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Prominent publications by Junqi Niu
BACKGROUND & AIMS: There is no satisfactory way to identify patients who will maintain a response after discontinuation of nuleos(t)ide analogue therapy for chronic hepatitis B virus (HBV) infection. We investigated whether patients with negative results from tests for HBV DNA and HBV RNA (double negative) at the end of treatment maintain a long-term response to treatment.
METHODS: We performed a post-hoc analysis of data from a 2-year multi-center randomized controlled trial, and its ...
Known for Hbv Dna | Clinical Relapse | Negative Patients | Antigens Hepatitis | Rna Treatment |
Seroprevalence and Risk Factors for Hepatitis B Infection in an Adult Population in Northeast China
[ PUBLICATION ]
BACKGROUND AND AIM: The prevalence of the hepatitis B virus (HBV) is higher in adults than in children. We determined the seroepidemiology of HBV infection in an adult population in JiLin, China, to guide effective preventive measures.
METHODS: A cross-sectional serosurvey was conducted throughout JiLin, China. A total of 3833 people was selected and demographic and behavioral information gathered. Serum samples were tested for HBV markers and liver enzymes.
RESULTS: The prevalence of ...
Known for Northeast China | Hbv Infection | Independent Predictors | Antigens Hepatitis | Adult Population |
Red blood cell distribution width and globulin, noninvasive indicators of fibrosis and inflammation in chronic hepatitis patients
[ PUBLICATION ]
AIMS: We aimed to develop new simple predictive models for significant fibrosis and inflammation in chronic hepatitis patients using routine laboratory parameters.
METHODS: A total of 218 patients who had undergone liver biopsy were enrolled in our study. Among these, 116 had chronic hepatitis B, 65 had primary biliary cirrhosis, and 37 had autoimmune hepatitis. Patients were divided into two groups: absent-mild (S0-S1, G0-G1) and moderate-severe (S2-S4, G2-G4) according to the ...
Known for Chronic Hepatitis | Liver Fibrosis | Blood Cell | Distribution Width | Sensitivity Specificity |
aMAP risk score predicts hepatocellular carcinoma development in patients with chronic hepatitis
[ PUBLICATION ]
BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) is the leading cause of death in patients with chronic hepatitis. In this international collaboration, we sought to develop a global universal HCC risk score to predict the HCC development for patients with chronic hepatitis.
METHODS: A total of 17,374 patients, comprising 10,578 treated Asian patients with chronic hepatitis B (CHB), 2,510 treated Caucasian patients with CHB, 3,566 treated patients with hepatitis C virus (including 2,489 ...
Known for Chronic Hepatitis | Amap Score | Hcc Risk | Hepatocellular Carcinoma | Development Patients |
Objective To investigate the clinical effect and safety of long-acting pegylated interferon-α-2b (Peg-IFN-α-2b) (Y shape, 40 kD) injection (180 μg/week) in the treatment of HBeAg-positive chronic hepatitis B (CHB) patients, with standard-dose Peg-IFN-α-2a as positive control. Methods This study was a multicenter, randomized, open-label, and positive-controlled phase III clinical trial. Eligible HBeAg-positive CHB patients were screened out and randomized to Peg-IFN-α-2b (Y shape, 40 ...
Known for Chronic Hepatitis | Pegylated Interferon | Hbeag Positive | 48 Weeks | Chb Patients |
The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation
[ PUBLICATION ]
The transcription factor forkhead box P3 (FOXP3) is essential for the development of regulatory T cells (Tregs) and their function in immune homeostasis. Previous studies have shown that in natural Tregs (nTregs), FOXP3 can be regulated by polyubiquitination and deubiquitination. However, the molecular players active in this pathway, especially those modulating FOXP3 by deubiquitination in the distinct induced Treg (iTreg) lineage, remain unclear. Here, we identify the ubiquitin-specific ...
