• Disease
  • Sialic
  • Sialic Acid
  • Martin Andrew Crook

    Prominent publications by Martin Andrew Crook

    KOL Index score: 12223

    OBJECTIVE: Inflammatory markers predict type 2 diabetes and relate to the metabolic syndrome. Gestational diabetes mellitus (GDM) predicts type 2 diabetes and may be part of this syndrome. To examine the association of inflammatory markers with GDM, we investigated total sialic acid (TSA) in women with and without previous GDM.

    RESEARCH DESIGN AND METHODS: All women with GDM and a random sample of women from one center of the Brazilian Study of Gestational Diabetes were invited to return ...

    Also Ranks for: Metabolic Syndrome |  gestational diabetes |  previous gdm |  total sialic acid |  inflammatory markers
    KOL Index score: 11336

    OBJECTIVE: To test the hypothesis that an increased plasma concentration of sialic acid, a marker of the acute-phase response, is related to the presence of diabetic micro- and macrovascular complications in type 1 diabetes.

    RESEARCH DESIGN AND METHODS: We investigated the relationship between plasma sialic acid concentration and nephropathy, retinopathy, neuropathy, and coronary heart disease (CHD) in a cross-sectional survey of 1,369 people with type 1 diabetes. Subjects were ...

    Also Ranks for: Type 1 Diabetes |  sialic acid |  macrovascular complications |  1 diabetic |  proliferative retinopathy
    KOL Index score: 10905

    Serum sialic acid is a risk factor for cardiovascular disease in the general population. Serum total sialic acid concentrations were therefore measured in 20 type 1 diabetic patients and in 20 age- and sex-matched non-diabetic subjects. Serum sialic acid were not significantly different in the type 1 diabetic patients and the normal subjects (2.00 +/- 0.37 vs. 1.98 +/- 0.67 mmol/l), but was significantly correlated with serum total cholesterol (r = 0.55, P < 0.02) and serum triglyceride ...

    Also Ranks for: Serum Sialic |  type 1 |  2 diabetes |  acute phase |  diabetic patients
    KOL Index score: 10505

    OBJECTIVES: Patients with adult GH-deficiency are thought to have an increased risk of cardiovascular disease. Sialic acid (SA) concentrations have been proposed as a marker of atherosclerotic disease probably related to an inflammatory response of the arterial wall. SA as a marker of cardiovascular disease in adult GH-deficiency and its relation to changes in fasting lipid profile and hormone concentrations have not yet been investigated.

    PATIENTS: We performed a randomised, ...

    Also Ranks for: Growth Hormone |  replacement therapy |  lipid profile |  cardiovascular disease |  sialic acid
    KOL Index score: 10261

    OBJECTIVE: An elevated serum sialic acid concentration has recently been shown to be a potent cardiovascular risk factor in the general population. Because clinical proteinuria is associated with a high frequency of cardiovascular disease, and because microalbuminuria predicts the development of renal and cardiovascular disease in diabetes, we investigated whether serum sialic acid levels are increased in insulin-dependent diabetes mellitus (IDDM) patients with microalbuminuria or ...

    Also Ranks for: Serum Sialic Acid |  cardiovascular disease |  iddm patients |  diabetes duration |  age bmi
    KOL Index score: 9906

    PURPOSE: The role of thyroxine replacement in subclinical hypothyroidism remains unclear. We performed a 6-month randomized, double-blind, placebo-controlled trial to evaluate the effects of thyroxine treatment for mild subclinical hypothyroidism, defined as a serum thyroid-stimulating hormone level between 5 to 10 microU/mL with a normal serum free thyroxine level (0.8-16 ng/dL).

    SUBJECTS AND METHODS: We randomly assigned 40 women with mild subclinical hypothyroidism who had presented ...

    Also Ranks for: Thyroxine Treatment |  subclinical hypothyroidism |  6 months |  energy expenditure |  lipid profiles
    KOL Index score: 9275

    As part of a randomised trial [Genetic Risk Assessment for Familial Hypercholesterolaemia (FH) Trial] of the psychological consequences of DNA-based and non-DNA-based diagnosis of FH, 338 probands with a clinical diagnosis of FH (46% with tendon xanthomas) were recruited. In the DNA-based testing arm (245 probands), using single-strand conformation polymorphism of all exons of the low-density lipoprotein receptor (LDLR) gene, 48 different pathogenic mutations were found in 62 probands ...

    Also Ranks for: Ldlr Mutations |  mutational analysis |  familial hypercholesterolaemia |  clinical diagnosis fh |  hyperlipoproteinemia type
    KOL Index score: 9133

    Serum total sialic acid (TSA) has gained medical interest, particularly as a cardiovascular risk factor and it has been hypothesized that serum levels relate to serum acute phase proteins, some of which are sialylated. We assayed serum TSA and also lipid associated sialic acid (LASA) in 50 normal individuals (24 male) and 15 subjects (12 male) who had experienced a myocardial infarct. The mean serum TSA in the normal individuals was 2.05 SD 0.38 mmol/L (range 1.16-2.74) and the mean ...

