• Celiac Disease
    • Alessio Fasano
    • Alessio Fasano: Influence Statistics

      Alessio Fasano

      Alessio Fasano

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      Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA | Department of Pediatrics, Massachusetts General Hospital, Boston, MA. | European Biomedical ...

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      Alessio Fasano:Expert Impact

      Concepts for whichAlessio Fasanohas direct influence:Celiac disease,Intestinal permeability,Zonula occludens,Coeliac disease,Zonula occludens toxin,Tight junctions,Gut microbiota,Vibrio cholerae.

      Alessio Fasano:KOL impact

      Concepts related to the work of other authors for whichfor which Alessio Fasano has influence:Celiac disease,Gut microbiota,Intestinal permeability,Escherichia coli,Glutenfree diet,Vibrio cholerae,Type 1 diabetes.

      KOL Resume for Alessio Fasano


      Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA

      European Biomedical Research Institute of Salerno (EBRIS), Salerno, Italy.

      Harvard Medical School, Boston, MA.


      Division of Pediatric Gastroenterology and Nutrition, MassGeneral Hospital for Children, Harvard Medical School, Boston, MA, 02114;

      Mucosal Immunology and Biology Research Center, Massachusetts General Hospital—Harvard Medical School, Boston, MA 02114, USA;,

      Massachusetts General Hospital, Department of Pediatrics

      European Biomedical Research Institute of Salerno, 84125 Salerno, Italy, ;

      Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA

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      Sample of concepts for which Alessio Fasano is among the top experts in the world.
      Concept World rank
      vibrio cholerae zonula #1
      enterospheres provide #1
      brain distribution doses #1
      cdrelated terms #1
      intestinal toxins #1
      members repeat testing #1
      igaaaa #1
      zonulin tight junction #1
      acd rcd groups #1
      toxin endotoxins #1
      dairy free #1
      east1 sequence analysis #1
      growth developmental consequences #1
      predicting mucosal recovery #1
      intestinal secretion elaboration #1
      tight junctions zonulin #1
      microbiotasiga complexes #1
      clinical studies ncgs #1
      postoperative delayed zonulin #1
      interferonγ gliadin #1
      iqr ncgs patients #1
      multiple unit structure #1
      intestinal tight junctions #1
      hladq2 hladq8 genes #1
      il23 gliadin humans #1
      bacterial pathogenesis discoveries #1
      shet2 ospd3 #1
      gluten exposure risk #1
      coeliac disease utility #1
      marsh iii ced #1
      at1002 presence #1
      hiszot #1
      isolated bacteriophage 2457t #1
      at1002 increased #1
      humans interleukin10 pilot #1
      celiac disease understanding #1
      gliadin induces #1
      drugs paracellular route #1
      csa csa at1002 #1
      consequent disassembly #1
      gluten grains #1
      prehaptoglobin2 #1
      zonulin mouse #1
      fens nec #1
      elisa iga antiendomysium #1
      papp zot #1
      potential putative biomarker #1
      zonulin bacterial products #1
      protective environmental factors #1
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      Prominent publications by Alessio Fasano

      KOL-Index: 17243

      Importance: Biological data are lacking with respect to risk of vertical transmission and mechanisms of fetoplacental protection in maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

      Objective: To quantify SARS-CoV-2 viral load in maternal and neonatal biofluids, transplacental passage of anti-SARS-CoV-2 antibody, and incidence of fetoplacental infection.

      Design, Setting, and Participants: This cohort study was conducted among pregnant women presenting for ...

      Known for Placental Pathology | Vertical Transmission | Sarscov2 Infection | Viral Load | Antibody Transfer
      KOL-Index: 15304

      Plasmids, bacteriophages, and pathogenicity islands are genomic additions that contribute to the evolution of bacterial pathogens. For example, Shigella spp., the causative agents of bacillary dysentery, differ from the closely related commensal Escherichia coli in the presence of a plasmid in Shigella that encodes virulence functions. However, pathogenic bacteria also may lack properties that are characteristic of nonpathogens. Lysine decarboxylase (LDC) activity is present in ...

