Prominent publications by Emelia J Benjamin

KOL Index score: 28054

BACKGROUND: Reliable and timely information on the leading causes of death in populations, and how these are changing, is a crucial input into health policy debates. In the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010), we aimed to estimate annual deaths for the world and 21 regions between 1980 and 2010 for 235 causes, with uncertainty intervals (UIs), separately by age and sex.

METHODS: We attempted to identify all available data on causes of death for 187 ...

Also Ranks for: Hiv Aids |  global burden |  systematic analysis |  leading death |  ischaemic heart disease
KOL Index score: 23721

BACKGROUND: Measuring disease and injury burden in populations requires a composite metric that captures both premature mortality and the prevalence and severity of ill-health. The 1990 Global Burden of Disease study proposed disability-adjusted life years (DALYs) to measure disease burden. No comprehensive update of disease burden worldwide incorporating a systematic reassessment of disease and injury-specific epidemiology has been done since the 1990 study. We aimed to calculate ...

Also Ranks for: Global Burden |  291 diseases |  systematic analysis |  child child |  disability ylds
KOL Index score: 20720

BACKGROUND: Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither effort quantified uncertainty in prevalence or years lived with disability (YLDs).

METHODS: Of the 291 diseases and ...

Also Ranks for: Systematic Analysis |  global burden |  disability ylds |  prevalence years |  health systems
KOL Index score: 18421

IMPORTANCE: Understanding the major health problems in the United States and how they are changing over time is critical for informing national health policy.

OBJECTIVES: To measure the burden of diseases, injuries, and leading risk factors in the United States from 1990 to 2010 and to compare these measurements with those of the 34 countries in the Organisation for Economic Co-operation and Development (OECD) countries.

DESIGN: We used the systematic analysis of descriptive epidemiology ...

Also Ranks for: United States |  diseases injuries |  life expectancy |  population health |  child child
KOL Index score: 17830

CONTEXT: New-onset atrial fibrillation (AF) has been reported in 6% to 20% of patients with severe sepsis. Chronic AF is a known risk factor for stroke and death, but the clinical significance of new-onset AF in the setting of severe sepsis is uncertain.

OBJECTIVE: To determine the in-hospital stroke and in-hospital mortality risks associated with new-onset AF in patients with severe sepsis.

DESIGN AND SETTING: Retrospective population-based cohort of California State Inpatient Database ...

Also Ranks for: Severe Sepsis |  patients newonset |  onset atrial |  stroke death |  hospital mortality
KOL Index score: 16671

BACKGROUND: Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, induces endothelial dysfunction. Although elevated ADMA has been associated with an increased risk of cardiovascular disease events and death in referral samples, the prognostic significance of ADMA in the community has not been adequately evaluated.

METHODS AND RESULTS: We related plasma ADMA, l-arginine (Arg), and the ratio of Arg to ADMA to the incidence of cardiovascular disease (fatal ...

Also Ranks for: Cardiovascular Disease |  arg adma |  plasma asymmetric |  1sd increment |  allcause mortality
KOL Index score: 16126

BACKGROUND: Comprehensive long-term data on atrial fibrillation trends in men and women are scant. We aimed to provide such data through analysis of the Framingham cohort over 50 years.

METHODS: We investigated trends in incidence, prevalence, and risk factors for atrial fibrillation and its association with stroke and mortality after onset in 9511 participants enrolled in the Framingham Heart Study between 1958 and 2007. We analysed trends within 10 year groups (1958-67, 1968-77, ...

Also Ranks for: Atrial Fibrillation |  framingham heart study |  1000 personyears |  incidence prevalence |  stroke mortality
KOL Index score: 15983

Importance: Nearly half of all patients with heart failure have preserved ejection fraction (HFpEF) as opposed to reduced ejection fraction (HFrEF), yet associations of biomarkers with future heart failure subtype are incompletely understood.

Objective: To evaluate the associations of 12 cardiovascular biomarkers with incident HFpEF vs HFrEF among adults from the general population.

Design, Setting, and Participants: This study included 4 longitudinal community-based cohorts: the ...

Also Ranks for: Heart Failure |  ejection fraction |  incident hfpef |  cardiovascular biomarkers |  natriuretic peptides
KOL Index score: 15611

BACKGROUND: Measurement of the global burden of disease with disability-adjusted life-years (DALYs) requires disability weights that quantify health losses for all non-fatal consequences of disease and injury. There has been extensive debate about a range of conceptual and methodological issues concerning the definition and measurement of these weights. Our primary objective was a comprehensive re-estimation of disability weights for the Global Burden of Disease Study 2010 through a ...

