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    • Randall T Higashida
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      Randall T Higashida

      Randall T Higashida

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      Department of Radiology and Biomedical Imaging University of California San Francisco San Francisco CA | Department of Radiology and Biomedical Imaging, Interventional ...

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      Randall T Higashida:Expert Impact

      Concepts for whichRandall T Higashidahas direct influence:Endovascular treatment,Carotid artery,Acute ischemic stroke,Intracranial aneurysms,Ischemic stroke,Galen malformations,Reporting standards,Transluminal angioplasty.

      Randall T Higashida:KOL impact

      Concepts related to the work of other authors for whichfor which Randall T Higashida has influence:Ischemic stroke,Endovascular treatment,Subarachnoid hemorrhage,Intracranial aneurysms,Cognitive impairment,Mechanical thrombectomy,Carotid artery.

      KOL Resume for Randall T Higashida

      Year
      2022

      Department of Radiology and Biomedical Imaging University of California San Francisco San Francisco CA

      2021

      From the Department of Radiology and Biomedical Imaging, Interventional Neuroradiology Section, University of California, San Francisco, San Francisco, California

      2020

      Division of Neurointerventional Radiology, Department of Radiology and Biomedical Imaging (A.C., G.D., M.T.C., E.R.S., D.L.C., M.R.A., C.F.D., V.V.H., R.T.H., S.W.H.), University of California, San Francisco.

      From the Departments of Radiology (J.A.K., D.B.M., D.C.M., P.J.H., C.F.D., V.V.H., R.T.H., M.R.A., S.W.H., D.L.C.) and

      2Department of Neurointerventional Radiology, University of California San Francisco Medical Center, San Francisco, California.

      2019

      University of California San Francisco Medical Center (R.T.H.).

      3Radiology and Biomedical Imaging, and.

      2018

      Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California

      2017

      3 Division of Interventional Neuroradiology, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, USA.

      Neurology (C.F.D., R.T.H., V.V.H.), University of California, San Francisco, San Francisco, California

      From the Department of Radiology and Biomedical Imaging (S.W.H., D.L.C., P.J., M.R.A., C.F.D., R.T.H., V.V.H.)

      2016

      Neurology.

      Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.

      Neurological Surgery, and.

      2015

      From the Division of Interventional Neuroradiology, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California

      Departments of 1Radiology and Biomedical Imaging,

      Department of Radiology and Biomedical Imaging (D.L.C., C.F.D., R.T.H., V.V.H., S.W.H.)

      Neurological Surgery.

      Neurology (C.F.D., R.T.H., V.V.H.)

      2014

      From the Division of Neurointerventional Radiology (S.W.H., D.L.C., M.R.A., J.A.N., P.M., H.M., C.F.D., R.T.H., V.V.H.), Department of Radiology and Biomedical Imaging

      Division of Interventional Neurovascular Radiology, Department of Neuroradiology, University California San Francisco Medical Center, San Francisco, CA, USA

      Neurological Surgery (V.V.H., R.T.H., C.F.D.), University of California, San Francisco, California

      2013

      Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA

      2012

      1Departments of Radiology and Biomedical Imaging,

      From the Departments of Radiology and Biomedical Imaging (S.W.H., K.K., J.D.E., C.F.D., R.T.H., V.V.H.)

      Department of Neurology, UCSF, San Francisco, California, USA

      2011

      Department of Neurological Surgery, University of California, San Francisco, California

      Professor of Neurology, Harvard-MIT Division of Health Science and Technology, Boston, Massachusetts

      Executive Director, Seattle Neuroscience Institute at Swedish Medical Center, Seattle, Washington

      Director, Dresden University Stroke Centre, Dresden, Germany

      2010

      University of California, San Francisco, California, USA

      From the Departments of Radiology (P.J., J.D.E., C.F.D., V.V.H., R.T.H., S.W.H.)

      Neurological Surgery (R.T.H., V.H., C.F.D., M.T.L.)

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      Sample of concepts for which Randall T Higashida is among the top experts in the world.
      Concept World rank
      article written #1
      clinically symptomatic patients #1
      vasospasm pct #1
      endovascular biopsy #1
      analysis fistula type #1
      therapeutic neuroradiology society #1
      dsa brain #1
      neurology computerized #1
      catheter heating scanning #1
      cerebrovascular neurosurgery society #1
      association intracranial hemorrhage #1
      cavernous sinus davf #1
      intracranial aneurysms vivo #1
      acceptable qpcr facs #1
      craniocaudal extent #1
      asymptomatic stenosis review #1
      mss wss #1
      iccfs angiography #1
      interventional therapeutic neuroradiology #1
      directly therapy #1
      parent artery cases #1
      transcranial vasospasm angiography #1
      cases subclavian arteries #1
      hemodynamic forces coils #1
      initial presentation comorbidities #1
      clazosentan mortality #1
      carotid fistulae #1
      aneurysms cavernous segment #1
      intracranial deployment #1
      comorbidities multiple aneurysms #1
      angioplasty intracranial #1
      scholarships internship residency #1
      intracranial circulation cases #1
      craniocervical arteries incidence #1
      fusiform aneurysm 95 #1
      gdc 55 #1
      2 years hypoperfusion #1
      standards intra #1
      cavernous sinus angiography #1
      preservation parent sinus #1
      joint writing society #1
      craniocervical arteries #1
      detection largevessel vasospasm #1
      pmavfs #1
      presented 1 #1
      total monocular blindness #1
      visual grading vasospasm #1
      review series safety #1
      clot independently #1
      12 weeks asah #1
      Sign-in to see all concepts, it's free!

