Roger Packer

Roger Packer

From The Divisions Of Neurology (Jch, Rp) And Infectious Diseases (Sp), The Children's Hospital Of Philadelphia, Philadelphia, Pa, And The Division Of Viral Diseases, Center ...

Direct Impact

Concepts for which Roger Packer has direct influence:

central nervous
nf1 tumors
stem cells
children neurofibromatosis
vision loss

External impact

Concepts related to the work of other authors for which Roger Packer has influence:

pontine gliomas
imaging features
non-necrotic t2-hyperintense foci
leptomeningeal dissemination
diffuse intrinsic
10-year population-based
canadian paediatric brain tumour

Prominent publications by Roger Packer

KOL-Index: 84 BACKGROUND: This study describes imaging features of diffuse intrinsic pontine glioma (DIPG) and correlates with overall survival (OS) and histone mutation status in the International DIPG Registry (IDIPGR). METHODS: Four hundred cases submitted to the IDIPGR with a local diagnosis of DIPG and baseline MRI were evaluated by consensus review of 2 neuroradiologists; 43 cases were excluded ...
Known for
Mri Features | Dipg Diagnosis | Local Central | Larger Size
KOL-Index: 63 Infant high-grade gliomas appear clinically distinct from their counterparts in older children, indicating that histopathologic grading may not accurately reflect the biology of these tumors. We have collected 241 cases under 4 years of age, and carried out histologic review, methylation profiling, and custom panel, genome, or exome sequencing. After excluding tumors representing other ...
Known for
Proportion | Targetable Mapk Alterations | Kinase Fusion-Positive Tumors | 4
KOL-Index: 38 BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) remains a clinico-radiologic diagnosis without routine tissue acquisition. Reliable imaging distinction between DIPG and other pontine tumors with potentially more favorable prognoses and treatment considerations is essential. METHODS: Cases submitted to the International DIPG registry (IDIPGR) with histopathologic and/or radiologic data ...
Known for
Diagnostic Brain Mris | Imaging Classified | Dipg Alternative | 77
KOL-Index: 28 Purpose Diffuse intrinsic pontine glioma (DIPG) is a brainstem malignancy with a median survival of < 1 year. The International and European Society for Pediatric Oncology DIPG Registries collaborated to compare clinical, radiologic, and histomolecular characteristics between short-term survivors (STSs) and long-term survivors (LTSs). Materials and Methods Data abstracted from registry ...
Known for
Longer Symptom Duration | Short-Term Survivors | Austria | Cranial Nerve Palsy
KOL-Index: 18 PURPOSE: Children with pediatric gliomas harboring a BRAF V600E mutation have poor outcomes with current chemoradiotherapy strategies. Our aim was to study the role of targeted BRAF inhibition in these tumors. PATIENTS AND METHODS: We collected clinical, imaging, molecular, and outcome information from patients with BRAF V600E-mutated glioma treated with BRAF inhibition across 29 centers ...
Known for
Plgg Responses | Current Chemoradiotherapy Strategies | 36 | Concomitant Homozygous Deletion
KOL-Index: 6 In the summer of 1987 five children were seen at The Children's Hospital of Philadelphia because of acute onset of flaccid paralysis of an arm or leg(s). Although there were documented exposures to oral poliovirus vaccine and coxsackievirus B3 in some of the cases, the clinical, epidemiologic and laboratory findings indicate that enterovirus 71 was the common etiologic agent for this unusual ...
Known for
Oral Poliovirus Vaccine | Paralysis Enterovirus | Acute Onset | Philadelphia
KOL-Index: 2 BACKGROUND: Cross-sectional tumor measures are traditional clinical trial endpoints; however volumetric measures may better assess tumor growth. We determined the correlation and compared the prognostic impact of cross-sectional and volumetric measures of progressive disease (PD) among patients with DIPG. METHODS: Imaging and clinical data were abstracted from the International DIPG ...
Known for
Landmark | Log-Rank | Ellipsoid | Nine-Month Timepoints
KOL-Index: 2 Objectives 1. Establish an induced pluripotent stem cell (iPSC) bank for phenotypically well-characterized patients with NF1.2. Develop isogenic NF1 wild-type (NF1+/+), NF1 heterozygous (NF1+/-) and NF1 homozygous (NF1-/-) iPSC lines from individual patients using CRISPR/CAS9 technology.3. Differentiate and characterize disease-relevant brain cells such as excitatory and inhibitory neurons, ...
Known for
Stem Lines | Children Neurofibromatosis | Morbidity Opgs | Isogenic Nf1
KOL-Index: 2 This study will evaluate the feasibility of combining two drugs, Tarceva (an anti-EGFR agent), and Rapamycin (an mTOR inhibitor), in children with progressive low-grade gliomas who have failed initial conventional treatment. In addition to evaluating the toxicity of this drug regimen, the potential efficacy of the regimen will be assessed.. This study will evaluate the feasibility of ...

From the Divisions of Neurology (JCH, RP) and Infectious Diseases (SP), The Children's Hospital of Philadelphia, Philadelphia, PA, and the Division of Viral Diseases, Center for Infectious Diseases (SGM, MP, LBS), and Division of Immunization, Center

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