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    • JianQiang Ni

      JianQiang Ni

      Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, China | Department of Neurology, The First Affiliated Hospital of Soochow University, ...



      KOL Resume for JianQiang Ni


      Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, China


      Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province China


      Department of Neurology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China


      Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China. Electronic address:


      Department of Physiology and Neurobiology, Centre for Ion Channelopathy, Medical College of Soochow University, Suzhou 215123, PR China


      Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China


      Department of Neurology, First Affiliated Hospital, Soochow University, Suzhou 215006, China.


      Department of Neurology at the First Affiliated Hospital of Soochow University, Medical College of Soochow University, Suzhou, Jiangsu, P.R. China, .

      Medical College of Soochow University Key Laboratory of Pain Basic Research & Clinical Therapy Suzhou China


      Department of Forensic Medicine, Medical College of Soochow University, 215123, Suzhou, China



      JianQiang Ni: Influence Statistics

      Sample of concepts for which JianQiang Ni is among the top experts in the world.
      Concept World rank
      cd3g hcc risk #3
      rs66465034 #3
      hcc susceptibility rs66465034 #3
      polymorphism rs66465034 #3
      rs66465034 proximal #3
      rs66465034 proximal promoter #3
      hcc disease g2 #3
      cd3 susceptibility #3
      291 hcc patients #4
      promoter cd3 #4
      migraine chinese population #5
      central disinhibition tnfα #5
      tnfr1 gabaar pathway #5
      mediated p2x4r #5
      disinhibition tnf #5
      gabaar cpsp #5
      tnfr1 cpsp #5
      p2x4r tnfα #5
      poststroke pain rats #5
      cpsp central disinhibition #5
      p2x4r tnfr1 #5
      tnfr1 gabaar #5
      polymorphisms cd3 #5
      pathway p2x4r #5
      cpsp p2x4r #5
      p2x4r contributes #5
      homozygote 4bp #5
      tnfr1 p2x4r #5
      mir133b3p targets #6
      cpsp rats vpl #6
      p2x4r vpl #6
      p2x4r transcripts #6
      gabapentin cpsp rats #6
      allodynia vpl #6
      mir133b3p inhibitor #6
      expression levels mir133b3p #6
      levels mir133b3p #6
      cpsp vpl #6
      cpsp rats allodynia #6
      decreased mir133b3p #6
      mir133b3p vpl #6
      mir133b3p expression #6
      p2x4r expression treatment #6
      vpl cpsp rats #6
      mir133b3p cpsp #6
      p2x4r neuropathic pain #6
      microrna133b3p mir133b3p #6
      vpl allodynia #6
      targets p2x4r #6
      plasma levels mir133b3p #6


      Prominent publications by JianQiang Ni

      KOL-Index: 9854

      Although recent studies have implicated serotonin 5-HT1B/D receptors in the nociceptive sensitivity of primary afferent neurons, the underlying molecular and cellular mechanisms remain unclear. In this study, we identified a novel functional role of the 5-HT1D receptor subtype in regulating A-type potassium (K(+)) currents (IA) as well as membrane excitability in small trigeminal ganglion (TG) neurons. We found that the selective activation of 5-HT1D, rather than 5-HT1B, receptors ...

      Known for Protein Kinase | Trigeminal Ganglion | Ht1d Receptor | Serotonin 5 | Potentials Mice
      KOL-Index: 9540

      Vascular endothelial growth factor (VEGF) is a key mediator of angiogenesis, which is crucial for development and metastasis of tumors including hepatocellular carcinoma (HCC), and elevated VEGF levels in serum and tissues have been known to be related with poor prognosis in patients with HCC. Polymorphisms in VEGF may alter VEGF protein concentrations, influence the process of angiogenesis, and may relate to interindividual variation in tumorigenesis. In this study, we carried out a ...

