• Disease
  • Central
  • Central Chondrosarcoma
  • Judith V M G Bovée

    Prominent publications by Judith V M G Bovée

    KOL Index score: 17778

    BACKGROUND: Pathological complete response to preoperative treatment in adults with soft-tissue sarcoma can be achieved in only a few patients receiving radiotherapy. This phase 2-3 trial evaluated the safety and efficacy of the hafnium oxide (HfO2) nanoparticle NBTXR3 activated by radiotherapy versus radiotherapy alone as a pre-operative treatment in patients with locally advanced soft-tissue sarcoma.

    METHODS: Act.In.Sarc is a phase 2-3 randomised, multicentre, international trial. ...

    Also Ranks for: Nbtxr3 Radiotherapy |  tissue sarcoma |  preoperative treatment |  hafnium oxide |  primary endpoint
    KOL Index score: 14478

    Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas that can show overlapping features with benign neurofibromas as well as high-grade sarcomas. Additional diagnostic markers are needed to aid in this often challenging differential diagnosis. Recently mutations in two critical components of the polycomb repressor 2 (PRC2) complex, SUZ12 and EED, were reported to occur specifically in MPNSTs while such mutations are absent in neurofibromas, both in the setting of ...

    Also Ranks for: Inferior Survival |  mpnsts loss |  diagnostic marker |  h3k27me3 immunohistochemistry |  h3k27 trimethylation
    KOL Index score: 14274

    BACKGROUND: Chondrosarcomas are malignant cartilage-forming tumors notorious for their resistance to conventional chemo- and radiotherapy. Postulated explanations describe the inaccessibility due to abundant hyaline cartilaginous matrix, presence of multidrug resistance (MDR) pumps, and expression of anti-apoptotic BCL-2 family members.

    MATERIALS AND METHODS: We studied the sensitivity of chondrosarcoma cell lines (SW1353, CH2879, JJ012, OUMS27) and two primary cultures for doxorubicin ...

    Also Ranks for: Doxorubicin Cisplatin |  chondrosarcoma cells |  bcl2 members |  inhibitory concentration |  multidrug resistance
    KOL Index score: 13862

    Chondrosarcomas are malignant cartilage-forming tumors arising centrally in bone (central chondrosarcoma) or within the cartilaginous cap of osteochondroma (peripheral chondrosarcoma). For hereditary multiple osteochondromas, two responsible genes, EXT1 and EXT2, have been cloned. Their recently elucidated role in heparan sulfate biosynthesis and Hedgehog diffusion leads to the hypothesis that EXT inactivation affects fibroblast growth factor (FGF) and Indian Hedgehog (IHh)/parathyroid ...

    Also Ranks for: Central Chondrosarcoma |  fibroblast growth factor |  neoplastic genes |  type 1 receptors |  pthrp fgf
    KOL Index score: 13825

    OBJECTIVE: The aim of this study was to evaluate a series of primary melanomas of the female urogenital tract for oncogenic mutations in KIT, NRAS and BRAF in order to identify patients who may be amenable to targeted therapy.

    METHODS: We reviewed twenty-four cases of female urogenital tract melanomas and used Sanger sequencing analysis for the detection of oncogenic mutations in exons 9, 11, 13, and 17 of KIT; exons 2 and 3 of NRAS; and exon 15 of BRAF.

    RESULTS: Twenty-four patients ...

    Also Ranks for: Kit Mutations |  melanomas female |  proto oncogene |  vaginal melanoma |  genital neoplasms
    KOL Index score: 13673

    Angiosarcomas constitute a heterogeneous group of highly malignant vascular tumors. Angiosarcoma of bone is rare and poorly characterized. For angiosarcoma of soft tissue, some pathways seem to be involved in tumor development. Our aim was to evaluate the role of these pathways in angiosarcoma of bone. We collected 37 primary angiosarcomas of bone and used 20 angiosarcomas of soft tissue for comparison. Immunohistochemistry was performed on constructed tissue microarrays to evaluate ...

    Also Ranks for: Soft Tissue |  bone angiosarcomas |  3 kinases |  class phosphatidylinositol |  hemangiosarcoma humans
    KOL Index score: 12725

    OBJECTIVES: To test the hypothesis that somatic phosphatidylinositol-4,5-bisphospate 3-kinase, catalytic subunit alpha (PIK3CA) mutations would be found in patients with more common disorders including isolated lymphatic malformation (LM) and Klippel-Trenaunay syndrome (KTS).

