• Disease
  • Endovascular
  • Endovascular Treatment
  • Randall T Higashida

    Prominent publications by Randall T Higashida

    KOL Index score: 27719

    BACKGROUND AND PURPOSE: The National Institutes of Health (NIH) estimates that stroke costs now exceed 45 billion dollars per year. Stroke is the third leading cause of death and one of the leading causes of adult disability in North America, Europe, and Asia. A number of well-designed randomized stroke trials and case series have now been reported in the literature to evaluate the safety and efficacy of thrombolytic therapy for the treatment of acute ischemic stroke. These stroke trials ...

    Also Ranks for: Reporting Standards |  ischemic stroke |  trial design |  thrombolytic therapy |  intra arterial
    KOL Index score: 19306

    PURPOSE: To evaluate the utility of perfusion CT (PCT) combined with CT angiography (CTA) for the diagnosis and management of vasospasm, by using conventional digital subtraction angiography (DSA) as the gold standard.

    METHODS: We retrospectively identified 27 patients with acute subarachnoid hemorrhage who had undergone CTA/PCT, DSA, and transcranial Doppler (TCD) ultrasonography within a time interval of 12 hours of one another. The patients' charts were reviewed for treatment of ...

    Also Ranks for: Subarachnoid Hemorrhage |  angiography cta |  diagnosis vasospasm |  gold standard |  perfusion pct
    KOL Index score: 18936

    BACKGROUND AND PURPOSE: This scientific statement provides an overview of the evidence on vascular contributions to cognitive impairment and dementia. Vascular contributions to cognitive impairment and dementia of later life are common. Definitions of vascular cognitive impairment (VCI), neuropathology, basic science and pathophysiological aspects, role of neuroimaging and vascular and other associated risk factors, and potential opportunities for prevention and treatment are reviewed. ...

    Also Ranks for: Cognitive Impairment |  vascular contributions |  vci dementia |  alzheimer disease |  heart association
    KOL Index score: 15362

    BACKGROUND AND PURPOSE: Current US guideline statements regarding primary and secondary cardiovascular risk prediction and prevention use absolute risk estimates to identify patients who are at high risk for vascular disease events and who may benefit from specific preventive interventions. These guidelines do not explicitly include patients with stroke, however. This statement provides an overview of evidence and arguments supporting (1) the inclusion of patients with stroke, and ...

    Also Ranks for: Cardiovascular Risk |  patients stroke |  10 years |  vascular disease |  atherosclerotic ischemic
    KOL Index score: 14165

    BACKGROUND AND PURPOSE: To test the safety and recanalization efficacy of intra-arterial local delivery of plasminogen activators in acute ischemic stroke, a randomized trial of recombinant pro-urokinase (rpro-UK) versus placebo was undertaken in patients with angiographically documented proximal middle cerebral artery occlusion.

    METHODS: After exclusion of intracranial hemorrhage by CT scan, patients with abrupt onset of symptoms of focal ischemia likely to receive treatment within 6 ...

    Also Ranks for: Cerebral Artery |  acute middle |  24 hours |  patients intravenous heparin |  neurological deterioration
    KOL Index score: 13887

    The authors demonstrate the technical feasibility of using intravascular stents in conjunction with electrolytically detachable coils (Guglielmi detachable coils [GDCs]) for treatment of fusiform, broad-based, acutely ruptured intracranial aneurysms and review the literature on endovascular approaches to ruptured aneurysms and cerebral stent placement. A 77-year-old man presented with an acute subarachnoid hemorrhage of the posterior fossa. A fusiform aneurysm with a broad-based neck ...

    Also Ranks for: Basilar Artery |  intravascular stent |  ruptured fusiform |  cerebral angiography |  occlusion dome
    KOL Index score: 13711

    PURPOSE: To evaluate the accuracy of multidetector-row CT angiography (CTA) for the diagnosis of large-vessel vasospasm following subarachnoid hemorrhage by comparison to digital subtraction angiography (DSA).