      Known for Hepatocellular Carcinoma | Vascular Endothelial | Deletion Polymorphism | Growth Factor | Susceptibility Hcc
      KOL-Index: 7157

      The aim of this study was to investigate the alterations in regional homogeneity assessed by fMRI in patients with migraine without aura (MWoA). Fifty-six eligible MWoA patients and 32 matched healthy volunteers were enrolled in this study. MWoA patients were divided into three groups according to the headache days per month within 3 months: infrequent episodic migraine (IEM) group, frequent episodic migraine (FEM) group, and chronic migraine (CM) group. Data collection and rest-state ...

      Known for Regional Homogeneity | Reho Values | Patients Migraine | Middle Temporal Gyrus | Aura Mwoa
      KOL-Index: 7090

      BACKGROUND: MOR1 is the main transcript of μ-opioid receptor (MOR) gene, which represents a mandatory molecule for the analgesic effects of opioids and plays an important role in the pathology of inflammatory pain. MicroRNAs (miR) are non-coding molecules that primarily modulate gene expression at the post-transcriptional level in various pathophysiological conditions. Based on in silico analysis, an exact match to the seed sequence of miR-134 was found in 3'-untranslated region of MOR1. ...

      Known for Inflammatory Pain | Dorsal Root | Mir134 Expression | Messenger Rats | 3untranslated Region
      KOL-Index: 6887

      OBJECTIVE: The research aim was to investigate the effects of dl-3-n-butylphthalide (NBP) on the level of circulating endothelial progenitor cells (EPCs) and clinical outcome in patients with acute ischemic stroke (AIS).

      MATERIALS AND METHODS: A total of 170 patients were included and randomly assigned to NBP group and control group. All patients were administrated a basic antiplatelet and lipid-lowering therapy. Among the patients, 86 received additional NBP administration for 30 days, ...

      Known for Endothelial Progenitor Cells | Stroke Patients | Nbp Level | Acute Ischemic | Dl3 Butylphthalide
      KOL-Index: 5279

      Migraine is a debilitating condition characterized by a multi-factorial and polygenic mode of inheritance. Tumor necrosis factor alpha (TNF-α), a pro-inflammatory cytokine, has been implicated in the pathophysiological mechanisms of migraine. The aim of this study was to investigate whether TNF receptor superfamily member 1b gene (TNFRSF1B) polymorphism affects the occurrence of migraine in the Chinese Han population. We focused on a 15 base pair (bp) insertion/deletion polymorphism ...

      Known for Chinese Population | Polymorphism Genetic | Necrosis Factor | Predisposition Disease | Migraine Disorders
      KOL-Index: 5272

      Genes involved in the production of nitric oxide (NO) have been suggested as genetic factors for migraine. It has been studied whether polymorphisms in the genes encoding for different types of NO synthase (NOS) could be involved in the liability to migraine; however, most studies yield negative results. The pentanucleotide repeat microsatellite in the promoter region of inducible NOS (NOS2) shows highly significant differences in allelic frequencies among ethnically diverse populations. ...

      Known for Chinese Population | Nitric Oxide | Polymorphism Genetic | Patients Migraine | Microsatellite Repeats
      KOL-Index: 4362

      Stroke is the leading cause of disability and death in the world. Central post-stroke pain (CPSP), a central neuropathic pain syndrome occurring after cerebral stroke, is a serious problem. But on account of the lack of reliable animal models, the mechanisms underlying CPSP remains poorly understood. To better understand of the pathophysiological basis of CPSP, we developed and characterized a new rat model of CPSP. This model is based on a hemorrhagic stroke lesion with intra-thalamic ...

      Known for P2x4 Receptor | Stroke Pain | Treatment Cpsp | Central Post | Animal Models
      KOL-Index: 4262

      As the main organelles for the clearance of damaged proteins and damaged organelles, the function of lysosomes is crucial for maintaining the intracellular homeostasis of long-lived neurons. A stable acidic environment is essential for lysosomes to perform their functions. TMEM175 has been identified as a new K+ channel that is responsible for regulating lysosomal membrane potential and pH stability in neurons. This study aimed to understand the role of TMEM175 in lysosomal function of ...