Known for Treg Function | Foxp3 Degradation | Immune Homeostasis | Regulatory Cells | Forkhead Transcription |
Long-term efficacy and safety of tenofovir disoproxil fumarate in Chinese patients with chronic hepatitis B: 5-year results
[ PUBLICATION ]
Background and aimLong-term treatment with tenofovir disoproxil fumarate (TDF) has demonstrated suppression of viral replication outside of China. This study aims to assess efficacy, resistance and safety of TDF for up to 240 weeks in Chinese patients with chronic hepatitis B virus (HBV) infection.MethodsPatients (HBeAg-positive or HBeAg-negative) who were randomised to receive TDF 300 mg or adefovir dipivoxil (ADV) 10 mg once daily in the 48-week double-blind phase (N = 498) were ...
Known for Chronic Hepatitis | Tenofovir Disoproxil Fumarate | Patients Tdf | Hbv Infection | Viral Replication |
Association of central obesity with hepatocellular carcinoma in patients with chronic hepatitis B receiving antiviral therapy
[ PUBLICATION ]
BACKGROUND: Obesity is typically associated with metabolic dysfunction, but its impact on hepatocellular carcinoma (HCC) remains unclear in patients with chronic hepatitis B (CHB).
AIM: To study the effect of obesity on HCC development in patients with CHB receiving antiviral therapy.
METHODS: We included patients from a Chinese multicentre, prospective, observational, treated CHB cohort in this study. General obesity was evaluated by body-mass index (BMI). Central obesity was evaluated ...
Known for Central Obesity | Chronic Hepatitis | Hepatocellular Carcinoma | Hcc Patients | Liver Neoplasms |
Alpha-fetoprotein to transaminase ratio is related to higher diagnostic efficacy for hepatocellular carcinoma.
[ PUBLICATION ]
Alpha-fetoprotein (AFP), as the most widely used biomarker of hepatocellular carcinoma (HCC), was correlated with ongoing liver damage. The aim of this study was to evaluate the ability of inflammatory correction-based AFP to identify HCC from other liver diseases.From March 2012 to March 2017, among 926 participants, a total of 501 patients whose transaminases were higher than the upper limit of normal range, including 166 treatment-naïve HCC patients were enrolled in our retrospective ...
Known for Hepatocellular Carcinoma | Afp Hcc | Hepatitis Virus | Liver Diseases | Biomarkers Tumor |
Analysis of related factors for primary hepatic carcinoma caused by chronic hepatitis B and hepatitis C
[ PUBLICATION ]
Objective To explore the related factors for primary hepatic carcinoma (PHC) caused by chronic hepatitis B (CHB) and hepatitis C (CHC). Methods According to the principle of cross-sectional study, a cluster random sample method was used, a total of 366 chronic hepatitis patients in hospitals were recruited from three provincial tertiary hospitals in Shanxi, Henan and Jilin between July 2016 and October 2016, respectively. Using a self-designed unified questionnaire, face-to-face ...
Hepatitis C Virus - Related Hepatocellular Carcinoma in the Era of Direct - Acting Antiviral Agents
[ PUBLICATION ]
Known for Hepatocellular Carcinoma |
Junqi Niu: Influence Statistics
Concept | World rank |
---|---|
height hcc development | #6 |
hcc risk height | #6 |
hcc development bmi | #6 |
hcc central obesity | #6 |
height hcc | #6 |
central obesity height | #14 |
chb bmi | #30 |
obesity hcc development | #37 |
hcc central | #44 |
rdw clinical | #45 |
evaluated waist | #48 |
patients hbv rna | #54 |
patients central obesity | #57 |
chb antiviral therapy | #63 |
male albumin | #66 |
platelets amap | #67 |
donafenib | #68 |
foxp3 degradation | #69 |
amap risk | #71 |
amap risk score | #80 |
chinese society hepatology | #91 |
hbv dna rna | #96 |
relapse hbv | #96 |
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Key People For Chronic Hepatitis
Junqi Niu:Expert Impact
Concepts for whichJunqi Niuhas direct influence:Chronic hepatitis, Hbv dna, Central obesity, Hepatocellular carcinoma, Primary liver cancer, Chronic hepatitis patients, Antiviral therapy, Hepatocellular carcinoma hcc.
Junqi Niu:KOL impact
Concepts related to the work of other authors for whichfor which Junqi Niu has influence:Chronic hepatitis, Hbv rna, Hepatocellular carcinoma, Amap score, Liver fibrosis, Hbsag loss, Hcc patients.
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