      Prominent publications by Randall T Higashida

      KOL-Index: 27719

      BACKGROUND AND PURPOSE: The National Institutes of Health (NIH) estimates that stroke costs now exceed 45 billion dollars per year. Stroke is the third leading cause of death and one of the leading causes of adult disability in North America, Europe, and Asia. A number of well-designed randomized stroke trials and case series have now been reported in the literature to evaluate the safety and efficacy of thrombolytic therapy for the treatment of acute ischemic stroke. These stroke trials ...

      Known for Reporting Standards | Ischemic Stroke | Trial Design | Thrombolytic Therapy | Intra Arterial
      KOL-Index: 19306

      PURPOSE: To evaluate the utility of perfusion CT (PCT) combined with CT angiography (CTA) for the diagnosis and management of vasospasm, by using conventional digital subtraction angiography (DSA) as the gold standard.

      METHODS: We retrospectively identified 27 patients with acute subarachnoid hemorrhage who had undergone CTA/PCT, DSA, and transcranial Doppler (TCD) ultrasonography within a time interval of 12 hours of one another. The patients' charts were reviewed for treatment of ...

      Known for Subarachnoid Hemorrhage | Angiography Cta | Diagnosis Vasospasm | Gold Standard | Perfusion Pct
      KOL-Index: 18936

      BACKGROUND AND PURPOSE: This scientific statement provides an overview of the evidence on vascular contributions to cognitive impairment and dementia. Vascular contributions to cognitive impairment and dementia of later life are common. Definitions of vascular cognitive impairment (VCI), neuropathology, basic science and pathophysiological aspects, role of neuroimaging and vascular and other associated risk factors, and potential opportunities for prevention and treatment are reviewed. ...

      Known for Cognitive Impairment | Vascular Contributions | Vci Dementia | Alzheimer Disease | Heart Association
      KOL-Index: 15362

      BACKGROUND AND PURPOSE: Current US guideline statements regarding primary and secondary cardiovascular risk prediction and prevention use absolute risk estimates to identify patients who are at high risk for vascular disease events and who may benefit from specific preventive interventions. These guidelines do not explicitly include patients with stroke, however. This statement provides an overview of evidence and arguments supporting (1) the inclusion of patients with stroke, and ...

      Known for Cardiovascular Risk | Patients Stroke | 10 Years | Vascular Disease | Atherosclerotic Ischemic
      KOL-Index: 14165

      BACKGROUND AND PURPOSE: To test the safety and recanalization efficacy of intra-arterial local delivery of plasminogen activators in acute ischemic stroke, a randomized trial of recombinant pro-urokinase (rpro-UK) versus placebo was undertaken in patients with angiographically documented proximal middle cerebral artery occlusion.

      METHODS: After exclusion of intracranial hemorrhage by CT scan, patients with abrupt onset of symptoms of focal ischemia likely to receive treatment within 6 ...

      Known for Cerebral Artery | Acute Middle | 24 Hours | Patients Intravenous Heparin | Neurological Deterioration
      KOL-Index: 13887

      The authors demonstrate the technical feasibility of using intravascular stents in conjunction with electrolytically detachable coils (Guglielmi detachable coils [GDCs]) for treatment of fusiform, broad-based, acutely ruptured intracranial aneurysms and review the literature on endovascular approaches to ruptured aneurysms and cerebral stent placement. A 77-year-old man presented with an acute subarachnoid hemorrhage of the posterior fossa. A fusiform aneurysm with a broad-based neck ...

      Known for Basilar Artery | Intravascular Stent | Ruptured Fusiform | Cerebral Angiography | Occlusion Dome
      KOL-Index: 13711

      PURPOSE: To evaluate the accuracy of multidetector-row CT angiography (CTA) for the diagnosis of large-vessel vasospasm following subarachnoid hemorrhage by comparison to digital subtraction angiography (DSA).

      METHODS: Thirty-three patients with acute subarachnoid hemorrhage were enrolled in a prospective study and underwent a total of 40 CTA and DSA examinations within 24 h of each other. Two neuroradiologists reviewed the CTA examinations independently. A third neuroradiologist blinded ...

