• Disease
  • Brain
  • Brain Damage
  • Bo K Siesjö

    Prominent publications by BO K Siesjö

    KOL Index score: 19948

    Recirculation following 2 h of focal ischemia due to transient middle cerebral artery (MCA) occlusion has previously been found to be accompanied by an initial, partial recovery of the cellular bioenergetic state and of mitochondrial respiratory functions, with secondary deterioration during the first 2-4 h of reflow. Both the free radical spin trap alpha-phenyl-N-tert-butyl nitrone (PBN) and the immunosuppressant drug FK506 ameliorate the damage incurred by the 2-h period of focal ...

    Also Ranks for: Secondary Mitochondrial |  transient focal |  immunosuppressant drug fk506 |  2 ischemia |  4 recirculation
    KOL Index score: 18179

    Kaasik, A. E., L. Nilsson and B. K. Siesjö. The effect of asphyxia upon the lactate, pyruvate and bicarbonate concentrations of brain tissue and cisternal CSF, and upon the tissue concentrations of phosphocreatine and adenine nucleotides in anesthetized rats. Acta physiol. scand. 1970. 78. 433–447. The effect of asphyxia upon the lactate, pyruvate and bicarbonate concentrations of brain tissue and cisternal CSF, and upon the tissue concentrations of phosphocreatine, ATP, ADP and AMP was ...

    Also Ranks for: Brain Tissue |  adenine nucleotides |  cisternal csf |  anesthetized rats |  phosphocreatine atp
    KOL Index score: 17983

    Kaasik, A. E., L. Nilsson and B. K. Siesjö. The effect of arterial hypotension upon the lactate, pyruvate and bicarbonate concentrations of brain tissue and cisternal CSF, and upon the tissue concentrations of phosphocreatine and adenine nucleotides in anesthetized rats. Acta physiol. scand. 1970. 78. 448–458. The effect of stagnant hypoxia upon the lactate, pyruvate and bicarbonate concentrations of brain tissue and cisternal CSF, and upon the tissue concentrations of phosphocreatine, ...

    Also Ranks for: Brain Tissue |  cisternal csf |  arterial hypotension |  adenine nucleotides |  anesthetized rats
    KOL Index score: 16463

    The present experiments were undertaken to explore the mechanisms of secondary brain damage in focal ischemia of long duration (2 h), followed by recirculation. Recirculation has previously been found to cause partial recovery and secondary deterioration of cellular bioenergetic state, the subsequent damage being ameliorated by a free radical spin trap, alpha-phenyl-N-tert-butyl nitrone (PBN), even when the drug was given 1 (or 3) h after the start of recirculation. Our objective was to ...

    Also Ranks for: Mitochondrial Dysfunction |  secondary deterioration |  1 recirculation |  cerebral ischemia |  cellular bioenergetic state
    KOL Index score: 16147

    The lactate and pyruvate concentrations in cisternal cerebrospinal fluid (CSF), and the lactate, pyruvate, ATP, ADP, phosphocreatine, and creatine concentrations in brain tissue were measured in cats during hyper- and hypocapnia. (PaCO2 10–100 mm Hg). Both the CSF and the tissue concentrations of lactate and pyruvate varied inversely with the arterial CO2 tension. In hypercapnia the tissue lactate/pyruvate ratio increased in accordance with a theoretical curve, calculated for a pH ...

    Also Ranks for: Brain Tissue |  pyruvate concentrations |  cerebrospinal fluid lactate |  hypercapnia hypocapnia |  progressive increase
    KOL Index score: 15906

    The objective of the present experiments was to study metabolic correlates to the localization of neuronal lesions during sustained seizures. To that end, status epilepticus was induced by i.v. administration of bicuculline in immobilized and artificially ventilated rats, since this model is known to cause neuronal cell damage in cerebral cortex and hippocampus but not in the cerebellum. After 20 or 120 min of continuous seizure activity, brain tissue was frozen in situ through the skull ...

    Also Ranks for: Cerebral Cortex |  hippocampus cerebellum |  cyclic nucleotides |  status epilepticus |  sustained seizures
    KOL Index score: 15701

    Levels of mRNA for nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and the tyrosine kinase receptors trkB and trkC have been studied using in situ hybridization in the rat brain after topical application of KCl to the cortical surface (which induces spreading depression). Repeated episodes of spreading depression during 2 h caused a rapid and marked increase of BDNF mRNA levels in deep and, in particular, superficial cortical layers of the ...

    Also Ranks for: Cortical Neurons |  bdnf mrna |  wistar receptor |  spreading depression |  messenger rats
    KOL Index score: 15441

    Release of cytochrome c (cyt c) into cytoplasm initiates caspase-mediated apoptosis, whereas activation of Akt kinase by phosphorylation at serine-473 prevents apoptosis in several cell systems. To investigate cell death and cell survival pathways, the authors studied release of cyt c, activation of caspase, and changes in Akt phosphorylation in rat brains subjected to 15 minutes of ischemia followed by varying periods of reperfusion. The authors found by electron microscopic study that ...

    Also Ranks for: Transient Cerebral Ischemia |  phosphorylation akt |  cell death |  release cyt |  24 hours
    KOL Index score: 14390

    In situ hybridization was used to study expression of mRNAs for members of the nerve growth factor (NGF) family in the rat brain after 2 and 10 min of forebrain ischemia and 1 and 30 min of insulin-induced hypoglycemic coma. Two hours after the ischemic insults, the level of brain-derived neurotrophic factor (BDNF) mRNA was markedly increased in the granule cells of the dentate gyrus, and at 24 h it was still significantly elevated. NGF mRNA showed a pronounced increase 4 h after 2 min ...

    Also Ranks for: Rat Brain |  differential regulation |  neurotrophin 3 |  hypoglycemic coma |  nerve growth factor
    KOL Index score: 13360

    The objective of the study was to estimate changes in extracellular pH (pHe) and intracellular pH (pHi) during seizures and in the recovery period following the arrest of seizure activity. Seizures of 5- and 20-min duration were induced in rats by fluorothyl added to the insufflated gas mixture, and recovery for 5, 15, and 45 min was instituted by withdrawal of the fluorothyl supply following 20 min of continuous seizures. Changes in pHe were measured by double-barreled, liquid ...

    Also Ranks for: Seizure Activity |  phe phi |  normoxic animals |  5 20 |  extra intracellular
    KOL Index score: 13180

    In order to evaluate the metabolism of citric acid cycle intermediates and amino acids in cerebral ischemia, brain tissue was sampled after occlusion of the cerebral circulation for 5 min and, in separate animals, after 15 min of recirculation, with subsequent analyses of cerebral cortex concentrations of citrate, α-ketoglutarate, succinate, fumarate, malate, glutamate, aspartate, GABA, alanine, glutamine, asparagine and ammonia.At the end of the ischemia the tissue was depleted of ...

    Also Ranks for: Acid Cycle |  cerebral cortex |  glycolytic metabolites |  complete ischemia |  gaba alanine
    KOL Index score: 13146

    The present study examines the effects of mild hypothermia and hyperthermia on the density and distribution of ischemic brain damage, and compares these effects to those induced by variations in the duration of ischemia. Body temperatures were maintained at 35 degrees C, 37 degrees C, and 39 degrees C, before, during, and after ischemia, and brain temperatures were held at similar values with a technique that in preliminary experiments proved to avoid intracerebral temperature gradients ...

    Also Ranks for: Brain Damage |  mild hyperthermia |  15 minutes |  induced hypothermia |  temperature effects
    KOL Index score: 12198

    The two immunosuppressants, cyclosporin A (CsA) and FK506, when given 1 and 3 h after the start of reperfusion following 2 h of middle cerebral artery (MCA) occlusion, reduce infarct volume to 30% of control. This suggests a common effect, e.g. one due to suppression of the activation of calcineurin. However, when given by the intracarotid (i.c.) route after only 5 min of recirculation CsA, but not FK506, reduced infarct volume even further, to 10% of control. This was attributed to the ...