      Known for Cerebral Ischemia | Reperfusion Injury | Tmem175 Lysosomal | Damaged Organelles | Protein Level
      KOL-Index: 4195

      Central post-stroke pain (CPSP) is a disabling condition in stroke patients. It is a type of neuropathic pain for which the mechanism and relevant drug pathways remain unknown. Inflammatory response and central disinhibition have been suggested recently. Our previous research has shown targeting P2X4 receptors (P2X4R) may be effective in the treatment of CPSP, but the downstream pathway of the P2X4R has not been studied. In this study, we found the increase in tumor necrosis factor alpha ...

      Known for Pain Rats | Tumor Necrosis Factor | Inflammatory Response | Tnf Α | Purinergic P2x4
      KOL-Index: 3634

      Vestibular migraine (VM) is a multidisciplinary disease under exploration. Multiple temporal patterns of vertigo and migraine make it difficult to diagnose VM, and their effect on the clinical features of VM is still unclear. Here we investigated the clinical features of VM under three temporal patterns. 172 VM patients were enrolled in this study and divided into three groups: 86 patients in group A had an earlier onset of migraine than vertigo, 35 patients in group B had an earlier ...

      Known for Vestibular Migraine | Longer Duration
      KOL-Index: 2670

      Hydrogen sulfide (H2S) is recognized to be a novel mediator after carbon monoxide and nitric oxide in the organism. It can be produced in various mammalian tissues and exert many physiological effects in many systems including the cardiovascular system. A great amount of recent studies have demonstrated that endogenous H2S and exogenous H2S-releasing compounds (such as NaHS, Na2S, and GYY4137) provide protection in many cardiovascular diseases, such as ischemia/reperfusion injury, heart ...

      Known for Hydrogen Sulfide | Reperfusion Injury | Cardiovascular Diseases | Exogenous H2s
      KOL-Index: 2234

      Hepatocellular carcinoma (HCC) represents the most common primary malignancy of the liver with a worldwide increasing incidence. Although the risk factors for HCC are well characterized, the molecular mechanisms responsible for malignant transformation of hepatocytes are not well understood. In this study, a case-control study including 291 HCC patients and 294 healthy controls was conducted to investigate the association between HCC susceptibility and with a 4-bp insertion/deletion ...

      Known for Hepatocellular Carcinoma | Hcc Liver Neoplasms | Hepatitis Virus | Cd3 Complex
      KOL-Index: 1669

      High-flow oxygen inhalation is one of the most effective acute treatments for cluster headache. The therapy was first described for the treatment of cluster headache in 1952 by Horton, and has exhibited some advantages and efficacy compared to other acute medicines. The mechanism is not very clear, but some evidence has demonstrated its relationship to the trigeminovascular system and neuroinflammation. High-flow oxygen inhalation via a non-rebreather mask during cluster headache attacks ...

      Known for Cluster Headache | Nonrebreather Mask | Oxygen Treatment | Effective Acute
      KOL-Index: 1273

      Background and PurposeAs a very common risk of adverse outcomes of the ischemic stroke patients, sarcopenia is associated with infectious complications and higher mortality. The goal of this retrospective study is to explore the predictive value of serum Cr/CysC ratio in acute ischemic stroke patients receiving nutritional intervention.MethodsWe reviewed adult patients with AIS from December 2019 to February 2020. Patients with acute kidney injury were excluded and all patients received ...

      Known for Serum Creatinine

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      JianQiang Ni:Expert Impact

      Concepts for whichJianQiang Nihas direct influence:Chinese population,  Cluster headache,  Central disinhibition,  Regional homogeneity,  Vestibular migraine,  Proximal promoter,  Endothelial progenitor cells,  P2x4 receptor.

      JianQiang Ni:KOL impact

      Concepts related to the work of other authors for whichfor which JianQiang Ni has influence:Neuropathic pain,  Collateral circulation,  Chinese population,  Morphine tolerance,  Intracerebral hemorrhage,  Brain edema,  Α5gabaa receptors.



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      Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, China | Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. Electronic address: | Department of N

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