Prominent publications by Robert Frederich Spetzler

KOL Index score: 15153

OBJECT: The authors report the 6-year results of the Barrow Ruptured Aneurysm Trial (BRAT). This ongoing randomized trial, with the final goal of a 10-year follow-up, compares the safety and efficacy of surgical clip occlusion and endovascular coil embolization in patients presenting with subarachnoid hemorrhage (SAH) from a ruptured aneurysm. The 1- and 3-year results of this trial have been previously reported.

METHODS: In total, 500 patients with an SAH met the entry criteria and were ...

Known for Ruptured Aneurysm |  Coiling Patients |  Retreatment Rates |  6 Years |  Clipping Treatment
KOL Index score: 14738

OBJECT: The authors prospectively compared a new technique of surgical microscope-based indocyanine green (ICG) videoangiography with intraoperative or postoperative digital subtraction (DS) angiography.

METHOD: The technique was performed during 187 surgical procedures in which 124 aneurysms in 114 patients were clipped. Using a newly developed setup, the ICG technique has been integrated into an operating microscope (Carl Zeiss Co., Oberkochen, Germany). A microscope-integrated light ...

Known for Green Videoangiography |  Aneurysm Surgery |  Infrared Indocyanine |  Prospective Evaluation |  Surgical Microscope
KOL Index score: 14498

OBJECTIVE: This study was designed to quantify the operative exposure obtained in the pterional, orbitozygomatic, and modified orbitozygomatic with maxillary extension surgical approaches.

METHODS: The pterional and orbitozygomatic approaches and a variation of the orbitozygomatic osteotomy that included an extra centimeter of bone resection in the inferior direction ("maxillary extension") were performed on cadaveric heads. For each surgical exposure, the working area was determined by ...

Known for Orbitozygomatic Approach |  Maxillary Extension |  Angle Attack |  Surgical Exposure |  Cranial Base
KOL Index score: 13148

OBJECTIVE: Recovery of posterior communicating artery aneurysm-induced oculomotor nerve palsy (ONP) after aneurysm coiling has been reported. However, the coil mass may compromise recovery of the nerve. Therefore, we compared the outcome of coiling and clipping for this indication.

METHODS: We retrospectively compared the outcomes of ONP in 13 patients, six of whom underwent endovascular coiling and seven of whom underwent surgical clipping.

RESULTS: Six of the seven surgical patients ...

Known for Oculomotor Nerve |  Onp Patients |  Communicating Artery |  Surgical Clipping |  Endovascular Coiling
KOL Index score: 12763

OBJECT: The purpose of this ongoing study is to compare the safety and efficacy of microsurgical clipping and endovascular coil embolization for the treatment of acutely ruptured cerebral aneurysms and to determine if one treatment is superior to the other by examining clinical and angiographic outcomes. The authors examined the null hypothesis that no difference exists between the 2 treatment modalities in the setting of subarachnoid hemorrhage (SAH). The current report is limited to ...

Known for Coil Embolization |  Ruptured Aneurysm |  1 Year |  Poor Outcome |  Patients Assigned
KOL Index score: 12547

BACKGROUND: Given advances in endovascular technique, the indications for revascularization in aneurysm surgery have declined.

OBJECTIVE: We sought to define indications, outline technical strategies, and evaluate the outcomes of patients treated with bypass in the endovascular era.

METHODS: We retrospectively reviewed all aneurysms treated between September 2006 and February 2013.

RESULTS: We identified 54 consecutive patients (16 males and 39 females) with 56 aneurysms. Aneurysms were ...

Known for Aneurysm Surgery |  Cerebral Artery |  Mca Female Humans |  Outcomes Endovascular |  Revascularization Child
KOL Index score: 12462

THE THERAPEUTIC APPROACH toward arteriovenous malformations (AVMs) located in the basal ganglia, thalamus, and brain stem has evolved from microsurgical resection as the predominant therapy to a combination of microsurgery, embolization, and radiosurgery. This multimodality treatment was used in the management of 32 patients with deep AVMs of all sizes. Twenty-two patients with surgically accessible AVMs (i.e., typically located in the brain stem and thalamus) underwent microsurgical ...

