• KOL
    • Chronic Fatigue Syndrome
    • Stephen E Straus
    • STEPHEN E Straus: Influence Statistics

      STEPHEN E Straus

      STEPHEN E Straus

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      Medical Virology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA | ...

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      STEPHEN E Straus:Expert Impact

      Concepts for whichSTEPHEN E Straushas direct influence:Chronic fatigue syndrome,Simplex virus,Herpes simplex,Lymphoproliferative syndrome,Fatigue syndrome,Simplex virus type,Chronic fatigue,Vitamin b12.

      STEPHEN E Straus:KOL impact

      Concepts related to the work of other authors for whichfor which STEPHEN E Straus has influence:Chronic fatigue syndrome,Herpes zoster,Simplex virus,Postherpetic neuralgia,Cfs patients,Cell death,Gene expression.

      KOL Resume for STEPHEN E Straus

      Year
      2011

      Medical Virology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

      2009

      Medical Virology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, 10 Center Drive, Room 11N234 Bethesda, MD 20892, USA

      Laboratory of Clinical Infectious Disease, NIAID, NIH, Bethesda, MD##Disclosure: 8; NSF, NIDRR, NIH

      2008

      Niaid, NIH, Bethesda, MD, USA

      2007

      Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892

      Medical Virology Section

      LCID, NIH/NIAID, Bethesda, MD, USA

      2006

      LCID/NIAID, NIHNational Institutes of Health, Bethesda, MD, USA

      Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

      2005

      Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA

      2004

      Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda Maryland USA

      National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland 20892; email:

      2003

      Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland

      2002

      Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

      NIH, 10 Center Drive, Rm. 11N228, 20892-1888, Bethesda, MD

      National Human Genome Research Institute, National Center for Complementary and Alternative Medicine and Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892

      2001

      Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland

      National Center for Complementary and Alternative Medicine

      2000

      From the Hematopathology Section, Laboratory of Pathology, National Cancer Institute, and Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD; Department of Pathology, Instituto Nacional de la Nutrición, México City, México; Institute for Pathology, GSF-Research Center for Environment and Health, Neuherberg, Germany.

      Dr. Straus is the director of the National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland. e-mail: 〈 sstraus@nih.gov 〉.

      Medical Virology Section, Laboratory of Clinical Investigation, National Institutes of Health, Bethesda, Maryland

      Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, 10 Center Drive, Bldg. 10, Rm. 11N-228, Bethesda,MD 20892-1888, USA

      National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, MD 20892-2182

      1999

      Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases,1 and

      National Institutes of Health, Bethesda, Md. (S.E.S.).

      1998

      Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA

      National Cancer Institute, the Laboratories of Clinical Investigation, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland

      1997

      From the Laboratory of Immunoregulation, Laboratory of Clinical Investigation, and Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Laboratory of Gene Transfer, Medical Genetics Branch, National Center for Human Genome Research, Laboratory of Pathology, National Cancer Institute, Clinical Center, National Institutes of Health, Bethesda, MD.

      HIV and AIDS Malignancy Branch and Viral Epidemiology Branch, National Cancer Institute, and Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland

      1996

      Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MA 20892, USA

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      Sample of concepts for which STEPHEN E Straus is among the top experts in the world.
      Concept World rank
      1988 centers #1
      orf 21 translation #1
      hsv1 infections hsv2 #1
      electron cowdry #1
      genetic transfection vzv #1
      chickenpox chromatography #1
      progressive epstein #1
      il6 coreceptor #1
      suppressive therapy patients #1
      frequency cfs patients #1
      transfection kb cells #1
      alps antibody specificity #1
      clinical isolate herpes #1
      serologic studies process #1
      nonmalignant lymphadenopathy #1
      treatment hsv1 infection #1
      usf cooperates #1
      alpha betadntcs #1
      prevention neuralgia #1
      usf2 activation #1
      vzv acyclovirresistant strains #1
      complement 10 percent #1
      persistently active infections #1
      viii alps #1
      cessation immunosuppressive agents #1
      chronic previewthe #1
      platelet serologies #1
      nccam area #1
      clinical features alps #1
      fetal damage cases #1
      alps neutrophil antibodies #1
      righthand ends #1
      lymphocyte homeostasis autoimmunity #1
      virionmediated effects #1
      clinical diagnosis hz #1
      vzv rna protein #1
      latent infection impact #1
      northern fibroblasts genes #1
      1 2 virions #1
      unanticipated risk #1
      lymphocyte surface protein #1
      vzv hsv infections #1
      orf terminator dna #1
      investigator adverse outcomes #1
      vpa alps #1
      liposomes transfect #1
      cutaneous zoster #1
      simplex virus dnas #1
      acv vm #1
      infections famciclovir #1
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      Prominent publications by STEPHEN E Straus

      KOL-Index: 15934

      BACKGROUND: The incidence and severity of herpes zoster and postherpetic neuralgia increase with age in association with a progressive decline in cell-mediated immunity to varicella-zoster virus (VZV). We tested the hypothesis that vaccination against VZV would decrease the incidence, severity, or both of herpes zoster and postherpetic neuralgia among older adults.

