrillation catheter ablation
    ventricular tachycardia catheter ablation atrial fibrillation
    William Gregory Stevenson
    ventricular tachycardia catheter ablation atrial fibrillation
    Fred Morady And Frank Pelosid Morady
    atrial fibrillation catheter ablation ventricular tachycardia
    Leonard N Horowitz
    ventricular tachycardia coronary artery disease electrophysiologic testing
    Hein J J Wellens
    ventricular tachycardia atrial fibrillation accessory pathway

    Douglas P Zipes:Expert Impact

    Concepts for whichDouglas P Zipeshas direct influence:Ventricular tachycardia,  Atrial fibrillation,  Ventricular arrhythmias,  Ventricular fibrillation,  Cardiac death,  Sudden cardiac death,  Cardiac arrhythmias,  Heart failure.

    Douglas P Zipes:KOL impact

    Concepts related to the work of other authors for whichfor which Douglas P Zipes has influence:Atrial fibrillation,  Ventricular tachycardia,  Sudden cardiac death,  Heart failure,  Myocardial infarction,  Catheter ablation,  Brugada syndrome.



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    Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, USA | Distinguished Professor, Professor Emeritus of Medicine, Pharmacology, and Toxicology | Director Emeritus, Division of Cardiology and the Krannert Institute