      Known for Shigella Spp | Black Holes | Enteroinvasive Escherichia | Bacterial Pathogenicity | Genomic Deletion
      KOL-Index: 14906

      BACKGROUND & AIMS: Celiac disease is an immune-mediated enteropathy triggered by gliadin, a component of the grain protein gluten. Gliadin induces an MyD88-dependent zonulin release that leads to increased intestinal permeability, a postulated early element in the pathogenesis of celiac disease. We aimed to establish the molecular basis of gliadin interaction with intestinal mucosa leading to intestinal barrier impairment.

      METHODS: Alpha-gliadin affinity column was loaded with intestinal ...

      Known for Intestinal Permeability | Zonulin Release | Chemokine Receptor | Celiac Disease | Mice Mice
      KOL-Index: 14753

      Celiac disease is an immune-mediated enteropathy caused by a permanent sensitivity to gluten in genetically susceptible individuals. It occurs in children and adolescents with gastrointestinal symptoms, dermatitis herpetiformis, dental enamel defects, osteoporosis, short stature, delayed puberty and persistent iron deficiency anemia and in asymptomatic individuals with type 1 diabetes, Down syndrome, Turner syndrome, Williams syndrome, selective immunoglobulin (Ig)A deficiency and first ...

      Known for Celiac Disease | Pediatric Gastroenterology | Children Adolescents | Hepatology Nutrition | North Society
      KOL-Index: 14441

      BACKGROUND: Autism spectrum disorders (ASD) are complex neurobiological disorders that impair social interactions and communication and lead to restricted, repetitive, and stereotyped patterns of behavior, interests, and activities. The causes of these disorders remain poorly understood, but gut microbiota, the 1013 bacteria in the human intestines, have been implicated because children with ASD often suffer gastrointestinal (GI) problems that correlate with ASD severity. Several ...

      Known for Microbiota Transfer Therapy | Autism Symptoms | Asd Microbiome | 8 Weeks | Label Study
      KOL-Index: 13787

      Importance: The prevalence of gluten-related disorders is rising, and increasing numbers of individuals are empirically trying a gluten-free diet for a variety of signs and symptoms. This review aims to present current evidence regarding screening, diagnosis, and treatment for celiac disease and nonceliac gluten sensitivity.

      Observations: Celiac disease is a gluten-induced immune-mediated enteropathy characterized by a specific genetic genotype (HLA-DQ2 and HLA-DQ8 genes) and ...

      Known for Celiac Disease | Gluten Sensitivity | Intestinal Mucosa | Differential Diet | Wheat Allergy
      KOL-Index: 13767

      OBJECTIVES: Many studies have reported the increased presence of gastrointestinal (GI) symptoms in children with autism spectrum disorders (ASD). Altered microbiome profiles, pro-inflammatory responses and impaired intestinal permeability have been observed in children with ASD and co-morbid GI symptoms, yet few studies have compared these findings to ASD children without GI issues or similarly aged typical developing children. The aim of this study was to determine whether there are ...

      Known for Gastrointestinal Symptoms | Children Asd | Microbiota Profiles | Immune Response | Spectrum Disorder
      KOL-Index: 13731

      BACKGROUND: Recent epidemiologic studies in Europe using antigliadin (AGA) and anti-endomysium antibodies (AEA) for initial screening have shown that the overall prevalence of celiac disease (CD) is about 1:300. There are no comparable scientific data for the USA, where CD is considered rare. The main aim of this study was to determine the prevalence of increased AEA in healthy blood donors in the USA.

      METHODS: Sera from 2000 healthy blood donors were screened for IgG AGA and IgA AGA ...

      Known for Blood Donors | Antiendomysium Antibodies | Celiac Disease | Study Prevalence | Monkey Esophagus
      KOL-Index: 13431

      BACKGROUND: The relationship between the risk of celiac disease and both the age at which gluten is introduced to a child's diet and a child's early dietary pattern is unclear.

