• Disease
  • Mycoplasma
  • Mycoplasma Pneumoniae
  • Joel Barry Baseman

    Prominent publications by Joel Barry Baseman

    KOL Index score: 17223

    The inflammasome is a major regulator of inflammation through its activation of procaspase-1, which cleaves prointerleukin-1β (pro-IL-1β) into its mature form. IL-1β is a critical proinflammatory cytokine that dictates the severity of inflammation associated with a wide spectrum of inflammatory diseases. NLRP3 is a key component of the inflammasome complex, and multiple signals and stimuli trigger formation of the NLRP3 inflammasome complex. In the current study, we uncovered a yet ...

    Also Ranks for: Mycoplasma Pneumoniae |  cards toxin |  nlrp3 inflammasome |  bacterial adp |  host pathogen
    KOL Index score: 13221

    Hydrosalpinx induction in mice by Chlamydia muridarum infection, a model that has been used to study C. trachomatis pathogenesis in women, is known to depend on the cryptic plasmid that encodes eight genes designated pgp1 to pgp8. To identify the plasmid-encoded pathogenic determinants, we evaluated C. muridarum transformants deficient in the plasmid-borne gene pgp3, -4, or -7 for induction of hydrosalpinx. C. muridarum transformants with an in-frame deletion of either pgp3 or -4 but not ...

    Also Ranks for: Chlamydia Muridarum |  virulence factor |  induce hydrosalpinx |  encoded pgp3 |  cryptic plasmid
    KOL Index score: 12714

    Chlamydia trachomatis genome is predicted to encode a type III secretion system consisting of more than 40 open reading frames (ORFs). To test whether these ORFs are expressed and immunogenic during chlamydial infection in humans, we expressed 55 chlamydial ORFs covering all putative type III secretion components plus control molecules as fusion proteins and measured the reactivity of these fusion proteins with antibodies from patients infected with C. trachomatis in the urogenital tract ...

    Also Ranks for: Chlamydia Trachomatis |  protective immunity |  type iii |  bacterial antigens |  genital tract
    KOL Index score: 12711

    Mycoplasma pneumoniae is an atypical bacterial respiratory pathogen known to cause a range of airway inflammation and lung and extrapulmonary pathologies. We recently reported that an M. pneumoniae-derived ADP-ribosylating and vacuolating toxin called community-acquired respiratory distress syndrome (CARDS) toxin is capable of triggering NLRP3 (NLR-family, leucine-rich repeat protein 3) inflammasome activation and interleukin-1β (IL-1β) secretion in macrophages. However, it is unclear ...

    Also Ranks for: Mycoplasma Pneumoniae |  nlrp3 inflammasome |  innate immune |  inflammatory response |  macrophages mice
    KOL Index score: 12569

    Chlamydia has been detected in the gastrointestinal tracts of both animals and humans. However, the mechanism by which Chlamydia colonizes the gut remains unclear. Chlamydia muridarum is known to spread from the genital to the gastrointestinal tracts hematogenously. The C. muridarum plasmid is a key pathogenic determinant in the mouse upper genital tract although plasmid-deficient C. muridarum is still able to colonize the upper genital tract. We now report that plasmid-deficient C. ...

    Also Ranks for: Gastrointestinal Tract |  chlamydia muridarum |  cryptic plasmid |  mouse genital |  intragastric inoculation
    KOL Index score: 11848

    Intravaginal infection with C. muridarum in mice often results in hydrosalpinx similar to that found in women urogenitally infected with C. trachomatis, making the C. muridarum lower genital tract infection murine model suitable for studying C. trachomatis pathogenesis. To our surprise, DBA1/j mice were highly resistant to hydrosalpinx following an intravaginal infection with C. muridarum although these mice were as susceptible to lower genital tract infection as other mouse strains. A ...