    STUDY DESIGN: We used next generation sequencing, droplet digital polymerase chain reaction, and single molecule molecular inversion probes to search for somatic PIK3CA mutations in affected tissue from patients ...

    Also Ranks for: Somatic Mutations |  patients lm |  overgrowth disorders |  boston childrens hospital |  3 kinases
    KOL Index score: 12391

    Osteochondromas occur as sporadic solitary lesions or as multiple lesions, characterizing the hereditary multiple exostoses syndrome (EXT). Approximately 15% of all chondrosarcomas arise within the cartilaginous cap of an osteochondroma. EXT is genetically heterogeneous, and two genes, EXT1 and EXT2, located on 8q24 and 11p11-p12, respectively, have been cloned. It is still unclear whether osteochondroma is a developmental disorder or a true neoplasm. Furthermore, it is unclear whether ...

    Also Ranks for: Mutation Analysis |  loss heterozygosity |  secondary chondrosarcomas |  multiple osteochondromas |  ext gene
    KOL Index score: 11732

    Specific H3F3A driver mutations and IDH2 mutations were recently described in giant cell tumor of bone (GCTB) and H3F3B driver mutations in chondroblastoma; these may be helpful as a diagnostic tool for giant cell-containing tumors of the bone. Using Sanger sequencing, we determined the frequency of H3F3A, H3F3B, IDH1, and IDH2 mutations in GCTBs (n=60), chondroblastomas (n=12), and other giant cell-containing tumors (n=24), including aneurysmal bone cyst, chondromyxoid fibroma, and ...

    Also Ranks for: Cell Tumor |  diagnostic tool |  h3f3a h3f3b |  bone gctb |  idh2 mutations
    KOL Index score: 11632

    Recently, heterozygous mutations in exon 2 of the mediator complex subunit 12 gene have been described in 50% to 70% of uterine leiomyomas; the recurrent nature of these mutations suggests an important role in their pathogenesis. Mediator complex subunit 12 is involved in regulation of transcription and Wnt signaling. So far, little is known about the pathogenesis of the different subtypes of extrauterine leiomyomas and leiomyosarcomas. We performed mutation analysis of mediator complex ...

    Also Ranks for: Mediator Complex Subunit |  smooth muscle tumors |  uterine leiomyomas |  mutation analysis |  genetic heterogeneity
    KOL Index score: 11615

    Ollier disease and Maffucci syndrome are non-hereditary skeletal disorders characterized by multiple enchondromas (Ollier disease) combined with spindle cell hemangiomas (Maffucci syndrome). We report somatic heterozygous mutations in IDH1 (c.394C>T encoding an R132C substitution and c.395G>A encoding an R132H substitution) or IDH2 (c.516G>C encoding R172S) in 87% of enchondromas (benign cartilage tumors) and in 70% of spindle cell hemangiomas (benign vascular lesions). In total, 35 of ...

    Also Ranks for: Ollier Disease |  maffucci syndrome |  idh2 mutations |  spindle cell |  cartilage tumors
    KOL Index score: 11005

    Vascular tumors of bone are a heterogeneous group. Numerous terms have been introduced as well as different classification systems. None of the classification schemes have been accepted due to lack of consistent terminology, accepted histologic criteria, and limited correlation with clinical outcome. It is acknowledged that vascular tumors of bone originate from endothelial cells, resulting in variable expression of endothelial markers. None of these markers are useful to discriminate ...

    Also Ranks for: Vascular Tumors |  epithelioid hemangioendothelioma |  classification intermediate category |  endothelial markers |  differential diagnosis
    KOL Index score: 10857

    Succinate dehydrogenase (SDH) and fumarate hydratase (FH) are tricarboxylic acid (TCA) cycle enzymes and tumor suppressors. Loss-of-function mutations give rise to hereditary paragangliomas/pheochromocytomas and hereditary leiomyomatosis and renal cell carcinoma. Inactivation of SDH and FH results in an abnormal accumulation of their substrates succinate and fumarate, leading to inhibition of numerous α-ketoglutarate dependent dioxygenases, including histone demethylases and the ...