      METHODS: We randomly assigned 832 newborns who had a first-degree relative with celiac disease to the introduction of dietary gluten at 6 months (group A) or 12 months (group B). The HLA genotype was determined at 15 months of age, and serologic screening for celiac disease was evaluated at 15, 24, and 36 months ...

      Known for Celiac Disease | 5 Years | Hla Genotype | 36 Months | Age Gluten
      KOL-Index: 12431

      Recent studies have demonstrated the importance of TLR signaling in intestinal homeostasis. Celiac disease (CD) is an autoimmune enteropathy triggered in susceptible individuals by the ingestion of gliadin-containing grains. In this study, we sought to test the hypothesis that gliadin initiates this response by stimulating the innate immune response to increase intestinal permeability and by up-regulating macrophage proinflammatory gene expression and cytokine production. To this end, ...

      Known for Intestinal Permeability | Celiac Disease | Gene Expression | Innate Immune | Gliadin Stimulation
      KOL-Index: 12268

      BACKGROUND: Dysbiosis has been recently demonstrated in patients with ankylosing spondylitis (AS) but its implications in the modulation of intestinal immune responses have never been studied. The aim of this study was to investigate the role of ileal bacteria in modulating local and systemic immune responses in AS.

      METHODS: Ileal biopsies were obtained from 50 HLA-B27+ patients with AS and 20 normal subjects. Silver stain was used to visualise bacteria. Ileal expression of tight and ...

      Known for Ankylosing Spondylitis | Tight Junctions | Vascular Barrier | Bacterial Products | Serum Levels
      KOL-Index: 11698

      OBJECTIVE: Tissue transglutaminase is the autoantigen recognized by the sera of celiac patients. An enzyme-linked immunosorbent assay (ELISA) based on guinea-pig tissue transglutaminase was recently used to measure serum tissue transglutaminase antibodies for the diagnosis of celiac disease. We determine the sensitivity and specificity of an ELISA test based on the use of human recombinant transglutaminase, compared with the guinea pig transglutaminase ELISA and IgA antiendomysium ...

      Known for Celiac Disease | Tissue Transglutaminase | Human Recombinant | Intestinal Biopsy | Specificity Elisa
      KOL-Index: 11402

      Critical to the design and assessment of interventions for enteropathy and its developmental consequences in children living in impoverished conditions are non-invasive biomarkers that can detect intestinal damage and predict its effects on growth and development. We therefore assessed fecal, urinary and systemic biomarkers of enteropathy and growth predictors in 375 6-26 month-old children with varying degrees of malnutrition (stunting or wasting) in Northeast Brazil. 301 of these ...

      Known for Northeast Brazil | Environmental Enteropathy | Inflammation Growth | Fecal Mpo | Intestinal Barrier
      KOL-Index: 11216

      OBJECTIVE: Little is known about the interaction of gliadin with intestinal epithelial cells and the mechanism(s) through which gliadin crosses the intestinal epithelial barrier. We investigated whether gliadin has any immediate effect on zonulin release and signaling.

      MATERIAL AND METHODS: Both ex vivo human small intestines and intestinal cell monolayers were exposed to gliadin, and zonulin release and changes in paracellular permeability were monitored in the presence and absence of ...

      Known for Intestinal Cell | Gut Permeability | Zonulin Release | Gene Expression | Mucosa Intestine
      KOL-Index: 11120

      Celiac disease (CD) is a unique autoimmune disorder in which the genetic factors (DQ2/DQ8) and the environmental trigger (gluten) are known and necessary but not sufficient for its development. Other environmental components contributing to CD are poorly understood. Studies suggest that aspects of gluten intake might influence the risk of CD occurrence and timing of its onset, i.e., the amount and quality of ingested gluten, together with the pattern of infant feeding and the age at ...

      Known for Celiac Disease | Risk Infants | Gluten Exposure | Genetic Factors | Gut Microbiota

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      Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA | Department of Pediatrics, Massachusetts General Hospital, Boston, MA. | European Biomedical Research Institute of Salerno (EBRIS), Salerno, Italy. | Massachusetts General Hos

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