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    • Yoichi Nakazato
    • Yoichi Nakazato

      Yoichi Nakazato

      Department of Pathology, Hidaka Hospital, Gunma 3700001, Japan;, nakazato_yoichi@gunma-u.ac.jp | Department of Pathology, Hidaka Hospital, 886 Nakao-machi, 370-0001, Takasaki, ...

       

       

      KOL Resume for Yoichi Nakazato

      Year
      2022

      Department of Pathology, Hidaka Hospital, Gunma 3700001, Japan;,

      2021

      Department of Pathology, Hidaka Hospital, 886 Nakao-machi, 370-0001, Takasaki, Gunma, Japan

      2020

      6Department of Pathology, Hidaka Hospital, Gunma, Japan; and.

      2019

      Department of Neurosurgery and Neuro-oncology, National Cancer Center Hospital, Tokyo, Japan

      2017

      From the Department of Neurology (S.H.), Gunma Rehabilitation Hospital, Agatsuma; Department of Neurology (S.H.), Gunma University Graduate School of Medicine, Maebashi; Department of Neurosurgery (N.A.), Numata Neurosurgery and Heart Disease Hospital; Department of Pathology (Y.N.), Hidaka Hospital, Takasaki; and Department of Neurology (K.O.), Geriatrics Research Institute and Hospital, Maebashi, Japan.

      2016

      Department of Pathology Hidaka Hospital Gunma Japan

      2015

      Department of Pathology, Hidaka Hospital, 886 Nakaomachi, 370-0001, Takasaki City, Gunma, Japan

      2014

      Department of Human Pathology, Gunma University Graduate School of Medicine, Maebashi, Japan

      2013

      10Department of Human Pathology, Gunma University Graduate School of Medicine, Gunma; and

      Department of Human Pathology, University of Gunma Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan

      2012

      Department of Human Pathology, Gunma University Graduate School of Medicine, 3-39-22, Showa, Maebashi, Gunma 371-8511, Japan

      2011

      9Department of Human Pathology, Gunma University, Gunma, Japan

      Pathology, Gunma University Graduate School of Medicine

      Departments of Human Pathology

      2010

      Department of Human Pathology, Graduate School of Medicine, Gunma University

      2009

      Department of Human Pathology, Gunma University Graduate School of Medicine, Maebashi 3718511, Japan

      2008

      Department of Human Pathology, Gunma University Graduate School of Medicine, and

      2007

      Department of Human Pathology, Gunma University Graduate School of Medicine, Maebashi and

      Pathology, Gunma University Graduate School of Medicine, Maebashishi, Gunma, Japan

      2006

      Department of Pathology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan

      2005

      First Department of Pathology, Gunma University School of Medicine

      2004

      Department of Human Pathology, Gunma University Graduate School of Medicine, Maebashi,

      2003

      Department of the First Pathology, Gunma University School of Medicine, Japan, JP

      2002

      Department of Pathology, Gunma University School of Medicine, Maebashi, Japan, JP

      2001

      Pathology, Gunma University School of Medicine, Maebashi-shi, Gunma, Japan

      First Department of Pathology

       

       

      Yoichi Nakazato: Influence Statistics

      Sample of concepts for which Yoichi Nakazato is among the top experts in the world.
      Concept World rank
      schwannoma degenerative structures #1
      gliomas nestin #1
      lsamp epithelioid glioblastoma #1
      neuropillike background #1
      468 154 #1
      etantr male neoplasms #1
      gliomas anaplastic #1
      rhabdoid appearance #1
      40yearoldmale #1
      leu 7 weeks #1
      olig2 tma technology #1
      injection srlp25 #1
      taupositive granules #1
      cnas epithelioid cells #1
      ppt pineocytoma #1
      glial cell components #1
      retroperitoneal epithelioid #1
      pinealoma adult antibodies #1
      neurocytic rosettes #1
      tumor extensive #1
      equivocal class staining #1
      antibody normallooking #1
      bielschowsky bodian #1
      variant picks disease #1
      antibodies pinealoma adult #1
      disease entity omt #1
      case picks disease #1
      pair intermediate filament #1
      sarcomas unclassified tumor #1
      malignant rts #1
      35000 50000 daltons #1
      parkinsons disease dlbd #1
      papillary rhabdoid #1
      immunoreactivity olig2 #1
      68 160 kda #1
      lowgrade intramedullary tumors #1
      19q1342 amplification diagnosis #1
      straight parallel tubules #1
      human pineal body #1
      primitive polar spongioblastoma #1
      neurodegenerative region putamen #1
      electron lucent core #1
      heterozygosity oligodendroglia #1
      epileptic clinical parameters #1
      shortsurvival periods #1
      egfr overexpression cases #1
      cadherin immunohistochemical biomarkers #1
      stomach cytokeratin #1
      cadherins hemangiopericytoma #1
      ependymoblastic #1

