Prominent publications by John Walter Kusek

KOL Index score: 19054

BACKGROUND: Little is known regarding chronic kidney disease (CKD) in Hispanics. We compared baseline characteristics of Hispanic participants in the Chronic Renal Insufficiency Cohort (CRIC) and Hispanic-CRIC (H-CRIC) Studies with non-Hispanic CRIC participants.

STUDY DESIGN: Cross-sectional analysis.

SETTING & PARTICIPANTS: Participants were aged 21-74 years with CKD using age-based estimated glomerular filtration rate (eGFR) at enrollment into the CRIC/H-CRIC Studies. H-CRIC included ...

Also Ranks for: Cric Studies |  blood pressure |  hispanics ckd |  chronic renal |  insufficiency cohort
KOL Index score: 18175

BACKGROUND: Among patients in the United States with chronic kidney disease, black patients are at increased risk for end-stage renal disease, as compared with white patients.

METHODS: In two studies, we examined the effects of variants in the gene encoding apolipoprotein L1 (APOL1) on the progression of chronic kidney disease. In the African American Study of Kidney Disease and Hypertension (AASK), we evaluated 693 black patients with chronic kidney disease attributed to hypertension. ...

Also Ranks for: Chronic Kidney Disease |  apol1 risk variants |  black patients |  cric study |  renal risk
KOL Index score: 18135

BACKGROUND: Serum cystatin C was proposed as a potential replacement for serum creatinine in glomerular filtration rate (GFR) estimation. We report the development and evaluation of GFR-estimating equations using serum cystatin C alone and serum cystatin C, serum creatinine, or both with demographic variables.

STUDY DESIGN: Test of diagnostic accuracy.

SETTING & PARTICIPANTS: Participants screened for 3 chronic kidney disease (CKD) studies in the United States (n = 2,980) and a clinical ...

Also Ranks for: Serum Cystatin |  sex race |  new equations |  measured gfr mgfr |  estimating gfr
KOL Index score: 18076

BACKGROUND: Identification of persons with chronic kidney disease (CKD) who are at highest risk to progress to end-stage renal disease (ESRD) is necessary to reduce the burden of kidney failure. The relative utility of traditional markers of kidney function, including estimated glomerular filtration rate (eGFR) and serum creatinine level, and emerging markers of kidney function, including cystatin C and beta-trace protein (BTP) levels, to predict ESRD and mortality has yet to be ...

Also Ranks for: Serum Creatinine |  measured gfr |  african americans |  esrd mortality |  kidney function
KOL Index score: 17877

BACKGROUND: Benign prostatic hyperplasia is commonly treated with alpha-adrenergic-receptor antagonists (alpha-blockers) or 5alpha-reductase inhibitors. The long-term effect of these drugs, singly or combined, on the risk of clinical progression is unknown.

METHODS: We conducted a long-term, double-blind trial (mean follow-up, 4.5 years) involving 3047 men to compare the effects of placebo, doxazosin, finasteride, and combination therapy on measures of the clinical progression of benign ...

Also Ranks for: Combination Therapy |  clinical progression |  benign prostatic hyperplasia |  placebo doxazosin |  finasteride humans
KOL Index score: 17644

PURPOSE: We compared the prevalence, level of bother and effect on daily activities of urinary incontinence among women with type 1 diabetes enrolled in the Epidemiology of Diabetes Interventions and Complications study to a population based sample of women with normal glucose.

MATERIALS AND METHODS: We performed a cross-sectional analysis of women with type 1 diabetes and normal glucose tolerance using 2 study populations. The Diabetes Control and Complications Trial cohort followup, ...

Also Ranks for: Urinary Incontinence |  type 1 diabetes |  adult cross |  interventions complications |  aged prevalence
KOL Index score: 17430

CONTEXT: The prevalence and incidence of kidney failure treated by dialysis and transplantation in the United States have increased from 1988 to 2004. Whether there have been changes in the prevalence of earlier stages of chronic kidney disease (CKD) during this period is uncertain.

OBJECTIVE: To update the estimated prevalence of CKD in the United States.

DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional analysis of the most recent National Health and Nutrition Examination Surveys ...

Also Ranks for: United States |  prevalence ckd |  chronic kidney disease |  stage 95 |  gfr serum creatinine
KOL Index score: 16636

BACKGROUND: Estimates of glomerular filtration rate (GFR) that are based on serum creatinine are routinely used; however, they are imprecise, potentially leading to the overdiagnosis of chronic kidney disease. Cystatin C is an alternative filtration marker for estimating GFR.

METHODS: Using cross-sectional analyses, we developed estimating equations based on cystatin C alone and in combination with creatinine in diverse populations totaling 5352 participants from 13 studies. These ...

