Sara Zarnegar

Sara Zarnegar

Department Of Molecular Genetics And Cell Biology, Department Of Medicine, And, Department Of Human Genetics, The University Of Chicago, Chicago, Illinois, Usa.

Direct Impact

Concepts for which Sara Zarnegar has direct influence:

vascular spasm
sarcoglycan complex
muscular dystrophy
smooth muscle
cardiomyocyte degeneration
plasma membrane
coronary arteries

Prominent publications by Sara Zarnegar

KOL-Index: 12 The dystrophin glycoprotein complex (DGC) is found at the plasma membrane of muscle cells, where it provides a link between the cytoskeleton and the extracellular matrix. A subcomplex within the DGC, the sarcoglycan complex, associates with dystrophin and mediates muscle membrane stability. Mutations in sarcoglycan genes lead to muscular dystrophy and cardiomyopathy in both humans and mice. ...
Known for
Muscle Membrane | Delta-Sarcoglycan | Component Sarcoglycan | Dystrophin Glycoprotein Complex
KOL-Index: 7
Known for
Cardiomyopathy
KOL-Index: 5 Genetic defects in the plasma membrane-associated sarcoglycan complex produce cardiomyopathy characterized by focal degeneration. The infarct-like pattern of cardiac degeneration has led to the hypothesis that coronary artery vasospasm underlies cardiomyopathy in this disorder. We evaluated the coronary vasculature of gamma-sarcoglycan mutant mice and found microvascular filling defects ...
Known for
Gamma-Sarcoglycan Mutant Mice | Treated Gamma | Left Ventricular Fractional Shortening | Vascular Smooth Muscle-Cell Extrinsic
KOL-Index: 4 Vascular spasm is a poorly understood but critical biomedical process because it can acutely reduce blood supply and tissue oxygenation. Cardiomyopathy in mice lacking gamma-sarcoglycan or delta-sarcoglycan is characterized by focal damage. In the heart, sarcoglycan gene mutations produce regional defects in membrane permeability and focal degeneration, and it was hypothesized that vascular ...
Known for
Muscle Sarcoglycan | Produce Vascular | Tissue Oxygenation

Department of Molecular Genetics and Cell Biology, Department of Medicine, and, Department of Human Genetics, The University of Chicago, Chicago, Illinois, USA.

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