       

      Prominent publications by Yoichi Nakazato

      KOL-Index: 14278

      Abnormal neuronal aggregates of α-internexin and the three neurofilament (NF) subunits, NF-L, NF-M, and NF-H have recently been identified as the pathological hallmarks of neuronal intermediate filament (IF) inclusion disease (NIFID), a novel neurological disease of early onset with a variable clinical phenotype including frontotemporal dementia, pyramidal and extrapyramidal signs. α-Internexin, a class IV IF protein, a major component of inclusions in NIFID, has not previously been ...

      Known for Neurodegenerative Diseases | Inclusion Disease | Neuronal Intermediate | Α Internexin | Major Component
      KOL-Index: 11463

      Evidence has been accumulated that glioblastoma cells release and exploit glutamate for proliferation and migration by autocrine or paracrine loops through Ca2+-permeable AMPA-type glutamate receptors. Here, we show that Ca2+ signaling mediated by AMPA receptor regulates the growth and motility of glioblastoma cells via activation of Akt. Ca2+ supplied through Ca2+-permeable AMPA receptor phosphorylated Akt at Ser-473, thereby facilitating proliferation and mobility. A dominant-negative ...

      Known for Ampa Receptor | Human Glioblastoma | Proliferation Migration | Tumor Cells | Activation Akt
      KOL-Index: 11097

      Abstract. We examined the brains of Tg2576 transgenic mice carrying human amyloid precursor protein with the Swedish mutation and Alzheimer's disease (AD) by means of immunohistochemistry and electron microscopy to clarify the characteristics of amyloid-associated pathology in the transgenic mice. In 12- to 29-month-old Tg2576 mice, congophilic cored plaques in the neocortex and hippocampus were labeled by all of the Aβ1-, Aβ40- and 42-specific antibodies, as seen in the classical ...

      Known for Transgenic Mice | Cored Plaques | Dystrophic Neurites | Activated Microglia | Antigens Differentiation
      KOL-Index: 10576

      We compared the ultrastructure between diffuse and primitive plaques in the brains of senile dementia, using pairs of routine electron microscopic ultrathin sections and adjacent semithin sections, which were immunolabeled for β protein. In the frontal cortex, amyloid fibrils were rarely seen in a minority of diffuse plaques, suggesting an initial stage of the diffuse plaques. A majority of the diffuse plaques had electrondense material and/or amyloid fibrils between cell processes in ...

      Known for Diffuse Plaques | Senile Dementia | Alzheimer Type | Amyloid Fibrils | Degenerating Neurites
      KOL-Index: 10473

      One of the type VI intermediate filament proteins, nestin, is expressed in neuroepithelial stem cells during neural embryogenesis. Nestin is also expressed in a variety of neoplasms. Its expression in brain tumors has not been thoroughly studied. The objectives of this study were to survey nestin expression in different types of brain tumor, and to evaluate nestin as a marker for diagnosis and prognosis. We used tissue microarrays of 257 brain tumors for an immunohistochemical overview ...

      Known for Nestin Expression | Brain Tumors | Grade Gliomas | Pathological Diagnosis | Tissue Microarrays
      KOL-Index: 10417

      Abstractp73 protein, a member of the p53 family protein, induce p21 and MDM2 transcription. In some carcinomas, the expression of p73 was higher in carcinoma than in normal tissue, and the overexpression was correlated to grade, stage or prognosis. However, either the expression of p73 protein or the relationship among p73, p21 and MDM2 proteins was not known well in glioma. In this study, we examined the expression of p73, p21 and MDM2 proteins immunohistochemically and analyzed the ...

      Known for P73 P21 | Mdm2 Proteins | Tumor Type | Proto Oncogene | Brain Neoplasms
      KOL-Index: 10077

      Neuronal intermediate filament (IF) inclusion disease (NIFID) is a novel neurological disease of early onset with a variable clinical phenotype including frontotemporal dementia, pyramidal, and extrapyramidal signs. Pathologically, in affected areas, there is neuronal loss, astrocytosis, and neuronal intracytoplasmic aggregates of abnormal neuronal IFs that contain neither tau nor alpha-synuclein. Thus, to characterize the neuronal IF protein profile of inclusions in NIFID, ...

