Prominent publications by Yoichi Nakazato

KOL Index score: 14278

Abnormal neuronal aggregates of α-internexin and the three neurofilament (NF) subunits, NF-L, NF-M, and NF-H have recently been identified as the pathological hallmarks of neuronal intermediate filament (IF) inclusion disease (NIFID), a novel neurological disease of early onset with a variable clinical phenotype including frontotemporal dementia, pyramidal and extrapyramidal signs. α-Internexin, a class IV IF protein, a major component of inclusions in NIFID, has not previously been ...

Known for Neurodegenerative Diseases |  Inclusion Disease |  Neuronal Intermediate |  Α Internexin |  Major Component
KOL Index score: 11463

Evidence has been accumulated that glioblastoma cells release and exploit glutamate for proliferation and migration by autocrine or paracrine loops through Ca2+-permeable AMPA-type glutamate receptors. Here, we show that Ca2+ signaling mediated by AMPA receptor regulates the growth and motility of glioblastoma cells via activation of Akt. Ca2+ supplied through Ca2+-permeable AMPA receptor phosphorylated Akt at Ser-473, thereby facilitating proliferation and mobility. A dominant-negative ...

Known for Ampa Receptor |  Human Glioblastoma |  Proliferation Migration |  Tumor Cells |  Activation Akt
KOL Index score: 11097

Abstract. We examined the brains of Tg2576 transgenic mice carrying human amyloid precursor protein with the Swedish mutation and Alzheimer's disease (AD) by means of immunohistochemistry and electron microscopy to clarify the characteristics of amyloid-associated pathology in the transgenic mice. In 12- to 29-month-old Tg2576 mice, congophilic cored plaques in the neocortex and hippocampus were labeled by all of the Aβ1-, Aβ40- and 42-specific antibodies, as seen in the classical ...

Known for Transgenic Mice |  Cored Plaques |  Dystrophic Neurites |  Activated Microglia |  Antigens Differentiation
KOL Index score: 10576

We compared the ultrastructure between diffuse and primitive plaques in the brains of senile dementia, using pairs of routine electron microscopic ultrathin sections and adjacent semithin sections, which were immunolabeled for β protein. In the frontal cortex, amyloid fibrils were rarely seen in a minority of diffuse plaques, suggesting an initial stage of the diffuse plaques. A majority of the diffuse plaques had electrondense material and/or amyloid fibrils between cell processes in ...

Known for Diffuse Plaques |  Senile Dementia |  Alzheimer Type |  Amyloid Fibrils |  Degenerating Neurites
KOL Index score: 10473

One of the type VI intermediate filament proteins, nestin, is expressed in neuroepithelial stem cells during neural embryogenesis. Nestin is also expressed in a variety of neoplasms. Its expression in brain tumors has not been thoroughly studied. The objectives of this study were to survey nestin expression in different types of brain tumor, and to evaluate nestin as a marker for diagnosis and prognosis. We used tissue microarrays of 257 brain tumors for an immunohistochemical overview ...

Known for Nestin Expression |  Brain Tumors |  Grade Gliomas |  Pathological Diagnosis |  Tissue Microarrays
KOL Index score: 10417

Abstractp73 protein, a member of the p53 family protein, induce p21 and MDM2 transcription. In some carcinomas, the expression of p73 was higher in carcinoma than in normal tissue, and the overexpression was correlated to grade, stage or prognosis. However, either the expression of p73 protein or the relationship among p73, p21 and MDM2 proteins was not known well in glioma. In this study, we examined the expression of p73, p21 and MDM2 proteins immunohistochemically and analyzed the ...

Known for P73 P21 |  Mdm2 Proteins |  Tumor Type |  Proto Oncogene |  Brain Neoplasms
KOL Index score: 10077

Neuronal intermediate filament (IF) inclusion disease (NIFID) is a novel neurological disease of early onset with a variable clinical phenotype including frontotemporal dementia, pyramidal, and extrapyramidal signs. Pathologically, in affected areas, there is neuronal loss, astrocytosis, and neuronal intracytoplasmic aggregates of abnormal neuronal IFs that contain neither tau nor alpha-synuclein. Thus, to characterize the neuronal IF protein profile of inclusions in NIFID, ...

Known for Inclusion Disease |  Intermediate Filament |  Neuronal Proteins |  Frontotemporal Dementia |  Cases Nifid
KOL Index score: 9925

Recently, it was reported that ependymoblastoma and embryonal tumor with abundant neuropil and true rosettes (ETANTR) show 19q13.42 amplification at a high frequency, suggesting that these tumors may constitute a single entity. As ependymoblastic rosettes are the most prominent features in both subtypes, embryonal tumor with multilayered rosettes (ETMR) was proposed, for which 19q13.42 amplification represents a specific molecular hallmark. However, ependymoblastic rosettes are not ...

Known for Multilayered Rosettes |  19q1342 Amplification |  Brain Tumors |  Etantr Ependymoblastoma |  Embryonal Tumor
KOL Index score: 9842

PurposeGlioblastoma (GBM) is one of the worst cancers in terms of prognosis. Standard therapy consists of resection with concomitant chemoradiotherapy. Resistance to nimustine hydrochloride (ACNU), an alkylating agent, has been linked to methylguanine DNA methyltransferase (MGMT). Daily administration of procarbazine (PCZ) has been reported to decrease MGMT activity. This study investigated the efficacy of ACNU + PCZ compared to ACNU alone for GBM and anaplastic astrocytoma ...

Known for Acnu Patients |  Nimustine Hydrochloride |  Anaplastic Astrocytoma |  Standard Therapy |  Primary Endpoint
KOL Index score: 9479

The Golgi apparatus (GA) of the large pyramidal motor neurons in the cerebral cortex (Betz cells), was examined in sixteen patients with sporadic amyotrophic lateral sclerosis (ALS), in one patient with familial ALS (FALS), and in ten non-ALS age matched controls including one patient with Huntington's disease and one patient with a brain infarct. The GA was immunostained with an antibody against the MG-160 protein, a conserved sialoglycoprotein of the medial cisternae of the organelle. ...

Known for Betz Cells |  Golgi Apparatus |  Lateral Sclerosis |  Motor Neurons |  Transgenic Mice
KOL Index score: 9326

Immunohistochemical localization of S-100 protein, its α andβ subunits, and glial fibrillary acidic protein (GFAP) in normal and neoplastic salivary glands was studied by the peroxidase-antiperoxidase method and immunoblot analysis. Positive immunostaining for S-100 protein was observed in pleomorphic adenoma, adenolymphoma, tubular adenoma, adenoid cystic carcinoma, acinic cell tumour, adenocarcinoma and carcinoma in pleomorphic adenoma. S-100 protein was localized in myoepithelial ...

Known for Salivary Gland |  S100 Protein |  Fibrillary Acidic |  Immunohistochemical Distribution |  Pleomorphic Adenoma
KOL Index score: 9228

BACKGROUND: Recently described neuronal intermediate filament inclusion disease (NIFID) shows considerable clinical heterogeneity.

OBJECTIVE: To assess the spectrum of the clinical and neuropathological features in 10 NIFID cases.

METHODS: Retrospective chart and comprehensive neuropathological review of these NIFID cases was conducted.

RESULTS: The mean age at onset was 40.8 (range 23 to 56) years, mean disease duration was 4.5 (range 2.7 to 13) years, and mean age at death was 45.3 ...

Known for Neuronal Intermediate |  Inclusion Disease |  Ftd Mnd |  Nifid Cases |  Spinal Cord
KOL Index score: 9190

Nestin is one of the intermediate filaments abundantly produced in the developing central nervous system and somites in the embryonic stage. Nestin is also reportedly detected in gliomas/glioblastomas. We retested nestin expression in brain tumors having a range of malignancy grades using immunostaining. The intensity of nestin immunostaining roughly paralleled the malignancy grade of the gliomas. However, many tumors were negative for nestin immunostaining, while nestin immunostaining ...

Known for Endothelial Cells |  Proliferative Endothelium |  Nestin Marker |  Brain Tumors |  Intermediate Filaments


Yoichi Nakazato: Influence Statistics

Sample of concepts for which Yoichi Nakazato is among the top experts in the world.
Concept World rank
antigfap asv #1
olig2 immunopositivity #1
welldemarcated cystic lesion #1
cord rosette #1
central nervous gp1 #1
fewer ependymal rosettes #1
egfr overexpression cases #1
metastatic foci report #1
oculomotor nerve schwannoma #1
etantr ependymoblastoma #1
ovoid organelles #1
vimentin carcinoids #1
anti18ffacbc events #1
ependymoblastoma histology absence #1
oligodendroglial phenotype #1
tumor glial components #1
disease entity omt #1
normal brains immunophenotype #1
distinct nuclear atypia #1
structure suggestive #1
antisera subunit proteins #1
microtubular tangles #1
mac variable immunoreactivity #1
classification indeterminacy #1
ependymoblastic #1
secondary conventional #1
diagnostic criteria indeterminacy #1
19q1342 amplification #1
visualized anti18ffacbc #1
tumor histological analysis #1
α bcrystallin antibodies #1
cish method #1
histopathological features tumors #1
differentiated ganglioglioma #1
nonrectal carcinoids #1
pathognomonic msa #1
primary oligoastrocytomas #1
case picks disease #1
trial anti18ffacbcpet imaging #1
degenerated neurons case #1
variant picks disease #1
regenerative structures #1
factors pxa #1
incidences cd34positive cells #1
gliomas cyclin d1 #1
cystic tumor cerebellar #1
japanese patients glioblastoma #1
vimentin carcinoid tumors #1
pair o6methylguaninedna #1
paired redgreen signal #1

Key People For Central Nervous

Top KOLs in the world
Hans P Lassmann
multiple sclerosis central nervous autoimmune encephalomyelitis
Richard M Ransohoff
multiple sclerosis central nervous chemokine receptors
Fred H Gage
stem cells dentate gyrus adult neurogenesis
Cedric S Raine
multiple sclerosis central nervous autoimmune encephalomyelitis
Wolfgang Brück
multiple sclerosis central nervous wallerian degeneration
Ben Anthony Barres
schwann cells oligodendrocyte differentiation astrocyte activation

Yoichi Nakazato:Expert Impact

Concepts for whichYoichi Nakazatohas direct influence:Central nervous,  Oligodendroglial tumors,  Schwann cells,  Brain tumors,  Diffuse plaques,  Tumor cells,  Diffuse astrocytomas,  Astrocytic tumors.

Yoichi Nakazato:KOL impact

Concepts related to the work of other authors for whichfor which Yoichi Nakazato has influence:Central nervous,  Alzheimer disease,  Spinal cord,  Amyotrophic lateral sclerosis,  Neurofibrillary tangles,  Tumor cells,  Pineal region.



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Department of Pathology, Hidaka Hospital, Gunma 3700001, Japan;, | Department of Pathology, Hidaka Hospital, 886 Nakao-machi, 370-0001, Takasaki, Gunma, Japan | Hidaka Center for Pathologic Diagnosis and Research, Hidaka

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