Known for Brain Stem |  Multimodality Treatment |  Radiosurgery Patients |  Arteriovenous Malformations |  Basal Ganglia
KOL Index score: 12215

OBJECT: The authors report the 3-year results of the Barrow Ruptured Aneurysm Trial (BRAT). The objective of this ongoing randomized trial is to compare the safety and efficacy of microsurgical clip occlusion and endovascular coil embolization for the treatment of acutely ruptured cerebral aneurysms and to compare functional outcomes based on clinical and angiographic data. The 1-year results have been previously reported.

METHODS: Two-hundred thirty-eight patients were assigned to clip ...

Known for Ruptured Aneurysm |  Coil Embolization |  Posterior Circulation |  Poor Outcome |  Rate Retreatment
KOL Index score: 12199

OBJECT: Greater extent of resection (EOR) for patients with low-grade glioma (LGG) corresponds with improved clinical outcome, yet remains a central challenge to the neurosurgical oncologist. Although 5-aminolevulinic acid (5-ALA)-induced tumor fluorescence is a strategy that can improve EOR in gliomas, only glioblastomas routinely fluoresce following 5-ALA administration. Intraoperative confocal microscopy adapts conventional confocal technology to a handheld probe that provides ...

Known for Confocal Microscopy |  Acid Fluorescence |  Grade Gliomas |  Microsurgical Resection |  Tumor Infiltration
KOL Index score: 11918

OBJECT: In this study the authors quantified a subgroup of patients with Spetzler-Martin Grades IV and V arteriovenous malformations (AVMs) recommended for complete, partial, or no treatment, and calculated the retrospective hemorrhage rate for these lesions.

METHODS: Between July 1997 and May 2000, 73 consecutive patients with Grades IV and V AVMs were evaluated prospectively by the cerebrovascular team at Barrow Neurological Institute. Treatment recommendations given to the patients or ...

Known for Treatment Avm |  Patients Hemorrhage |  Martin Grades |  Intracranial Arteriovenous |  Retrospective Studies
KOL Index score: 11866

BACKGROUND: Although the Fisher scale is commonly used to grade vasospasm risk in aneurysmal subarachnoid hemorrhage (aSAH) patients, it fails to account for increasing subarachnoid hemorrhage (SAH) thickness.

OBJECTIVE: We developed a simple quantitative scale based on maximal SAH thickness and compared its reproducibility and ability to predict symptomatic vasospasm against the Fisher scale.

METHODS: The incidence of radiographic and symptomatic vasospasm among 250 aSAH patients ...

Known for Symptomatic Vasospasm |  Fisher Scale |  Computed Tomography |  Subarachnoid Hemorrhage |  Tests Reproducibility
KOL Index score: 11744

Modified Linac radiosurgery was utilized at our institution between 1990 and 1995 in 54 patients with cerebral arteriovenous malformations (AVMs) as part of a multimodality therapeutic approach. Most patients also underwent surgery and embolization of the AVMs prior to radiosurgery. The goal of the adjunctive radiosurgical treatment was the complete angiographic obliteration of the deep residual AVM after subtotal embolization and resection. Radiosurgery was used as the primary treatment ...

Known for Arteriovenous Malformations |  Multimodality Treatment |  Surgery Radiosurgery |  37 Patients |  Embolization Avms
KOL Index score: 11711

Recent laboratory studies have demonstrated that intracisternal administration of recombinant tissue plasminogen activator (rt-PA) can facilitate the normal clearing of blood from the subarachnoid space and prevent or ameliorate delayed arterial spasm. The results of a preliminary Phase I trial of intracisternal rt-PA in 10 patients are reported with documented aneurysmal subarachnoid hemorrhage (SAH). All patients enrolled were classified as clinical Grade III or IV (according to Hunt ...