    Also Ranks for: Myocardial Infarction |  normal individuals |  acute phase |  sialic acid |  serum tsa
    KOL Index score: 8636

    This trial tests the hypothesis that confirming a clinical diagnosis of familial hypercholesterolemia (FH) by finding a genetic mutation reduces patients' perceptions of control over the disease and adherence to risk-reducing behaviors. Three hundred forty-one families, comprising 341 hypercholesterolemia probands and 128 adult relatives, were randomized to one of two groups: (a) routine clinical diagnosis; (b) routine clinical diagnosis plus genetic testing (mutation searching in ...

    Also Ranks for: Genetic Testing |  familial hypercholesterolemia |  psychological impact |  randomized controlled trial |  perceptions control
    KOL Index score: 8594

    BACKGROUND: The acute-phase response involves molecules including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and C-reactive protein (CRP). This study aimed to determine whether subgingival scaling resulted in rapid changes in plasma concentrations of these molecules.

    METHODS: Twenty-three non-smoking adults with chronic periodontitis received subgingival scaling for 60 minutes. Venous blood samples were taken at 0, 15, 30, 60, and 120 minutes. TNF-alpha and IL-6 were ...

    Also Ranks for: Chronic Periodontitis |  reactive protein |  tumor necrosis |  dental scaling |  alpha tnf
    KOL Index score: 8565

    OBJECTIVE: To establish risk factor causal associations for coronary artery disease (CAD) in the native Pakistani population.

    METHODS: We conducted a hospital-based, case-control study of 200 cases with angiographically documented CAD and 200 age- and sex-matched controls without angiographic evidence of CAD. Patients on lipid lowering therapy were excluded. Lifestyle, anthropometric and biochemical risk factors were assessed in both groups.

    RESULTS: The presence of CAD was associated ...

    Also Ranks for: Coronary Artery Disease |  whr cad |  low hdl |  hip ratio |  reactive protein
    KOL Index score: 8016

    AIMS: C-reactive protein (CRP) is a predictor of many diseases including type II diabetes and cardiovascular disease. Fewer studies have similarly shown sialic acid (SA) to be a predictor of obesity-related diseases, but importantly SA shows less intra-individual variability than CRP and acts as an integrated marker of the activity of a number of acute-phase proteins. This study examines the association between both CRP and SA with individual and combined features of the metabolic ...

    Also Ranks for: Metabolic Syndrome |  sialic acid |  cardiovascular disease |  insulin resistance |  creactive protein


    Martin Andrew Crook: Influence Statistics

    Sample of concepts for which Martin Andrew Crook is among the top experts in the world.
    Concept World rank
    112 litre #1
    factors sialic #1
    differential humans adh #1
    bmt 41 #1
    55 litre #1
    prothrombinase expression #1
    management severe hypophosphatemia #1
    normal subjects correlation #1
    direct hsct #1
    lipaemic #1
    atheromatous load #1
    metabolic components insight #1
    malignancies atherosclerosis #1
    factitious increase #1
    hyperlipidaemic acute #1
    separative parameter platelets #1
    2adrenoreceptor status #1
    dm dental disease #1
    severe hyponatraemia #1
    new millennium topic #1
    hormones 125 #1
    248 34 years #1
    nigricans ear #1
    significance platelet lifespans #1
    1361086 mmol #1
    single mmol increase #1
    cardiovascular risk xanthelasma #1
    rationale panel #1
    amg fib #1
    tsa correlated #1
    seasonal factitious increase #1
    management hyperlipidaemic #1
    musclerelated effects worsening #1
    cardiogenic starvation #1
    consequence therapies #1
    total sialic acid #1
    300 microg protein #1
    nadir plasma sodium #1
    iqr district humans #1
    hyponatraemic patients controls #1
    syndrome acetylneuraminic #1
    hypokalemia addition #1
    ca153 appropriateness #1

    Key People For Sialic Acid

    Top KOLs in the world
    Roland SCHAUER
    sialic acids acetylneuraminic acid clostridium perfringens
    Ajit P Varki
    sialic acids rat liver human evolution
    Leonard Warren
    sialic acids adele marion fielde surface membrane
    James C Paulson
    influenza virus sialic acid receptor specificity
    gaucher disease fatty acids cerebrospinal fluid
    Saul Roseman
    escherichia coli sugar transport sialic acids

    Martin Andrew Crook:Expert Impact

    Concepts for whichMartin Andrew Crookhas direct influence:Sialic acid,  Metabolic syndrome,  Serum sialic,  Serum sialic acid,  Plasma sialic acid,  Cardiovascular disease,  Innate immune,  Acute phase.

    Martin Andrew Crook:KOL impact

    Concepts related to the work of other authors for whichfor which Martin Andrew Crook has influence:Insulin resistance,  Sialic acid,  Type 2 diabetes,  Metabolic syndrome,  Cardiovascular disease,  Subclinical hypothyroidism,  Familial hypercholesterolemia.



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    Department of Chemical Pathology, Guy’s and St Thomas’ and Lewisham and Greenwich Trust, London, United Kingdom | Department of Clinical Biochemistry and Metabolic Medicine, Guys and St Thomas’ Hospital, London, United Kingdom | Department of Clinica