• Disease
  • Type
  • Type 1
  • Type 1 Diabetes
  • Mikael Knip

    Prominent publications by Mikael Knip

    KOL Index score: 23154

    IMPORTANCE: Type 1 diabetes usually has a preclinical phase identified by circulating islet autoantibodies, but the rate of progression to diabetes after seroconversion to islet autoantibodies is uncertain.

    OBJECTIVE: To determine the rate of progression to diabetes after islet autoantibody seroconversion.

    DESIGN, SETTING, AND PARTICIPANTS: Data were pooled from prospective cohort studies performed in Colorado (recruitment, 1993-2006), Finland (recruitment, 1994-2009), and Germany ...

    Also Ranks for: Islet Autoantibodies |  1 diabetes children |  progression diabetes |  autoantibody seroconversion |  risk type
    KOL Index score: 19037

    OBJECTIVE: Antiepileptic drugs (AEDs) have endocrine effects that may interfere with growth and sexual maturation in children. The aim of this study was to evaluate the effects of AEDs on growth and pubertal development in girls with epilepsy.

    STUDY DESIGN: Forty girls taking valproate (VPA), 19 girls taking carbamazepine (CBZ), and 18 girls taking oxcarbazepine (OXC) for epilepsy and 49 healthy control girls participated in the study, which included a cross-sectional clinical ...

    Also Ranks for: Girls Epilepsy |  cbz oxc |  sexual maturation |  effects aeds |  valproate vpa
    KOL Index score: 17025

    PURPOSE: Antiepileptic drugs may affect the serum thyroid hormone concentrations. The aim of this study was to evaluate thyroid function in 78 girls taking carbamazepine (CBZ), oxcarbazepine (OXC), or valproate (VPA) monotherapy for epilepsy and after withdrawal of the treatment.

    METHODS: Forty-one girls taking VPA, 19 taking CBZ, and 18 taking OXC for epilepsy, as well as 54 healthy age-matched controls, aged 8 to 18 years, participated in the study. All the girls were examined ...

    Also Ranks for: Thyroid Function |  valproate monotherapy |  cbz oxc |  epilepsy vpa |  hormone concentrations
    KOL Index score: 15639

    Aims/hypothesisWe evaluated the intake of vitamin D by pregnant Finnish women and examined associations between maternal intake of vitamin D and the development of advanced beta cell autoimmunity and type 1 diabetes in their offspring.MethodsThe research was carried out within the Diabetes Prediction and Prevention study (DIPP), which is a population-based birth cohort of infants at genetic risk of type 1 diabetes. Mothers of 3,723 infants born between 1997 and 2002 completed a validated ...

    Also Ranks for: 1 Diabetes |  maternal intake |  vitamin pregnancy |  risk offspring |  beta cell
    KOL Index score: 15336

    OBJECTIVE: To study the associations between timing and diversity of introduction of complementary foods during infancy and atopic sensitization in 5-year-old children.

    METHODS: In the Finnish DIPP (type 1 diabetes prediction and prevention) birth cohort (n = 3781), data on the timing of infant feeding were collected up to the age of 2 years and serum IgE antibodies toward four food and four inhalant allergens measured at the age of 5 years. Logistic regression was used for the ...

    Also Ranks for: Complementary Foods |  food diversity |  5 years |  birth cohort |  age risk
    KOL Index score: 15246

    BACKGROUND: Vitamin D is known to have a number of immunological effects and it may play a role in preventing allergic diseases. Objectives To study the effect of maternal intake of vitamin D during pregnancy on the emergence of asthma, allergic rhinitis (AR), and atopic eczema by the age of 5 years in children with HLA-DQB1-conferred susceptibility for type 1 diabetes.

    METHODS: Children (1669) participating in the population-based birth cohort study were followed for asthma, AR, and ...

    Also Ranks for: Maternal Vitamin |  allergic rhinitis |  pregnancy asthma |  5 years |  atopic eczema
    KOL Index score: 14595

    OBJECTIVE: The goal was to examine the relationship between age at the introduction of solid foods during the first year of life and allergic sensitization in 5-year-old children.

    METHODS: We analyzed data from the Finnish Type 1 Diabetes Prediction and Prevention nutrition study, a prospective, birth cohort study. We studied 994 children with HLA-conferred susceptibility to type 1 diabetes mellitus for whom information on breastfeeding, age at the introduction of solid foods, and ...

    Also Ranks for: Solid Foods |  5 years |  age introduction |  allergic sensitization |  infant food
    KOL Index score: 14512

    The aim of this study was to evaluate the frequency and predictive value of diabetes-associated autoantibodies, such as islet cell antibodies (ICA) and autoantibodies to insulin (IAA), GAD65 (GADA), and the IA-2 molecule (IA-2A) in genetically susceptible children from the general population during the first 2 yr of life. Of 12,170 newborn infants, 1,005 with increased genetic risk of type 1 diabetes (high risk, human leukocyte antigen DQB1*02/*0302; moderate risk, DQB1*0302/x, where x = ...

    Also Ranks for: 1 Diabetes |  young children |  iaa gada |  cell autoimmunity |  genetic susceptibility
    KOL Index score: 14177

    BACKGROUND: In mouse models of diabetes, prophylactic administration of insulin reduced incidence of the disease. We investigated whether administration of nasal insulin decreased the incidence of type 1 diabetes, in children with HLA genotypes and autoantibodies increasing the risk of the disease.

    METHODS: At three university hospitals in Turku, Oulu, and Tampere (Finland), we analysed cord blood samples of 116 720 consecutively born infants, and 3430 of their siblings, for the HLA-DQB1 ...