    Also Ranks for: Csa Fk506 |  infarct volume |  transient focal ischemia |  cakt rats rats |  proto oncogene
    KOL Index score: 11721

    The protein-tyrosine kinases Trk, TrkB, and TrkC are signal-transducing receptors for a family of neurotrophic factors known as the neurotrophins. Here we show that seizures induced by hippocampal kindling lead to a rapid, transient increase of trkB mRNA and protein in the hippocampus. TrkB is a component of a high affinity receptor for brain-derived neurotrophic factor (BDNF). No change was detected in mRNAs for Trk or TrkC, components of the high affinity nerve growth factor or ...

    Also Ranks for: Trkb Protein |  wistar receptor |  increase bdnf |  brainderived neurotrophic factor |  messenger rats rats


    BO K Siesjö: Influence Statistics

    Sample of concepts for which BO K Siesjö is among the top experts in the world.
    Concept World rank
    phosphorylationproteolysis #1
    time factors phosphofructokinase1 #1
    concentration lactate #1
    cbf metabolic capacity #1
    37 degrees survival #1
    optimal freezing conditions #1
    hypoxia lactates #1
    72 glucose infusion #1
    acid—base balance #1
    acidlabile fraction rate #1
    phenobarbital anesthesia carbohydrate #1
    perfusion defects 5 #1
    unanaesthetized animals #1
    astrocytes ph1 #1
    damage transient ischemia #1
    determinations eeg pattern #1
    seizures hyperglycemic animals #1
    bicarbonate ions plasma #1
    pao2 minimal values #1
    ph1 buffer capacity #1
    brain tissue concentrations #1
    pentylenetetrazole alterations #1
    focal perifocal #1
    dying neurons minutes #1
    brain cells phe #1
    caudoputamen hypercapnia #1
    nxy059 effects #1
    accumulation calcium #1
    decrease bicarbonate concentration #1
    cessation eeg activity #1
    membrane conductances ions #1
    reflow incomplete ischemia #1
    animals needle insertion #1
    phosphocreatine creatine concentrations #1
    gad activity ccx #1
    control shunted groups #1
    ml100g1min1 #1
    phenobarbitone cbf #1
    kety schmidt technique #1
    tissue co2 content #1
    extra intracellular phases #1
    ischemic transient #1
    spite cbf #1
    ischemia brain temperatures #1
    deterioration pbn #1
    co2method #1
    recovery temperature rise #1
    phenobarbital anesthesia cmrgl #1
    30 hypoglycemic #1
    local cerebral circulation #1

    Key People For Brain Damage

    Top KOLs in the world
    BO K Siesjö
    brain damage cerebral cortex blood flow
    Henrik H Hagberg
    brain injury amniotic fluid cervical length
    James B Brierley
    brain damage nadh fluorescence ischaemic cell
    Michael A Moskowitz
    nitric oxide dura mater cerebral ischemia
    Michael Chopp†
    traumatic brain injury functional recovery embolic stroke
    Robert C VANNUCCI
    brain damage newborn dogs immature rat

    BO K Siesjö:Expert Impact

    Concepts for whichBO K Siesjöhas direct influence:Brain damage,  Rat brain,  Cerebral cortex,  Blood flow,  Oxygen consumption,  Brain ischemia,  Cerebral blood flow,  Preischemic hyperglycemia.

    BO K Siesjö:KOL impact

    Concepts related to the work of other authors for whichfor which BO K Siesjö has influence:Cerebral ischemia,  Blood flow,  Rat brain,  Ischemic stroke,  Cell death,  Oxidative stress,  Cardiac arrest.



    Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

    Laboratory for Experimental Brain Research, Lund University, Lund, Sweden | Center for the study of Neurological Disease, The Queen's Medical Center, Honolulu, HI, USA | Laboratory for Experimental Brain Research, Experimental Research Center, Lund U