Known for Plasminogen Activator |  Subarachnoid Hemorrhage |  Patients Patient |  48 Hours |  Fisher Grade
KOL Index score: 11551

Revascularization is an important component of treatment for complex aneurysms that cannot be directly clipped and instead require parent vessel occlusion. A consecutive series of 61 patients with 63 aneurysms requiring cerebral revascularization is presented. Aneurysms were located along the petrous internal carotid artery (ICA) (n = 5), the cavernous ICA (n = 16), the supraclinoid ICA (n = 12), the middle cerebral artery (n = 17), the anterior cerebral artery (n = 4), the vertebral ...

Known for Aneurysm Surgery |  Current Techniques |  Superficial Temporal Artery |  Cerebral Revascularization |  Supraclinoid Ica
KOL Index score: 11467

When dealing with skull base tumors that encase the internal carotid artery (ICA), the surgeon must decide between ICA preservation and incomplete tumor resection, or radical resection with ICA sacrifice. In our experience with more than 300 anterior skull base tumors, the ICA was sacrificed in only 10 patients. These tumors were malignant, except for one meningioma that occluded the ICA and produced translent ischemic symptoms. All patients had the ICA resected with the tumor, and all ...

Known for Skull Base Tumors |  Radical Resection |  Internal Carotid Artery |  Ica Sacrifice |  Bonnet Bypass


Robert Frederich Spetzler: Influence Statistics

Sample of concepts for which Robert Frederich Spetzler is among the top experts in the world.
Concept World rank
thalamus treatment cavernous #1
cerebral aneurysms aneurysm #1
surgical resection bscms #1
ppix visualization #1
transanterior perforating #1
surgeries patient outcomes #1
brain cervical spine #1
icp nimodipine infusion #1
training vascular neurosurgery #1
clfla #1
vertical angle approach #1
pru ≥170 #1
dvs sss #1
early rebleeding avms #1
intraoperative stereoscopic #1
acute sialadenitis #1
branch eca #1
basilar artery pret #1
width sss #1
vertical exposure moz #1
vasospasm incidence #1
ruptured mca aneurysms #1
approach exposure #1
patients pericallosal aneurysms #1
capillary telangiectasia #1
neck tear #1
aih approach lesions #1
bscm patients #1
fornix column exposure #1
fistula intraoperative angiography #1
barbiturateinduced coma #1
novo presentation #1
attack orbitozygomatic approach #1
large juvenile angiofibromas #1
transsylvian transchoroidal #1
primary repair arteriotomy #1
willis angles #1
eaa hypothermia #1
intracerebral avm #1
coiling 1 year #1
noneloquent cortex #1
37 patients radiosurgery #1
sth approaches scit #1
cotton aneurysms #1
eor gliomas #1
ruptured aneurysm location #1
aneurysm circle #1
lesions intradural lesions #1
microsurgical brat #1
nbca liquid adhesive #1

Key People For Cavernous Malformations

Top KOLs in the world
Robert Frederich Spetzler
cavernous malformations subarachnoid hemorrhage intracranial aneurysms
Issam A Awad
cerebral cavernous malformations intraventricular hemorrhage magnetic resonance
Daniele R Rigamonti
cavernous malformations superficial siderosis spinal epidural abscess
Joseph M Zabramski
cavernous malformations subarachnoid hemorrhage saccular aneurysms
computed tomography magnetic resonance cavernous malformations
John R Robinson
vascular malformations cavernous angioma clinical disability

Robert Frederich Spetzler:Expert Impact

Concepts for whichRobert Frederich Spetzlerhas direct influence:Cavernous malformations,  Arteriovenous malformations,  Subarachnoid hemorrhage,  Intracranial aneurysms,  Spinal cord,  Surgical management,  Intracranial aneurysm,  Skull base.

Robert Frederich Spetzler:KOL impact

Concepts related to the work of other authors for whichfor which Robert Frederich Spetzler has influence:Arteriovenous malformations,  Subarachnoid hemorrhage,  Intracranial aneurysms,  Endovascular treatment,  Magnetic resonance,  Spinal cord,  Vertebral artery.



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Department of Neurological Surgery, Barrow Neurological Institute, Phoenix, AZ, United States. | Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona. | 1Department of Neurosurgery, Bar

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