Also Ranks for: Minute 173 |  serum creatinine |  glomerular filtration rate |  combined equation |  gfr cystatin
KOL Index score: 16452

BACKGROUND: β-Trace protein (BTP) and β2-microglobulin (B2M) are novel glomerular filtration markers that have stronger associations with adverse outcomes than creatinine. Comparisons of BTP and B2M to creatinine and cystatin C are limited by the absence of rigorously developed glomerular filtration rate (GFR) estimating equations for the novel markers.

STUDY DESIGN: Study of diagnostic test accuracy.

SETTING & PARTICIPANTS: Pooled database of 3 populations with chronic kidney disease ...

Also Ranks for: Creatinine Cystatin |  btp b2m |  gfr estimation |  sex race |  chronic reproducibility
KOL Index score: 16340

Patients with advanced renal disease randomized to the very low-protein diet group in the Modification of Diet in Renal Disease (MDRD) Study had a marginally (P = 0.066) slower mean glomerular filtration rate (GFR) decline compared with patients randomized to the low-protein diet group. The objective of these secondary analyses was to determine the relationship between achieved, in addition to prescribed, dietary protein intake and the progression of advanced renal disease. A randomized ...

Also Ranks for: Renal Disease |  dietary protein |  gfr decline |  mdrd study |  modification diet
KOL Index score: 15779

CONTEXT: The arteriovenous fistula is the preferred type of vascular access for hemodialysis because of lower thrombosis and infection rates and lower health care expenditures compared with synthetic grafts or central venous catheters. Early failure of fistulas due to thrombosis or inadequate maturation is a barrier to increasing the prevalence of fistulas among patients treated with hemodialysis. Small, inconclusive trials have suggested that antiplatelet agents may reduce thrombosis of ...

Also Ranks for: Early Failure |  arteriovenous fistulas |  fistula thrombosis |  randomized controlled trial |  6 weeks
KOL Index score: 15380

BACKGROUND: Previous studies of lower urinary tract symptoms (LUTS) have focused on men, with few studies including minority populations. The Boston Area Community Health (BACH) Survey is designed to study the prevalence and impact of LUTS among both men and women in a racially, ethnically, and socioeconomically diverse population.

METHODS: The BACH Survey used a stratified 2-stage cluster design to randomly sample 5506 adults aged 30 to 79 from the city of Boston, Mass (2301 men, 3205 ...

Also Ranks for: Prevalence Luts |  quality life |  urinary symptoms |  boston area |  ethnically diverse
KOL Index score: 15003

CONTEXT: A high level of the phosphate-regulating hormone fibroblast growth factor 23 (FGF-23) is associated with mortality in patients with end-stage renal disease, but little is known about its relationship with adverse outcomes in the much larger population of patients with earlier stages of chronic kidney disease.

OBJECTIVE: To evaluate FGF-23 as a risk factor for adverse outcomes in patients with chronic kidney disease.

DESIGN, SETTING, AND PARTICIPANTS: A prospective study of 3879 ...

Also Ranks for: Chronic Kidney Disease |  stage renal |  fgf23 risk factor |  fibroblast growth |  adverse outcomes
KOL Index score: 14754

African Americans (blacks) have a disproportionately high incidence of end-stage renal disease due to hypertension. The Modification of Diet in Renal Disease (MDRD) Study found that strict blood pressure control slowed the decline in glomerular filtration rate (GFR) only in the subgroup of patients with proteinuria. The present report compares the effects of blood pressure control in black and white MDRD Study participants. Fifty-three black and 495 white participants with baseline GFRs ...

Also Ranks for: Renal Disease |  blood pressure control |  blacks whites |  gfr decline |  continental ancestry
KOL Index score: 14594

BACKGROUND: Restricting protein intake and controlling hypertension delay the progression of renal disease in animals. We tested these interventions in 840 patients with various chronic renal diseases.

METHODS: In study 1, 585 patients with glomerular filtration rates of 25 to 55 ml per minute per 1.73 m2 of body-surface area were randomly assigned to a usual-protein diet or a low-protein diet (1.3 or 0.58 g of protein per kilogram of body weight per day) and to a usual- or a ...

Also Ranks for: Renal Disease |  low protein |  minute 173 |  glomerular filtration rate |  day usual

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John Walter Kusek:Expert Impact

Concepts for whichJohn Walter Kusekhas direct influence:Chronic kidney disease,  Kidney disease,  Urinary incontinence,  Interstitial cystitis,  African americans,  Chronic kidney,  Chronic prostatitis,  Cardiovascular disease.

John Walter Kusek:KOL impact

Concepts related to the work of other authors for whichfor which John Walter Kusek has influence:Chronic kidney disease,  Renal function,  Blood pressure,  Heart failure,  Urinary incontinence,  Type 2 diabetes,  Glomerular filtration.



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Center for Clinical Epidemiology and Biostatistics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania | Division of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases,