• Disease
  • Esophagogastric
  • Esophagogastric Junction
  • Peter James Kahrilas

    Prominent publications by Peter James Kahrilas

    KOL Index score: 17303

    OBJECTIVES: Esomeprazole, the S isomer of omeprazole, has been shown to have higher healing rates of erosive esophagitis than omeprazole. This study compared esomeprazole with lansoprazole for the healing of erosive esophagitis and resolution of heartburn.

    METHODS: This United States multicenter, randomized, double blind, parallel group trial was performed in 5241 adult patients (intent-to-treat population) with endoscopically documented erosive esophagitis, which was graded by severity ...

    Also Ranks for: Erosive Esophagitis |  esomeprazole lansoprazole |  healing rates |  sustained resolution |  heartburn patients
    KOL Index score: 16849

    Importance: Case series suggest favorable results of peroral endoscopic myotomy (POEM) for treatment of patients with achalasia. Data comparing POEM with pneumatic dilation, the standard treatment for patients with achalasia, are lacking.

    Objective: To compare the effects of POEM vs pneumatic dilation as initial treatment of treatment-naive patients with achalasia.

    Design, Setting, and Participants: This randomized multicenter clinical trial was conducted at 6 hospitals in the ...

    Also Ranks for: Pneumatic Dilation |  poem treatment |  patients achalasia |  symptom severity |  esophageal sphincter
    KOL Index score: 16214

    Background: Patient-rated symptom assessments are needed for evaluating the effectiveness of medical treatments and for monitoring outcomes in gastroparesis. Objective: This paper summarizes the development and psychometric evaluation of a new instrument, the Gastroparesis Cardinal Symptom Index (GCSI), for assessing severity of symptoms associated with gastroparesis. Methods: The GCSI was based on reviews of the medical literature, patient focus groups, and interviews with clinicians. A ...

    Also Ranks for: Gastroparesis Symptoms |  patients gcsi |  symptom severity |  united states |  total score
    KOL Index score: 15124

    OBJECTIVE: In patients with gastroesophageal reflux disease (GERD), esomeprazole, the S-isomer of omeprazole, has demonstrated pharmacological and clinical benefits beyond those seen with the racemic parent compound. This study was designed to further evaluate the efficacy and tolerability of esomeprazole relative to that of omeprazole in healing erosive esophagitis and resolving accompanying symptoms of GERD.

    METHODS: Esomeprazole 40 mg was compared with omeprazole 20 mg once daily in ...

    Also Ranks for: Gerd Patients |  erosive esophagitis |  esomeprazole omeprazole |  safety tolerability |  randomized controlled trial
    KOL Index score: 14045

    BackgroundPeroral endoscopic myotomy (POEM) is a novel endoscopic surgical procedure for the treatment of achalasia. The comparative effects of POEM and laparoscopic Heller myotomy (LHM) on esophagogastric junction (EGJ) physiology are unknown. A novel measurement catheter, the functional lumen imaging probe (FLIP), allows for intraoperative evaluation of EGJ compliance by measuring luminal geometry and pressure during volume-controlled distensions.MethodsDistensibility index (DI) ...

    Also Ranks for: Intraoperative Flip |  lhm poem |  heller myotomy |  esophagogastric junction |  luminal geometry
    KOL Index score: 13837

    BackgroundFor laparoscopic Heller myotomy (LHM), the optimal myotomy length proximal to the esophagogastric junction (EGJ) is unknown. In this study, we used a functional lumen imaging probe (FLIP) to measure EGJ distensibility changes resulting from variable proximal myotomy lengths during LHM and peroral esophageal myotomy (POEM).MethodsDistensibility index (DI) (defined as the minimum cross-sectional area at the EGJ divided by pressure) was measured with FLIP after each operative ...

    Also Ranks for: Poem Lhm |  heller myotomy |  egj distensibility |  mm2 mmhg |  esophagogastric junction
    KOL Index score: 12897

    BACKGROUND: The functional lumen imaging probe (FLIP), measures esophagogastric junction (EGJ) distensibility (cross-sectional area/luminal pressure) during volume-controlled distension. The aim of this study is to apply this tool to the assessment of the EGJ in untreated and treated achalasia patients and to compare EGJ distensibility with other diagnostic tools utilized in managing achalasia.

    METHODS: Findings from FLIP, high-resolution manometry (HRM), timed barium esophagram, and ...

    Also Ranks for: Esophagogastric Junction |  achalasia patients |  imaging probe |  egj distensibility |  electric impedance
    KOL Index score: 12858


    The functional

    lumen imaging probe (FLIP) is a novel diagnostic tool that can be used to measure esophagogastric junction (EGJ) distensibility. In this study, we performed intraoperative FLIP measurements during laparoscopic Heller myotomy (LHM) and peroral esophageal myotomy (POEM) for treatment of achalasia and evaluated the relationship between EGJ distensibility and postoperative symptoms.MethodsDistensibility index (DI) (defined as the minimum cross-sectional area at the ...

    Also Ranks for: Esophagogastric Junction |  heller myotomy |  lhm poem |  mm2 mmhg |  symptomatic outcomes
    KOL Index score: 12437

    OBJECTIVES: Although globus sensation is a common symptom, its pathogenesis is poorly defined. The aim of this study was to quantify the timing and magnitude of respiratory variation in upper esophageal sphincter (UES) pressure with high-resolution manometry (HRM) in patients with globus sensation, normal controls, and gastroesophageal reflux disease (GERD) patients without globus sensation.

    METHODS: HRM recordings spanning from the hypopharynx to the stomach were analyzed in 131 ...

    Also Ranks for: Globus Sensation |  esophageal sphincter |  ues pressure |  gerd patients |  normal controls
    KOL Index score: 12074

    As the U.S. population ages, there is increasing need for data on the effects of aging in healthy elderly individuals over age 80. This investigation compared the swallowing ability of 8 healthy younger men between the ages of 21 and 29 and 8 healthy older men between the ages of 80 and 94 during two swallows each of 1 ml and 10 ml liquid. Videofluoroscopic studies of these swallows were analyzed to confirm the absence of swallowing disorders. Biomechanical analysis of each swallow was ...

    Also Ranks for: Oropharyngeal Swallow |  younger older |  cricopharyngeal opening |  aged 80 |  biomechanical analysis
    KOL Index score: 11904

    BACKGROUND & AIMS: Esophageal adenocarcinoma (EA) is increasingly common among patients with Barrett's esophagus (BE). We aimed to provide consensus recommendations based on the medical literature that clinicians could use to manage patients with BE and low-grade dysplasia, high-grade dysplasia (HGD), or early-stage EA.

    METHODS: We performed an international, multidisciplinary, systematic, evidence-based review of different management strategies for patients with BE and dysplasia or ...

    Also Ranks for: Delphi Process |  consensus statements |  esophageal adenocarcinoma |  patients hgd |  endoscopic resection
    KOL Index score: 11363

    BACKGROUND: The pharmacologic profile of the new proton pump inhibitor esomeprazole has demonstrated advantages over omeprazole that suggest clinical benefits for patients with acid-related disease.

    METHODS: 1960 patients with endoscopy-confirmed reflux oesophagitis (RO) were randomized to once daily esomeprazole 40 mg (n=654) or 20 mg (n=656), or omeprazole 20 mg (n=650), the standard recommended dose for RO, for up to 8 weeks in a US, multicentre, double-blind trial. The primary ...

    Also Ranks for: Reflux Oesophagitis |  esomeprazole omeprazole |  heartburn resolution |  randomized controlled trial |  healing week
    KOL Index score: 11268

    This study examined the temporal effects of bolus volume on closure of the laryngeal vestibule at the arytenoid to epiglottic base and the mobile portion of the epiglottis, the temporal relationships between these levels of airway closure and cricopharyngeal opening for various bolus volumes, and the mechanisms responsible for these two levels of airway protection during deglutition. Closure of the laryngeal vestibule progressed inferiorly to superiorly at all bolus volumes. Duration of ...

    Also Ranks for: Laryngeal Vestibule |  epiglottic base |  bolus volume |  closure arytenoid |  cricopharyngeal opening
    KOL Index score: 11247

    BACKGROUND & AIMS: The functional lumen imaging probe (FLIP) could improve the characterization of achalasia subtypes by detecting nonocclusive esophageal contractions not observed with standard manometry. We aimed to evaluate esophageal contractions during volumetric distention in patients with achalasia using FLIP topography.

    METHODS: Fifty-one treatment-naive patients with achalasia, defined and subclassified by high-resolution esophageal pressure topography, and 10 asymptomatic ...

    Also Ranks for: Esophageal Contractility |  patients achalasia |  flip topography |  imaging probe |  functional lumen
    KOL Index score: 11244

    OBJECTIVES: Esophagogastric junction (EGJ) distensibility and distension-mediated peristalsis can be assessed with the functional lumen imaging probe (FLIP) during a sedated upper endoscopy. We aimed to describe esophageal motility assessment using FLIP topography in patients presenting with dysphagia.

    METHODS: In all, 145 patients (aged 18-85 years, 54% female) with dysphagia that completed upper endoscopy with a 16-cm FLIP assembly and high-resolution manometry (HRM) were included. HRM ...

    Also Ranks for: Esophageal Motility |  upper endoscopy |  imaging probe |  functional lumen |  esophagogastric junction


    Peter James Kahrilas: Influence Statistics

    Sample of concepts for which Peter James Kahrilas is among the top experts in the world.
    Concept World rank
    flip achalasia #1
    tml method stipulation #1
    series procedure time #1
    laryngeal penetration coordination #1
    cdp ibp #1
    manofluorography evaluation #1
    globus esq #1
    acid exposure 1 #1
    esophagus eightyfive individuals #1
    iqr upright position #1
    7 patients iem #1
    phrenic ampullary emptying #1
    patients motor disorders #1
    ppi refluxlike symptoms #1
    daily ppi ppis #1
    food impaction dilation #1
    egj transducers #1
    achalasics events #1
    gastric pressure liquid #1
    nonreducinghernia reducinghernia #1
    chronic laryngitis patients #1
    modulation swallowing #1
    hrm tbe #1
    radiographic evidence egjoo #1
    pseudoachalasia achalasia #1
    iwgco #1
    fundoplication gastric wall #1
    23 events point #1
    gastric distention patients #1
    hrm tbe measurements #1
    physician interpreter #1
    pharyngeal reconfiguration #1
    symptomatic cricopharyngeal bar #1
    esophagitis grading schemes #1
    disorders esophagogastric #1
    uos relaxation #1
    classification peristalsis #1
    esophagogastric junction illness #1
    increasing bolus volume #1
    esophagogastric #1
    egj csas #1
    egjci gerd patients #1
    factual endoscopy gerd #1
    patients hypercontractility #1
    healed esophagitis wk #1
    ph‐metry #1
    gaviscon studies #1
    swallows temporal relationship #1
    swallow air injections #1
    lhm egj #1

    Key People For Esophagogastric Junction

    Top KOLs in the world
    Hubert Jakob Stein
    esophageal cancer esophagogastric junction distal esophagus
    JörgRüdiger Siewert
    gastric cancer neoadjuvant chemotherapy bone marrow
    Tom R DeMeester
    gastroesophageal reflux intestinal metaplasia esophageal adenocarcinoma
    Marcus Feith
    esophagogastric junction neoadjuvant chemotherapy esophageal cancer
    J Jan B van Lanschot
    esophageal cancer neoadjuvant chemoradiotherapy active surveillance
    Mitsuru Sasako
    gastric cancer adjuvant chemotherapy lymph node

    Peter James Kahrilas:Expert Impact

    Concepts for whichPeter James Kahrilashas direct influence:Esophagogastric junction,  Chicago classification,  Gastroesophageal reflux disease,  Reflux disease,  Gastroesophageal reflux,  Flip panometry,  Hiatal hernia,  Esophageal motility.

    Peter James Kahrilas:KOL impact

    Concepts related to the work of other authors for whichfor which Peter James Kahrilas has influence:Gastroesophageal reflux disease,  Eosinophilic esophagitis,  Hiatal hernia,  Esophageal motility,  Proton pump,  Reflux symptoms,  Gerd patients.



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    Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA | Department of Medicine, Northwestern University Medical School, Chicago, IL, USA | Division of Gastroenterology and Hepatology, Department of Medicine, Feinberg School of