    Also Ranks for: Chlamydia Muridarum |  intravaginal inoculation |  mice hydrosalpinx |  tract infections |  mouse strains
    KOL Index score: 11519

    Mycoplasma pneumoniae causes acute and chronic respiratory infections, including tracheobronchitis and community acquired pneumonia, and is linked to asthma and an array of extra-pulmonary disorders. Recently, we identified an ADP-ribosylating and vacuolating toxin of M. pneumoniae, designated Community Acquired Respiratory Distress Syndrome (CARDS) toxin. In this study we analysed CARDS toxin gene (annotated mpn372) transcription and identified its promoter. We also compared CARDS toxin ...

    Also Ranks for: Mycoplasma Pneumoniae |  distress syndrome |  cards toxin |  acquired respiratory |  mammalian cells
    KOL Index score: 11477

    Plasmid-free Chlamydia trachomatis and Chlamydia muridarum fail to induce severe pathology. To evaluate whether the attenuated pathogenicity is due to insufficient infection or inability of the plasmidless chlamydial organisms to trigger pathological responses, we compared plasmid-competent and plasmid-free C. muridarum infections in 5 different strains of mice. All 5 strains developed hydrosalpinx following intravaginal inoculation with plasmid-competent, but not inoculation with ...

    Also Ranks for: Chlamydia Muridarum |  hydrosalpinx mice |  attenuated pathogenicity |  plasmid free |  live organism
    KOL Index score: 10732

    Mice were infected with Mycoplasma pneumoniae and monitored for the synthesis and distribution of the unique adenosine diphosphate-ribosylating and vacuolating Community Acquired Respiratory Distress Syndrome (CARDS) toxin in bronchiolar lavage fluid (BALF) and lung. We noted direct relationships between the concentration of CARDS toxin and numbers of mycoplasma genomes in BALF and the degree of histologic pulmonary inflammation. Immunostaining of lungs revealed extensive colonization by ...

    Also Ranks for: Cards Toxin |  mycoplasma pneumoniae |  lung mice |  lavage fluid |  bacterial proteins
    KOL Index score: 10231

    Previous serological data have demonstrated cross-reactive antigens between two pathogenic species of mycoplasmas, M. pneumoniae and M. genitalium. Preliminary analysis of sera and monoclonal antibodies (MAbs) to protein antigens of these species showed an immunodominance of adhesin P1 (165 kilodaltons [kDa]) of M. pneumoniae in mice and hamsters and a 140-kDa protein of M. genitalium in mice and experimentally infected chimpanzees. To further characterize these two proteins, we assayed ...

    Also Ranks for: Mycoplasma Pneumoniae |  adhesin protein |  antigens bacterial |  140 kda |  monoclonal antibodies
    KOL Index score: 10018

    Mycoplasma genitalium and Mycoplasma pneumoniae are morphologically and serologically related pathogens that colonize the human host. Their successful parasitism appears to be dependent on the product, an adhesin protein, of a gene that is carried by each of these mycoplasmas. Here we describe the cloning and determine the sequence of the structural gene for the putative adhesin of M. genitalium and compare its sequence to the counterpart P1 gene of M. pneumoniae. Regions of homology ...

    Also Ranks for: Mycoplasma Pneumoniae |  bacterial genes |  protein sequence |  trich codons |  adhesin gene
    KOL Index score: 9837

    The specificity of the interaction between Treponema pallidum and fibronectin was demonstrated. Treatment of host cells with only antifibronectin sera and not anticollagen or antilaminin sera, inhibited treponemal cytadsorption. Incubation of fibronectin-coated coverslips with monoclonal antibody to the cell-binding domain of fibronectin reduced treponemal attachment to the same extent as antifibronectin serum. Both iodinated fibronectin and iodinated cell-binding domain bound to T. ...

    Also Ranks for: Treponema Pallidum |  binding domain |  fibronectin receptors |  host cells |  specificity interaction
    KOL Index score: 9825

    BACKGROUND: The role of Mycoplasma pneumoniae (Mp) in the initiation and persistence of asthma remains elusive. Mp community-acquired respiratory distress syndrome toxin (CARDS Tx) is a unique virulence factor that induces an intense lymphocytic response and exacerbates asthma in animal models. We sought to determine the incidence of Mp infection and the presence of CARDS Tx in subjects with refractory asthma (RA).

    METHODS: We conducted a prospective observational study in 64 subjects ...

    Also Ranks for: Refractory Asthma |  mycoplasma pneumoniae |  distress syndrome |  acquired respiratory |  cards tx
    KOL Index score: 9785

    Mycoplasma pneumoniae synthesizes a novel human surfactant protein A (SP-A)-binding cytotoxin, designated community-acquired respiratory distress syndrome (CARDS) toxin, that exhibits ADP-ribosylating and vacuolating activities in mammalian cells and is directly linked to a range of acute and chronic airway diseases, including asthma. In our attempt to detect additional CARDS toxin-binding proteins, we subjected the membrane fraction of human A549 airway cells to affinity chromatography ...

    Also Ranks for: Cards Toxin |  mycoplasma pneumoniae |  distress syndrome |  acquired respiratory |  mammalian cells
    KOL Index score: 9584

    Mycoplasma pneumoniae produces an ADP-ribosylating and vacuolating toxin known as the CARDS (Community Acquired Respiratory Distress Syndrome) toxin that has been shown to be cytotoxic to mammalian cells in tissue and organ culture. In this study we tested the ability of recombinant CARDS (rCARDS) toxin to elicit changes within the pulmonary compartment in both mice and baboons. Animals responded to a respiratory exposure to rCARDS toxin in a dose and activity-dependent manner by ...

    Also Ranks for: Cards Toxin |  mycoplasma pneumoniae |  pulmonary inflammation |  mammalian cells |  animals bacterial


    Joel Barry Baseman: Influence Statistics

    Sample of concepts for which Joel Barry Baseman is among the top experts in the world.
    Concept World rank
    repmp1 sequence #1
    rabbit syphilitic sera #1
    adsorb erythrocytes #1
    mg427 mycoplasma genitalium #1
    mpn133 cytotoxic nuclease #1
    p140 p110 mg218 #1
    synthesis pallidum dna #1
    vacuoles recombinant cards #1
    antigenic probes concentrations #1
    h2o2mediated hemoxidation #1
    pallidum sodium #1
    adherence operons #1
    pneumoniae cytadsorption #1
    pallidum surfaces #1
    mycoplasma viability metabolism #1
    reiteri #1
    operons rtpcr #1
    elisa immunoblot assessments #1
    genitalium smallest #1
    annexin mediates mycoplasma #1
    pathogen monoclonal antibody #1
    avirulent mycoplasmas #1
    140kda genitalium protein #1
    classification clinical isolates #1
    mythical shepherd pathogenesis #1
    genitalium codons #1
    pallidum organisms #1
    loci mg191 #1
    tninduced transformants #1
    pneumoniae pdh #1
    mycoplasmas virulent #1
    surface components ability #1
    protein comigrating peptide #1
    mpn372 adp #1
    region eks #1
    mythical shepherd #1
    transcriptional response genitalium #1
    mycoplasma protein structures #1
    phosphate dehy #1
    interaction penetrans #1
    mycoplasmas terms #1
    genitalium oligonucleotide #1
    avirulent spirochaete protein #1
    lipoprotein acquisition #1
    mg218 strain jb1 #1
    mycoplasma cards tx #1
    treponemal surface proteins #1
    mycoplasmas small genomes #1
    cell density4 #1
    compared cards #1

    Key People For Mycoplasma Pneumoniae

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    Joel Barry Baseman:Expert Impact

    Concepts for whichJoel Barry Basemanhas direct influence:Mycoplasma pneumoniae,  Mycoplasma genitalium,  Treponema pallidum,  Cards toxin,  Bacterial genes,  Chlamydia muridarum,  Gastrointestinal tract,  Clinical isolates.

    Joel Barry Baseman:KOL impact

    Concepts related to the work of other authors for whichfor which Joel Barry Baseman has influence:Mycoplasma pneumoniae,  Treponema pallidum,  Chlamydia trachomatis,  Epithelial cells,  Bacterial proteins,  Escherichia coli,  Diphtheria toxin.



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    Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health San Antonio, 78229, San Antonio, TX, USA | Department of Microbiology, Immunology and Molecular Genetics, The University of Texas Health Science Center at San A