      Known for Subarachnoid Hemorrhage | Cta Dsa | Subtraction Angiography | Diagnosis Vasospasm | Gold Standard
      KOL-Index: 13440

      BACKGROUND: Previous studies have suggested that baseline computed tomographic (CT) scans might be a useful tool for selecting particular ischemic stroke patients who would benefit from thrombolysis. The aim of the present study was to assess whether the baseline CT scan, assessed with the Alberta Stroke Program Early CT Score (ASPECTS), could identify ischemic stroke patients who might particularly benefit from intra-arterial thrombolysis of middle cerebral artery occlusion.

      METHODS: ...

      Known for Stroke Patients | Acute Ischemic | Baseline Aspects | Arterial Thrombolysis | Randomized Controlled Trials
      KOL-Index: 13100

      CONTEXT: Intravenous tissue-type plasminogen activator can be beneficial to some patients when given within 3 hours of stroke onset, but many patients present later after stroke onset and alternative treatments are needed.

      OBJECTIVE: To determine the clinical efficacy and safety of intra-arterial (IA) recombinant prourokinase (r-proUK) in patients with acute stroke of less than 6 hours' duration caused by middle cerebral artery (MCA) occlusion.

      DESIGN: PROACT II (Prolyse in Acute ...

      Known for Acute Ischemic Stroke | Randomized Controlled Trial | Onset Patients | Neurological Deterioration | Modified Rankin Score
      KOL-Index: 13041

      Evolution of intracranial aneurysms is known to be related to hemodynamic forces such as wall shear stress (WSS) and maximum shear stress (MSS). Estimation of these parameters can be performed using numerical simulations with computational fluid dynamics (CFD), but can also be directly measured with magnetic resonance imaging (MRI) using a time-dependent 3D phase-contrast sequence with encoding of each of the three components of the velocity vectors (7D-MRV). To study the accuracy of ...

      Known for Computational Fluid Dynamics | Flow Pattern | Velocity Fields | Magnetic Resonance | Intracranial Aneurysms
      KOL-Index: 12489

      OBJECTIVE: Cerebral hyperperfusion syndrome is a recognized complication of carotid endarterectomy, with a reported incidence of 0.3 to 1.2%. The incidence of cerebral hyperperfusion after endovascular revascularization procedures of the craniocervical arteries remains unknown. We evaluated the incidence of cerebral hyperperfusion syndrome in our endovascular revascularization series. To our knowledge, there are no previous studies evaluating the incidence of hyperperfusion syndrome ...

      Known for Cerebral Hyperperfusion | Percutaneous Transluminal | Hemorrhage Patients | Angioplasty Stenting | Carotid Endarterectomy
      KOL-Index: 12196

      BACKGROUND AND PURPOSE: Excessive degradation of the vascular matrix by matrix metalloproteinases (MMPs) can lead to structural instability of vessels. In this study we examined the expression of MMPs and tissue inhibitors of metalloproteinases (TIMPs) in brain arteriovenous malformations (BAVMs).

      METHODS: We performed gelatin zymography for MMPs and Western blot for MMP-9, MMP-2, TIMP-1, TIMP-2, TIMP-3, and TIMP-4. MMP-9 expression was localized by immunohistochemistry.

      RESULTS: We ...

      Known for Matrix Metalloproteinases | Arteriovenous Malformations | Tissue Inhibitors | Abnormal Expression | Mmp9 Timp1
      KOL-Index: 12151

      Computational fluid dynamics (CFD) methods can be used to compute the velocity field in patient-specific vascular geometries for pulsatile physiological flow. Those simulations require geometric and hemodynamic boundary values. The purpose of this study is to demonstrate that CFD models constructed from patient-specific magnetic resonance (MR) angiography and velocimetry data predict flow fields that are in good agreement with in vivo measurements and therefore can provide valuable ...

      Known for Numerical Simulations | Cerebral Aneurysms | Flow Fields | Cfd Models | Vivo Measurements
      KOL-Index: 11954

      BACKGROUND: Clazosentan, an endothelin receptor antagonist, significantly and dose-dependently reduced angiographic vasospasm after aneurysmal subarachnoid haemorrhage (aSAH). We investigated whether clazosentan reduced vasospasm-related morbidity and all-cause mortality.

      METHODS: In this randomised, double-blind, placebo-controlled, phase 3 study, we randomly assigned patients with aSAH secured by surgical clipping to clazosentan (5 mg/h, n=768) or placebo (n=389) for up to 14 days (27 ...

      Known for Surgical Clipping | Clazosentan Patients | Endothelin Receptor | 3 Trial | Subarachnoid Haemorrhage

      Key People For Endovascular Treatment

      Top KOLs in the world
      #1
      Elad I Levy
      acute ischemic stroke intracranial aneurysms endovascular treatment
      #2
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      #3
      Randall T Higashida
      endovascular treatment carotid artery acute ischemic stroke
      #4
      Christophe Cognard
      endovascular treatment intracranial aneurysms acute ischemic stroke
      #5
      Gary R Duckwiler
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      Department of Radiology and Biomedical Imaging University of California San Francisco San Francisco CA | Department of Radiology and Biomedical Imaging, Interventional Neuroradiology Section, University of California San Francisco, 505 Parnassus Ave,

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