    METHODS: Thirty-three patients with acute subarachnoid hemorrhage were enrolled in a prospective study and underwent a total of 40 CTA and DSA examinations within 24 h of each other. Two neuroradiologists reviewed the CTA examinations independently. A third neuroradiologist blinded ...

    Also Ranks for: Subarachnoid Hemorrhage |  cta dsa |  subtraction angiography |  diagnosis vasospasm |  gold standard
    KOL Index score: 13440

    BACKGROUND: Previous studies have suggested that baseline computed tomographic (CT) scans might be a useful tool for selecting particular ischemic stroke patients who would benefit from thrombolysis. The aim of the present study was to assess whether the baseline CT scan, assessed with the Alberta Stroke Program Early CT Score (ASPECTS), could identify ischemic stroke patients who might particularly benefit from intra-arterial thrombolysis of middle cerebral artery occlusion.

    METHODS: ...

    Also Ranks for: Stroke Patients |  acute ischemic |  baseline aspects |  arterial thrombolysis |  randomized controlled trials
    KOL Index score: 13100

    CONTEXT: Intravenous tissue-type plasminogen activator can be beneficial to some patients when given within 3 hours of stroke onset, but many patients present later after stroke onset and alternative treatments are needed.

    OBJECTIVE: To determine the clinical efficacy and safety of intra-arterial (IA) recombinant prourokinase (r-proUK) in patients with acute stroke of less than 6 hours' duration caused by middle cerebral artery (MCA) occlusion.

    DESIGN: PROACT II (Prolyse in Acute ...

    Also Ranks for: Acute Ischemic Stroke |  randomized controlled trial |  onset patients |  neurological deterioration |  modified rankin score
    KOL Index score: 13041

    Evolution of intracranial aneurysms is known to be related to hemodynamic forces such as wall shear stress (WSS) and maximum shear stress (MSS). Estimation of these parameters can be performed using numerical simulations with computational fluid dynamics (CFD), but can also be directly measured with magnetic resonance imaging (MRI) using a time-dependent 3D phase-contrast sequence with encoding of each of the three components of the velocity vectors (7D-MRV). To study the accuracy of ...

    Also Ranks for: Computational Fluid Dynamics |  flow pattern |  velocity fields |  magnetic resonance |  intracranial aneurysms
    KOL Index score: 12489

    OBJECTIVE: Cerebral hyperperfusion syndrome is a recognized complication of carotid endarterectomy, with a reported incidence of 0.3 to 1.2%. The incidence of cerebral hyperperfusion after endovascular revascularization procedures of the craniocervical arteries remains unknown. We evaluated the incidence of cerebral hyperperfusion syndrome in our endovascular revascularization series. To our knowledge, there are no previous studies evaluating the incidence of hyperperfusion syndrome ...

    Also Ranks for: Cerebral Hyperperfusion |  percutaneous transluminal |  hemorrhage patients |  angioplasty stenting |  carotid endarterectomy
    KOL Index score: 12196

    BACKGROUND AND PURPOSE: Excessive degradation of the vascular matrix by matrix metalloproteinases (MMPs) can lead to structural instability of vessels. In this study we examined the expression of MMPs and tissue inhibitors of metalloproteinases (TIMPs) in brain arteriovenous malformations (BAVMs).

    METHODS: We performed gelatin zymography for MMPs and Western blot for MMP-9, MMP-2, TIMP-1, TIMP-2, TIMP-3, and TIMP-4. MMP-9 expression was localized by immunohistochemistry.

    RESULTS: We ...

    Also Ranks for: Matrix Metalloproteinases |  arteriovenous malformations |  tissue inhibitors |  abnormal expression |  mmp9 timp1
    KOL Index score: 12151

    Computational fluid dynamics (CFD) methods can be used to compute the velocity field in patient-specific vascular geometries for pulsatile physiological flow. Those simulations require geometric and hemodynamic boundary values. The purpose of this study is to demonstrate that CFD models constructed from patient-specific magnetic resonance (MR) angiography and velocimetry data predict flow fields that are in good agreement with in vivo measurements and therefore can provide valuable ...