      METHODS: We enrolled 38,546 adults 60 years of age or older in a randomized, double-blind, placebo-controlled trial of an ...

      Known for Herpes Zoster | Postherpetic Neuralgia | Vaccine Recipients | Burden Illness | Pain Discomfort
      KOL-Index: 13806

      Programmed cell death (apoptosis) of activated lymphocytes is critical to immune homeostasis. The cell surface protein Fas (CD95) and its ligand play a pivotal role in regulating lymphocyte apoptosis, and defective expression of either Fas or Fas ligand results in marked over accumulation of mature lymphocytes and autoimmune disease in mice. The results of recent studies suggest that defective lymphocyte apoptosis caused by mutations of the Fas gene can result in a severe autoimmune ...

      Known for Lymphocyte Apoptosis | Patients Alps | Cultured Child | Genetic Features | Mutations Gene
      KOL-Index: 13710

      BACKGROUND: A herpes simplex virus (HSV)-2 candidate vaccine consisting of glycoprotein D (gD2) in alum and monophosphoryl lipid A (MPL) reduced genital herpes disease in HSV-1-seronegative women but not in men or HSV-1-seropositive women.

      METHODS: To determine the effect of HSV-1 serostatus on effectiveness of different vaccines, we tested gD2 in alum/MPL, gD2 in Freund's adjuvant, and dl5-29 (a replication-defective HSV-2 mutant) in HSV-1-seropositive or HSV-1-seronegative guinea ...

      Known for Simplex Virus | Guinea Pigs | Gd2 Vaccines | Vaginal Challenge | Dl5 29
      KOL-Index: 13645

      The varicella-zoster virus (VZV) open reading frame 61 (ORF61) protein is thought to be the homolog of herpes simplex virus type 1 (HSV-1) ICP0, based on gene location and limited amino acid homology. However, HSV-1 ICP0 trans activates HSV-1 genes, while VZV ORF61 protein trans represses the function of VZV trans activators on VZV promoters in transient expression assays. To investigate the functional relatedness of HSV-1 ICP0 and VZV ORF61 protein, we established Vero and MeWo cell ...

      Known for Vzv Orf61 | 1 Icp0 | Simplex Virus Type | Reading Frame | Zoster Virus
      KOL-Index: 13603

      OBJECTIVE: Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of apoptosis, often presenting in childhood. Similarly, MRL/lpr(-/-) mice homozygous for Fas mutations develop an ALPS-like disease with autoimmunity, lymphadenopathy, splenomegaly, and expansion of double-negative T cells. Currently, there are no proven therapies with adequate safety margins for sustained abolition of the lymphoproliferation associated with ALPS. We sought to test the ability of valproic acid (VPA), ...

      Known for Valproic Acid | Histone Deacetylase | Autoimmune Lymphoproliferative | Patients Alps | Mrl Lpr Mice
      KOL-Index: 13552

      The varicella-zoster virus (VZV) open reading frame 61 (ORF61) protein is the homolog of herpes simplex virus type 1 (HSV-1) ICP0. Both genes are located in similar parts of the genome, their predicted products share a cysteine-rich motif, and cell lines expressing VZV ORF61 are able to complement an HSV-1 ICP0 deletion mutant (H. Moriuchi, M. Moriuchi, H. A. Smith, S. E. Straus, and J. I. Cohen, J. Virol. 66:7303-7308, 1992). In transient expression assays, HSV-1 ICP0 is a ...

      Known for Vzv Orf61 | Reading Frame | Zoster Virus | Transient Expression | Viral Proteins
      KOL-Index: 13320

      CONTEXT: Influenza virus neuraminidase is thought to be essential for virus replication in humans; however, to date, available neuraminidase inhibitors are limited to zanamivir, which is topically administered.

      OBJECTIVE: To determine the safety, tolerability, and antiviral activity of oral neuraminidase inhibitor oseltamivir (GS4104/Ro64-0796) for prevention and the early treatment of influenza in experimentally infected humans.

      DESIGN: Two randomized, double-blind, placebo-controlled ...

      Known for Oral Neuraminidase | Virus Influenza | Randomized Controlled Trials | Viral Shedding | Placebo Oseltamivir
      KOL-Index: 13230

      To better understand the mechanisms responsible for the observed effects of deletions in the promoter region of the latency-associated transcript (LAT) gene in impairing herpes simplex virus (HSV) reactivation, we generated mice transgenic for a 5.5-kb HSV type 2 (HSV-2) genomic fragment spanning the major LAT, along with the LAT promoter and flanking regions, in the C57BL/6 background. The mice expressed abundant 2.2-kb major LATs in trigeminal ganglia (TG) and other tissues. The ...