    Also Ranks for: Sdh Fh |  succinate dehydrogenase |  paraganglioma pheochromocytoma |  5 hmc |  mixed function
    KOL Index score: 10840

    Chondrosarcomas are notorious for their resistance to conventional chemotherapy and radiotherapy, indicating there are no curative treatment possibilities for patients with inoperable or metastatic disease. We therefore explored the existence of molecular targets for systemic treatment of chondrosarcoma using kinome profiling. Peptide array was performed for four chondrosarcoma cell lines and nine primary chondrosarcoma cultures with GIST882, MSCs, and colorectal cancer cell lines as ...

    Also Ranks for: Kinome Profiling |  src kinase |  chondrosarcoma cell |  systemic treatment |  conventional chemotherapy
    KOL Index score: 10771

    Osteosarcoma is a bone tumor, displaying significant cellular and histological heterogeneity and a complex genetic phenotype. Although multiple studies strongly suggest the presence of cancer stem cells in osteosarcoma, a consensus on their characterization is still missing. We used a combination of functional assays (sphere-forming, Aldefluor, and side-population) for identification of cancer stem cell populations in osteosarcoma cell lines. Expression of stemness-related transcription ...

    Also Ranks for: Stem Cells |  osteosarcoma cell |  transcription factors |  bone tumor |  catenin signaling


    Judith V M G Bovée: Influence Statistics

    Sample of concepts for which Judith V M G Bovée is among the top experts in the world.
    Concept World rank
    osteochondroma low #1
    integrating morphology #1
    nras mutation treatment #1
    peripheral chondrosarcomagenesis mouse #1
    ext1 drive #1
    newly introduced entities #1
    increasing histological grade #1
    underlying osteoid osteoma #1
    malignant cartilage #1
    ch2879 #1
    dedifferentiation chondrosarcoma #1
    entities soft #1
    rare chondrosarcoma #1
    6osulphated disaccharide #1
    ext1 loss #1
    dedifferentiated subtype #1
    gct giant #1
    chondrosarcoma cell lines #1
    rational targeted #1
    differentiated chordoma summary #1
    fusions vascular #1
    flat copy profiles #1
    positive sts samples #1
    msi metabolite #1
    increasing histological #1
    progression sulphation #1
    rtks chondrosarcoma #1
    validate psme1 #1
    cases conventional chondrosarcoma #1
    cartilageforming tumors bone #1
    chondrosarcoma prognosis #1
    chondrosarcoma metabolome #1
    hey1ncoa2 fusions immense #1
    enchondroma development #1
    mesenchymal clear cell #1
    sixteen chondrosarcomas #1
    myxoid tumors activation #1
    psme1 poor survival #1
    molecular pathogenesis diagnostic #1
    fticrmsi #1
    experimental guideline #1
    growth chondrosarcoma #1
    clinically targeted biomarkers #1
    diagnosis cartilage tumors #1
    subset chondrosarcomas #1
    polyploidization chromosomes #1
    subsequent polyploidization #1
    mouse osteochondroma #1
    conventional chemo #1
    swapping gene #1

    Key People For Central Chondrosarcoma

    Top KOLs in the world
    Pancras C W Hogendoorn•
    ewing sarcoma cell lines soft tissue
    Judith V M G Bovée
    soft tissue cell lines vascular tumors
    Antonie H M Taminiau
    ollier disease long bones functional ability
    Alberto G Ayala
    urinary bladder cell carcinoma prostate cancer
    Marvin M Romsdahl
    colorectal carcinoma radiation therapy tumor cells
    Harry L Evans
    clinicopathologic study soft tissue lymph nodes

    Judith V M G Bovée:Expert Impact

    Concepts for whichJudith V M G Bovéehas direct influence:Central chondrosarcoma,  Soft tissue,  Cell lines,  Tissue factor,  Vascular tumors,  Clear cell,  Multiple osteochondromas,  Bone tumors.

    Judith V M G Bovée:KOL impact

    Concepts related to the work of other authors for whichfor which Judith V M G Bovée has influence:Soft tissue,  Mass spectrometry,  Giant cell tumor,  Dna methylation,  Chondrosarcoma cells,  Bone sarcomas,  Situ hybridization.



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    Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands | Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands | Department of Pathology, Leiden University Medical Center, 2333 ZA Leiden, The N