    Also Ranks for: Numerical Simulations |  cerebral aneurysms |  flow fields |  cfd models |  vivo measurements
    KOL Index score: 11954

    BACKGROUND: Clazosentan, an endothelin receptor antagonist, significantly and dose-dependently reduced angiographic vasospasm after aneurysmal subarachnoid haemorrhage (aSAH). We investigated whether clazosentan reduced vasospasm-related morbidity and all-cause mortality.

    METHODS: In this randomised, double-blind, placebo-controlled, phase 3 study, we randomly assigned patients with aSAH secured by surgical clipping to clazosentan (5 mg/h, n=768) or placebo (n=389) for up to 14 days (27 ...

    Also Ranks for: Surgical Clipping |  clazosentan patients |  endothelin receptor |  3 trial |  subarachnoid haemorrhage


    Randall T Higashida: Influence Statistics

    Sample of concepts for which Randall T Higashida is among the top experts in the world.
    Concept World rank
    cervical carotid angioplasty #1
    hemorrhage neurological dysfunction #1
    eca dural #1
    standards intracranial atherosclerosis #1
    lcm fluorescence #1
    doppler transcranial angioplasty #1
    case embolization #1
    clot independently #1
    embolization branches #1
    occluded occipital sinus #1
    transvascular coil treatment #1
    tests subarachnoid hemorrhage #1
    diameter return #1
    pediatric pial #1
    rapid cta ctp #1
    conventional techniques angiography #1
    calcified fragments injection #1
    hypoperfusion stable lesions #1
    polyarteritis nodosa methods #1
    neck region meningiomas #1
    stroke neurology neurosurgery #1
    outcomes stroke trials #1
    interventional approach patients #1
    intrathecal venous drainage #1
    intrathecal venous #1
    progression fistulas #1
    flow fields vivo #1
    subarachnoid hemorrhage comparison #1
    dural avf role #1
    deployment aneurysm #1
    avf oestrogen #1
    directly aneurysm #1
    clinical followup examination #1
    extracranial conjunction #1
    joint cerebrovascular #1
    recommendationsat #1
    adjacent medulla #1
    cases cervical angioplasty #1
    embolization liquid embolics #1
    clazosentan vasospasm #1
    technique current status #1
    cardiovascular surgery anesthesia #1
    cavernous carotid fistulae #1
    stents intracranial deployment #1
    novo fistulas #1
    acquired pial #1
    vascular supply tumor #1
    observer variation perfusion #1
    ica stenting case #1
    disability atherosclerosis #1

    Key People For Endovascular Treatment

    Top KOLs in the world
    Elad I Levy
    acute ischemic stroke intracranial aneurysms endovascular treatment
    Willem Jan J van Rooij
    intracranial aneurysms endovascular treatment carotid artery
    Randall T Higashida
    endovascular treatment carotid artery acute ischemic stroke
    Christophe Cognard
    endovascular treatment intracranial aneurysms acute ischemic stroke
    Gary R Duckwiler
    mechanical thrombectomy endovascular treatment acute ischemic stroke
    Alain Weill
    endovascular treatment intracranial aneurysms flow diversion

    Randall T Higashida:Expert Impact

    Concepts for whichRandall T Higashidahas direct influence:Endovascular treatment,  Carotid artery,  Acute ischemic stroke,  Intracranial aneurysms,  Ischemic stroke,  Galen malformations,  Reporting standards,  Transluminal angioplasty.

    Randall T Higashida:KOL impact

    Concepts related to the work of other authors for whichfor which Randall T Higashida has influence:Ischemic stroke,  Endovascular treatment,  Subarachnoid hemorrhage,  Intracranial aneurysms,  Cognitive impairment,  Mechanical thrombectomy,  Carotid artery.



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    Department of Radiology and Biomedical Imaging University of California San Francisco San Francisco CA | Department of Radiology and Biomedical Imaging, Interventional Neuroradiology Section, University of California San Francisco, 505 Parnassus Ave,