    Also Ranks for: Nasal Insulin |  1 diabetes |  controlled trial |  hla genotypes |  autoantibodies type
    KOL Index score: 14139

    A nationwide mumps-measles-rubella vaccination was introduced in 1982 in Finland to children aged 1.5 to 6 years and since then mumps has virtually disappeared in the country. We investigated whether this rapid epidemiological change had any impact on antibody activity against mumps virus in Type 1 (insulin-dependent) diabetic children or on the incidence of Type 1 diabetes in Finland. Two case-control series were collected before (series I and II) and three series after (series III–V) ...

    Also Ranks for: Type 1 |  diabetic children |  rubella vaccine |  rising incidence |  measles mumps
    KOL Index score: 14138

    OBJECTIVE: The pathophysiological mechanisms of growth impairment frequently associated with the obstructive sleep apnea syndrome (OSAS) in children are poorly defined. The main objective of this study was to evaluate whether nighttime upper airway obstruction attributable to adenotonsillar hypertrophy and subsequent surgical treatment affect the circulating concentrations of insulin-like growth factor-I (IGF-I) and IGF-binding protein 3 (IGFBP-3) along with other growth parameters in ...

    Also Ranks for: Obstructive Sleep |  osas children |  biochemical markers |  circulating concentrations |  igfi igfbp3
    KOL Index score: 14091

    BACKGROUND: Recent observations have indicated that reproductive endocrine disorders are common among women taking valproate (VPA) for epilepsy, but it is not known whether respective abnormalities develop in men taking VPA for epilepsy. Carbamazepine (CBZ) may induce endocrine disorders in men with epilepsy, but the endocrine effects of oxcarbazepine (OXC) are not known.

    METHODS: Reproductive endocrine function was evaluated in 90 men taking VPA (n = 21), CBZ (n = 40), or OXC (n = 29) ...

    Also Ranks for: Vpa Epilepsy |  cbz oxc |  endocrine effects |  serum concentrations |  valproate carbamazepine
    KOL Index score: 13938

    We recently reported the frequent occurrence of polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy, especially when the medication was started before the age of 20 years. In the present study we evaluated the association of obesity and hyperinsulinemia with valproate-related polycystic ovaries and hyperandrogenism in women with epilepsy. Sixty-five women participated in the study. Twenty-two received valproate monotherapy and 43 received carbamazepine ...

    Also Ranks for: Women Valproate |  polycystic ovaries |  binding protein |  growth factor |  obesity hyperinsulinemia
    KOL Index score: 13911

    OBJECTIVE: Young children have an unacceptably high prevalence of diabetic ketoacidosis (DKA) at the clinical diagnosis of type 1 diabetes. The aim of this study was to determine whether knowledge of genetic risk and close follow-up for development of islet autoantibodies through participation in The Environmental Determinants of Diabetes in the Young (TEDDY) study results in lower prevalence of DKA at diabetes onset in children aged <2 and <5 years compared with population-based ...

    Also Ranks for: Young Children |  type 1 diabetes |  diabetic ketoacidosis |  dka diagnosis |  5 years


    Mikael Knip: Influence Statistics

    Sample of concepts for which Mikael Knip is among the top experts in the world.
    Concept World rank
    vaccinated mice cvb1 #1
    icas siblings #1
    femoral bmds survivors #1
    early‐life exposure #1
    genus acinetobacter sensitization #1
    ljungan virus seropositivity #1
    land cover children #1
    interleukin 10 genotypes #1
    children sporadic disease #1
    enterovirus antibody #1
    infant formula age #1
    diabetes antibodies #1
    zinc transporter diagnosis #1
    t1d life #1
    children northern europe #1
    girls vpa #1
    genetic susceptibility type #1
    nct00179777 #1
    mbl2 genotype risk #1
    01156 #1
    seroconversion hla risk #1
    early hormonal #1
    enterovirus antibody levels #1
    introduction diet #1
    autoantibodypositive donors #1
    hladr3dq2 haplotype children #1
    maternal antibodies duration #1
    elimination infants #1
    children ica #1
    prediabetic children #1
    iaa positivity #1
    pfas infants #1
    oats 95 #1
    enterovirus infections pathogenesis #1
    gad65 gad65mab #1
    gd weight #1
    appearance autoantibodies #1
    autoantibodynegative children #1
    insulin‐binding activity #1
    diabetes¶methods #1
    enterovirus positivity children #1
    gadas ia2as #1
    n11p0026 #1
    risk 1 diabetes #1
    t1d—an #1
    whf bovine insulin #1
    putative environmental factors #1
    boys diagnosis #1
    hladqb1 genotype #1
    evs clinical development #1

    Key People For Type 1 Diabetes

    Top KOLs in the world
    John M Lachin
    type 1 diabetes cardiovascular disease complications trial
    David Matthew Nathan
    type 2 diabetes insulin resistance cardiovascular disease
    William V Tamborlane
    type 1 diabetes young children growth hormone
    Patricia A Cleary
    type 1 diabetes optic neuritis intensive therapy
    George S Eisenbarth
    type 1 diabetes nod mice celiac disease
    Marian J Rewers
    type 1 diabetes islet autoimmunity celiac disease

    Mikael Knip:Expert Impact

    Concepts for whichMikael Kniphas direct influence:Type 1 diabetes,  1 diabetes,  Type 1,  Celiac disease,  Diabetes mellitus,  Preschool diabetes mellitus,  Islet autoimmunity,  Enterovirus infections.

    Mikael Knip:KOL impact

    Concepts related to the work of other authors for whichfor which Mikael Knip has influence:Type 1 diabetes,  Celiac disease,  Gut microbiota,  Insulin resistance,  Metabolic syndrome,  Islet autoimmunity,  Physical activity.



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    Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, 00100 Helsinki, Finland. | Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Fin