      Known for Transgenic Mice | Herpes Simplex Virus | Latency Reactivation | Type 2 | Lat Promoter
      KOL-Index: 13019

      This study describes the clinicopathologic features of 5 patients who developed a fulminant Epstein-Barr virus (EBV)-positive clonal T-cell lymphoproliferative disorder (LPD) after acute EBV infection. One additional patient developed a similar disorder in the setting of long-standing chronic active EBV infection. Detailed immunophenotyping, in situ hybridization for EBV early RNA-1 (EBER1) and polymerase chain reaction (PCR) analyses for immunoglobulin (Ig) heavy chain and T-cell ...

      Known for Ebv Infection | Cell Lymphoproliferative | Liver Spleen | Situ Hybridization | 2 Cases
      KOL-Index: 12983

      Many candidate vaccines are effective in animal models of genital herpes simplex virus type 2 (HSV-2) infection. Among them, clinical trials showed moderate protection from genital disease with recombinant HSV-2 glycoprotein D (gD2) in alum-monophosphoryl lipid A adjuvant only in HSV women seronegative for both HSV-1 and HSV-2, encouraging development of additional vaccine options. Therefore, we undertook direct comparative studies of the prophylactic and therapeutic efficacies and ...

      Known for Guinea Pigs | Dna Vaccines | Herpes Simplex | Virus 2 | Animal Models
      KOL-Index: 12671

      The varicella-zoster virus (VZV) open reading frame 10 (ORF10) protein is the homolog of the herpes simplex virus type 1 (HSV-1) protein VP16. These are two virion tegument proteins that have extensive amino acid sequence identity in their amino-terminal and middle domains. ORF10, however, lacks the acidic carboxy terminus which is critical for transactivation by VP16. Earlier studies showed that VZV ORF10 does not form a tertiary complex with the TAATGARAT regulatory element (where R is ...

      Known for Reading Frame | 10 Protein | Early Gene | Zoster Virus | Herpes Simplex
      KOL-Index: 12509

      The ability of the pleotropic, proinflammatory cytokine interleukin-6 (IL-6) to affect the replication, latency, and reactivation of herpes simplex virus type 1 (HSV-1) in cell culture and in IL-6 knockout (KO) mice was studied. In initial studies, we found no effect of exogenous IL-6, monoclonal antibodies to IL-6, or monoclonal antibody to the IL-6 coreceptor, gp130, on HSV-1 replication in vitro by plaque assay or reactivation ex vivo by explant cocultivation of latently infected ...

      Known for Simplex Virus Type | Il6 Mice | Latency Reactivation | 1 Hsv1 | Plaque Assay
      KOL-Index: 12480

      BACKGROUND: We describe severe and unexpected multisystem toxicity that occurred during a study of the antiviral nucleoside analogue fialuridine (1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodouracil, or FIAU) as therapy for chronic hepatitis B virus infection.

      METHODS: Fifteen patients with chronic hepatitis B were randomly assigned to receive fialuridine at a dose of either 0.10 or 0.25 mg per kilogram of body weight per day for 24 weeks and were monitored every 1 to 2 weeks by ...

      Known for Lactic Acidosis | Chronic Hepatitis | Hepatic Failure | Nucleoside Analogue | Fialuridine Fiau
      KOL-Index: 12319

      Caspase-8, a proapoptotic protease, has an essential role in lymphocyte activation and protective immunity. We show that caspase-8 deficiency (CED) in humans and mice specifically abolishes activation of the transcription factor nuclear factor kappaB (NF-kappaB) after stimulation through antigen receptors, Fc receptors, or Toll-like receptor 4 in T, B, and natural killer cells. Caspase-8 also causes the alphabeta complex of the inhibitor of NF-kappaB kinase (IKK) to associate with the ...

      Known for Antigen Receptor | Signal Transduction | Protein Kinase | Lymphocyte Activation | Caspase8 Deficiency

      Key People For Chronic Fatigue Syndrome

      Top KOLs in the world
      #1
      Michael C Sharpe
      chronic fatigue syndrome major depression lung cancer
      #2
      STEPHEN E Straus
      chronic fatigue syndrome simplex virus autoimmune lymphoproliferative
      #3
      James G Dobbins
      chronic fatigue syndrome san francisco united states
      #4
      Keiji Fukuda
      united states advisory committee immunization practices
      #5
      Ian Hickie
      chronic fatigue syndrome comprehensive approach fatigued persons
      #6
      Anthony Komaroff
      chronic fatigue syndrome comprehensive approach fatigued persons

      Medical Virology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA | Laboratory of Infectious Diseases, National Institute of Allergy and Infectio

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