Also Ranks for: Global Burden |  health outcomes |  study 2010 |  disability weights |  disease injury
KOL Index score: 15533

BACKGROUND: The natriuretic peptides are counterregulatory hormones involved in volume homeostasis and cardiovascular remodeling. The prognostic significance of plasma natriuretic peptide levels in apparently asymptomatic persons has not been established.

METHODS: We prospectively studied 3346 persons without heart failure. Using proportional-hazards regression, we examined the relations of plasma B-type natriuretic peptide and N-terminal pro-atrial natriuretic peptide to the risk of ...

Also Ranks for: Cardiovascular Event |  peptide levels |  risk death |  plasma natriuretic |  heart failure
KOL Index score: 15450

CONTEXT: Several reports have suggested the usefulness of plasma brain natriuretic peptide (BNP) as a screening test for left ventricular hypertrophy (LVH) and systolic dysfunction (LVSD). Prior studies were limited by small sample sizes and selection bias and none compared the diagnostic performance of these peptides in men and women.

OBJECTIVES: To examine the usefulness of natriuretic peptides for screening for elevated LV mass and LVSD in the community.


Also Ranks for: Natriuretic Peptides |  systolic dysfunction |  community screening |  framingham heart study |  ventricular hypertrophy
KOL Index score: 14893

BACKGROUND: Heart failure is a major public health problem. Long-term trends in the incidence of heart failure and survival after its onset in the community have not been characterized.

METHODS: We used statistical models to assess temporal trends in the incidence of heart failure and Cox proportional-hazards regression to evaluate survival after the onset of heart failure among subjects in the Framingham Heart Study. Cases of heart failure were classified according to the date of onset: ...

Also Ranks for: Heart Failure |  incidence survival |  term trends |  aged mortality |  rate ratio
KOL Index score: 14835

BACKGROUND: Previous clinical studies have suggested that there is an association between mitral annular calcification and the risk of stroke, but it is unclear whether this association is independent of the traditional risk factors for stroke. We examined the relation between mitral annular calcification and the incidence of stroke in a population-based study.

METHODS: Subjects in the Framingham Study receiving a routine examination underwent M-mode echocardiography to determine the ...

Also Ranks for: Mitral Annular Calcification |  risk stroke |  elderly cohort |  congestive heart failure |  coronary heart disease
KOL Index score: 14786

BACKGROUND: Hyperuricaemia, a highly heritable trait, is a key risk factor for gout. We aimed to identify novel genes associated with serum uric acid concentration and gout.

METHODS: Genome-wide association studies were done for serum uric acid in 7699 participants in the Framingham cohort and in 4148 participants in the Rotterdam cohort. Genome-wide significant single nucleotide polymorphisms (SNPs) were replicated in white (n=11 024) and black (n=3843) individuals who took part in the ...

Also Ranks for: Uric Acid |  genetic loci |  aric study |  snps gout |  genome wide
KOL Index score: 14736

CONTEXT: Vascular stiffness increases with advancing age and is a major risk factor for age-related morbidity and mortality. Vascular stiffness and blood pressure pulsatility are related; however, temporal relationships between vascular stiffening and blood pressure elevation have not been fully delineated.

OBJECTIVE: To examine temporal relationships among vascular stiffness, central hemodynamics, microvascular function, and blood pressure progression.


Also Ranks for: Incident Hypertension |  blood pressure |  aortic stiffness |  temporal relationships |  cfpwv fwa

Key People For Atrial Fibrillation

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Emelia J Benjamin:Expert Impact

Concepts for whichEmelia J Benjaminhas direct influence:Atrial fibrillation,  Framingham heart study,  Heart failure,  Cardiovascular disease,  African americans,  Arterial stiffness,  Framingham heart,  Heart study.

Emelia J Benjamin:KOL impact

Concepts related to the work of other authors for whichfor which Emelia J Benjamin has influence:Atrial fibrillation,  Heart failure,  Cardiovascular disease,  Blood pressure,  Ischemic stroke,  Myocardial infarction,  Arterial stiffness.



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Cardiology and Preventative Medicine Sections, Boston University School of Medicine, Boston, Massachusetts, USA | Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts | The Framingham Heart Study, Framingham, M