      Known for Inclusion Disease | Intermediate Filament | Neuronal Proteins | Frontotemporal Dementia | Cases Nifid
      KOL-Index: 9925

      Recently, it was reported that ependymoblastoma and embryonal tumor with abundant neuropil and true rosettes (ETANTR) show 19q13.42 amplification at a high frequency, suggesting that these tumors may constitute a single entity. As ependymoblastic rosettes are the most prominent features in both subtypes, embryonal tumor with multilayered rosettes (ETMR) was proposed, for which 19q13.42 amplification represents a specific molecular hallmark. However, ependymoblastic rosettes are not ...

      Known for Multilayered Rosettes | 19q1342 Amplification | Brain Tumors | Etantr Ependymoblastoma | Embryonal Tumor
      KOL-Index: 9842

      PurposeGlioblastoma (GBM) is one of the worst cancers in terms of prognosis. Standard therapy consists of resection with concomitant chemoradiotherapy. Resistance to nimustine hydrochloride (ACNU), an alkylating agent, has been linked to methylguanine DNA methyltransferase (MGMT). Daily administration of procarbazine (PCZ) has been reported to decrease MGMT activity. This study investigated the efficacy of ACNU + PCZ compared to ACNU alone for GBM and anaplastic astrocytoma ...

      Known for Acnu Patients | Nimustine Hydrochloride | Anaplastic Astrocytoma | Standard Therapy | Primary Endpoint
      KOL-Index: 9479

      The Golgi apparatus (GA) of the large pyramidal motor neurons in the cerebral cortex (Betz cells), was examined in sixteen patients with sporadic amyotrophic lateral sclerosis (ALS), in one patient with familial ALS (FALS), and in ten non-ALS age matched controls including one patient with Huntington's disease and one patient with a brain infarct. The GA was immunostained with an antibody against the MG-160 protein, a conserved sialoglycoprotein of the medial cisternae of the organelle. ...

      Known for Betz Cells | Golgi Apparatus | Lateral Sclerosis | Motor Neurons | Transgenic Mice
      KOL-Index: 9326

      Immunohistochemical localization of S-100 protein, its α andβ subunits, and glial fibrillary acidic protein (GFAP) in normal and neoplastic salivary glands was studied by the peroxidase-antiperoxidase method and immunoblot analysis. Positive immunostaining for S-100 protein was observed in pleomorphic adenoma, adenolymphoma, tubular adenoma, adenoid cystic carcinoma, acinic cell tumour, adenocarcinoma and carcinoma in pleomorphic adenoma. S-100 protein was localized in myoepithelial ...

      Known for Salivary Gland | S100 Protein | Fibrillary Acidic | Immunohistochemical Distribution | Pleomorphic Adenoma
      KOL-Index: 9228

      BACKGROUND: Recently described neuronal intermediate filament inclusion disease (NIFID) shows considerable clinical heterogeneity.

      OBJECTIVE: To assess the spectrum of the clinical and neuropathological features in 10 NIFID cases.

      METHODS: Retrospective chart and comprehensive neuropathological review of these NIFID cases was conducted.

      RESULTS: The mean age at onset was 40.8 (range 23 to 56) years, mean disease duration was 4.5 (range 2.7 to 13) years, and mean age at death was 45.3 ...

      Known for Neuronal Intermediate | Inclusion Disease | Ftd Mnd | Nifid Cases | Spinal Cord
      KOL-Index: 9190

      Nestin is one of the intermediate filaments abundantly produced in the developing central nervous system and somites in the embryonic stage. Nestin is also reportedly detected in gliomas/glioblastomas. We retested nestin expression in brain tumors having a range of malignancy grades using immunostaining. The intensity of nestin immunostaining roughly paralleled the malignancy grade of the gliomas. However, many tumors were negative for nestin immunostaining, while nestin immunostaining ...

      Known for Endothelial Cells | Proliferative Endothelium | Nestin Marker | Brain Tumors | Intermediate Filaments

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      Yoichi Nakazato:Expert Impact

      Concepts for whichYoichi Nakazatohas direct influence:Central nervous,  Oligodendroglial tumors,  Schwann cells,  Brain tumors,  Diffuse plaques,  Tumor cells,  Diffuse astrocytomas,  Astrocytic tumors.

      Yoichi Nakazato:KOL impact

      Concepts related to the work of other authors for whichfor which Yoichi Nakazato has influence:Central nervous,  Alzheimer disease,  Spinal cord,  Amyotrophic lateral sclerosis,  Neurofibrillary tangles,  Tumor cells,  Pineal region.


       

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      Department of Pathology, Hidaka Hospital, Gunma 3700001, Japan;, nakazato_yoichi@gunma-u.ac.jp | Department of Pathology, Hidaka Hospital, 886 Nakao-machi, 370-0001, Takasaki, Gunma, Japan | Hidaka Center for Pathologic Diagnosis and Research, Hidaka

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